| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Song, Jue Yang, Wenfeng Y. Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer's Disease: An Integrated Epigenomic-Transcriptomic Analysis. Frontiers in cell and developmental biology. vol 9. 2022-03-21. PMID:35310542. |
alzheimer's disease (ad) is characterized by the abnormal deposition of amyloid-β (aβ) plaques and tau tangles in the brain and accompanied with cognitive impairment. |
2022-03-21 |
2023-08-13 |
Not clear |
| Anniina Snellman, Juan Lantero-Rodriguez, Andreja Emeršič, Agathe Vrillon, Thomas K Karikari, Nicholas J Ashton, Milica Gregorič Kramberger, Saša Čučnik, Claire Paquet, Uroš Rot, Henrik Zetterberg, Kaj Blenno. N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases. Brain : a journal of neurology. 2022-03-21. PMID:35311972. |
brain-derived tau secreted into csf and blood consists of different n-terminal and mid-domain fragments, which may have a differential temporal course and thus, biomarker potential across the alzheimer's disease continuum or in other neurological diseases. |
2022-03-21 |
2023-08-13 |
human |
| Adam M Brickman, Jennifer J Manly, Lawrence S Honig, Danurys Sanchez, Dolly Reyes-Dumeyer, Rafael A Lantigua, Jean Paul Vonsattel, Andrew F Teich, Min Suk Kang, Jeffrey L Dage, Richard Mayeu. Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease. Annals of clinical and translational neurology. 2022-03-20. PMID:35306760. |
blood-based phosphorylated tau (ptau) 181 and 217 biomarkers are sensitive and specific for alzheimer's disease. |
2022-03-20 |
2023-08-13 |
human |
| Estrella Morenas-Rodríguez, Yan Li, Brigitte Nuscher, Nicolai Franzmeier, Chengjie Xiong, Marc Suárez-Calvet, Anne M Fagan, Stephanie Schultz, Brian A Gordon, Tammie L S Benzinger, Jason Hassenstab, Eric McDade, Regina Feederle, Celeste M Karch, Kai Schlepckow, John C Morris, Gernot Kleinberger, Bengt Nellgard, Jonathan Vöglein, Kaj Blennow, Henrik Zetterberg, Michael Ewers, Mathias Jucker, Johannes Levin, Randall J Bateman, Christian Haas. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study. The Lancet. Neurology. vol 21. issue 4. 2022-03-19. PMID:35305339. |
although studies in animal models suggest that trem2 is protective against alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with alzheimer's disease is still unclear. |
2022-03-19 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with alzheimer's disease and dementia with lewy bodies. |
2022-03-17 |
2023-08-13 |
Not clear |
| Heidi I L Jacobs, John Alex Becker, Kenneth Kwong, Diana Munera, Liliana Ramirez-Gomez, Nina Engels-Domínguez, Justin S Sanchez, Clara Vila-Castelar, Ana Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Yakeel T Quiro. Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-03-17. PMID:35298083. |
waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant alzheimer's disease. |
2022-03-17 |
2023-08-13 |
Not clear |
| Heidi I L Jacobs, John Alex Becker, Kenneth Kwong, Diana Munera, Liliana Ramirez-Gomez, Nina Engels-Domínguez, Justin S Sanchez, Clara Vila-Castelar, Ana Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Yakeel T Quiro. Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-03-17. PMID:35298083. |
autopsy studies recognize the locus coeruleus (lc) as one of the first sites accumulating tau in alzheimer's disease (ad). |
2022-03-17 |
2023-08-13 |
Not clear |
| Phuong Hoang Nguyen, Pierre Tufféry, Philippe Derreumau. Dynamics of Amyloid Formation from Simplified Representation to Atomistic Simulations. Methods in molecular biology (Clifton, N.J.). vol 2405. 2022-03-17. PMID:35298810. |
aggregates of the aβ and tau proteins, the α-synuclein protein, and the prion protein are observed in the brain of alzheimer's, parkinson's, and prion disease patients, respectively. |
2022-03-17 |
2023-08-13 |
Not clear |
| Anam Islam, Takashi Saito, Takaomi Saido, Afia B Al. Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer's disease. Seminars in cell & developmental biology. 2022-03-16. PMID:35292192. |
the presubiculum (prs) is an integral component of the perforant pathway that has recently been recognised as a relatively unscathed region in clinical alzheimer's disease (ad), despite neighbouring components of the perforant pathway, ca1 and the entorhinal cortex, responsible for formation of episodic memory and storage, showing severe hallmarks of ad including, amyloid-beta (aβ) plaques, tau tangles and marked gliosis. |
2022-03-16 |
2023-08-13 |
mouse |
| Sydney M A Juan, Maria Daglas, Paul Adlar. Tau pathology, metal dyshomeostasis and repetitive mild traumatic brain injury: an unexplored link paving the way for neurodegeneration. Journal of neurotrauma. 2022-03-16. PMID:35293225. |
