| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohsina Patwekar, Faheem Patwekar, Shahzad Khan, Rohit Sharma, Dileep Kuma. Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-Beta Complexities and Pioneering Precision Medicine Approaches. Current topics in medicinal chemistry. 2024-04-22. PMID:38644708. |
combination therapies are becoming increasingly popular as a way to address the multifaceted pathology of alzheimer's by simultaneously attacking aβ plaques, tau tangles, neuroinflammation, and other factors. |
2024-04-22 |
2024-04-24 |
Not clear |
| Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644999. |
tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. |
2024-04-22 |
2024-04-24 |
mouse |
| Anthony J Griswold, Farid Rajabli, Tianjie Gu, Jamie Arvizu, Charles G Golightly, Patrice L Whitehead, Kara L Hamilton-Nelson, Larry D Adams, Jose Javier Sanchez, Pedro R Mena, Takiyah D Starks, Maryenela Illanes-Manrique, Concepcion Silva, William S Bush, Michael L Cuccaro, Jeffery M Vance, Mario R Cornejo-Olivas, Briseida E Feliciano-Astacio, Goldie S Byrd, Gary W Beecham, Jonathan L Haines, Margaret A Pericak-Vanc. Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645114. |
generalizability of tau and amyloid plasma biomarkers in alzheimer's disease cohorts of diverse genetic ancestries. |
2024-04-22 |
2024-04-24 |
Not clear |
| Anthony J Griswold, Farid Rajabli, Tianjie Gu, Jamie Arvizu, Charles G Golightly, Patrice L Whitehead, Kara L Hamilton-Nelson, Larry D Adams, Jose Javier Sanchez, Pedro R Mena, Takiyah D Starks, Maryenela Illanes-Manrique, Concepcion Silva, William S Bush, Michael L Cuccaro, Jeffery M Vance, Mario R Cornejo-Olivas, Briseida E Feliciano-Astacio, Goldie S Byrd, Gary W Beecham, Jonathan L Haines, Margaret A Pericak-Vanc. Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645114. |
plasma phosphorylated threonine-181 of tau and amyloid beta are biomarkers for differential diagnosis and preclinical detection of alzheimer disease (ad). |
2024-04-22 |
2024-04-24 |
Not clear |
| Gérard N Bischof, Elena Jaeger, Kathrin Giehl, Frank Jessen, Oezguer A Onur, Sid O'Bryant, Esra Kara, Peter H Weiss, Alexander Drzezg. Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645131. |
cortical tau aggregation patterns associated with apraxia in alzheimer's disease. |
2024-04-22 |
2024-04-24 |
Not clear |
| Gérard N Bischof, Elena Jaeger, Kathrin Giehl, Frank Jessen, Oezguer A Onur, Sid O'Bryant, Esra Kara, Peter H Weiss, Alexander Drzezg. Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645131. |
here, we systematically investigated apraxia profiles in a well-defined group of patients with alzheimer's disease (ad; n=32) who additionally underwent pet imaging with the second-generation tau pet tracer [18f]pi-2620. |
2024-04-22 |
2024-04-24 |
Not clear |
| Fang Frank Yu, James Rathnakar, Bryan Ryder, Brian Hitt, Omar M Kashmer, A Dean Sherry, Elena Vinogrado. Differentiation and characterization of healthy versus pathological tau using chemical exchange saturation transfer. NMR in biomedicine. 2024-04-22. PMID:38646677. |
neurofibrillary tangles of tau constitute one of the key biological hallmarks of alzheimer's disease. |
2024-04-22 |
2024-04-24 |
Not clear |
| Aditya Singh, Shubhrat Maheshwari, Jagat Pal Yadav, Aditya Prakash Varshney, Sudarshan Singh, Bhupendra G Prajapat. A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases. Central nervous system agents in medicinal chemistry. 2024-04-22. PMID:38646682. |
a review on tau targeting biomimetics nano formulations: novel approach for targeting alzheimer's diseases. |
2024-04-22 |
2024-04-24 |
Not clear |
| Aditya Singh, Shubhrat Maheshwari, Jagat Pal Yadav, Aditya Prakash Varshney, Sudarshan Singh, Bhupendra G Prajapat. A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases. Central nervous system agents in medicinal chemistry. 2024-04-22. PMID:38646682. |
recent research has revealed that tau pathology can occur independently of amyloid-β and is closely correlated with the clinical progression of alzheimer's symptoms. |
2024-04-22 |
2024-04-24 |
Not clear |
| Aditya Singh, Shubhrat Maheshwari, Jagat Pal Yadav, Aditya Prakash Varshney, Sudarshan Singh, Bhupendra G Prajapat. A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases. Central nervous system agents in medicinal chemistry. 2024-04-22. PMID:38646682. |
in alzheimer's disease, beta-amyloid plaques and neurofibrillary tau tangles hinder neuron transmission and function. |
