All Relations between Alzheimer Disease and microtubule-associated protein tau

Reference Sentence Publish Date Extraction Date Species
Zhijun He, Huajie Zhang, Xiaoqian Li, Sixin Tu, Zi Wang, Shuangxue Han, Xiubo Du, Liming Shen, Nan Li, Qiong Li. The protective effects of Esculentoside A through AMPK in the triple transgenic mouse model of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology vol 109 issue 2023 36610160 neurofibrillary tangles comprising hyperphosphorylated tau are vital factors associated with the pathogenesis of alzheimer's disease (ad). 2023-01-07 2023-01-08 Not clear
Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron vol issue 2023 36610398 tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. 2023-01-07 2023-01-08 Not clear
Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron vol issue 2023 36610398 this study thus identifies several points of intervention to reduce tau levels and demonstrates that reduction of tau levels via regulation of this pathway is a viable therapeutic strategy for alzheimer disease and other tauopathies. 2023-01-07 2023-01-08 Not clear
Wang Liao, Haoyu Luo, Yuting Ruan, Yingren Mai, Chongxu Liu, Jiawei Chen, Shaoqing Yang, Aiguo Xuan, Jun Li. Identification of candidate genes associated with clinical onset of Alzheimer's disease. Frontiers in neuroscience vol 16 issue 2023 36605552 alzheimer's disease (ad) is the most common type of dementia, with its pathology like beta-amyloid and phosphorylated tau beginning several years before the clinical onset. 2023-01-06 2023-01-08 Not clear
Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J Ray, Kevin F Bieniek, Bess Fros. Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation. Science advances vol 9 issue 1 2023 36608133 deposition of tau protein aggregates in the brain of affected individuals is a defining feature of "tauopathies," including alzheimer's disease. 2023-01-06 2023-01-08 Not clear
Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J Ray, Kevin F Bieniek, Bess Fros. Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation. Science advances vol 9 issue 1 2023 36608133 we find that dsrna and dsrna sensing machinery are elevated in astrocytes of postmortem brain tissue from patients with alzheimer's disease and progressive supranuclear palsy and in brains of tau transgenic mice. 2023-01-06 2023-01-08 Not clear
John R Dickson, Matthew P Frosch, Bradley T Hyma. Altered localization of nucleoporin 98 in primary tauopathies. Brain communications vol 5 issue 1 2023 36601621 nucleoporin 98 is a nuclear pore complex component that is mislocalized in alzheimer's disease and the alteration in nucleoporin 98 has been attributed to tau. 2023-01-05 2023-01-08 Not clear
John R Dickson, Matthew P Frosch, Bradley T Hyma. Altered localization of nucleoporin 98 in primary tauopathies. Brain communications vol 5 issue 1 2023 36601621 in the context of prior research demonstrating nucleoporin 98 mislocalization in alzheimer's disease and an interaction between tau and nucleoporin 98, these results further support the hypothesis that pathological tau may contribute to nucleoporin 98 mislocalization. 2023-01-05 2023-01-08 Not clear
Thamires Naela Cardoso Magalh\\xc3\\xa3es, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Fl\\xc3\\xa1via Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthaza. Whole-brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease. Brain and behavior vol issue 2023 36601694 whole-brain dti parameters associated with tau protein and hippocampal volume in alzheimer's disease. 2023-01-05 2023-01-08 Not clear
Mervat Hassan, Hisham Ismail, Olfat Hammam, Abdullrahman Elsayed, Othman Othman, Sohair Al. Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and \\xce\\xb2-amyloid in Alzheimer's rat model. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals vol issue 2023 36594248 natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and \xce\xb2-amyloid in alzheimer's rat model. 2023-01-03 2023-01-05 Not clear
Yu Zou, Lulu Guan, Jingwang Tan, Bote Qi, Ying Wang, Qingwen Zhang, Yunxiang Su. Atomistic Insights into the Inhibitory Mechanism of Tyrosine Phosphorylation against the Aggregation of Human Tau Fragment PHF6. The journal of physical chemistry. B vol issue 2023 36594671 abnormal aggregation of the microtubule-associated protein tau into intracellular fibrillary inclusions is characterized as the hallmark of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. 2023-01-03 2023-01-05 Not clear
