All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Margreet B Koopman, Luca Ferrari, Stefan G D Rüdige. How do protein aggregates escape quality control in neurodegeneration? Trends in neurosciences. 2022-02-25. PMID:35210101. we focus primarily on the protein tau, which aggregates in alzheimer's disease (ad) and other tauopathies. 2022-02-25 2023-08-13 Not clear
Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L Villemagne, Nobuyuki Okamur. Imaging of Reactive Astrogliosis by Positron Emission Tomography. Frontiers in neuroscience. vol 16. 2022-02-25. PMID:35210989. many neurodegenerative diseases are neuropathologically characterized by neuronal loss, gliosis, and the deposition of misfolded proteins such as β-amyloid (aβ) plaques and tau tangles in alzheimer's disease (ad). 2022-02-25 2023-08-13 Not clear
Longfei Li, Yanli Jiang, Jian-Zhi Wang, Rong Liu, Xiaochuan Wan. Tau Ubiquitination in Alzheimer's Disease. Frontiers in neurology. vol 12. 2022-02-25. PMID:35211074. tau ubiquitination in alzheimer's disease. 2022-02-25 2023-08-13 Not clear
Longfei Li, Yanli Jiang, Jian-Zhi Wang, Rong Liu, Xiaochuan Wan. Tau Ubiquitination in Alzheimer's Disease. Frontiers in neurology. vol 12. 2022-02-25. PMID:35211074. paired helical filaments (phfs) from the alzheimer's disease (ad) brain are highly ubiquitinated and ubiquitination likely plays a vital role in tau filament formation. 2022-02-25 2023-08-13 Not clear
Heidi I L Jacobs, Adrienne O'Donnell, Claudia L Satizabal, Cristina Lois, Daniel Kojis, Bernard J Hanseeuw, Emma Thibault, Justin S Sanchez, Rachel F Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A Sperling, Keith A Johnson, Alexa S Beiser, Sudha Seshadr. Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study. Journal of Alzheimer's disease : JAD. 2022-02-25. PMID:35213372. the brainstem is among the first regions to accumulate alzheimer's disease (ad)-related hyperphosphorylated tau pathology during aging. 2022-02-25 2023-08-13 Not clear
Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Sagar Gaikwad, Mauro Montalbano, Arijit Bhuyan, Stephanie Garcia, Salome McAllen, Minal Sonawane, Cynthia Jerez, Yingxin Zhao, Rakez Kaye. Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease. The Journal of biological chemistry. 2022-02-24. PMID:35202653. lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of alzheimer's disease. 2022-02-24 2023-08-13 human
Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Sagar Gaikwad, Mauro Montalbano, Arijit Bhuyan, Stephanie Garcia, Salome McAllen, Minal Sonawane, Cynthia Jerez, Yingxin Zhao, Rakez Kaye. Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease. The Journal of biological chemistry. 2022-02-24. PMID:35202653. ubiquitin-modified tau aggregates are abundantly found in human brains diagnosed with alzheimer's disease (ad) and other tauopathies. 2022-02-24 2023-08-13 human
Fabian Kreilaus, Magdalena Przybyla, Lars Ittner, Tim Kar. Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice. Behavioural brain research. 2022-02-24. PMID:35202719. frontotemporal dementia (ftd) and alzheimer's disease (ad) share the pathological hallmark of intracellular neurofibrillary tangles, which result from the hyperphosphorylation of microtubule associated protein tau. 2022-02-24 2023-08-13 mouse
Laura Torres-Garcia, Joana M P Domingues, Edoardo Brandi, Caroline Haikal, Janitha M Mudannayake, Inês C Brás, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F Outeiro, Gunnar K Gouras, Jia-Yi L. Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation. Scientific reports. vol 12. issue 1. 2022-02-23. PMID:35194057. parkinson's disease (pd) and alzheimer's disease (ad) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (asyn) in pd, and amyloid-β (aβ) and tau in ad. 2022-02-23 2023-08-13 mouse
Denis S Smirnov, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simrén, Juan Lantero-Rodriguez, Thomas K Karikari, Annie Hiniker, Robert A Rissman, David P Salmon, Douglas Galask. Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change. Acta neuropathologica. 2022-02-23. PMID:35195758. plasma biomarkers related to amyloid, tau, and neurodegeneration (atn) show great promise for identifying these pathological features of alzheimer's disease (ad) as shown by recent clinical studies and selected autopsy studies. 2022-02-23 2023-08-13 human
