| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick W Cullinane, Sarah Wrigley, Jacy Bezerra Parmera, Fernanda Valerio, Thomas O Millner, Karen Shaw, Eduardo De Pablo-Fernandez, Thomas T Warner, Zane Jaunmuktan. Pathology of neurodegenerative disease for the general neurologist. Practical neurology. 2023-12-21. PMID:38124186. |
this review aims to elucidate the hallmark pathological features of neurodegenerative diseases commonly seen in general neurology clinics, such as alzheimer's disease and parkinson's disease; rare but well-known diseases, including progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy and more recently described entities such as chronic traumatic encephalopathy and age-related tau astrogliopathy. |
2023-12-21 |
2023-12-23 |
Not clear |
| Anna Stockbauer, Leonie Beyer, Maria Huber, Annika Kreuzer, Carla Palleis, Sabrina Katzdobler, Boris-Stephan Rauchmann, Silvia Morbelli, Andrea Chincarini, Rose Bruffaerts, Rik Vandenberghe, Milica G Kramberger, Maja Trost, Valentina Garibotto, Nicolas Nicastro, Aurélien Lathuilière, Afina W Lemstra, Bart N M van Berckel, Andrea Pilotto, Alessandro Padovani, Miguel A Ochoa-Figueroa, Anette Davidsson, Valle Camacho, Enrico Peira, Matteo Bauckneht, Matteo Pardini, Gianmario Sambuceti, Dag Aarsland, Flavio Nobili, Mattes Gross, Jonathan Vöglein, Robert Perneczky, Oliver Pogarell, Katharina Buerger, Nicolai Franzmeier, Adrian Danek, Johannes Levin, Günter U Höglinger, Peter Bartenstein, Paul Cumming, Axel Rominger, Matthias Brende. Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission. European journal of nuclear medicine and molecular imaging. 2023-11-16. PMID:37971501. |
the goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with lewy bodies (dlb) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of fdg-pet for discrimination of patients with early dlb from other neurodegenerative disorders (alzheimer's disease, parkinson's disease, multiple system atrophy) at individual patient level via principal component analysis (pca). |
2023-11-16 |
2023-11-20 |
human |
| Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Che. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-22. PMID:37735487. |
here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including alzheimer's disease, parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia with lewy bodies and huntington's disease. |
2023-09-22 |
2023-10-07 |
Not clear |
| Noah J Graves, Yann Gambin, Emma Siereck. α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569510. |
in addition to pd, αsyn pathological aggregation is also detected in atypical parkinsonism, including dementia with lewy bodies (dlb), multiple system atrophy (msa), as well as neurodegeneration with brain iron accumulation, some cases of traumatic brain injuries, and variants of alzheimer's disease. |
2023-08-12 |
2023-08-16 |
Not clear |
| Katherine Fodder, Rohan de Silva, Thomas T Warner, Conceição Bettencour. The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-06-29. PMID:37386505. |
however, a central feature consists of regional aggregation of proteins in the brain, such as the accumulation of β-amyloid plaques in alzheimer's disease (ad), inclusions of hyperphosphorylated microtubule-binding tau in ad and other tauopathies, or inclusions containing α-synuclein in parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2023-06-29 |
2023-08-14 |
Not clear |
| Hao Chen, Yajie Li, Jingwen Gao, Qi Cheng, Lei Liu, Rong Ca. Activation of Pgk1 Results in Reduced Protein Aggregation in Diverse Neurodegenerative Conditions. Molecular neurobiology. 2023-05-30. PMID:37249790. |
through in vivo studies, we examined neuron-specific overexpression of tau in drosophila, mouse models of app/ps1 alzheimer's disease (ad), and a rat model of multiple system atrophy (msa) via the viral expression of α-synuclein in the striatum. |
2023-05-30 |
2023-08-14 |
mouse |
| Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo, Yuming X. Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases. Translational neurodegeneration. vol 12. issue 1. 2023-03-16. PMID:36922862. |
similarly, olfactory dysfunction precedes the onset of typical clinical manifestations by several years in prion diseases and other neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, dementia with lewy bodies, and multiple system atrophy. |
2023-03-16 |
2023-08-14 |
Not clear |
| YuHong Fu, Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford, Ping Wu, Nicolas Dzamko, Glenda M Halliday, Woojin Scott Ki. Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376990. |
we were therefore interested in the manifestation of lipid peroxidation in synucleinopathies, a group of neurodegenerative diseases characterized by the central pathology of α-synuclein aggregates, including parkinson's disease, multiple system atrophy, dementia with lewy bodies and alzheimer's disease with lewy bodies. |
2022-11-15 |
2023-08-14 |
Not clear |
| Grace M Lloyd, Zachary A Sorrentino, Stephan Quintin, Kimberly-Marie M Gorion, Brach M Bell, Giavanna Paterno, Brooke Long, Stefan Prokop, Benoit I Giasso. Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice. Acta neuropathologica. 2022-04-30. PMID:35488930. |
accumulation of αsyn inclusions is a key feature of dementia with lewy bodies (dlb) and multiple system atrophy (msa), and are found as additional pathology in alzheimer's disease (ad) such as ad with amygdala predominant lewy bodies (ad/alb). |
2022-04-30 |
2023-08-13 |
mouse |
| Alice Drobny, Susy Prieto Huarcaya, Jan Dobert, Annika Kluge, Josina Bunk, Theresia Schlothauer, Friederike Zunk. The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches. Biochimica et biophysica acta. Molecular cell research. 2022-02-26. PMID:35217144. |
