All Relations between Alzheimer Disease and cholinergic receptor, nicotinic

Publication Sentence Publish Date Extraction Date Species
Mohanasundaram ArunSundar, Thukani Sathanantham Shanmugarajan, Velayutham Ravichandira. 3,4-Dihydroxyphenylethanol Assuages Cognitive Impulsivity in Alzheimer's Disease by Attuning HPA-Axis via Differential Crosstalk of α7 nAChR with MicroRNA-124 and HDAC6. ACS chemical neuroscience. vol 9. issue 12. 2019-12-23. PMID:29901389. 3,4-dihydroxyphenylethanol assuages cognitive impulsivity in alzheimer's disease by attuning hpa-axis via differential crosstalk of α7 nachr with microrna-124 and hdac6. 2019-12-23 2023-08-13 Not clear
Gwenn S Smit. Molecular Imaging of the Nicotinic Cholinergic Receptor in Alzheimer Disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 25. issue 4. 2019-07-17. PMID:28209287. molecular imaging of the nicotinic cholinergic receptor in alzheimer disease. 2019-07-17 2023-08-13 Not clear
Florian Delbart, Marijke Brams, Fabian Gruss, Sam Noppen, Steve Peigneur, Sandro Boland, Patrick Chaltin, Jose Brandao-Neto, Frank von Delft, Wouter G Touw, Robbie P Joosten, Sandra Liekens, Jan Tytgat, Chris Ulen. An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein. The Journal of biological chemistry. vol 293. issue 7. 2019-02-05. PMID:29237730. among the different existing receptor subtypes, the homomeric α7 nachr has attracted considerable attention because of its possible implication in several neurological and psychiatric disorders, including cognitive decline associated with alzheimer's disease or schizophrenia. 2019-02-05 2023-08-13 human
Kyoko Nakaizumi, Yasuomi Ouchi, Tatsuhiro Terada, Etsuji Yoshikawa, Akihiro Kakimoto, Takashi Isobe, Tomoyasu Bunai, Masamichi Yokokura, Katsuaki Suzuki, Yasuhiro Magat. In vivo Depiction of α7 Nicotinic Receptor Loss for Cognitive Decline in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 61. issue 4. 2019-01-24. PMID:29376856. the α7 subtype of the nicotinic acetylcholine receptor (nachr) is considered important in higher cognitive functions, and cholinergic loss underpins the pathophysiology of alzheimer's disease (ad). 2019-01-24 2023-08-13 Not clear
Justin R King, Nadine Kabban. Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone. PloS one. vol 13. issue 5. 2018-12-11. PMID:29768467. the α7 nicotinic acetylcholine receptor (nachr) is a ligand-gated ion channel that plays an important role in cellular calcium signaling contributing to synaptic development and plasticity, and is a key drug target for the treatment of neurodegenerative conditions such as alzheimer's disease. 2018-12-11 2023-08-13 Not clear
Dongting Zhangsun, Xiaopeng Zhu, Quentin Kaas, Yong Wu, David J Craik, J Michael McIntosh, Sulan Lu. αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype. Neuropharmacology. vol 127. 2018-07-11. PMID:28416445. nicotinic acetylcholine receptor (nachr) subtypes exhibit distinct neuropharmacological properties that are involved in a range of neuropathological conditions, including pain, addiction, epilepsy, autism, schizophrenia, tourette's syndrome, alzheimer's and parkinson's diseases, as well as many types of cancer. 2018-07-11 2023-08-13 human
Jogeshwar Mukherjee, Patrick J Lao, Tobey J Betthauser, Gurleen K Samra, Min-Liang Pan, Ishani H Patel, Christopher Liang, Raju Metherate, Bradley T Christia. Human brain imaging of nicotinic acetylcholine α4β2* receptors using [ The Journal of comparative neurology. vol 526. issue 1. 2018-06-26. PMID:28875553. human brain imaging of nicotinic acetylcholine α4β2* receptors using [ nicotinic acetylcholinergic receptors (nachr's) have been implicated in several brain disorders, including addiction, parkinson's disease, alzheimer's disease and schizophrenia. 2018-06-26 2023-08-13 human
Wang Huan, Wu Aiqin, Liu Jianping, Xue Qianqian, Lu Xia, Yin Lei, Fang Yu, Zhang Huabe. Radiosynthesis and in-vivo evaluation of [125I]IBT: a single-photon emission computed tomography radiotracer for α7-nicotinic acetylcholine receptor imaging. Nuclear medicine communications. vol 38. issue 8. 2018-03-09. PMID:28658053. the aim of this study was to develop several novel α7-nicotinic acetylcholine receptor (nachr) radioligands for the early diagnosis and treatment of alzheimer's disease. 2018-03-09 2023-08-13 Not clear
David L Sultzer, Rebecca J Melrose, Hannah Riskin-Jones, Theresa A Narvaez, Joseph Veliz, Timothy K Ando, Kevin O Juarez, Dylan G Harwood, Arthur L Brody, Mark A Mandelker. Cholinergic Receptor Binding in Alzheimer Disease and Healthy Aging: Assessment In Vivo with Positron Emission Tomography Imaging. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 25. issue 4. 2018-02-15. PMID:28162919. to compare regional nicotinic cholinergic receptor binding in older adults with alzheimer disease (ad) and healthy older adults in vivo and to assess relationships between receptor binding and clinical symptoms. 2018-02-15 2023-08-13 Not clear
Michael R Weed, Joseph Polino, Laura Signor, Mark Bookbinder, Deborah Keavy, Yulia Benitex, Daniel G Morgan, Dalton King, John E Macor, Robert Zaczek, Richard Olson, Linda J Bristo. Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning. PloS one. vol 12. issue 12. 2018-01-08. PMID:29261656. agonists at the nicotinic acetylcholine alpha 7 receptor (nachr α7) subtype have the potential to treat cognitive deficits in patients with alzheimer's disease (ad) or schizophrenia. 2018-01-08 2023-08-13 monkey