Emily Eufaula Beaman, Anders Nissen Bonde, Sara Marie Ulv Larsen, Brice Ozenne, Terhi Johanna Lohela, Maiken Nedergaard, Gunnar Hilmar Gíslason, Gitte Moos Knudsen, Sebastian Camillo Hols. Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension. Brain : a journal of neurology. 2022-02-23. PMID:35196379. alzheimer's disease is a neurodegenerative disorder where pathological accumulation of amyloid-β and tau begin years before symptom onset. 2022-02-23 2023-08-13 Not clear
Gabriel Cassinelli Petersen, Michelle Roytman, Gloria C Chiang, Yi Li, Marc L Gordon, Ana M Francesch. Overview of tau PET molecular imaging. Current opinion in neurology. 2022-02-22. PMID:35191407. this article reviews tau pet imaging with an emphasis on first-generation and second-generation tau radiotracers and their application in neurodegenerative disorders, including alzheimer's disease and non-alzheimer's disease tauopathies. 2022-02-22 2023-08-13 Not clear
Cécilia Tremblay, Geidy E Serrano, Anthony J Intorcia, Jasmine Curry, Lucia I Sue, Courtney M Nelson, Jessica E Walker, Michael J Glass, Richard A Arce, Adam S Fleisher, Michael J Pontecorvo, Alireza Atri, Thomas J Montine, Kewei Chen, Thomas G Beac. Hemispheric Asymmetry and Atypical Lobar Progression of Alzheimer-Type Tauopathy. Journal of neuropathology and experimental neurology. 2022-02-22. PMID:35191506. the spread of neurofibrillary tau pathology in alzheimer disease (ad) mostly follows a stereotypical pattern of topographical progression but atypical patterns associated with interhemispheric asymmetry have been described. 2022-02-22 2023-08-13 Not clear
Abhisek Mukherjee, Rabab Al-Lahham, Mark E Corkins, Sourav Samanta, Ann M Schmeichel, Wolfgang Singer, Phillip A Low, Thimmaiah Govindaraju, Claudio Sot. Identification of Multicolor Fluorescent Probes for Heterogeneous Aβ Deposits in Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2022-02-21. PMID:35185519. accumulation of amyloid-beta (aβ) into amyloid plaques and hyperphosphorylated tau into neurofibrillary tangles (nfts) are pathological hallmarks of alzheimer's disease (ad). 2022-02-21 2023-08-13 human
Jéssica Abdo Gonçalves Tosatti, Adriana Fialho da Silva Fontes, Paulo Caramelli, Karina Braga Gome. Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials. Drugs & aging. 2022-02-21. PMID:35187615. alzheimer's disease (ad) comprises 60-70% of diagnosed dementia cases, and is characterized by the deposition of β-amyloid peptide and the formation of neurofibrillary tangles of tau protein. 2022-02-21 2023-08-13 Not clear
Solomiia Boyko, Witold K Surewic. Tau liquid-liquid phase separation in neurodegenerative diseases. Trends in cell biology. 2022-02-19. PMID:35181198. aggregation of the microtubule-associated protein tau plays a major role in alzheimer's disease and several other neurodegenerative disorders. 2022-02-19 2023-08-13 Not clear
Tammy T Tran, Caroline L Speck, Michela Gallagher, Arnold Bakke. Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment. Neurobiology of aging. vol 112. 2022-02-19. PMID:35182842. specifically, the lateral entorhinal cortex shows significant accumulation of tau neurofibrillary tangles in the amnestic mild cognitive impairment (amci) phase of alzheimer's disease. 2022-02-19 2023-08-13 human
Elena Ficulle, Sarubini Kananathan, David Airey, Severine I Gharbi, Neil Humphryes-Kirilov, James Scherschel, Charlotte Dunbar, Brian J Eastwood, Emma Laing, David A Collier, Suchira Bos. A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-02-18. PMID:35177665. a human tau seeded neuronal cell model recapitulates molecular responses associated with alzheimer's disease. 2022-02-18 2023-08-13 human
Elena Ficulle, Sarubini Kananathan, David Airey, Severine I Gharbi, Neil Humphryes-Kirilov, James Scherschel, Charlotte Dunbar, Brian J Eastwood, Emma Laing, David A Collier, Suchira Bos. A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-02-18. PMID:35177665. we seeded rat primary cortical neurons with tau isolated from alzheimer's disease brains to induce a time-dependent increase in endogenous tau inclusions. 2022-02-18 2023-08-13 human
Caitlin S Latimer, Jade G Stair, Joshua C Hincks, Heather N Currey, Thomas D Bird, C Dirk Keene, Brian C Kraemer, Nicole F Liachk. TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic C. elegans. Disease models & mechanisms. 2022-02-18. PMID:35178571. while amyloid (a) β and tau aggregates define the neuropathology of alzheimer's disease (ad), tdp-43 has recently emerged as a co-morbid pathology in over half of patients with ad. 2022-02-18 2023-08-13 caenorhabditis_elegans