| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren H Fairley, Imane Lejri, Amandine Grimm, Anne Ecker. Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982371. |
abnormal tau build-up is a hallmark of alzheimer's disease (ad) and more than 20 other serious neurodegenerative diseases. |
2023-03-29 |
2023-08-14 |
human |
| Prechiel A Barredo, Mannix P Balana. Recent Advances in Molecular Dynamics Simulations of Tau Fibrils and Oligomers. Membranes. vol 13. issue 3. 2023-03-29. PMID:36984665. |
the study of tau protein aggregation and interactions with other molecules or solvents using molecular dynamics simulations (mds) is of interest to many researchers to propose new mechanism-based therapeutics for neurodegenerative diseases such as alzheimer's disease, pick's disease, chronic traumatic encephalopathy, and other tauopathies. |
2023-03-29 |
2023-08-14 |
Not clear |
| Christina Magdy Wadie, Radwa Hassan Ali, Abd El-Hamid A Mohamed, Jolly M W Labib, Abdel Rhman Sabaa, Hossam Eldin Ahmed Awad, Doaa Ahmed Abou-Bak. A comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl Canadian journal of physiology and pharmacology. 2023-03-29. PMID:36988119. |
a comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in alcl alzheimer's disease (ad) is a worldwide chronic progressive neurodegenerative disease. |
2023-03-29 |
2023-08-14 |
Not clear |
| Courtney M Kloske, Christopher J Barnum, Andre F Batista, Elizabeth M Bradshaw, Adam M Brickman, Guojun Bu, Jessica Dennison, Mary D Gearon, Alison M Goate, Christian Haass, Michael T Heneka, William T Hu, Lenique K L Huggins, Nahdia S Jones, Radosveta Koldamova, Cynthia A Lemere, Shane A Liddelow, Edoardo Marcora, Samuel E Marsh, Henrietta M Nielsen, Kellen K Petersen, Melissa Petersen, Stefanie D Piña-Escudero, Wei Qiao Qiu, Yakeel T Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia Tcw, Charlotte E Teunissen, Betty M Tijms, Rik van der Kant, Rebecca Wallings, Stacie C Weninger, Whitney Wharton, Donna M Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C Carrill. APOE and immunity: Research highlights. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-03-28. PMID:36975090. |
at the alzheimer's association's apoe and immunity virtual conference, held in october 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein e gene (apoe) and facets of immunity play in neurodegenerative diseases, including alzheimer's disease and other dementias. |
2023-03-28 |
2023-08-14 |
Not clear |
| Julie Novakova Martinkova, Maria Teresa Ferretti, Alberto Ferrari, Ondrej Lerch, Veronika Matuskova, Juraj Secnik, Jakub Hor. Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status. Frontiers in psychiatry. vol 14. 2023-03-27. PMID:36970283. |
choroid plexus (cp)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including alzheimer's disease. |
2023-03-27 |
2023-08-14 |
Not clear |
| Haruaki Sato, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Takeshi Ikeuchi, Yukiko Hori, Taisuke Tomit. Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion. Neuroscience research. 2023-03-26. PMID:36967088. |
extracellular tau has been highlighted in the pathogenesis of alzheimer disease (ad), which is the most common neurodegenerative disease. |
2023-03-26 |
2023-08-14 |
mouse |
| Yu-Qing Liu, Chu-Qiao Liang, Zhi-Wei Chen, Jun Hu, Jin-Jian Hu, Yun-Yi Luo, Yong-Xiang Chen, Yan-Mei L. 14-3-3ζ Participates in the Phase Separation of Phosphorylated and Glycated Tau and Modulates the Physiological and Pathological Functions of Tau. ACS chemical neuroscience. 2023-03-20. PMID:36939323. |
tau plays a major role in alzheimer's disease (ad) and several other neurodegenerative diseases. |
2023-03-20 |
2023-08-14 |
Not clear |
| Lucie Van Emmeni. Soyon Hong: My role is to empower. The Journal of experimental medicine. vol 220. issue 4. 2023-03-20. PMID:36939561. |
her lab is interested in investigating how multiple cell types work together to maintain brain function, and how these interactions are affected and altered in neurodegenerative disease states such as alzheimer's disease. |
2023-03-20 |
2023-08-14 |
Not clear |
| Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo, Yuming X. Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases. Translational neurodegeneration. vol 12. issue 1. 2023-03-16. PMID:36922862. |
similarly, olfactory dysfunction precedes the onset of typical clinical manifestations by several years in prion diseases and other neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, dementia with lewy bodies, and multiple system atrophy. |
2023-03-16 |
2023-08-14 |
Not clear |
| Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C Saido, Minako It. Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease. Inflammation and regeneration. vol 43. issue 1. 2023-03-16. PMID:36922861. |
