| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manickam Rajkumar, Prabha Govindaraj, Karuppaiya Vimala, Ramasundaram Thangaraj, Soundarapandian Kanna. Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation and neurotoxicity in rat models of Alzheimer's disease. Metabolic brain disease. 2023-12-12. PMID:38085467. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by amyloid-beta (aβ) aggregation, neuroinflammation, oxidative stress, and dysfunction in the mitochondria and cholinergic system. |
2023-12-12 |
2023-12-17 |
rat |
| Andrea Amerio, Luca Magnani, Gabriele Arduino, Fabio Fesce, Renato de Filippis, Alberto Parise, Alessandra Costanza, Khoa D Nguyen, Daniele Saverino, Domenico De Berardis, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Pasquale De Fazio, Mario Amor. Immunomodulatory Effects of Clozapine: More Than Just a Side Effect in Schizophrenia. Current neuropharmacology. 2023-12-04. PMID:38031778. |
several studies are concurrently highlighting the importance of microglia, the resident immune cells of the central nervous system, in a huge number of neurodegenerative diseases, including multiple sclerosis, alzheimer's and parkinson's diseases, as well as ssds. |
2023-12-04 |
2023-12-10 |
Not clear |
| Drew A Gillett, Rebecca L Wallings, Oihane Uriarte Huarte, Malú Gámez Tanse. Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease. Journal of neuroinflammation. vol 20. issue 1. 2023-12-01. PMID:38037070. |
alterations in progranulin (pgrn) expression are associated with multiple neurodegenerative diseases (nds), including frontotemporal dementia (ftd), alzheimer's disease (ad), parkinson's disease (pd), and lysosomal storage disorders (lsds). |
2023-12-01 |
2023-12-10 |
Not clear |
| Tsukasa Hara, Ryosuke Amagai, Ryuji Sakakibara, Ayako Okado-Matsumot. Supercomplex formation of mitochondrial respiratory chain complexes in leukocytes from patients with neurodegenerative diseases. Journal of biochemistry. 2023-11-28. PMID:38016934. |
with population aging, cognitive impairments and movement disorders due to neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), and dementia with lewy bodies (dlb), are increasingly considered as key social issues. |
2023-11-28 |
2023-12-07 |
Not clear |
| Lubna H Tahtamouni, Sydney A Alderfer, Thomas B Kuhn, Laurie S Minamide, Soham Chanda, Michael R Ruff, James R Bambur. Characterization of a Human Neuronal Culture System for the Study of Cofilin-Actin Rod Pathology. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001943. |
cofilactin rod pathology, which can initiate synapse loss, has been extensively studied in rodent neurons, hippocampal slices, and in vivo mouse models of human neurodegenerative diseases such as alzheimer's disease (ad). |
2023-11-25 |
2023-11-28 |
mouse |
| Amany Digal Ladagu, Funmilayo Eniola Olopade, Adeboye Adejare, James Olukayode Olopad. GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases. Pharmaceuticals (Basel, Switzerland). vol 16. issue 11. 2023-11-25. PMID:38004401. |
the presence of glun2a and glun2b subunits is particularly important for cognitive processes and has been strongly implicated in neurodegenerative diseases like parkinson's disease and alzheimer's disease. |
2023-11-25 |
2023-11-28 |
Not clear |
| Ahmet Sarper Bozkurt, Şenay Görücü Yílma. Ferroptotic Potency of ISM1 Expression in the Drug-Induced Alzheimer's Disease-Like Phenotype Under the Influence of Betulin. Journal of Alzheimer's disease : JAD. 2023-11-19. PMID:37980676. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by two main pathological mechanisms, mostly hyperphosphorylated tau and amyloid-β toxicity. |
2023-11-19 |
2023-11-29 |
Not clear |
| Chengfeng Wang, Yu Cui, Tong Xu, Yu Zhou, Rong Yang, Ting Wan. New insights into glycogen synthase kinase-3: A common target for neurodegenerative diseases. Biochemical pharmacology. 2023-11-19. PMID:37981175. |
in this review, we summarize recent findings about the regulatory role of gsk-3 in the occurrence and development of multiple neurodegenerative diseases, mainly focusing on alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2023-11-19 |
2023-11-29 |
Not clear |
| Nicole A Teaney, Nicole E Cy. FoxO1 as a tissue-specific therapeutic target for type 2 diabetes. Frontiers in endocrinology. vol 14. 2023-11-09. PMID:37941908. |
however, increased foxo1 may mitigate alzheimer's disease, a neurodegenerative disease strongly associated with t2d. |
2023-11-09 |
2023-11-20 |
Not clear |
| Fardin Nabizade. sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology. Brain communications. vol 5. issue 6. 2023-11-09. PMID:37942087. |
mutations in trem2 are strongly linked with a higher risk of developing neurodegenerative diseases, including alzheimer's disease. |
2023-11-09 |
2023-11-20 |
human |
| Susu Kong, Xi Wen, Yueju Wang, Rong Tan, Huiling Li, Yifeng T. Development of a P-tau217 Electrochemiluminescent Immunosensor Reinforced with Au-Cu Nanoparticles for Alzheimer's Disease Precaution. ACS chemical neuroscience. 2023-11-08. PMID:37939215. |
