Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
William M Pardridg. Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier. Frontiers in drug delivery. vol 3. 2023-08-16. PMID:37583474. |
therapeutic antibodies have been re-engineered as bsas that target the insulin receptor, tfr, or igfr rmt systems at the bbb for the treatment of alzheimer's disease and parkinson's disease. |
2023-08-16 |
2023-09-07 |
Not clear |
Lisa A Post, Joshua A Kulas, Joshua L Milstein, Sarah V L Sebastian, Seyyedmohsen Hosseini-Barkooie, Max E Stevenson, George S Bloom, Heather A Ferri. Inceptor as a regulator of brain insulin sensitivity. Scientific reports. vol 13. issue 1. 2023-07-18. PMID:37463909. |
we saw little difference in insulin receptor signaling following inceptor knockdown in neuron cultures, or in inceptor levels with high-fat diet in mouse or alzheimer's disease in mouse or human tissue. |
2023-07-18 |
2023-08-14 |
mouse |
Timothy M Hughes, Suzanne Craf. Cerebral insulin receptors: a nexus for vascular and metabolic contributions to Alzheimer's disease. Brain : a journal of neurology. 2022-11-19. PMID:36402144. |
cerebral insulin receptors: a nexus for vascular and metabolic contributions to alzheimer's disease. |
2022-11-19 |
2023-08-14 |
Not clear |
Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Emond, David A Bennett, Frédéric Calo. Cerebrovascular insulin receptors are defective in Alzheimer's disease. Brain : a journal of neurology. 2022-10-24. PMID:36280236. |
such an activation of vascular insulin receptor was blunted in 3xtg-ad mice, suggesting that alzheimer's disease neuropathology induces insulin resistance at the level of the blood-brain barrier. |
2022-10-24 |
2023-08-14 |
mouse |
Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Emond, David A Bennett, Frédéric Calo. Cerebrovascular insulin receptors are defective in Alzheimer's disease. Brain : a journal of neurology. 2022-10-24. PMID:36280236. |
cerebrovascular insulin receptors are defective in alzheimer's disease. |
2022-10-24 |
2023-08-14 |
mouse |
Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Emond, David A Bennett, Frédéric Calo. Cerebrovascular insulin receptors are defective in Alzheimer's disease. Brain : a journal of neurology. 2022-10-24. PMID:36280236. |
overall, the present data in post-mortem alzheimer's disease brains and an animal model of alzheimer's disease indicate that defects in the insulin receptor localized at the blood-brain barrier strongly contribute to brain insulin resistance in alzheimer's disease, in association with β-amyloid pathology. |
2022-10-24 |
2023-08-14 |
mouse |
Wei-Bin Shen, Montasir Elahi, Bingbing Wang, Min Zhan, Penghua Yang, Peixin Yan. Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology. Journal of Alzheimer's disease : JAD. 2022-10-03. PMID:36189587. |
oxidative stress kinase activation and impaired insulin receptor signaling precede overt alzheimer's disease neuropathology. |
2022-10-03 |
2023-08-14 |
Not clear |
Genaro G Ortiz, Miguel Huerta, Héctor A González-Usigli, Erandis D Torres-Sánchez, Daniela Lc Delgado-Lara, Fermín P Pacheco-Moisés, Mario A Mireles-Ramírez, Blanca Mg Torres-Mendoza, Roxana I Moreno-Cih, Irma E Velázquez-Brizuel. Cognitive disorder and dementia in type 2 diabetes mellitus. World journal of diabetes. vol 13. issue 4. 2022-05-18. PMID:35582669. |
at the receptor level, in aging and alzheimer's disease (ad) models, the amount of insulin receptors and their functions are decreased. |
2022-05-18 |
2023-08-13 |
mouse |
Priyanka Sengupta, Debashis Mukhopadhya. Insulin dysregulation as a prominent driver of cell cycle re-entry in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108922. |
the ccr markers were monitored and correlated functionally with upregulation of insulin receptor (insr) and insulin like growth factor 1 receptor (igf1r) in alzheimer's disease (ad) cell model and mouse brain tissue. |
2022-02-03 |
2023-08-13 |
mouse |
Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, David A Bennett, Frederic Calo. Alterations of neurovascular insulin receptor in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109311. |
alterations of neurovascular insulin receptor in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
human |
Steven Nguyen, William A Banks, Elizabeth M Rhe. Effects of Rapamycin on Insulin Brain Endothelial Cell Binding and Blood-Brain Barrier Transport. Medical sciences (Basel, Switzerland). vol 9. issue 3. 2021-09-23. PMID:34449653. |
