| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy F Strain, Nicolas Barthelemy, Kanta Horie, Brian A Gordon, Collin Kilgore, Andrew Aschenbrenner, Carlos Cruchaga, Chengjie Xiong, Nelly Joseph-Mathurin, Jason Hassenstab, Anne M Fagan, Yan Li, Celeste M Karch, Richard Perrin, Sarah B Berman, Jasmeer P Chhatwal, Neill R Graff-Radford, Hiroshi Mori, Johannes Levin, James M Noble, Ricardo Allegri, Peter R Schofield, Daniel S Marcus, David M Holtzman, John C Morris, Tammie L S Benzinger, Eric M McDade, Randall J Bateman, Beau M Ance. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of disease. 2022-03-31. PMID:35358703. |
hyperphosphorylation of tau leads to conformational changes that destabilize microtubules and hinder axonal transport in alzheimer's disease (ad). |
2022-03-31 |
2023-08-13 |
Not clear |
| Laetitia Miguel, Anne Rovelet-Lecrux, Pascal Chambon, Géraldine Joly-Helas, Stéphane Rousseau, David Wallon, Stéphane Epelbaum, Thierry Frébourg, Dominique Campion, Gaël Nicolas, Magalie Lecourtoi. Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies. Stem cell research. vol 61. 2022-03-31. PMID:35358831. |
tau accumulates in patients' brain in several neurodegenerative diseases, including fronto-temporal dementia and alzheimer's disease. |
2022-03-31 |
2023-08-13 |
Not clear |
| Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V Kamath, Mansuo Hayashi, Bradley T Hyma. Tau propagation is dependent on the genetic background of mouse strains. Brain communications. vol 4. issue 2. 2022-03-30. PMID:35350555. |
progressive cognitive decline in alzheimer's disease correlates closely with the spread of tau protein aggregation across neural networks of the cortical mantle. |
2022-03-30 |
2023-08-13 |
mouse |
| Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V Kamath, Mansuo Hayashi, Bradley T Hyma. Tau propagation is dependent on the genetic background of mouse strains. Brain communications. vol 4. issue 2. 2022-03-30. PMID:35350555. |
genetic factors may contribute to tau pathology progression across brain networks, which could help refine mechanisms underlying tau cell-to-cell transfer and accumulation, and potentially provide targets for understanding patient-to-patient variability in the rate of disease progression in alzheimer's disease. |
2022-03-30 |
2023-08-13 |
mouse |
| Xinyang Feng, Frank A Provenzano, Scott A Smal. A deep learning MRI approach outperforms other biomarkers of prodromal Alzheimer's disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-03-30. PMID:35351193. |
the three core pathologies of alzheimer's disease (ad) are amyloid pathology, tau pathology, and neurodegeneration. |
2022-03-30 |
2023-08-13 |
Not clear |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
apoe status (presence of the e4 allele), a known genetic risk factor for alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. |
2022-03-30 |
2023-08-13 |
human |
| Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J van der Lee, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijm. Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-03-29. PMID:35346299. |
cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in alzheimer's disease. |
2022-03-29 |
2023-08-13 |
Not clear |
| Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J van der Lee, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijm. Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-03-29. PMID:35346299. |
increased total tau (t-tau) in cerebrospinal fluid (csf) is a key characteristic of alzheimer's disease (ad) and is considered to result from neurodegeneration. |
2022-03-29 |
2023-08-13 |
Not clear |
| Filipa Gouveia, Antoni Camins, Miren Ettcheto, Joana Bicker, Amílcar Falcão, M Teresa Cruz, Ana Fortun. Targeting Brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: past, present and future. Ageing research reviews. 2022-03-29. PMID:35346852. |
alzheimer's disease (ad) is a well-known neurodegenerative disease characterized by the presence of two main hallmarks - tau hyperphosphorylation and aβ deposits. |
2022-03-29 |
2023-08-13 |
Not clear |
| Alessandro Soloperto, Deborah Quaglio, Paola Baiocco, Isabella Romeo, Mattia Mori, Matteo Ardini, Caterina Presutti, Ida Sannino, Silvia Ghirga, Antonia Iazzetti, Rodolfo Ippoliti, Giancarlo Ruocco, Bruno Botta, Francesca Ghirga, Silvia Di Angelantonio, Alberto Boff. Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons. Scientific reports. vol 12. issue 1. 2022-03-29. PMID:35347170. |
