| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Anekson Widjaya, Shin-Da Lee, Wei-Chung Cheng, Bor-Tsang W. Effects of Exercise Training on Immune-Related Genes and Pathways in the Cortex of Animal Models of Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. 2024-04-05. PMID:38578886. |
alzheimer's disease (ad) is a chronic neurodegenerative disease that affects the immune system due to the accumulation of amyloid-β (aβ) and tau associated molecular pathology and other pathogenic processes. |
2024-04-05 |
2024-04-10 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
neurodegenerative diseases, like alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. |
2024-03-30 |
2024-04-02 |
Not clear |
| Laia Ramos-Casademont, Daniel Martin-Jimenez, Brenda Villarreal-Garza, Serafín Sánchez-Gomez, María Amparo Callejon-Lebli. The Value of Subjective Olfactometry as a Predictive Biomarker of Neurodegenerative Diseases: A Systematic Review. Life (Basel, Switzerland). vol 14. issue 3. 2024-03-28. PMID:38541625. |
olfactory disorders (ods) are reported to be an early non-motor sign before the onset of deterioration in neurodegenerative diseases (nds) such as alzheimer's and parkinson's. |
2024-03-28 |
2024-03-30 |
Not clear |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
alzheimer's disease (ad) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (aβ) aggregates and intraneuronal hyperphosphorylated tau. |
2024-03-22 |
2024-03-24 |
mouse |
| Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. |
the microtubule-associated protein, tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| Yanxian Li. Preparation of Tau Condensates by Liquid-Liquid Phase Separation to Study Tau Amyloid Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512667. |
amyloid aggregation of tau is a hallmark of alzheimer's disease and other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
microtubule-associated protein tau is an intracellular protein that self-aggregates into neurofibrillary tangles in alzheimer's disease and many other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Fangjia Yang, Paula Beltran-Lobo, Katherine Sung, Caoimhe Goldrick, Cara L Croft, Agnes Nishimura, Erin Hedges, Farah Mahiddine, Claire Troakes, Todd E Golde, Beatriz G Perez-Nievas, Diane P Hanger, Wendy Noble, Maria Jimenez-Sanche. Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Science advances. vol 10. issue 12. 2024-03-20. PMID:38507480. |
molecular chaperones are protective in neurodegenerative diseases by preventing protein misfolding and aggregation, such as extracellular amyloid plaques and intracellular tau neurofibrillary tangles in alzheimer's disease (ad). |
2024-03-20 |
2024-03-23 |
human |
| Shlok Bodke, Nachiket Joshi, Rajasekhar Reddy Alavala, Divya Suare. In silico exploration of CB2 receptor agonist in the management of neuroinflammatory conditions by pharmacophore modeling. Computational biology and chemistry. vol 110. 2024-03-20. PMID:38507844. |
endocannabinoid system plays a pivotal role in controlling neuroinflammation, and modulating this system may not only aid in managing symptoms of neurodegenerative diseases such as alzheimer's disease, parkinson's disease, multiple sclerosis, epilepsy, central and peripheral neuropathic pain, but also, have the potential to target these diseases at an early-stage. |
2024-03-20 |
2024-03-23 |
Not clear |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Kevin Lee, Meem Mahmud, Darby Marx, Weiye Yasen, Omna Sharma, Jana Ivanidze, Elcin Zan, Liangdong Zhou, Yi Li, Mony J de Leon, Anna S Nordvig, Gloria C Chian. Clinical Arterial Spin-Labeling MR Imaging to Screen for Typical and Atypical Neurodegenerative Disease in the New Era of Alzheimer Treatment. AJNR. American journal of neuroradiology. 2024-03-14. PMID:38485200. |
clinical arterial spin-labeling mr imaging to screen for typical and atypical neurodegenerative disease in the new era of alzheimer treatment. |
2024-03-14 |
2024-03-17 |
Not clear |
| Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Le. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta neuropathologica. vol 147. issue 1. 2024-03-13. PMID:38472475. |
inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include alzheimer's disease (ad). |
2024-03-13 |
2024-03-15 |
mouse |
| Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kub. Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model Frontiers in aging neuroscience. vol 16. 2024-03-12. PMID:38469162. |
effects of early tooth loss on chronic stress and progression of neuropathogenesis of alzheimer's disease in adult alzheimer's model alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. |
2024-03-12 |
2024-03-14 |
Not clear |
| Kefu Liu, Ailikemu Aierken, Mengyao Liu, Nazakat Parhat, Wei Kong, Xingyu Yin, Gang Liu, Ding Yu, Jie Hong, Junjun Ni, Zhenzhen Quan, Xiaoyun Liu, Simei Ji, Jian Mao, Weijun Peng, Chao Chen, Yan Yan, Hong Qin. The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease. iScience. vol 27. issue 3. 2024-03-08. PMID:38455972. |
alzheimer's disease (ad) is the most common neurodegenerative disease often associated with olfactory dysfunction. |
2024-03-08 |
2024-03-10 |
mouse |
| Ruihua Liu, Linli Guo, Yanan Zhao, Dan Wu, Jiasi Yu, Ping Li. Study on multi-target effects of the novel HDAC6 inhibitor W5 on Aβ/Cu Brain research. 2024-03-05. PMID:38442843. |
study on multi-target effects of the novel hdac6 inhibitor w5 on aβ/cu histone deacetylase 6 (hdac6) is a key therapeutic target in neurodegenerative diseases such as alzheimer's disease (ad), which has been demonstrated to play an essential role in memory function and microtubule-associated tau physiology. |
2024-03-05 |
2024-03-08 |
rat |
| Tetsuro Tago, Muneyuki Sakata, Masakatsu Kanazawa, Shigeyuki Yamamoto, Kenji Ishii, Jun Toyohar. Preclinical validation of a novel brain-penetrant PET ligand for visualization of histone deacetylase 6: a potential imaging target for neurodegenerative diseases. European journal of nuclear medicine and molecular imaging. 2024-03-05. PMID:38441662. |
histone deacetylase 6 (hdac6) has emerged as a therapeutic target for neurodegenerative diseases such as alzheimer's disease. |
2024-03-05 |
2024-03-07 |
Not clear |
| Jessica A Bernar. Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging. Cerebellum (London, England). 2024-03-04. PMID:38438826. |
given the role of both regions in cognition and aging, and emerging evidence indicating that the cerebellum is impacted in age-related neurodegenerative disease such as alzheimer's, i propose that further attention to this circuit is warranted. |
2024-03-04 |
2024-03-07 |
human |
| Kristen H Schuster, Annie J Zalon, Danielle M DiFranco, Alexandra F Putka, Nicholas R Stec, Sabrina I Jarrah, Arsal Naeem, Zaid Haque, Hanrui Zhang, Yuanfang Guan, Hayley S McLoughli. ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-03-02. PMID:38429929. |
evidence of disease-associated oligodendrocyte signatures has also been reported in other neurodegenerative diseases, including alzheimer's disease, amyotrophic lateral sclerosis, parkinson's disease, and huntington's disease. |
2024-03-02 |
2024-03-04 |
mouse |