rapamycin is an exogenous compound that has been shown to improve cognition in alzheimer's disease mouse models and can regulate pathways downstream of the insulin receptor signaling pathway. |
2021-09-23 |
2023-08-13 |
mouse |
Nazia Siddiqui, Javed Ali, Suhel Parvez, Saima Zameer, Abul Kalam Najmi, Mohd Akhta. Linagliptin, a DPP-4 inhibitor, ameliorates Aβ (1-42) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in rat model of Alzheimer's disease. Neuropharmacology. vol 195. 2021-09-13. PMID:34119519. |
linagliptin, a dpp-4 inhibitor, ameliorates aβ (1-42) peptides induced neurodegeneration and brain insulin resistance (bir) via insulin receptor substrate-1 (irs-1) in rat model of alzheimer's disease. |
2021-09-13 |
2023-08-13 |
rat |
Hilaree N Frazier, Katie L Anderson, Adam O Ghoweri, Ruei-Lung Lin, Tara R Hawkinson, Gabriel J Popa, Pradoldej Sompol, Michael D Mendenhall, Christopher M Norris, Olivier Thibaul. Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Aging cell. vol 19. issue 10. 2021-08-26. PMID:32852134. |
as demonstrated by increased hippocampal insulin receptor density following learning in animal models and decreased insulin signaling, receptor density, and memory decline in aging and alzheimer's diseases, numerous studies have emphasized the importance of insulin in learning and memory processes. |
2021-08-26 |
2023-08-13 |
human |
Royal Patel, Karamjeet Kaur, Shamsher Sing. Protective effect of andrographolide against STZ induced Alzheimer's disease in experimental rats: possible neuromodulation and Aβ Inflammopharmacology. vol 29. issue 4. 2021-07-23. PMID:34235591. |
protective effect of andrographolide against stz induced alzheimer's disease in experimental rats: possible neuromodulation and aβ stz is a glucosamine-nitrosourea compound, causes dysfunctioning of insulin receptors in the brain and disrupts glucose metabolism, produces cognitive decline and ad-like symptoms. |
2021-07-23 |
2023-08-13 |
rat |
Valentina Siino, Pia Jensen, Peter James, Sonya Vasto, Antonella Amato, Flavia Mulè, Giulia Accardi, Martin Røssel Larse. Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains. Nutrition and metabolic insights. vol 14. 2021-05-23. PMID:34017182. |
as an example, in post-mortem brain of patients with alzheimer's disease (ad), several studies have reported reduction of insulin, insulin-like growth factor 1 and insulin receptor and an increase in tau protein and glycogen-synthase kinase-3β compared to healthy controls suggesting an impairment of metabolism in the ad patient's brain. |
2021-05-23 |
2023-08-13 |
mouse |
Mingcui Zheng, Pengwen Wan. Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease. 3 Biotech. vol 11. issue 4. 2021-05-02. PMID:33927970. |
role of insulin receptor substance-1 modulating pi3k/akt insulin signaling pathway in alzheimer's disease. |
2021-05-02 |
2023-08-13 |
Not clear |
Sadegh Salarinasab, Leila Salimi, Neda Alidadiani, Elhameh Shokrollahi, Pishva Arzhanga, Saedeh Karbasforush, Faroogh Marofi, Mahdieh Nasirzadeh, Reza Rahbarghazi, Alireza Nourazarian, Masoud Nikanfa. Interaction of opioid with insulin/IGFs signaling in Alzheimer's disease. Journal of molecular neuroscience : MN. vol 70. issue 6. 2021-01-22. PMID:32026387. |
the large distribution of the insulin receptor on the cell surface and its regulatory role in the central nervous system suggests that the pathogenesis of alzheimer's disease could be ascribed to insulin signaling. |
2021-01-22 |
2023-08-13 |
Not clear |
Jaume Folch, Miren Ettcheto, Oriol Busquets, Elena Sánchez-López, Rubén D Castro-Torres, Ester Verdaguer, Patricia R Manzine, Saghar Rabiei Poor, María Luisa García, Jordi Olloquequi, Carlos Beas-Zarate, Carme Auladell, Antoni Camin. The Implication of the Brain Insulin Receptor in Late Onset Alzheimer's Disease Dementia. Pharmaceuticals (Basel, Switzerland). vol 11. issue 1. 2020-09-30. PMID:29382127. |
the implication of the brain insulin receptor in late onset alzheimer's disease dementia. |
2020-09-30 |
2023-08-13 |
Not clear |
Daisuke Tanokashira, Wataru Fukuokaya, Akiko Taguch. Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. Neural regeneration research. vol 14. issue 8. 2020-09-30. PMID:30964050. |
involvement of insulin receptor substrates in cognitive impairment and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
mouse |
Corrigendum: Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. Neural regeneration research. vol 15. issue 6. 2020-09-28. PMID:31823898. |
corrigendum: involvement of insulin receptor substrates in cognitive impairment and alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |