| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Flavia Cantone, Chiara Burgaletto, Giulia Di Benedetto, Anna Pannaccione, Agnese Secondo, Carlo Maria Bellanca, Egle Augello, Antonio Munafò, Paola Tarro, Renato Bernardini, Giuseppina Cantarell. Taming Microglia in Alzheimer's Disease: Exploring Potential Implications of Choline Alphoscerate via α7 nAChR Modulation. Cells. vol 13. issue 4. 2024-02-23. PMID:38391922. |
taming microglia in alzheimer's disease: exploring potential implications of choline alphoscerate via α7 nachr modulation. |
2024-02-23 |
2024-02-25 |
Not clear |
| Ahmed F Abdel-Magi. Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases. ACS medicinal chemistry letters. vol 15. issue 1. 2024-01-17. PMID:38229741. |
these compounds are positive allosteric modulators of α7 nachr and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders such as cognitive impairments in alzheimer's disease, parkinson's disease, schizophrenia, and l-dopa-induced dyskinesia as well as inflammation and cough. |
2024-01-17 |
2024-01-19 |
Not clear |
| Markus M Hilscher, Sanja Mikulovic, Sharn Perry, Stina Lundberg, Klas Kullande. The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells. Pharmacological research. 2023-08-31. PMID:37652281. |
nicotinic acetylcholine receptors (nachrs) play crucial roles in various human disorders, with the α7, α4, α6, and α3-containing nachr subtypes extensively studied in relation to conditions such as alzheimer's disease, parkinson's disease, nicotine dependence, mood disorders, and stress disorders. |
2023-08-31 |
2023-09-07 |
human |
| Ana Sofía Vallés, Francisco J Barrante. Nicotinic Acetylcholine Receptor Dysfunction in Addiction and in Some Neurodegenerative and Neuropsychiatric Diseases. Cells. vol 12. issue 16. 2023-08-26. PMID:37626860. |
we discuss the preclinical evidence demonstrating the therapeutic potential of nachr ligands in alzheimer disease, parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. |
2023-08-26 |
2023-09-07 |
Not clear |
| Amanda Amorim Mugayar, Giovanna da Silva Guimarães, Paulo Henrique Tavares de Oliveira, Renan Lyra Miranda, Aline Araujo Dos Santo. Apoptosis in the neuroprotective effect of α7 nicotinic receptor in neurodegenerative models. Journal of neuroscience research. 2023-08-24. PMID:37615647. |
in alzheimer's models, the literature shows that α7 nachr activation attenuates aβ-induced neurotoxicity through modulation of different intrinsic apoptotic pathways via pi3k/akt and mitogen-activated protein kinase (mapk). |
2023-08-24 |
2023-09-07 |
Not clear |
| Maryna Sko. Universal nature of cholinergic regulation demonstrated with nicotinic acetylcholine receptors. BBA advances. vol 2. 2023-04-21. PMID:37082580. |
investigation of autonomic ganglia with the nachr subunit-specific antibodies was followed by identification of nachrs in b lymphocytes, discovery of mitochondrial nachrs and their role in mitochondrial apoptosis pathway, and revealing the role of α7 nachrs and α7-specific antibodies in neuroinflammation-related alzheimer disease and covid-19. |
2023-04-21 |
2023-08-14 |
Not clear |
| E Costantini, C Carrarini, P Borrelli, M De Rosa, D Calisi, S Consoli, D D'Ardes, F Cipollone, M Di Nicola, M Onofrj, M Reale, L Bonann. Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer's disease. Immunity & ageing : I & A. vol 20. issue 1. 2023-01-16. PMID:36647139. |
indeed, the deregulated function of the nachr was previously correlated with cognitive decline and neuropsychiatric symptoms in alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2023-01-16 |
2023-08-14 |
Not clear |
| Hugo R Arias, Allison L Germann, Spencer R Pierce, Seiji Sakamoto, Marcelo O Ortells, Itaru Hamachi, Gustav Ak. Modulation of the mammalian GABA British journal of pharmacology. 2022-09-09. PMID:36082615. |
modulation of the mammalian gaba positive allosteric modulators of the α7 nachr (α7-pams) possess promnesic and procognitive properties, and have potential in the treatment of cognitive and psychiatric disorders including alzheimer's disease and schizophrenia. |
2022-09-09 |
2023-08-14 |
Not clear |
| Kun Cao, Jie Xiang, Yang-Ting Dong, Yi Xu, Zhi-Zhong Gua. Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 28. 2022-01-04. PMID:34980874. |
background to reveal the mechanism underlying the effect of alpha7 nicotinic acetylcholine receptor (nachr) on neurodegeneration in alzheimer disease (ad), the influence of the receptor on recognition in app/ps1 mice was evaluated by using its selective agonist (pnu-282987). |
2022-01-04 |
2023-08-13 |
mouse |
| Agnieszka Potasiewicz, Agata Faron-Gorecka, Piotr Popik, Agnieszka Nikiforu. Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats. Behavioural brain research. vol 409. 2021-10-18. PMID:33940049. |
the α7 nicotinic acetylcholine receptor (α7 nachr) is a potential target for the treatment of cognitive decline in patients with schizophrenia, alzheimer's disease, and attention-deficit/hyperactivity disorder. |
