| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiya Oba, Daiki Homma, Sophia Jobien M Limlingan, Aoi Fukuchi, Akiko Asada, Taro Saito, Kanae And. A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity. Neurobiology of disease. 2023-10-26. PMID:37884211. |
abnormal activation of microtubule affinity-regulating kinase 4 (mark4) and its phosphorylation of the microtubule-associated protein tau are believed to play a role in the pathogenesis of alzheimer's disease, and mark4 inhibition can be a strategy to develop disease-modifying therapy. |
2023-10-26 |
2023-11-08 |
human |
| Mohd Adnan, Debarati DasGupta, Saleha Anwar, Anas Shamsi, Arif Jamal Siddiqui, Mejdi Snoussi, Fevzi Bardakci, Mitesh Patel, Md Imtaiyaz Hassa. Mechanistic insights into MARK4 inhibition by galantamine toward therapeutic targeting of Alzheimer's disease. Frontiers in pharmacology. vol 14. 2023-10-05. PMID:37795023. |
mechanistic insights into mark4 inhibition by galantamine toward therapeutic targeting of alzheimer's disease. |
2023-10-05 |
2023-10-07 |
Not clear |
| Manzar Alam, Sarfraz Ahmed, Mohammad Abid, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. Therapeutic targeting of microtubule affinity-regulating kinase 4 in cancer and neurodegenerative diseases. Journal of cellular biochemistry. 2023-09-04. PMID:37661636. |
mark4 is a promising drug target for cancer, diabetes, and alzheimer's. |
2023-09-04 |
2023-09-07 |
Not clear |
| Saleha Anwar, Taj Mohammad, Md Khabeer Azhar, Hera Fatima, Afsar Alam, Gulam Mustafa Hasan, Asimul Islam, Punit Kaur, Md Imtaiyaz Hassa. Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer's disease. International journal of biological macromolecules. 2023-06-14. PMID:37315665. |
microtubule affinity regulating kinase (mark4) is known to hyperphosphorylate tau protein, which subsequently causes alzheimer's disease (ad). |
2023-06-14 |
2023-08-14 |
Not clear |
| Saleha Anwar, Taj Mohammad, Md Khabeer Azhar, Hera Fatima, Afsar Alam, Gulam Mustafa Hasan, Asimul Islam, Punit Kaur, Md Imtaiyaz Hassa. Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer's disease. International journal of biological macromolecules. 2023-06-14. PMID:37315665. |
investigating mark4 inhibitory potential of bacopaside ii: targeting alzheimer's disease. |
2023-06-14 |
2023-08-14 |
Not clear |
| Riyadh Ahmed Atto Al-Shuaeeb, H R Abd El-Mageed, Shimaa Ahmed, Hussein S Mohamed, Zeinab S Hamza, Md Oliullah Rafi, Iqrar Ahmad, Harun Pate. Journal of biomolecular structure & dynamics. 2023-05-15. PMID:37184133. |
mark4 has been associated with tau protein phosphorylation and, consequently, alzheimer's disease. |
2023-05-15 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Debarati DasGupta, Ghulam Md Ashraf, Anwar L Bilgrami, Fahad A Alhumaydhi, Waleed Al Abdulmonem, Moyad Shahwan, Abdulrhman Alsayari, Akhtar Atiya, Anas Shams. Inhibition of microtubule affinity regulating kinase 4 by an acetylcholinesterase inhibitor, Huperzine A: Computational and experimental approaches. International journal of biological macromolecules. 2023-03-04. PMID:36870649. |
thus mark4 plays a key role in alzheimer's disease (ad) pathology. |
2023-03-04 |
2023-08-14 |
Not clear |
| Mohd Adnan, Saleha Anwar, Debarati DasGupta, Mitesh Patel, Abdelbaset Mohamed Elasbali, Hassan H Alhassan, Alaa Shafie, Arif Jamal Siddiqui, Fevzi Bardakci, Mejdi Snoussi, Md Imtaiyaz Hassa. Targeting inhibition of microtubule affinity regulating kinase 4 by Harmaline: Strategy to combat Alzheimer's disease. International journal of biological macromolecules. 2022-10-18. PMID:36257368. |
due to its direct role in the hyper-phosphorylation of tau protein, mark4 is considered as an attractive target to fight alzheimer's disease and neuroinflammation. |
2022-10-18 |
2023-08-14 |
Not clear |
| Saleha Anwar, Moyad Shahwan, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy. Cellular signalling. 2022-08-12. PMID:35961526. |
aberrant expression of mark4 is linked with several pathologies such as cancer, alzheimer's disease, obesity, etc. |
2022-08-12 |
2023-08-14 |
human |
| Anas Shamsi, Debarati DasGupta, Fahad A Alhumaydhi, Mohd Shahnawaz Khan, Suliman A Alsagaby, Waleed Al Abdulmonem, Md Imtaiyaz Hassan, Dharmendra Kumar Yada. Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation. RSC medicinal chemistry. vol 13. issue 6. 2022-07-11. PMID:35814926. |
since mark4 is a potential drug target and can be exploited for drug design and discovery for cancer and neurodegenerative disorders, the results presented here are of interest and may be further exploited for alzheimer's disease (ad) and other neurodegenerative diseases. |