\\xc5\\x9eenay G\\xc3\\xb6r\\xc3\\xbcc\\xc3\\xbc Y\\xc4\\xb1lmaz, Salam Almasri, Yasemin Yuyucu Karabulut, Murat Korkmaz, \\xc3\\x96znur Bucak, Sibel O\\xc4\\x9fuzkan Balc\\xc4\\xb. Okadaic Acid-Induced Alzheimer's in Rat Brain: Phytochemical Cucurbitacin E Contributes to Memory Gain by Reducing TAU Protein Accumulation. Omics : a journal of integrative biology vol issue 2023 36594931 okadaic acid-induced alzheimer's in rat brain: phytochemical cucurbitacin e contributes to memory gain by reducing tau protein accumulation. 2023-01-03 2023-01-05 Not clear
\\xc5\\x9eenay G\\xc3\\xb6r\\xc3\\xbcc\\xc3\\xbc Y\\xc4\\xb1lmaz, Salam Almasri, Yasemin Yuyucu Karabulut, Murat Korkmaz, \\xc3\\x96znur Bucak, Sibel O\\xc4\\x9fuzkan Balc\\xc4\\xb. Okadaic Acid-Induced Alzheimer's in Rat Brain: Phytochemical Cucurbitacin E Contributes to Memory Gain by Reducing TAU Protein Accumulation. Omics : a journal of integrative biology vol issue 2023 36594931 alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive memory loss and cognitive decline, with hallmark pathologies related to amyloid beta (a\xce\xb2) and tau. 2023-01-03 2023-01-05 Not clear
Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications vol 11 issue 1 2023 36597124 the dentate gyrus (dg), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the alzheimer's type due to alzheimer's disease (dat-ad), but less is known about the susceptibility of the dg to other tauopathies. 2023-01-03 2023-01-05 Not clear
Christina B Young, Emily Johns, Gabriel Kennedy, Michael E Belloy, Philip S Insel, Michael D Greicius, Reisa A Sperling, Keith A Johnson, Kathleen L Poston, Elizabeth C Mormin. APOE effects on regional tau in preclinical Alzheimer's disease. Molecular neurodegeneration vol 18 issue 1 2023 36597122 apoe effects on regional tau in preclinical alzheimer's disease. 2023-01-03 2023-01-05 Not clear
Ya-Nan Lv, Yu Cui, Bo Zhang, Shu-Ming Huan. Sleep deficiency promotes Alzheimer's disease development and progression. Frontiers in neurology vol 13 issue 2023 36588906 sleep deficiency was found to be associated with oxidative stress, \xce\xb2-amyloid protein deposition, tau hyperphosphorylation, and neuroinflammation, which are known to increase the risk for alzheimer's disease. 2023-01-02 2023-01-05 Not clear
Ningtian Ma, Yuyang Liang, Lingyun Yue, Pu Liu, Yuxia Xu, Cuiqing Zh. The identities of insulin signaling pathway are affected by overexpression of Tau and its phosphorylation form. Frontiers in aging neuroscience vol 14 issue 2023 36589543 hyperphosphorylated tau formed neurofibrillary tangles was one of the major neuropathological hallmarks of alzheimer's disease (ad). 2023-01-02 2023-01-05 Not clear
Alexandra Milani, Markus Morawski, Ingo Bechman. Inter-hemispherical comparison of tau-pathology in the human temporal lobe. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft vol issue 2023 36592871 alzheimer's disease (ad) is characterized histopathologically by hyperphosphorylated and aggregated tau and amyloid plaques. 2023-01-02 2023-01-05 Not clear
Teresa H Evering, Jez L Marston, Li Gan, Douglas F Nixo. Transposable elements and Alzheimer's disease pathogenesis. Trends in neurosciences vol issue 2023 36588011 alzheimer's disease (ad) is characterized by the pathological accumulation of amyloid \xce\xb2 (a\xce\xb2) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. 2023-01-01 2023-01-05 Not clear
Deepti Putcha, Yuta Katsumi, Michael Brickhouse, Ryn Flaherty, David H Salat, Alexandra Touroutoglou, Bradford C Dickerso. Gray to white matter signal ratio as a novel biomarker of neurodegeneration in Alzheimer's disease. NeuroImage. Clinical vol 37 issue 2022 36586361 alzheimer's disease (ad) is characterized neuropathologically by \xce\xb2-amyloid (a\xce\xb2) plaques, hyperphosphorylated tau neurofibrillary tangles, and neurodegeneration, which lead to a phenotypically heterogeneous cognitive-behavioral dementia syndrome. 2022-12-31 2023-01-05 Not clear
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