All Relations between Alzheimer Disease and cholinergic receptor, nicotinic

Reference Sentence Publish Date Extraction Date Species
Hugo R Arias, Allison L Germann, Spencer R Pierce, Seiji Sakamoto, Marcelo O Ortells, Itaru Hamachi, Gustav Ak. Modulation of the mammalian GABA British journal of pharmacology vol issue 2022 36082615 modulation of the mammalian gaba positive allosteric modulators of the \xce\xb17 nachr (\xce\xb17-pams) possess promnesic and procognitive properties, and have potential in the treatment of cognitive and psychiatric disorders including alzheimer's disease and schizophrenia. 2022-09-09 2022-09-14 Not clear
Agnieszka Potasiewicz, Agata Faron-Gorecka, Piotr Popik, Agnieszka Nikiforu. Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats. Behavioural brain research vol 409 issue 2021 33940049 the \xce\xb17 nicotinic acetylcholine receptor (\xce\xb17 nachr) is a potential target for the treatment of cognitive decline in patients with schizophrenia, alzheimer's disease, and attention-deficit/hyperactivity disorder. 2022-01-27 2022-01-13 Not clear
Kun Cao, Jie Xiang, Yang-Ting Dong, Yi Xu, Zhi-Zhong Gua. Activation of \\xce\\xb17 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway. Medical science monitor : international medical journal of experimental and clinical research vol 28 issue 2022 34980874 background to reveal the mechanism underlying the effect of alpha7 nicotinic acetylcholine receptor (nachr) on neurodegeneration in alzheimer disease (ad), the influence of the receptor on recognition in app/ps1 mice was evaluated by using its selective agonist (pnu-282987). 2022-01-04 2022-01-13 Not clear
Agnieszka Potasiewicz, Agata Faron-Gorecka, Piotr Popik, Agnieszka Nikiforu. Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats. Behavioural brain research vol 409 issue 2021 33940049 the \xce\xb17 nicotinic acetylcholine receptor (\xce\xb17 nachr) is a potential target for the treatment of cognitive decline in patients with schizophrenia, alzheimer's disease, and attention-deficit/hyperactivity disorder. 2021-10-18 2022-01-13 Not clear
Xiaosa Wu, David J Craik, Quentin Kaa. Interactions of Globular and Ribbon [\\xce\\xb34E]GID with \\xce\\xb14\\xce\\xb22 Neuronal Nicotinic Acetylcholine Receptor. Marine drugs vol 19 issue 9 2021 34564144 the \xce\xb14\xce\xb22 nachr is implicated in a range of diseases and disorders including nicotine addiction, epilepsy and parkinson's and alzheimer's diseases. 2021-09-30 2022-01-13 Not clear
Chenghuan Song, Jiyun Shi, Jianrong Xu, Lanxue Zhao, Yongfang Zhang, Wanying Huang, Yu Qiu, Rui Zhang, Hongzhuan Chen, Hao Wan. Post-transcriptional regulation of \\xce\\xb17 nAChR expression by miR-98-5p modulates cognition and neuroinflammation in an animal model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 35 issue 6 2021 34010470 post-transcriptional regulation of \xce\xb17 nachr expression by mir-98-5p modulates cognition and neuroinflammation in an animal model of alzheimer's disease. 2021-07-19 2022-01-13 Not clear
Jenny L Wilkerson, Farah Deba, Morgan L Crowley, Ayman K Hamouda, Lance R McMaho. Advances in the In vitro and In vivo pharmacology of Alpha4beta2 nicotinic receptor positive allosteric modulators. Neuropharmacology vol 168 issue 2021 32113032 further, as the \xce\xb14\xce\xb22 nachr has been implicated in cognition, therapeutics that act as \xce\xb14\xce\xb22 nachr agonists are also being examined as treatments for cognitive disorders and neurological diseases that impact cognitive function, such as alzheimer's disease and schizophrenia. 2021-05-27 2022-01-13 Not clear
Yanli Liu, Yifeng Yin, Yunyang Song, Kang Wang, Fanghui Wu, Hui Jian. \\xce\\xb1-Conotoxin as Potential to \\xce\\xb17-nAChR Recombinant Expressed in Marine drugs vol 18 issue 8 2021 32806654 \xce\xb1-conotoxin as potential to \xce\xb17-nachr recombinant expressed in \xce\xb17 nicotinic acetylcholine receptors (nachr) is an important nicotinic acetylcholine receptors subtype and closely associated with cognitive disorders, such as alzheimer's and schizophrenia disease. 2021-05-18 2022-01-14 Not clear
Xiao-Ling Wang, Yu-Xin Deng, Yu-Mei Gao, Yang-Ting Dong, Fan Wang, Zhi-Zhong Guan, Wei Hong, Xiao-Lan Q. Activation of \\xce\\xb17 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway. Aging vol 12 issue 1 2021 31905173 the present study used primary hippocampus cells and appswe/psen1de9 double-transgenic mice models to study the possible therapeutic effect and underlying mechanism of the specific activation of \xce\xb17 nachr by pnu-282987 in the pathogenesis of alzheimer's disease. 2021-01-11 2022-01-13 Not clear
Kun Cao, Yang-Ting Dong, Jie Xiang, Yi Xu, Yi Li, Hui Song, Wen-Feng Yu, Xiao-Lan Qi, Zhi-Zhong Gua. The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of \\xce\\xb17 nicotinic acetylcholine receptors. Aging vol 12 issue 2 2021 32003755 the aim was to determine whether the neuroprotective effect of sirt1 in alzheimer's disease (ad), due to inhibition of aggregation of the \xce\xb2-amyloid peptide (a\xce\xb2), involves activation of \xce\xb17 nachr. 2021-01-08 2022-01-13 Not clear