Yuan Liao, Xiao-Lan Qi, Ying Cao, Wen-Feng Yu, Rivka Ravid, Bengt Winblad, Jin-Jing Pei, Zhi-Zhong Gua. Elevations in the Levels of NF-κB and Inflammatory Chemotactic Factors in the Brains with Alzheimer's Disease - One Mechanism May Involve α3 Nicotinic Acetylcholine Receptor. Current Alzheimer research. vol 13. issue 11. 2017-10-04. PMID:27396406. the purpose of this study was to investigate the alterations in the levels of nuclear factor κbp65 (nf-κbp65), monocyte chemoattractant protein 1 (mcp-1/ccl-2) and macrophage inflammatory protein 1α (mip-1α/ccl-3) in relationship to the expression of α3 nicotinic acetylcholine receptor (nachr) during the pathogenesis of alzheimer's disease (ad). 2017-10-04 2023-08-13 human
Morten S Thomsen, Maria Arvaniti, Majbrit M Jensen, Mikhail A Shulepko, Dmitry A Dolgikh, Lars H Pinborg, Wolfgang Härtig, Ekaterina N Lyukmanova, Jens D Mikkelse. Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes. Neurobiology of aging. vol 46. 2017-09-28. PMID:27460145. it is not known to which extent lynx1 can bind to endogenous nachr subunits in the brain or how this interaction is affected by alzheimer's disease pathology. 2017-09-28 2023-08-13 mouse
Morten S Thomsen, Maria Arvaniti, Majbrit M Jensen, Mikhail A Shulepko, Dmitry A Dolgikh, Lars H Pinborg, Wolfgang Härtig, Ekaterina N Lyukmanova, Jens D Mikkelse. Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes. Neurobiology of aging. vol 46. 2017-09-28. PMID:27460145. our data suggest that lynx1 binds to multiple nachr subtypes in the brain and that this interaction might have functional and pathophysiological implications in relation to alzheimer's disease. 2017-09-28 2023-08-13 mouse
Paloma Vicens, Luis Heredia, Margarita Torrente, José L Doming. Behavioural effects of PNU-282987 and stress in an animal model of Alzheimer's disease. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 17. issue 1. 2017-04-04. PMID:26817787. this study was aimed at evaluating the possible therapeutic role of pnu-282987 (pnu), an α7 nicotinic cholinergic receptor agonist, and the possible effects of stress in precipitating the onset of behavioural deficits in animals with susceptibility to alzheimer's disease. 2017-04-04 2023-08-13 Not clear
Hans O Kalkman, Dominik Feuerbac. Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders. Cellular and molecular life sciences : CMLS. vol 73. issue 13. 2017-02-15. PMID:26979166. the clinical development of selective alpha-7 nicotinic acetylcholine receptor (α7 nachr) agonists has hitherto been focused on disorders characterized by cognitive deficits (e.g., alzheimer's disease, schizophrenia). 2017-02-15 2023-08-13 Not clear
Hans O Kalkman, Dominik Feuerbac. Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders. Cellular and molecular life sciences : CMLS. vol 73. issue 13. 2017-02-15. PMID:26979166. since sterile inflammation is a frequently observed phenomenon in both psychiatric disorders (e.g., schizophrenia, melancholic and bipolar depression) and neurological disorders (e.g., alzheimer's disease, parkinson's disease, and multiple sclerosis), α7 nachr agonists might show beneficial effects in these central nervous system disorders. 2017-02-15 2023-08-13 Not clear
Shi Shi, Dongli Liang, Min Bao, Yilin Xie, Wangjie Xu, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways. Journal of Alzheimer's disease : JAD. vol 50. issue 3. 2016-10-31. PMID:26836188. recent studies have revealed that the α7 nicotinic acetylcholine receptor (α7 nachr) is a critical link between inflammation and neurodegeneration, which is closely associated with alzheimer's disease (ad). 2016-10-31 2023-08-13 Not clear
Rex M Philpo. Potential Use of Nicotinic Receptor Agonists for the Treatment of Chemotherapy-Induced Cognitive Deficits. Neurochemical research. vol 40. issue 10. 2016-09-02. PMID:25652578. several drugs that enhance cholinergic function and/or increase nicotinic acetylcholine receptor (nachr) activity have been demonstrated to improve cognitive performance and/or reverse cognitive deficits in animals, findings that have led to the use of these compounds to treat the cognitive deficits present in a variety of disorders including attention deficit disorder, alzheimer's disease, parkinson's disease and schizophrenia. 2016-09-02 2023-08-13 Not clear
Shenyan Gu, Jose A Matta, Brian Lord, Anthony W Harrington, Steven W Sutton, Weston B Davini, David S Bred. Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO. Neuron. vol 89. issue 5. 2016-07-13. PMID:26875622. enhancing α7-type nachr signaling improves symptoms in alzheimer's disease and schizophrenia. 2016-07-13 2023-08-13 mouse
Christopher B Marotta, Henry A Lester, Dennis A Doughert. An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors. Chemistry & biology. vol 22. issue 8. 2016-06-14. PMID:26211363. the α7 nachr has been implicated in alzheimer's disease and schizophrenia, and allosteric modulators have become one focus of drug development efforts. 2016-06-14 2023-08-13 Not clear