| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lorise C Gahring, Karina Persiyanov, Emily L Days, Scott W Roger. Age-related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase-2 and PPAR gamma expression and is altered by long-term NS398 administration. Journal of neurobiology. vol 62. issue 4. 2005-04-28. PMID:15551346. |
age-related changes in the mammalian dorsal hippocampus are associated with diminished expression of neuronal nicotinic acetylcholine receptors (nachr), which is particularly severe in pathologies such as those associated with dementias, including alzheimer's disease. |
2005-04-28 |
2023-08-12 |
mouse |
| Hugo Geerts, Pierre-Olivier Guillaumat, Christopher Grantham, Wilhelmina Bode, Katelijne Anciaux, Sohel Sacha. Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits. Brain research. vol 1033. issue 2. 2005-04-13. PMID:15694923. |
galantamine is a rather weak acetylcholinesterase (ache) inhibitor, currently approved for the symptomatic treatment of alzheimer's disease, with possible additional allosteric potentiating effects at the nicotinic ach receptor (nachr). |
2005-04-13 |
2023-08-12 |
mouse |
| Dominik Feuerbach, Kurt Lingenhöhl, Peter Dobbins, Johannes Mosbacher, Nicola Corbett, Joachim Nozulak, Daniel Hoye. Coupling of human nicotinic acetylcholine receptors alpha 7 to calcium channels in GH3 cells. Neuropharmacology. vol 48. issue 2. 2005-04-13. PMID:15695160. |
the neuronal nicotinic acetylcholine receptor alpha7 (nachr alpha7) may be involved in cognitive deficits in schizophrenia and alzheimer's disease. |
2005-04-13 |
2023-08-12 |
human |
| Salvatore Oddo, Antonella Caccamo, Kim N Green, Kevin Liang, Levina Tran, Yiling Chen, Frances M Leslie, Frank M LaFerl. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 8. 2005-03-24. PMID:15705720. |
the association between nicotinic acetylcholine receptor (nachr) dysfunction and cognitive decline in alzheimer's disease (ad) has been widely exploited for its therapeutic potential. |
2005-03-24 |
2023-08-12 |
mouse |
| Nancyellen C de Fiebre, Christopher M de Fiebr. alpha7 Nicotinic acetylcholine receptor knockout selectively enhances ethanol-, but not beta-amyloid-induced neurotoxicity. Neuroscience letters. vol 373. issue 1. 2005-02-01. PMID:15555774. |
the alpha7 subtype of nicotinic acetylcholine receptor (nachr) has been implicated as a potential site of action for two neurotoxins, ethanol and the alzheimer's disease related peptide, beta-amyloid. |
2005-02-01 |
2023-08-12 |
mouse |
| Manickavasagon Alkondon, Edna F R Pereira, Ping Yu, Emerson Z Arruda, Luis E F Almeida, Paolo Guidetti, William P Fawcett, Michael T Sapko, William R Randall, Robert Schwarcz, Danilo A Tagle, Edson X Albuquerqu. Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140935. |
our findings that alpha7* nachrs are major targets for kyna in the brain may provide insights into the pathophysiology of schizophrenia and alzheimer's disease, disorders in which brain kyna levels are increased and alpha7* nachr functions are impaired. |
2004-08-13 |
2023-08-12 |
mouse |
| Kaori Koike, Kenji Hashimoto, Naoe Okamura, Shintaro Ohgake, Eiji Shimizu, Hiroki Koizumi, Naoya Komatsu, Masaomi Iy. Decreased cell proliferation in the dentate gyrus of alpha 7 nicotinic acetylcholine receptor heterozygous mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 3. 2004-06-17. PMID:15093959. |
it is suggested that deficits of alpha 7 nicotinic acetylcholine receptors (nachrs) might be associated with the cognitive impairments of alzheimer's disease and schizophrenia, and that agonists for alpha 7 nachr could be useful for treatment of cognitive dysfunction in these diseases. |
2004-06-17 |
2023-08-12 |
mouse |
| J R Paul. Nicotinic cholinergic receptor deficits in Alzheimer's disease: where's the smoke? Journal of Alzheimer's disease : JAD. vol 1. issue 4-5. 2004-05-04. PMID:12214121. |
nicotinic cholinergic receptor deficits in alzheimer's disease: where's the smoke? |
2004-05-04 |
2023-08-12 |
human |
| Silvia Di Angelantonio, Rashid Giniatullin, Valeria Costa, Elena Sokolova, Andrea Nistr. Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. British journal of pharmacology. vol 139. issue 6. 2004-03-30. PMID:12871824. |
the availability of novel cgrp derivatives with a strong enhancing action on nachrs may offer new leads for the drug design targeted for potentiation of nachrs in the autonomic nervous system as well as in the brain, a subject of interest to counteract the deficit of the nachr function associated with neurodegenerative diseases like alzheimer's and parkinson's diseases. |
2004-03-30 |
2023-08-12 |
human |
| R C Hogg, M Raggenbass, D Bertran. Nicotinic acetylcholine receptors: from structure to brain function. Reviews of physiology, biochemistry and pharmacology. vol 147. 2003-12-18. PMID:12783266. |
dysfunction of nachr has been linked to a number of human diseases such as schizophrenia, alzheimer's and parkinson's diseases. |
2003-12-18 |
2023-08-12 |
human |
| Francesca Grassi, Eleonora Palma, Raffaella Tonini, Mascia Amici, Marc Ballivet, Fabrizio Euseb. Amyloid beta(1-42) peptide alters the gating of human and mouse alpha-bungarotoxin-sensitive nicotinic receptors. The Journal of physiology. vol 547. issue Pt 1. 2003-08-21. PMID:12562926. |
the beta-amyloid(1-42) peptide (abeta(1-42)), a major constituent of the alzheimer's disease amyloid plaque, specifically binds to the neuronal alpha-bungarotoxin (alpha-butx)-sensitive alpha7 nicotinic acetylcholine receptor (alpha7 nachr). |
2003-08-21 |
2023-08-12 |
mouse |
| Marek Samochocki, Anja Höffle, Andreas Fehrenbacher, Ruth Jostock, Jürgen Ludwig, Claudia Christner, Martin Radina, Marion Zerlin, Christoph Ullmer, Edna F R Pereira, Hermann Lübbert, Edson X Albuquerque, Alfred Maelick. Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics. vol 305. issue 3. 2003-07-07. PMID:12649296. |
galantamine (reminyl), an approved treatment for alzheimer's disease (ad), is a potent allosteric potentiating ligand (apl) of human alpha 3 beta 4, alpha 4 beta 2, and alpha 6 beta 4 nicotinic receptors (nachrs), and of the chicken/mouse chimeric alpha 7/5-hydroxytryptamine3 receptor, as was shown by whole-cell patch-clamp studies of human embryonic kidney-293 cells stably expressing a single nachr subtype. |
2003-07-07 |
2023-08-12 |
human |
| Vladimir V Uteshev, Edwin M Meyer, Roger L Papk. Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors. Journal of neurophysiology. vol 89. issue 4. 2003-05-29. PMID:12611953. |
we conclude that factors that regulate choline accumulation in the brain and in experimental slices such as choline uptake, hydrolysis of ach, membrane phosphatidylcholine catabolism, and solution perfusion rate influence alpha7 nachr neuronal and synaptic functions, especially under pathological conditions such as stroke, seizures, alzheimer's disease, and head trauma, when the choline concentration in the csf is expected to rise. |
2003-05-29 |
2023-08-12 |
Not clear |
| Wen-Feng Yu, Agneta Nordberg, Rivka Ravid, Zhi-Zhong Gua. Correlation of oxidative stress and the loss of the nicotinic receptor alpha 4 subunit in the temporal cortex of patients with Alzheimer's disease. Neuroscience letters. vol 338. issue 1. 2003-04-10. PMID:12565129. |
the correlation between oxidative stress and the loss of nicotinic acetylcholine receptor (nachr) alpha4 subunit has been investigated in the temporal cortex from patients with alzheimer's disease (ad). |
2003-04-10 |
2023-08-12 |
Not clear |
| David H Small, Lisa R Foder. Cholinergic regulation of synaptic plasticity as a therapeutic target in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 4. issue 5. 2003-04-04. PMID:12446967. |
there is increasing evidence for disturbances in nicotinic acetylcholine receptor (nachr) function in alzheimer's disease (ad). |
2003-04-04 |
2023-08-12 |
Not clear |
| P L Chazot, O V Godukhin, A McDonald, T P Obrenovitc. Spreading depression-induced preconditioning in the mouse cortex: differential changes in the protein expression of ionotropic nicotinic acetylcholine and glutamate receptors. Journal of neurochemistry. vol 83. issue 5. 2003-01-16. PMID:12437595. |
these data complement recent studies implicating alpha7 nachr overexpression in the amelioration of chronic neuropathologies, notably alzheimer's disease (ad). |
2003-01-16 |
2023-08-12 |
mouse |
| Michael W Quick, Robin A J Leste. Desensitization of neuronal nicotinic receptors. Journal of neurobiology. vol 53. issue 4. 2003-01-13. PMID:12436413. |
this type of mechanism can be extended to explain how the continuous occupation of desensitized receptors during chronic nicotine exposure contributes to drug addiction, and highlights the potential significance of prolonged nachr desensitization that would also occur as a result of extended acetylcholine lifetime during treatment of alzheimer's disease with cholinesterase inhibitors. |
2003-01-13 |
2023-08-12 |
Not clear |
| Jenny Apelt, Ashok Kumar, Reinhard Schlieb. Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein. Brain research. vol 953. issue 1-2. 2003-01-10. PMID:12384234. |
to address the question of whether beta-amyloid peptides also affect cholinergic neurotransmission in vivo, brain tissue from transgenic tg2576 mice with alzheimer plaque pathology at ages ranging from 7 to 24 months were examined by immuno- and histochemical staining for choline acetyltransferase (chat) and acetycholinesterase (ache), by assaying cholinergic enzyme activities and high-affinity choline uptake as well muscarinic and nicotinic cholinergic receptor binding levels by quantitative autoradiography. |
2003-01-10 |
2023-08-12 |
mouse |
| R T Reid, M N Sabbagh, L J Tha. Does apolipoprotein E (Apo-E) genotype influence nicotinic receptor binding in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 8-9. 2002-04-29. PMID:11716140. |
we wished to determine the influence of the apolipoprotein e (apo-e) genotype on the loss of high affinity nicotinic acetylcholine receptor (nachr) binding in alzheimer's disease (ad). |
2002-04-29 |
2023-08-12 |
human |
| M N Sabbagh, R T Reid, L A Hansen, M Alford, L J Tha. Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 10. 2002-04-16. PMID:11725817. |
we investigated the relationship between the loss of nicotinic acetylcholine receptors (nachr) and the cognitive decline or neuropathological changes seen in alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2002-04-16 |
2023-08-12 |
Not clear |