| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa Lancini, Lena Haag, Franziska Bartl, Maren Rühling, Nicholas J Ashton, Henrik Zetterberg, Emrah Düzel, Dorothea Hämmerer, Matthew J Bett. Cerebrospinal fluid and positron-emission tomography biomarkers for noradrenergic dysfunction in neurodegenerative diseases: a systematic review and meta-analysis. Brain communications. vol 5. issue 3. 2023-05-08. PMID:37151227. |
the noradrenergic system shows pathological modifications in aging and neurodegenerative diseases and undergoes substantial neuronal loss in alzheimer's disease and parkinson's disease. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
tau seeds occur before earliest alzheimer's changes and are prevalent across neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
this study suggests 3r/4r tau seeds are widespread even prior to the earliest stages of alzheimer's disease changes, including in normal, and even young individuals, with prevalence across multiple neurodegenerative diseases to further define disease subtypes. |
2023-05-08 |
2023-08-14 |
Not clear |
| Yongheum Choi, Chang Su Jeon, Kwang Bok Kim, Hyun-Jong Kim, Sung Hyun Pyun, Young Min Par. Quantitative detection of dopamine in human serum with surface-enhanced Raman scattering (SERS) of constrained vibrational mode. Talanta. vol 260. 2023-05-05. PMID:37146455. |
dopamine (da) is a crucial neurotransmitter involved in the hormonal, nervous, and vascular systems being considered as an index to diagnose neurodegenerative diseases, including parkinson's and alzheimer's disease. |
2023-05-05 |
2023-08-14 |
human |
| Anchalee Prasansuklab, Suporn Sukjamnong, Atsadang Theerasri, Valerie W Hu, Tewarit Sarachana, Tewin Tencomna. Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer's drugs. Scientific reports. vol 13. issue 1. 2023-05-04. PMID:37142620. |
glutamate-induced neurotoxicity in the ht22 mouse hippocampal neuronal cell line has been recognized as a valuable cell model for the study of neurotoxicity associated with neurodegenerative diseases including alzheimer's disease (ad). |
2023-05-04 |
2023-08-14 |
mouse |
| Jiaying Lu, Zhengwei Zhang, Ping Wu, Xiaoniu Liang, Huiwei Zhang, Jimin Hong, Christoph Clement, Tzu-Chen Yen, Saineng Ding, Min Wang, Zhenxu Xiao, Axel Rominger, Kuangyu Shi, Yihui Guan, Chuantao Zuo, Qianhua Zha. The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer's disease. NeuroImage. Clinical. vol 38. 2023-05-03. PMID:37137254. |
left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it's less discussed in typical alzheimer's disease (ad). |
2023-05-03 |
2023-08-14 |
Not clear |
| Wilma Großman. Listening with an Ageing Brain - a Cognitive Challenge. Laryngo- rhino- otologie. vol 102. issue S 01. 2023-05-02. PMID:37130528. |
this review provides a comprehensive overview on the effects of healthy and pathological aging on auditory as well as cognitive functioning on speech perception and comprehension, as well as specific auditory deficits in the 2 most common neurodegenerative diseases in old age: alzheimer disease and parkinson syndrome. |
2023-05-02 |
2023-08-14 |
Not clear |
| Tingting Zhang, Tuancheng Feng, Kenton Wu, Jennifer Guo, Alissa L Nana, Guang Yang, William W Seeley, Fenghua H. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination. Acta neuropathologica. 2023-04-30. PMID:37120788. |
polymorphisms in the grn gene have also been associated with several other neurodegenerative diseases, including alzheimer's disease (ad), and parkinson's disease (pd). |
2023-04-30 |
2023-08-14 |
mouse |
| Si-Jia Peng, Ya Feng, Xuan Li, Xi-Xi Wang, Yu Wang, Bu-Tian Zhou, Ye Liu, Te Liu, Yun-Cheng W. Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway. International immunopharmacology. vol 119. 2023-04-30. PMID:37121113. |
neuroinflammation plays a pivotal role in neurodegenerative diseases, including parkinson's disease, alzheimer's disease, amyotrophic lateral sclerosis and stroke, and is accompanied by excessive release of inflammatory cytokines and mediators by activated microglia. |
2023-04-30 |
2023-08-14 |
mouse |
| Anna Pisani, Fabiola Paciello, Valeria Del Vecchio, Rita Malesci, Eugenio De Corso, Elena Cantone, Anna Rita Feton. The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration. Journal of personalized medicine. vol 13. issue 4. 2023-04-28. PMID:37109038. |
several clinical and experimental research studies showed alterations in bdnf levels in neurodegenerative diseases affecting the central and peripheral nervous system, suggesting that bdnf can be a promising biomarker in most neurodegenerative conditions, including alzheimer's disease, shearing loss, or olfactory impairment. |