particularly, alterations in lysosomal cathepsins ctsd, ctsb and ctsl can contribute to the pathogenesis of neurodegenerative diseases as seen for neuronal ceroid lipofuscinosis, synucleinopathies (parkinson's disease, dementia with lewy body and multiple system atrophy) as well as alzheimer's and huntington disease. |
2022-02-26 |
2023-08-13 |
Not clear |
| Sushma, Amal Chandra Monda. Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes. CNS & neurological disorders drug targets. 2021-12-29. PMID:34963438. |
these proteins are amyloid-β peptide, tau, α-synuclein, and mhtt, which cause alzheimer's disease, frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, parkinson's disease, multiple system atrophy, dementia with lewy-body and huntington's disease. |
2021-12-29 |
2023-08-13 |
Not clear |
| Surabhi Mehra, Laxmikant Gadhe, Riya Bera, Ajay Singh Sawner, Samir K Maj. Structural and Functional Insights into α-Synuclein Fibril Polymorphism. Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680054. |
abnormal accumulation of aggregated α-synuclein (α-syn) is seen in a variety of neurodegenerative diseases, including parkinson's disease (pd), multiple system atrophy (msa), dementia with lewy body (dlb), parkinson's disease dementia (pdd), and even subsets of alzheimer's disease (ad) showing lewy-body-like pathology. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xiu-Rong Huang, Bei-Sha Tang, Peng Jin, Ji-Feng Gu. The Phenotypes and Mechanisms of NOTCH2NLC-Related GGC Repeat Expansion Disorders: a Comprehensive Review. Molecular neurobiology. 2021-10-31. PMID:34718964. |
increasing studies were conducted to verify the relationship between notch2nlc gene and many neurological diseases, such as neuronal intranuclear inclusion disease, essential tremor, multiple system atrophy, parkinson's disease, alzheimer's disease, and even oculopharyngodistal myopathy. |
2021-10-31 |
2023-08-13 |
Not clear |
| Takayuki Katayama, Jun Sawada, Kae Takahashi, Osamu Yahara, Naoyuki Haseb. Meta-analysis of cerebrospinal fluid neuron-specific enolase levels in Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-14. PMID:34610837. |
this study examined the usefulness of cerebrospinal fluid (csf) neuron-specific enolase (nse) levels as a candidate biomarker of neurodegeneration in alzheimer's disease (ad), parkinson's disease (pd), pd with dementia (pdd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2021-10-14 |
2023-08-13 |
Not clear |
| Christos Proukaki. Somatic mutations in neurodegeneration: An update. Neurobiology of disease. vol 144. 2021-09-24. PMID:32712267. |
in common sporadic neurodegenerative disorders, relevant mutations have been reported in synucleinopathies, comprising somatic gains of snca in parkinson's disease and multiple system atrophy, and in alzheimer's disease, where a novel recombination mechanism leading to somatic variants of app, as well as an excess of somatic snvs affecting tau phosphorylation, have been reported. |
2021-09-24 |
2023-08-13 |
human |
| Lanxiao Cao, Yaping Yan, Guohua Zha. NOTCH2NLC-related repeat expansion disorders: an expanding group of neurodegenerative disorders. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 10. 2021-09-17. PMID:34333668. |
since then, the number of reported cases with notch2nlc ggc repeat expansion in asian and european populations has increased rapidly, indicating that the expanded mutation not only leads to the onset or progression of the niid, but also may play an important role in multiple progressive neurological disorders, including parkinson's disease, essential tremor, multiple system atrophy, alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, leukoencephalopathy, and oculopharyngodistal myopathy type 3. |
2021-09-17 |
2023-08-13 |
Not clear |
| Ethan W Hass, Zachary A Sorrentino, Yuxing Xia, Grace M Lloyd, John Q Trojanowski, Stefan Prokop, Benoit I Giasso. Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies. Acta neuropathologica communications. vol 9. issue 1. 2021-09-10. PMID:34454615. |
synucleinopathies, including parkinson's disease (pd), lewy body dementia (lbd), alzheimer's disease with amygdala restricted lewy bodies (ad/alb), and multiple system atrophy (msa) comprise a spectrum of neurodegenerative disorders characterized by the presence of distinct pathological α-synuclein (αsyn) inclusions. |
2021-09-10 |
2023-08-13 |
Not clear |
| Matteo Manca, Allison Krau. Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays. Biomolecules. vol 10. issue 9. 2021-09-07. PMID:32854212. |
to date, rt-quic assays have been developed for the detection of protein seeds related to known prion diseases of mammals, the αsyn aggregates of parkinson's disease, dementia with lewy bodies, and multiple system atrophy, and the tau aggregates of alzheimer's disease, chronic traumatic encephalopathy, and other tauopathies including progressive supranuclear palsy. |
2021-09-07 |
2023-08-13 |
human |
| Chloe A Stewart, Elizabeth C Finge. The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration. Handbook of clinical neurology. vol 180. 2021-07-28. PMID:34225924. |
this chapter reviews the involvement of the son and pvn, the hypothalamic-pituitary axes, and the peptide hormones produced in both nuclei in healthy aging and in neurodegeneration, with a focus on alzheimer's disease (ad), frontotemporal dementia (ftd), amyotrophic lateral sclerosis, progressive supranuclear palsy, parkinson's disease (pd), dementia with lewy bodies (dlb), multiple system atrophy, and huntington's disease. |
2021-07-28 |
2023-08-13 |
Not clear |
| Saranna Fanning, Dennis Selkoe, Ulf Dettme. Parkinson's disease: proteinopathy or lipidopathy? NPJ Parkinson's disease. vol 6. 2021-06-04. PMID:31909184. |
the 14 kda protein α-synuclein (αs) is strongly associated with parkinson's disease (pd), dementia with lewy bodies (dlb), other synucleinopathies such as multiple system atrophy, and even certain forms of alzheimer's disease. |
2021-06-04 |
2023-08-13 |
Not clear |