2024-04-22 |
2024-04-24 |
Not clear |
| Vinita Sharma, Prabodh Chander Sharma, Jurnal Reang, Vivek Yadav, Rajiv Kumar Tonk, Jaseela Majeed, Kalicharan Sharm. Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach. Bioorganic chemistry. vol 147. 2024-04-21. PMID:38643562. |
gsk-3β and ck-1δ are multifunctional kinases known for their roles in tau hyperphosphorylation, amyloid processing, and synaptic dysfunction, all of which are major hallmarks of alzheimer's disease. |
2024-04-21 |
2024-04-24 |
Not clear |
| Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughe. Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces. PLoS pathogens. vol 20. issue 4. 2024-04-19. PMID:38640117. |
prions or prion-like aggregates such as those composed of prp, α-synuclein, and tau are key features of proteinopathies such as prion, parkinson's and alzheimer's diseases, respectively. |
2024-04-19 |
2024-04-22 |
mouse |
| Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughe. Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces. PLoS pathogens. vol 20. issue 4. 2024-04-19. PMID:38640117. |
tau rt-quic detected tau seeding activity on steel exposed to alzheimer's disease brain tissue diluted as much as a billion fold. |
2024-04-19 |
2024-04-22 |
mouse |
| Han Soo Yoo, Han-Kyeol Kim, Jae-Hoon Lee, Joong-Hyun Chun, Hye Sun Lee, Michel J Grothe, Stefan Teipel, Enrica Cavedo, Andrea Vergallo, Harald Hampel, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyo. Association of Basal Forebrain Volume with Amyloid, Tau, and Cognition in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-19. PMID:38640150. |
association of basal forebrain volume with amyloid, tau, and cognition in alzheimer's disease. |
2024-04-19 |
2024-04-22 |
Not clear |
| Erratum to: Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 98. issue 4. 2024-04-19. PMID:38640189. |
erratum to: ubiquitin specific protease 13 regulates tau accumulation and clearance in models of alzheimer's disease. |
2024-04-19 |
2024-04-22 |
Not clear |
| Dennis J Selko. The advent of Alzheimer treatments will change the trajectory of human aging. Nature aging. vol 4. issue 4. 2024-04-19. PMID:38641654. |
a salient example is the discovery that antibodies to amyloid ß-protein, long debated as a causative factor in alzheimer's disease (ad), clear amyloid plaques, decrease levels of abnormal tau proteins and slow cognitive decline. |
2024-04-19 |
2024-04-22 |
human |
| Hsin-Hsi Tsai, Chia-Ju Liu, Bo-Ching Lee, Ya-Fang Chen, Ruoh-Fang Yen, Jiann-Shing Jeng, Li-Kai Tsa. Cerebral tau pathology in cerebral amyloid angiopathy. Brain communications. vol 6. issue 2. 2024-04-19. PMID:38638152. |
tau, a hallmark of alzheimer's disease, is poorly characterized in cerebral amyloid angiopathy. |
2024-04-19 |
2024-04-21 |
Not clear |
| Shan Jiang, Eric J Sydney, Avery M Runyan, Rossana Serpe, Malavika Srikanth, Helen Y Figueroa, Mu Yang, Natura Myek. 5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy. Frontiers in cellular neuroscience. vol 18. 2024-04-19. PMID:38638303. |
accumulation of tau in synapses in the early stages of alzheimer's disease (ad) has been shown to cause synaptic damage, synaptic loss, and the spread of tau pathology through trans-synaptically connected neurons. |
2024-04-19 |
2024-04-21 |
mouse |
| Ahmed Imtiaz, Shotaro Shimonaka, Mohammad Nasir Uddin, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Moto. Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer's disease seed-dependent formation of tau aggregates. Frontiers in aging neuroscience. vol 16. 2024-04-18. PMID:38633982. |
selection of lansoprazole from an fda-approved drug library to inhibit the alzheimer's disease seed-dependent formation of tau aggregates. |
2024-04-18 |
2024-04-20 |
mouse |
| BinShu Chai, Yong Wu, HengHui Yang, BiaoFeng Fan, SiYu Cao, XiaoFei Zhang, YaQing Xie, ZhiXiang Hu, ZhongLiang Ma, YunKui Zhang, Wei Pan, Wei Meng, Jiao Meng, WenJuan Tian, JiaLi Zhang, YanLi Li, Yang Shao, ShaoJia Wan. Tau Aggregation-Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14-3-3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-04-18. PMID:38634567. |
therefore, based on this results, ferroptosis caused by tau aggregation occurs in eoc cells, which is not only in alzheimer's disease- or parkinson's disease-related cells and this kind of ferroptosis driven by the hsa_circ_0001546/14-3-3/camk2d/tau complex is lpo-dependent rather than gpx4-dependent is hypothesized. |
2024-04-18 |
2024-04-20 |
Not clear |