numerous studies have shown a strong correlation between the number of neurofibrillary tangles of the tau protein and alzheimer's disease progression, making the quantitative detection of tau very promising from a clinical point of view. |
2022-03-29 |
2023-08-13 |
human |
| Mónica Rosselli, Idaly Vélez Uribe, Emily Ahne, Layaly Shihade. Culture, Ethnicity, and Level of Education in Alzheimer's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-03-29. PMID:35347644. |
alzheimer's disease (ad) is the most frequent cause of dementia, where the abnormal accumulation of beta-amyloid (aβ) and tau lead to neurodegeneration as well as loss of cognitive, behavioral, and functional abilities. |
2022-03-29 |
2023-08-13 |
Not clear |
| Saloua Fray, Afef Achouri Achouri-Rassas, Sondes Hadj Fredj, Taieb Messaoud, Samir Bela. Association between H2 haplotype of microtubule associated protein tau gene (deletion / insertion) with Alzheimer Disease in Tunisian patients. Neurological research. 2022-03-29. PMID:35348036. |
association between h2 haplotype of microtubule associated protein tau gene (deletion / insertion) with alzheimer disease in tunisian patients. |
2022-03-29 |
2023-08-13 |
Not clear |
| Hyunjun Park, Yeong-Bae Lee, Keun-A Chan. miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease. International journal of biological sciences. vol 18. issue 5. 2022-03-28. PMID:35342350. |
mir-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xfad mouse model of alzheimer's disease. |
2022-03-28 |
2023-08-13 |
mouse |
| Qiuzhi Zhou, Shihong Li, Mengzhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Enjie Liu, Jian-Zhi Wan. Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration. EBioMedicine. vol 78. 2022-03-27. PMID:35339896. |
human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: a vicious cycle in alzheimer neurodegeneration. |
2022-03-27 |
2023-08-13 |
human |
| Qiuzhi Zhou, Shihong Li, Mengzhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Enjie Liu, Jian-Zhi Wan. Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration. EBioMedicine. vol 78. 2022-03-27. PMID:35339896. |
glycogen synthase kinase-3β (gsk-3β) is one of the most effective kinases in promoting tau hyperphosphorylation and accumulation in alzheimer's disease (ad). |
2022-03-27 |
2023-08-13 |
human |
| Kathryn V Papp, Rachel F Buckley, Heidi I L Jacobs, Aaron P Schultz, Michael J Properzi, Patrizia Vannini, Bernard J Hanseeuw, Dorene M Rentz, Keith A Johnson, Reisa A Sperlin. Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. 2022-03-26. PMID:35338074. |
alzheimer's disease (ad) clinical trials are moving earlier in the disease process, based on emerging signs of beta-amyloid (aβ) and tau pathology. |
2022-03-26 |
2023-08-13 |
Not clear |
| Francisca Villavicencio-Tejo, Margrethe A Olesen, Alejandra Aránguiz, Rodrigo A Quintanill. Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 11. issue 3. 2022-03-25. PMID:35326165. |
activation of the nrf2 pathway prevents mitochondrial dysfunction induced by caspase-3 cleaved tau: implications for alzheimer's disease. |
2022-03-25 |
2023-08-13 |
Not clear |
| Francisca Villavicencio-Tejo, Margrethe A Olesen, Alejandra Aránguiz, Rodrigo A Quintanill. Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 11. issue 3. 2022-03-25. PMID:35326165. |
alzheimer's disease (ad) is characterized by memory and cognitive impairment, accompanied by the accumulation of extracellular deposits of amyloid β-peptide (aβ) and the presence of neurofibrillary tangles (nfts) composed of pathological forms of tau protein. |
2022-03-25 |
2023-08-13 |
Not clear |
| Michael Rullmann, Matthias Brendel, Matthias L Schroeter, Dorothee Saur, Johannes Levin, Robert G Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L Villemagne, Joseph Classen, Andrew W Stephens, Osama Sabri, Henryk Barthel, On Behalf Of The German Imaging Initiative For Tauopathies Gii . Multicenter Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327650. |
multicenter tau aggregates accumulate in the alzheimer's disease (ad) brain according to the established braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. |
2022-03-25 |
2023-08-13 |
Not clear |
| Teresa Gómez-Isla, Matthew P Frosc. Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes. Nature reviews. Neurology. 2022-03-25. PMID:35332316. |
since the original description of amyloid-β plaques and tau tangles more than 100 years ago, these lesions have been considered the neuropathological hallmarks of alzheimer disease (ad). |
2022-03-25 |
2023-08-13 |
Not clear |