2023-04-28 |
2023-08-14 |
Not clear |
| Kumarappan Chidambara. Identification of BACE-1 Inhibitors against Alzheimer's Disease through E-Pharmacophore-Based Virtual Screening and Molecular Dynamics Simulation Studies: An Insilco Approach. Life (Basel, Switzerland). vol 13. issue 4. 2023-04-28. PMID:37109481. |
alzheimer is a severe memory and cognitive impairment neurodegenerative disease that is the most common cause of dementia worldwide and characterized by the pathological accumulation of tau protein and amyloid-beta peptides. |
2023-04-28 |
2023-08-14 |
Not clear |
| Igor A Schepetkin, Zhangeldy S Nurmaganbetov, Serik D Fazylov, Oralgazy A Nurkenov, Andrei I Khlebnikov, Tulegen M Seilkhanov, Anarkul S Kishkentaeva, Elvira E Shults, Mark T Quin. Inhibition of Acetylcholinesterase by Novel Lupinine Derivatives. Molecules (Basel, Switzerland). vol 28. issue 8. 2023-04-28. PMID:37110594. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment due in part to a severe loss of cholinergic neurons in specific brain areas. |
2023-04-28 |
2023-08-14 |
Not clear |
| Chuqiao Pan, Shijie Mao, Zeping Xiong, Zhao Chen, Ning X. Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease. European journal of pharmacology. 2023-04-28. PMID:37116563. |
the dysfunction of gdh may induce the occurrence of many neurodegenerative diseases, such as parkinson's disease, epilepsy, alzheimer's disease, schizophrenia, and frontotemporal dementia. |
2023-04-28 |
2023-08-14 |
Not clear |
| Nadia El Mammeri, Olivia Gampp, Pu Duan, Mei Hon. Membrane-induced tau amyloid fibrils. Communications biology. vol 6. issue 1. 2023-04-28. PMID:37117483. |
the intrinsically disordered protein tau aggregates into β-sheet amyloid fibrils that spread in human brains afflicted with alzheimer's disease and other neurodegenerative diseases. |
2023-04-28 |
2023-08-14 |
human |
| Mengjin Dong, Long Xie, Sandhitsu R Das, Jiancong Wang, Laura E M Wisse, Robin deFlores, David A Wolk, Paul A Yushkevic. Regional Deep Atrophy: a Self-Supervised Learning Method to Automatically Identify Regions Associated With Alzheimer's Disease Progression From Longitudinal MRI. ArXiv. 2023-04-24. PMID:37090239. |
longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as alzheimer's disease (ad). |
2023-04-24 |
2023-08-14 |
Not clear |
| Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefe. Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation. Neurobiology of disease. 2023-04-22. PMID:37086756. |
intraneuronal aggregates of the microtubule binding protein tau are a hallmark of different neurodegenerative diseases including alzheimer's disease (ad). |
2023-04-22 |
2023-08-14 |
mouse |
| Liting Han, Hanni Jiang, Xufeng Yao, Zhe Ren, Zhongsen Qu, Tonggang Yu, Shichang Luo, Tao W. Revealing the correlations between brain cortical characteristics and susceptibility genes for Alzheimer disease: a cross-sectional study. Quantitative imaging in medicine and surgery. vol 13. issue 4. 2023-04-17. PMID:37064375. |
alzheimer disease (ad) is a progressive neurodegenerative disease closely related to genes and characterized by the atrophy of the cerebral cortex. |
2023-04-17 |
2023-08-14 |
human |
| Vanessa Hall, Katja Maria Sahlgren Bendtse. Getting closer to modeling the gut-brain axis using induced pluripotent stem cells. Frontiers in cell and developmental biology. vol 11. 2023-04-17. PMID:37065853. |
the ability to mimic complex physiological functions of the gba is needed in basic mechanistic research as well as disease research of psychiatric, neurodevelopmental, functional, and neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. |
2023-04-17 |
2023-08-14 |
Not clear |
| Ramiz Demir, Remziye Devec. In silico analysis of the possible crosstalk between O-linked β-GlcNAcylation and phosphorylation sites of Disabled 1 adaptor protein in vertebrates. Amino acids. 2023-04-17. PMID:37067567. |
understanding these modifications might change the point of view of the dab1 signaling process and treatment for pathological conditions in neurodegenerative diseases such as alzheimer's disease. |
2023-04-17 |
2023-08-14 |
human |
| Sydney Sunna, Christine A Bowen, Christina C Ramelow, Juliet V Santiago, Prateek Kumar, Srikant Rangaraj. Advances in proteomic phenotyping of microglia in neurodegeneration. Proteomics. 2023-04-15. PMID:37060300. |
in this review, we discuss molecular insights gained from transcriptomic studies of microglia in the context of alzheimer's disease as a prototypic neurodegenerative disease, and highlight existing and emerging approaches for proteomic profiling of microglia derived from in vivo model systems and human brain. |
2023-04-15 |
2023-08-14 |
human |