Cornelius K Donat, Henrik H Hansen, Hanne D Hansen, Ronnie C Mease, Andrew G Horti, Martin G Pomper, Elina T L'Estrade, Matthias M Herth, Dan Peters, Gitte M Knudsen, Jens D Mikkelse. In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [ Molecules (Basel, Switzerland) vol 25 issue 6 2020 32245032 in vitro and in vivo characterization of dibenzothiophene derivatives [ the \xce\xb17 nicotinic acetylcholine receptor (\xce\xb17 nachr) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and alzheimer's disease, which makes it a relevant drug target. 2020-12-29 2022-01-13 Not clear
Xiaohai Wang, Ian M Bell, Jason M Uslane. Activators of \\xce\\xb17 nAChR as Potential Therapeutics for Cognitive Impairment. Current topics in behavioral neurosciences vol 45 issue 2020 32451955 the \xce\xb17 nicotinic acetylcholine receptor (nachr) is a promising target for the treatment of cognitive deficits associated with psychiatric and neurological disorders, including schizophrenia and alzheimer's disease (ad). 2020-11-09 2022-01-13 Not clear
Zsolt Krist\\xc3\\xb3f Bali, N\\xc3\\xb3ra Bruszt, Sai Ambika Tadepalli, Roland Csurgy\\xc3\\xb3k, Lili Veronika Nagy, M\\xc3\\xa1rton Tompa, Istv\\xc3\\xa1n Hern\\xc3\\xa1d. Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. Frontiers in pharmacology vol 10 issue 2020 30804787 memantine, an approved substance for alzheimer's disease treatment, is an antagonist of the n-methyl-d-aspartate receptor (nmdar) and also acts as an alpha7 nachr antagonist. 2020-10-01 2022-01-13 Not clear
David J Titus, Timothy Johnstone, Nathan H Johnson, Sidney H London, Meghana Chapalamadugu, Derk Hogenkamp, Kelvin W Gee, Coleen M Atkin. Positive allosteric modulation of the \\xce\\xb17 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury. PloS one vol 14 issue 10 2020 31581202 the \xce\xb17 nicotinic acetylcholine receptor (nachr) is highly expressed in the hippocampus and reduced expression and function of this receptor are linked with cognitive impairments in alzheimer's disease and schizophrenia. 2020-03-11 2022-01-13 Not clear
Mohanasundaram ArunSundar, Thukani Sathanantham Shanmugarajan, Velayutham Ravichandira. 3,4-Dihydroxyphenylethanol Assuages Cognitive Impulsivity in Alzheimer's Disease by Attuning HPA-Axis via Differential Crosstalk of \\xce\\xb17 nAChR with MicroRNA-124 and HDAC6. ACS chemical neuroscience vol 9 issue 12 2019 29901389 3,4-dihydroxyphenylethanol assuages cognitive impulsivity in alzheimer's disease by attuning hpa-axis via differential crosstalk of \xce\xb17 nachr with microrna-124 and hdac6. 2019-12-23 2022-01-13 Not clear
Gwenn S Smit. Molecular Imaging of the Nicotinic Cholinergic Receptor in Alzheimer Disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry vol 25 issue 4 2019 28209287 molecular imaging of the nicotinic cholinergic receptor in alzheimer disease. 2019-07-17 2022-01-13 Not clear
Florian Delbart, Marijke Brams, Fabian Gruss, Sam Noppen, Steve Peigneur, Sandro Boland, Patrick Chaltin, Jose Brandao-Neto, Frank von Delft, Wouter G Touw, Robbie P Joosten, Sandra Liekens, Jan Tytgat, Chris Ulen. An allosteric binding site of the \\xce\\xb17 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein. The Journal of biological chemistry vol 293 issue 7 2019 29237730 among the different existing receptor subtypes, the homomeric \xce\xb17 nachr has attracted considerable attention because of its possible implication in several neurological and psychiatric disorders, including cognitive decline associated with alzheimer's disease or schizophrenia. 2019-02-05 2022-01-13 Not clear
Kyoko Nakaizumi, Yasuomi Ouchi, Tatsuhiro Terada, Etsuji Yoshikawa, Akihiro Kakimoto, Takashi Isobe, Tomoyasu Bunai, Masamichi Yokokura, Katsuaki Suzuki, Yasuhiro Magat. In vivo Depiction of \\xce\\xb17 Nicotinic Receptor Loss for Cognitive Decline in Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol 61 issue 4 2019 29376856 the \xce\xb17 subtype of the nicotinic acetylcholine receptor (nachr) is considered important in higher cognitive functions, and cholinergic loss underpins the pathophysiology of alzheimer's disease (ad). 2019-01-24 2022-01-13 Not clear
Justin R King, Nadine Kabban. Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone. PloS one vol 13 issue 5 2018 29768467 the \xce\xb17 nicotinic acetylcholine receptor (nachr) is a ligand-gated ion channel that plays an important role in cellular calcium signaling contributing to synaptic development and plasticity, and is a key drug target for the treatment of neurodegenerative conditions such as alzheimer's disease. 2018-12-11 2022-01-13 Not clear
Dongting Zhangsun, Xiaopeng Zhu, Quentin Kaas, Yong Wu, David J Craik, J Michael McIntosh, Sulan Lu. \\xce\\xb1O-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human \\xce\\xb19\\xce\\xb110 subtype. Neuropharmacology vol 127 issue 2018 28416445 nicotinic acetylcholine receptor (nachr) subtypes exhibit distinct neuropharmacological properties that are involved in a range of neuropathological conditions, including pain, addiction, epilepsy, autism, schizophrenia, tourette's syndrome, alzheimer's and parkinson's diseases, as well as many types of cancer. 2018-07-11 2022-01-13 Not clear
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