All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Samantha M Rossano, Aubrey S Johnson, Anna Smith, Galen Ziaggi, Andrew Roetman, Diana Guzman, Amarachukwu Okafor, Julia Klein, Zeljko Tomljanovic, Yaakov Stern, Adam M Brickman, Seonjoo Lee, William C Kreisl, Patrick La. Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-01. PMID:38298155. evidence suggests microglial activation precedes regional tau and neurodegeneration in alzheimer's disease (ad). 2024-02-01 2024-02-03 Not clear
Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. The Journal of clinical investigation. vol 134. issue 3. 2024-02-01. PMID:38299587. synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. 2024-02-01 2024-02-03 mouse
Yunkwon Nam, Ritu Prajapati, Sujin Kim, Soo Jung Shin, Da Yeon Cheong, Yong Ho Park, Hyun Ha Park, Danyou Lim, Yoojeong Yoon, Gyudo Lee, Hyun Ah Jung, Insu Park, Dong-Hyun Kim, Jae Sue Choi, Minho Moo. Dual regulatory effects of neferine on amyloid-β and tau aggregation studied by in silico, in vitro, and lab-on-a-chip technology. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-01. PMID:38301421. alzheimer's disease (ad) is characterized by the presence of two critical pathogenic factors: amyloid-β (aβ) and tau. 2024-02-01 2024-02-04 Not clear
Minyoung Oh, Seung Jun Oh, Sang Ju Lee, Jungsu S Oh, Seung Yeon Seo, Soorack Ryu, Jee Hoon Roh, Jae-Hong Lee, Jae Seung Ki. One-Year Longitudinal Changes in Tau Accumulation on [ Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024-02-01. PMID:38302152. one-year longitudinal changes in tau accumulation on [ we investigated the longitudinal changes in cortical tau accumulation and their association with cognitive decline in patients in the alzheimer disease (ad) continuum using 2-(2-([ 2024-02-01 2024-02-04 Not clear
Gargi Banerjee, Simon F Farmer, Harpreet Hyare, Zane Jaunmuktane, Simon Mead, Natalie S Ryan, Jonathan M Schott, David J Werring, Peter Rudge, John Colling. Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone. Nature medicine. 2024-01-29. PMID:38287166. alzheimer's disease (ad) is characterized pathologically by amyloid-beta (aβ) deposition in brain parenchyma and blood vessels (as cerebral amyloid angiopathy (caa)) and by neurofibrillary tangles of hyperphosphorylated tau. 2024-01-29 2024-02-01 human
Zhouquan Jiang, Jing Wang, Yongpeng Qin, Shanggong Liu, Bin Luo, Fan Bai, Huiyi Wei, Shaojuan Zhang, Junjie Wei, Guoyu Ding, Long Ma, Shu He, Rongjie Chen, Ying Sun, Yi Chen, Lu Wang, Hao Xu, Xiangyu Wang, Gong Chen, Wenliang Le. A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau. Alzheimer's research & therapy. vol 16. issue 1. 2024-01-27. PMID:38281031. a nonhuman primate model with alzheimer's disease-like pathology induced by hippocampal overexpression of human tau. 2024-01-27 2024-01-30 human
Ryszard Pluta, Stanisław J Czuczwa. Ischemia-Reperfusion Programming of Alzheimer's Disease-Related Genes-A New Perspective on Brain Neurodegeneration after Cardiac Arrest. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279289. the data include amyloid accumulation, tau protein modification, neurodegenerative and cognitive changes, and gene and protein changes associated with alzheimer's disease. 2024-01-27 2024-01-29 Not clear
Catherine Sharo, Tianhua Zhai, Zuyi Huan. Investigation of Potential Drug Targets Involved in Inflammation Contributing to Alzheimer's Disease Progression. Pharmaceuticals (Basel, Switzerland). vol 17. issue 1. 2024-01-26. PMID:38276010. alzheimer's disease is known to arise from a build-up of amyloid beta (aβ) plaques as well as tangles of tau proteins. 2024-01-26 2024-01-28 Not clear
Jun-Fei Zhang, Zhi-Ting Fang, Jun-Ning Zhao, Gong-Ping Liu, Xin Shen, Gao-Feng Jiang, Qian Li. Acetylated tau exacerbates apoptosis by disturbing mitochondrial dynamics in HEK293 cells. Journal of neurochemistry. 2024-01-26. PMID:38275215. an increase in tau acetylation at k274 and k281 and abnormal mitochondrial dynamics have been observed in the brains of alzheimer's disease (ad) patients. 2024-01-26 2024-01-28 human
Karthikeyan Selvarasu, Abhay Kumar Singh, Avinash Dakshinamoorthy, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Moorthi Radhakrishnan, Supriti Patnaik, Jian-Dong Huang, Leonard L Williams, Sanjib Senapati, Siva Sundara Kumar Durairaja. Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation. Biomedicines. vol 12. issue 1. 2024-01-26. PMID:38275365. natively unfolded tau has a low propensity to form aggregates, but in tauopathies, such as alzheimer's disease (ad), tau aggregates into paired helical filaments (phfs) and neurofibrillary tangles (nfts). 2024-01-26 2024-01-28 mouse
