| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenxin Wang, Tao Su. Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases. Molecules (Basel, Switzerland). vol 29. issue 1. 2024-01-11. PMID:38202764. |
recent studies have shown the strong pathogenetic associations of trpv1 with neurodegenerative diseases (nds), in particular alzheimer's disease (ad), parkinson's disease (pd) and multiple sclerosis (ms) via regulating neuroinflammation. |
2024-01-11 |
2024-01-13 |
Not clear |
| Yucong Xu, Wei Gao, Yingnan Sun, Minghua W. New insight on microglia activation in neurodegenerative diseases and therapeutics. Frontiers in neuroscience. vol 17. 2024-01-08. PMID:38188026. |
microglia are immune cells within the central nervous system (cns) closely linked to brain health and neurodegenerative diseases such as alzheimer's disease and parkinson's disease. |
2024-01-08 |
2024-01-10 |
Not clear |
| Zicheng Ling, Sirui Zhou, Yancheng Zhou, Wanyu Zhong, Zhonghao Su, Zhenxia Qi. Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration. Neuropharmacology. 2024-01-05. PMID:38181970. |
aside from abnormal accumulation of l-isoasp, pimt knockout (ko) mice mirrors some neuropathological hallmarks such as anxiety-like behaviors, impaired spatial memory and aberrant synaptic plasticity in the hippocampus of neurodegenerative diseases (nds), including alzheimer's disease (ad) and related dementias, and parkinson's disease (pd). |
2024-01-05 |
2024-01-08 |
mouse |
| Xiaojuan Han, Qing Lei, Huanhuan Liu, Tianying Zhang, Xingchun Go. SerpinA3N regulates the secretory phenotype of mouse senescent astrocytes contributing to neurodegeneration. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-01-04. PMID:38175667. |
senescent astrocyte accumulation in the brain during normal aging is a driver of age-related neurodegenerative diseases such as alzheimer's disease (ad). |
2024-01-04 |
2024-01-06 |
mouse |
| Yi-Wen Wu, Wei-Chun HuangFu, Tony Eight Lin, Chao-Hiang Peng, Huang-Ju Tu, Ting-Yi Sung, Tzu-Ying Sung, Shih-Chung Yen, Shiow-Lin Pan, Kai-Cheng Hs. Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule. International journal of biological macromolecules. 2024-01-01. PMID:38163507. |
the overexpression of dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a), commonly observed in neurodegenerative diseases like alzheimer's disease (ad) and down syndrome (ds), can induce the formation of neurofibrillary tangles (nfts) and amyloid plaques. |
2024-01-01 |
2024-01-05 |
Not clear |
| Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteol. Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development. Immunity. 2023-12-30. PMID:38159572. |
triggering receptor expressed on myeloid cells 2 (trem2) is a myeloid cell-specific gene expressed in brain microglia, with variants that are associated with neurodegenerative diseases, including alzheimer's disease. |
2023-12-30 |
2024-01-05 |
Not clear |
| Mathias Holsey Gramkow, Frederikke Kragh Clemmensen, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederikse. Test-retest reliability and short-term variability of quantitative light reflex pupillometry in a mixed memory clinic cohort. Journal of the neurological sciences. vol 456. 2023-12-28. PMID:38154247. |
quantitative light reflex pupillometry (qlrp) may be a promising digital biomarker in neurodegenerative diseases such as alzheimer's disease (ad), as neuropathological changes have been found in the midbrain structures governing the light reflex. |
2023-12-28 |
2023-12-31 |
Not clear |
| Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyma. Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau Biochemistry. 2023-12-28. PMID:38154792. |
reconstitution of the alzheimer's disease tau core structure from recombinant tau the protein tau misfolds into disease-specific fibrillar structures in more than 20 neurodegenerative diseases collectively referred to as tauopathies. |
2023-12-28 |
2023-12-31 |
Not clear |
| Longlong Wang, Shuangyan Li, Runze Li, Guizhi X. [Study on effects of 40 Hz light flicker stimulation on spatial working memory in rats and its neural mechanism]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 40. issue 6. 2023-12-28. PMID:38151937. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by cognitive impairment, with the predominant clinical diagnosis of spatial working memory (swm) deficiency, which seriously affects the physical and mental health of patients. |
2023-12-28 |
2023-12-30 |
rat |
| Kamila Łuczyńska, Zhengwen Zhang, Tadeusz Pietras, Yiguo Zhang, Hiroaki Taniguch. NFE2L1/Nrf1 serves as a potential therapeutical target for neurodegenerative diseases. Redox biology. vol 69. 2023-12-27. PMID:38150994. |
the potential of nfe2l1 to fulfill its unique neuronal function to serve as a novel therapeutic target for neurodegenerative diseases is explored by evaluating the hitherto established preclinical and clinical studies of alzheimer's and parkinson's diseases. |
2023-12-27 |
2023-12-30 |
caenorhabditis_elegans |
| Yamei Wang, Jianhao Wang, Hongyu Chen, Xiang Li, Ruifeng Xu, Feng Gao, Hang Yu, Fang Li, Dongdong Qin, Jiabei Wang, Yuke Shi, Yiyi Li, Songyan Liu, Xi Zhang, Shuai Ding, Yiqian Hu, Liqin Huang, Xin-Ya Gao, Zuneng Lu, Jin Luo, Zhi-Hao Wan. A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function. Frontiers in aging neuroscience. vol 15. 2023-12-22. PMID:38131009. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease characterized by extracellular senile plaques including amyloid-β peptides and intracellular neurofibrillary tangles consisting of abnormal tau. |