alzheimer's disease (ad) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (aβ) aggregates and phosphorylated tau with aging. |
2023-03-16 |
2023-08-14 |
mouse |
| Alaa Alghanimy, Conor Martin, Lindsay Gallagher, William M Holme. The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PloS one. vol 18. issue 3. 2023-03-15. PMID:36920936. |
therefore, enhancing aqp4 function might protect against neurodegenerative diseases such as alzheimer's disease (ad), in which the accumulation of harmful proteins and solutes is a hallmark feature. |
2023-03-15 |
2023-08-14 |
rat |
| Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud François, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jocker. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. eLife. vol 12. 2023-03-14. PMID:36917493. |
aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and alzheimer's disease (ad). |
2023-03-14 |
2023-08-14 |
Not clear |
| Yusuf Tamam, Beran Yokuş, Cüneyt Tamam, Hande Yüceer, Selim Karahan, Bernan Em, Şerife Banu Tamam, Erdem Tüzü. The Effect of Lidocaine on the Experimental Model of Streptozotocin-Induced Alzheimer's Disease. Noro psikiyatri arsivi. vol 60. issue 1. 2023-03-13. PMID:36911558. |
alzheimer's disease (ad) is a neurodegenerative disease caused by the accumulation of amyloid plaques in the cerebral cortex and hippocampus. |
2023-03-13 |
2023-08-14 |
rat |
| Possemato Elena, La Barbera Livia, Nobili Annalisa, Krashia Paraskevi, D'Amelio Marcell. The role of dopamine in NLRP3 inflammasome inhibition: implications for neurodegenerative diseases. Ageing research reviews. 2023-03-09. PMID:36893920. |
the persistent and uncontrolled nlrp3 inflammasome activation has a leading role during the pathophysiology of neuroinflammation in age-related neurodegenerative diseases such as parkinson's (pd) and alzheimer's (ad). |
2023-03-09 |
2023-08-14 |
Not clear |
| Jinjian Wu, Yuqi Fang, Xin Tan, Shangyu Kang, Xiaomei Yue, Yawen Rao, Haoming Huang, Mingxia Liu, Shijun Qiu, Pew-Thian Ya. Detecting type 2 diabetes mellitus cognitive impairment using whole-brain functional connectivity. Scientific reports. vol 13. issue 1. 2023-03-09. PMID:36894561. |
resting-state functional magnetic resonance imaging (rs-fmri) is used to diagnose neurodegenerative diseases, such as cognitive impairment (ci), alzheimer's disease (ad), and vascular dementia (vad). |
2023-03-09 |
2023-08-14 |
Not clear |
| b' Daniel Alcolea, Michal Schnaider Beeri, Julio C Rojas, Raquel C Gardner, Alberto Lle\\xc3\\xb. Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist. Neurology. 2023-03-06. PMID:36878698.' |
currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to alzheimer's disease (aß peptides, p-tau), as well as non-specific blood markers of neuronal (neurofilament light, ß-synuclein, ubiquitin-c-terminal-hydrolase-l1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiological processes in several neurodegenerative diseases. |
2023-03-06 |
2023-08-14 |
Not clear |
| Eric Goffin, Pierre Fraikin, Dayana Abboud, Pascal de Tullio, Caroline Beaufour, Iuliana Botez, Julien Hanson, Laurence Danober, Pierre Francotte, Bernard Pirott. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European journal of medicinal chemistry. vol 250. 2023-03-02. PMID:36863228. |
positive allosteric modulators of the ampa receptors (ampar pams) have been proposed as new drugs for the management of various neurodegenerative diseases such as alzheimer's disease, parkinson's disease, attention deficit hyperactivity disorder, depression, and schizophrenia. |
2023-03-02 |
2023-08-14 |
mouse |
| Xiuli Dan, Beimeng Yang, Ross A McDevitt, Samuel Gray, Xixia Chu, Quia Claybourne, David M Figueroa, Yongqing Zhang, Deborah L Croteau, Vilhelm A Boh. Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice. Aging cell. 2023-02-27. PMID:36846960. |
olfactory dysfunction is a prevalent symptom and an early marker of age-related neurodegenerative diseases in humans, including alzheimer's and parkinson's diseases. |
2023-02-27 |
2023-08-14 |
mouse |
| Władysław Lasoń, Danuta Jantas, Monika Leśkiewicz, Magdalena Regulska, Agnieszka Basta-Kai. The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer's and Parkinson's Diseases: A Narrative Review. Cells. vol 12. issue 4. 2023-02-25. PMID:36831327. |
the vitamin d receptor as a potential target for the treatment of age-related neurodegenerative diseases such as alzheimer's and parkinson's diseases: a narrative review. |
2023-02-25 |
2023-08-14 |
Not clear |
| Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolise. Imaging Methods Applicable in the Diagnostics of Alzheimer's Disease, Considering the Involvement of Insulin Resistance. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834741. |
alzheimer's disease (ad) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphosphorylated tau proteins. |
2023-02-25 |
2023-08-14 |
Not clear |