Sanaz Arezoumandan, Katheryn A Q Cousins, Daniel T Ohm, MaKayla Lowe, Min Chen, James Gee, Jeffrey S Phillips, Corey T McMillan, Kelvin C Luk, Andres Deik, Meredith A Spindler, Thomas F Tropea, Daniel Weintraub, David A Wolk, Murray Grossman, Virginia Lee, Alice S Chen-Plotkin, Edward B Lee, David J Irwi. Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Annals of clinical and translational neurology. 2024-01-24. PMID:38263854. tau maturation in the clinicopathological spectrum of lewy body and alzheimer's disease. 2024-01-24 2024-01-26 Not clear
Sanaz Arezoumandan, Katheryn A Q Cousins, Daniel T Ohm, MaKayla Lowe, Min Chen, James Gee, Jeffrey S Phillips, Corey T McMillan, Kelvin C Luk, Andres Deik, Meredith A Spindler, Thomas F Tropea, Daniel Weintraub, David A Wolk, Murray Grossman, Virginia Lee, Alice S Chen-Plotkin, Edward B Lee, David J Irwi. Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Annals of clinical and translational neurology. 2024-01-24. PMID:38263854. here, we examined tau epitopes marking various stages of tangle maturation to test the hypotheses that tau maturation is more strongly associated with beta-amyloid compared to alpha-synuclein, and within the context of mixed pathology, mature tau is linked to alzheimer's disease clinical phenotype and negatively associated with lewy body dementia. 2024-01-24 2024-01-26 Not clear
Huahua Shi, Yan Zha. Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255905. modulation of tau pathology in alzheimer's disease by dietary bioactive compounds. 2024-01-23 2024-01-25 Not clear
Huahua Shi, Yan Zha. Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255905. the abnormal intracellular accumulation of tau aggregates is a major characteristic of brains from patients with alzheimer's disease (ad) and other tauopathies. 2024-01-23 2024-01-25 Not clear
Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. one such factor is hypoxia, which is strongly linked to alzheimer's disease because of its association with obstructive sleep apnea and has been reported to affect molecular pathways related to the dysfunction and aggregation of tau proteins and other biomarkers of neurological damage. 2024-01-23 2024-01-25 Not clear
Lise Colmant, Emilien Boyer, Thomas Gerard, Kristel Sleegers, Renaud Lhommel, Adrian Ivanoiu, Philippe Lefèvre, Pascal Kienlen-Campard, Bernard Hanseeu. Definition of a Threshold for the Plasma Aβ42/Aβ40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256246. alzheimer's disease (ad) is characterized by amyloid beta (aβ) plaques and hyperphosphorylated tau in the brain. 2024-01-23 2024-01-25 human
Monica Neațu, Anca Covaliu, Iulia Ioniță, Ana Jugurt, Eugenia Irene Davidescu, Bogdan Ovidiu Popesc. Monoclonal Antibody Therapy in Alzheimer's Disease. Pharmaceutics. vol 16. issue 1. 2024-01-23. PMID:38258071. alzheimer's disease is a neurodegenerative condition marked by the progressive deterioration of cognitive abilities, memory impairment, and the accumulation of abnormal proteins, specifically beta-amyloid plaques and tau tangles, within the brain. 2024-01-23 2024-01-25 Not clear
Chloé Jacquemin, Nicolas Villain, Rita Azevedo, Susana Boluda, Etienne A Thévenot, François Fenaille, Foudil Lamari, François Beche. Evaluation of SP3 for antibody-free quantification of tau in CSF mimic and brain by mass spectrometry. European journal of mass spectrometry (Chichester, England). 2024-01-23. PMID:38258392. tubulin-associated unit (tau) has an important role in the pathogenesis and the diagnosis of alzheimer's disease (ad) and other tauopathies. 2024-01-23 2024-01-25 human
Yang Ye, Mingzhu Gao, Wentao Shi, Yan Gao, Yilu Li, Wenhui Yang, Xiaomin Zheng, Xiaojie L. The immunomodulatory effects of mesenchymal stem cell-derived extracellular vesicles in Alzheimer's disease. Frontiers in immunology. vol 14. 2024-01-23. PMID:38259476. neuroinflammation has been identified as another significant pathogenic factor in alzheimer's disease following aβ amyloid deposition and tau protein hyperphosphorylation, activated in the central nervous system by glial cells in response to injury-related and pathogen-related molecular patterns. 2024-01-23 2024-01-25 Not clear
August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle Travaglini, Mariano Gabitto, Rebecca Hodge, Eitan Kaplan, Ed Lein, Philip L De Jager, David A Bennett, Eunjung Alice Lee, Christopher A Wals. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260600. alzheimer's disease (ad) is an age-associated neurodegenerative disorder characterized by progressive neuronal loss and pathological accumulation of the misfolded proteins amyloid-β and tau 2024-01-23 2024-01-25 Not clear