2022-07-11 |
2023-08-14 |
Not clear |
| Anas Shamsi, Debarati DasGupta, Fahad A Alhumaydhi, Mohd Shahnawaz Khan, Suliman A Alsagaby, Waleed Al Abdulmonem, Md Imtaiyaz Hassan, Dharmendra Kumar Yada. Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation. RSC medicinal chemistry. vol 13. issue 6. 2022-07-11. PMID:35814926. |
inhibition of mark4 by serotonin as an attractive therapeutic approach to combat alzheimer's disease and neuroinflammation. |
2022-07-11 |
2023-08-14 |
Not clear |
| Rashid Waseem, Saleha Anwar, Shama Khan, Anas Shamsi, Md Imtaiyaz Hassan, Farah Anjum, Alaa Shafie, Asimul Islam, Dharmendra Kumar Yada. MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681645. |
in addition, mark4 has been explored as a potential drug target for cancer and alzheimer's disease therapy. |
2021-10-26 |
2023-08-13 |
Not clear |
| Sajjad Ahrari, Navid Mogharrab, Leila Navapou. Structure and dynamics of inactive and active MARK4: conformational switching through the activation process. Journal of biomolecular structure & dynamics. vol 38. issue 8. 2021-06-18. PMID:31411112. |
mark4 isoform is mainly found in brain tissue, causing microtubule destabilization in neuronal cells and also tau-protein phosphorylation seen in alzheimer's disease. |
2021-06-18 |
2023-08-13 |
human |
| Ahmad Abu Turab Naqvi, Deeba Shamim Jairajpuri, Omar Mohammed Ali Noman, Afzal Hussain, Asimul Islam, Faizan Ahmad, Mohammed F Alajmi, Md Imtaiyaz Hassa. Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 38. issue 13. 2021-06-18. PMID:31512980. |
targeting the modulation of mark4 activity is an effective strategy for therapeutic intervention of alzheimer's and other mark4 associated neurodegenerative diseases. |
2021-06-18 |
2023-08-13 |
Not clear |
| Anas Shamsi, Saleha Anwar, Taj Mohammad, Mohamed F Alajmi, Afzal Hussain, Md Tabish Rehman, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer's Disease Therapy. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443670. |
microtubule affinity-regulating kinase (mark4) plays a key role in alzheimer's disease (ad) development as its overexpression is directly linked to increased tau phosphorylation. |
2021-04-02 |
2023-08-13 |
Not clear |
| Anas Shamsi, Saleha Anwar, Taj Mohammad, Mohamed F Alajmi, Afzal Hussain, Md Tabish Rehman, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer's Disease Therapy. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443670. |
mark4 inhibited by ache inhibitors, donepezil and rivastigmine tartrate: insights into alzheimer's disease therapy. |
2021-04-02 |
2023-08-13 |
Not clear |
| Saleha Anwar, Anas Shamsi, Rajiv K Kar, Aarfa Queen, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases. International journal of biological macromolecules. vol 161. 2021-03-23. PMID:32535203. |
since the role of mark4 in the phosphorylation of tau protein and subsequently alzheimer's disease has been established, therefore, we have investigated the binding affinity and mark4 inhibitory potential of cholic acid (cha) using both computational and spectroscopic methods. |
2021-03-23 |
2023-08-13 |
Not clear |
| Farha Naz, Neha Sami, Abu Turab Naqvi, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Evaluation of human microtubule affinity-regulating kinase 4 inhibitors: fluorescence binding studies, enzyme, and cell assays. Journal of biomolecular structure & dynamics. vol 35. issue 14. 2018-07-30. PMID:27748164. |
human microtubule affinity-regulating kinase 4 (mark4) is considered as an encouraging drug target for the design and development of inhibitors to cure several life-threatening diseases such as alzheimer disease, cancer, obesity, and type-ii diabetes. |
2018-07-30 |
2023-08-13 |
human |
| John S Sack, Mian Gao, Susan E Kiefer, Joseph E Myers, John A Newitt, Sophie Wu, Chunhong Ya. Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor. Acta crystallographica. Section F, Structural biology communications. vol 72. issue Pt 2. 2016-11-01. PMID:26841763. |
abnormal activity of mark4 has been proposed to contribute to neurofibrillary tangle formation in alzheimer's disease. |
2016-11-01 |
2023-08-13 |
Not clear |
| Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark, Gabriel von Eule. MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24533944. |
mark4 and mark3 associate with early tau phosphorylation in alzheimer's disease granulovacuolar degeneration bodies. |
2014-12-08 |
2023-08-12 |
Not clear |