2021-10-18 |
2023-08-13 |
rat |
| Xiaosa Wu, David J Craik, Quentin Kaa. Interactions of Globular and Ribbon [γ4E]GID with α4β2 Neuronal Nicotinic Acetylcholine Receptor. Marine drugs. vol 19. issue 9. 2021-09-30. PMID:34564144. |
the α4β2 nachr is implicated in a range of diseases and disorders including nicotine addiction, epilepsy and parkinson's and alzheimer's diseases. |
2021-09-30 |
2023-08-13 |
rat |
| Chenghuan Song, Jiyun Shi, Jianrong Xu, Lanxue Zhao, Yongfang Zhang, Wanying Huang, Yu Qiu, Rui Zhang, Hongzhuan Chen, Hao Wan. Post-transcriptional regulation of α7 nAChR expression by miR-98-5p modulates cognition and neuroinflammation in an animal model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 6. 2021-07-19. PMID:34010470. |
post-transcriptional regulation of α7 nachr expression by mir-98-5p modulates cognition and neuroinflammation in an animal model of alzheimer's disease. |
2021-07-19 |
2023-08-13 |
Not clear |
| Jenny L Wilkerson, Farah Deba, Morgan L Crowley, Ayman K Hamouda, Lance R McMaho. Advances in the In vitro and In vivo pharmacology of Alpha4beta2 nicotinic receptor positive allosteric modulators. Neuropharmacology. vol 168. 2021-05-27. PMID:32113032. |
further, as the α4β2 nachr has been implicated in cognition, therapeutics that act as α4β2 nachr agonists are also being examined as treatments for cognitive disorders and neurological diseases that impact cognitive function, such as alzheimer's disease and schizophrenia. |
2021-05-27 |
2023-08-13 |
Not clear |
| Yanli Liu, Yifeng Yin, Yunyang Song, Kang Wang, Fanghui Wu, Hui Jian. α-Conotoxin as Potential to α7-nAChR Recombinant Expressed in Marine drugs. vol 18. issue 8. 2021-05-18. PMID:32806654. |
α-conotoxin as potential to α7-nachr recombinant expressed in α7 nicotinic acetylcholine receptors (nachr) is an important nicotinic acetylcholine receptors subtype and closely associated with cognitive disorders, such as alzheimer's and schizophrenia disease. |
2021-05-18 |
2023-08-13 |
Not clear |
| Xiao-Ling Wang, Yu-Xin Deng, Yu-Mei Gao, Yang-Ting Dong, Fan Wang, Zhi-Zhong Guan, Wei Hong, Xiao-Lan Q. Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway. Aging. vol 12. issue 1. 2021-01-11. PMID:31905173. |
the present study used primary hippocampus cells and appswe/psen1de9 double-transgenic mice models to study the possible therapeutic effect and underlying mechanism of the specific activation of α7 nachr by pnu-282987 in the pathogenesis of alzheimer's disease. |
2021-01-11 |
2023-08-13 |
mouse |
| Kun Cao, Yang-Ting Dong, Jie Xiang, Yi Xu, Yi Li, Hui Song, Wen-Feng Yu, Xiao-Lan Qi, Zhi-Zhong Gua. The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors. Aging. vol 12. issue 2. 2021-01-08. PMID:32003755. |
the aim was to determine whether the neuroprotective effect of sirt1 in alzheimer's disease (ad), due to inhibition of aggregation of the β-amyloid peptide (aβ), involves activation of α7 nachr. |
2021-01-08 |
2023-08-13 |
mouse |
| Cornelius K Donat, Henrik H Hansen, Hanne D Hansen, Ronnie C Mease, Andrew G Horti, Martin G Pomper, Elina T L'Estrade, Matthias M Herth, Dan Peters, Gitte M Knudsen, Jens D Mikkelse. In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [ Molecules (Basel, Switzerland). vol 25. issue 6. 2020-12-29. PMID:32245032. |
in vitro and in vivo characterization of dibenzothiophene derivatives [ the α7 nicotinic acetylcholine receptor (α7 nachr) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and alzheimer's disease, which makes it a relevant drug target. |
2020-12-29 |
2023-08-13 |
Not clear |
| Xiaohai Wang, Ian M Bell, Jason M Uslane. Activators of α7 nAChR as Potential Therapeutics for Cognitive Impairment. Current topics in behavioral neurosciences. vol 45. 2020-11-09. PMID:32451955. |
the α7 nicotinic acetylcholine receptor (nachr) is a promising target for the treatment of cognitive deficits associated with psychiatric and neurological disorders, including schizophrenia and alzheimer's disease (ad). |
2020-11-09 |
2023-08-13 |
Not clear |
| Zsolt Kristóf Bali, Nóra Bruszt, Sai Ambika Tadepalli, Roland Csurgyók, Lili Veronika Nagy, Márton Tompa, István Hernád. Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30804787. |
memantine, an approved substance for alzheimer's disease treatment, is an antagonist of the n-methyl-d-aspartate receptor (nmdar) and also acts as an alpha7 nachr antagonist. |
2020-10-01 |
2023-08-13 |
rat |
| David J Titus, Timothy Johnstone, Nathan H Johnson, Sidney H London, Meghana Chapalamadugu, Derk Hogenkamp, Kelvin W Gee, Coleen M Atkin. Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury. PloS one. vol 14. issue 10. 2020-03-11. PMID:31581202. |
the α7 nicotinic acetylcholine receptor (nachr) is highly expressed in the hippocampus and reduced expression and function of this receptor are linked with cognitive impairments in alzheimer's disease and schizophrenia. |
2020-03-11 |
2023-08-13 |
human |