to simply and rapidly detect the highly phosphorylated tau protein at threonine 217 (p-tau217) as a precautionary measure against alzheimer's disease and distinguish it from other neurodegenerative diseases, a novel immunosensor was prepared using luminol as the electrochemiluminescent (ecl) sensing probe reinforced by au-cu nanoparticles (au-cu nps). |
2023-11-08 |
2023-11-20 |
human |
| Alexandria D Samson, Sricharana Rajagopal, Stamatoula Pasvanis, Sylvia Villeneuve, Anthony R McIntosh, M Natasha Raja. Sex differences in longitudinal changes of episodic memory-related brain activity and cognition in cognitively unimpaired older adults with a family history of Alzheimer's disease. NeuroImage. Clinical. vol 40. 2023-11-06. PMID:37931333. |
episodic memory decline is an early symptom of alzheimer's disease (ad) - a neurodegenerative disease that has a higher prevalence rate in older females compared to older males. |
2023-11-06 |
2023-11-08 |
Not clear |
| Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Su Koo, Hyung-Kyoon Cho. Effect of woohwangchungsimwon and donepezil co-treatment on cognitive function and serum metabolic profiles in a scopolamine-induced model of Alzheimer's disease. Journal of ethnopharmacology. 2023-11-04. PMID:37924999. |
reported pharmacological properties include antioxidant effects, enhanced learning and memory, and protection against ischemic neuronal cell death, supporting its use in treating neurodegenerative diseases like alzheimer's disease (ad). |
2023-11-04 |
2023-11-08 |
Not clear |
| Tingting Han, Yuxiang Xu, Lin Sun, Makoto Hashimoto, Jianshe We. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905870. |
this review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including alzheimer's disease, huntington's chorea, and parkinson's disease. |
2023-10-31 |
2023-11-08 |
Not clear |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Gupta, Christine T O Nguyen, David I Finkelstein, Yuyi You, Paul A Haynes, Ghasem H Salekdeh, Stuart L Graham, Mehdi Mirzae. Amyloid-beta and tau protein beyond Alzheimer's disease. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905874. |
recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like glaucoma and age-related macular degeneration. |
2023-10-31 |
2023-11-08 |
human |
| Haiying Wang, Beiyi Guo, Xiaoqiang Gu. Histone demethylases in neurodevelopment and neurodegenerative diseases. The International journal of neuroscience. 2023-10-30. PMID:37902510. |
functional disorders of specific kdms such as kdm1a can lead to the development of neurodegenerative diseases, including alzheimer's disease (ad) and parkinson's disease (pd). |
2023-10-30 |
2023-11-08 |
human |
| Terjahna Richards, Jeanette C Perron, Ketan Patel, John Wurpel, Sandra E Reznik, Francis Schann. Therapeutic Intervention of Neuroinflammatory Alzheimer Disease Model by Inhibition of Classical Complement Pathway with the Use of Anti-C1r Loaded Exosomes. Research square. 2023-10-27. PMID:37886595. |
alzheimer's disease (ad) is a complex neurodegenerative disease associated with memory decline, cognitive impairment, amyloid plaque formation and tau tangles. |
2023-10-27 |
2023-11-08 |
Not clear |
| Sanjesh Kumar, Siva Prasad Pand. Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions. Current molecular medicine. 2023-10-25. PMID:37877564. |
dementia in neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), and dementia with lewy bodies (dlb) is a progressive neurological condition affecting millions worldwide. |
2023-10-25 |
2023-11-08 |
human |
| Meng Mei, Maochang Liu, Yan Mei, Jing Zhao, Yang L. Sphingolipid metabolism in brain insulin resistance and neurological diseases. Frontiers in endocrinology. vol 14. 2023-10-24. PMID:37867511. |
in addition to metabolic diseases, like type 2 diabetes, brain insulin resistance is also involved in the progression of neurodegenerative diseases including alzheimer's disease and parkinson's disease. |
2023-10-24 |
2023-11-08 |
Not clear |
| Catherine E Munro, Rory Boyle, Xi Chen, Gillian Coughlan, Christopher Gonzalez, Roos J Jutten, Jairo Martinez, Irina Orlovsky, Talia Robinson, Emma Weizenbaum, Celina F Pluim, Yakeel T Quiroz-Gaviria, Jennifer R Gatchel, Patrizia Vannini, Rebecca Amarigli. Recent contributions to the field of subjective cognitive decline in aging: A literature review. Alzheimer's & dementia (Amsterdam, Netherlands). vol 15. issue 4. 2023-10-24. PMID:37869044. |
although scd was initially thought to represent the "worried well," these concerns can be linked to subtle brain changes prior to changes in objective cognitive performance and, therefore, in some individuals, scd may represent the early stages of an underlying neurodegenerative disease process (e.g., alzheimer's disease). |
2023-10-24 |
2023-11-08 |
Not clear |