2023-12-22 |
2023-12-24 |
mouse |
| Enzo Spisni, Maria Chiara Valerii, Maria Lina Massimin. Essential Oil Molecules Can Break the Loop of Oxidative Stress in Neurodegenerative Diseases. Biology. vol 12. issue 12. 2023-12-22. PMID:38132330. |
in this mini narrative review, we have collected the results of in vitro and in vivo studies, which tested these eos on validated models of neurodegeneration and in particular of the two main neurodegenerative diseases (nds) that afflict humans: alzheimer's and parkinson's. |
2023-12-22 |
2023-12-24 |
Not clear |
| Patrick W Cullinane, Sarah Wrigley, Jacy Bezerra Parmera, Fernanda Valerio, Thomas O Millner, Karen Shaw, Eduardo De Pablo-Fernandez, Thomas T Warner, Zane Jaunmuktan. Pathology of neurodegenerative disease for the general neurologist. Practical neurology. 2023-12-21. PMID:38124186. |
this review aims to elucidate the hallmark pathological features of neurodegenerative diseases commonly seen in general neurology clinics, such as alzheimer's disease and parkinson's disease; rare but well-known diseases, including progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy and more recently described entities such as chronic traumatic encephalopathy and age-related tau astrogliopathy. |
2023-12-21 |
2023-12-23 |
Not clear |
| Lamiaa Bahnassawy, Nathalie Nicolaisen, Christopher Untucht, Benjamin Mielich-Süss, Lydia Reinhardt, Janina S Ried, Martina P Morawe, Daniela Geist, Anja Finck, Elke Käfer, Jürgen Korffmann, Matthew Townsend, Brinda Ravikumar, Viktor Lakics, Miroslav Cik, Peter Reinhard. Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations. SLAS discovery : advancing life sciences R & D. 2023-12-21. PMID:38128829. |
aberrant protein aggregation is a pathological cellular hallmark of many neurodegenerative diseases, such as alzheimer's disease (ad) and frontotemporal dementia (ftd), where the tau protein is aggregating, forming neurofibrillary tangles (nfts), and propagating from neuron to neuron. |
2023-12-21 |
2023-12-24 |
human |
| Jie Yang, Naiting Shen, Jianying Shen, Ying Yang, Hong-Lian L. Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer's Disease and Other Tauopathies. Molecular neurobiology. 2023-12-19. PMID:38114762. |
perturbations in tau's structure and function are implicated in the pathogenesis of neurodegenerative diseases collectively known as tauopathies, the most common disorder of which is alzheimer's disease (ad). |
2023-12-19 |
2023-12-23 |
Not clear |
| Yan Wang, Limei Cui, He Zhao, Huhuifen He, Liang Chen, Xicheng Song, Dawei Liu, Jingjing Qiu, Yan Su. Exploring the Connectivity of Neurodegenerative Diseases: Microglia as the Center. Journal of inflammation research. vol 16. 2023-12-19. PMID:38107384. |
this review discussed the specific mechanisms underlying microglia in neurodegenerative diseases, age-related hearing loss, alzheimer's disease, parkinson's disease, and peripheral nervous system (pns) degenerative diseases. |
2023-12-19 |
2023-12-21 |
Not clear |
| Vijay Singh, Marissa A Menard, Geidy E Serrano, Thomas G Beach, Hien T Zhao, Alexis Riley-DiPaolo, Nitya Subrahmanian, Matthew J LaVoie, Laura A Volpicelli-Dale. Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain. Acta neuropathologica communications. vol 11. issue 1. 2023-12-19. PMID:38110990. |
the involvement of rab10 in neurodegenerative disease, including both pd and alzheimer's disease makes pinpointing the cellular and subcellular localization of rab10 and prab10 in the brain an important step in understanding its functional role, and how post-translational modifications could impact function. |
2023-12-19 |
2023-12-21 |
mouse |
| Irene Navarro-Lobato, Mariam Masmudi-Martín, Manuel F López-Aranda, Juan F López-Téllez, Gloria Delgado, Pablo Granados-Durán, Celia Gaona-Romero, Marta Carretero-Rey, Sinforiano Posadas, María E Quiros-Ortega, Zafar U Kha. Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents. Neural regeneration research. vol 19. issue 8. 2023-12-16. PMID:38103251. |
in this study, we demonstrated that the same treatment with rgs14414 in visual area v2, which is relatively unaffected in neurodegenerative diseases such as alzheimer's disease, produced long-lasting enhancement of orm in young animals and prevent orm deficits in rodent models of aging and alzheimer's disease. |
2023-12-16 |
2023-12-19 |
mouse |
| Manickam Rajkumar, Prabha Govindaraj, Karuppaiya Vimala, Ramasundaram Thangaraj, Soundarapandian Kanna. Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation and neurotoxicity in rat models of Alzheimer's disease. Metabolic brain disease. 2023-12-12. PMID:38085467. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by amyloid-beta (aβ) aggregation, neuroinflammation, oxidative stress, and dysfunction in the mitochondria and cholinergic system. |
2023-12-12 |
2023-12-17 |
rat |
| Andrea Amerio, Luca Magnani, Gabriele Arduino, Fabio Fesce, Renato de Filippis, Alberto Parise, Alessandra Costanza, Khoa D Nguyen, Daniele Saverino, Domenico De Berardis, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Pasquale De Fazio, Mario Amor. Immunomodulatory Effects of Clozapine: More Than Just a Side Effect in Schizophrenia. Current neuropharmacology. 2023-12-04. PMID:38031778. |
several studies are concurrently highlighting the importance of microglia, the resident immune cells of the central nervous system, in a huge number of neurodegenerative diseases, including multiple sclerosis, alzheimer's and parkinson's diseases, as well as ssds. |
2023-12-04 |
2023-12-10 |
Not clear |