there is now mounting evidence suggesting that tau phosphorylation may be regulated by metal ions (such as iron, zinc and copper), which themselves are implicated in ageing and neurodegenerative disorders such as alzheimer's disease (ad). |
2022-03-16 |
2023-08-13 |
Not clear |
| Hongsun Park, Tomoyuki Yamanaka, Nobuyuki Nukin. Proteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions. Scientific reports. vol 12. issue 1. 2022-03-15. PMID:35289333. |
alpha-synuclein and tau are representative disease-related idps with low complexity regions in their sequences, accumulating in the brains of patients with parkinson disease and alzheimer disease, respectively. |
2022-03-15 |
2023-08-13 |
mouse |
| Savannah Tallino, Wendy Winslow, Samantha K Bartholomew, Ramon Velazque. Temporal and brain region-specific elevations of soluble Amyloid-β Aging cell. 2022-03-15. PMID:35290711. |
temporal and brain region-specific elevations of soluble amyloid-β down syndrome (ds) is a leading cause of intellectual disability that also results in hallmark alzheimer's disease (ad) pathologies such as amyloid beta (aβ) plaques and hyperphosphorylated tau. |
2022-03-15 |
2023-08-13 |
mouse |
| Xinjie Lin, Yong Fan, Fan Zhang, Yao Li. Cerebral microinfarct is emergency consequence of Alzheimer's disease: a new insight into development of neurodegenerative diseases. International journal of biological sciences. vol 18. issue 4. 2022-03-14. PMID:35280690. |
imbalance of aβ and tau protein production and clearance are the key factors among many causes of alzheimer's disease that leading to neurons degeneration and cognitive disorders. |
2022-03-14 |
2023-08-13 |
Not clear |
| Xinjie Lin, Yong Fan, Fan Zhang, Yao Li. Cerebral microinfarct is emergency consequence of Alzheimer's disease: a new insight into development of neurodegenerative diseases. International journal of biological sciences. vol 18. issue 4. 2022-03-14. PMID:35280690. |
as a novel approach, glymphatic system quickly clear metabolic waste (especially aβ and tau) from cerebral environment, and dysfunction of glymphatic system may relate to occurrence of alzheimer's disease. |
2022-03-14 |
2023-08-13 |
Not clear |
| Xinjie Lin, Yong Fan, Fan Zhang, Yao Li. Cerebral microinfarct is emergency consequence of Alzheimer's disease: a new insight into development of neurodegenerative diseases. International journal of biological sciences. vol 18. issue 4. 2022-03-14. PMID:35280690. |
microinfarcts destruct the integrity of microvascular and microstructural tissue, result in aβ deposition and tau phosphorylation that form neurofibrillary tangles and associated with the cause of alzheimer's disease. |
2022-03-14 |
2023-08-13 |
Not clear |
| Amir Abbas Tahami Monfared, Michael J Byrnes, Leigh Ann White, Quanwu Zhan. Alzheimer's Disease: Epidemiology and Clinical Progression. Neurology and therapy. 2022-03-14. PMID:35286590. |
factors shown to increase risk include lower mini-mental state examination (mmse) score, higher alzheimer's disease assessment scale (adas-cog) score, positive apoe4 status, white matter hyperintensities volume, entorhinal cortex atrophy, cerebrospinal fluid (csf) total tau, csf neurogranin levels, dependency in instrumental activities of daily living (iadl), and being female. |
2022-03-14 |
2023-08-13 |
Not clear |
| Wenting Hu, Zhuoqun Wang, Huiliang Zhang, Yacoubou Abdoul Razak Mahaman, Fang Huang, Dongli Meng, Ying Zhou, Shiyi Wang, Nan Jiang, Jing Xiong, Jukka Westermarck, Youming Lu, Jianzhi Wang, Xiaochuan Wang, Yangping Shentu, Rong Li. Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-03-14. PMID:35286657. |
in conclusion, our study uncovers a mechanism by which dna damage-induced chk1 activation promotes cip2a-mediated tau and app hyperphosphorylation and cognitive dysfunction in alzheimer's disease and highlights the therapeutic potential of chk1 inhibitors in ad. |
2022-03-14 |
2023-08-13 |
mouse |
| Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-Kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min L. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models. Redox biology. vol 51. 2022-03-14. PMID:35286997. |
accumulation of amyloid-β (aβ) oligomers and phosphorylated tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and cognitive impairments in alzheimer's disease (ad). |
2022-03-14 |
2023-08-13 |
mouse |
| Frédérique K Kok, Suzanne L van Leerdam, Elizabeth C M de Lang. Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology. Journal of Alzheimer's disease : JAD. 2022-03-11. PMID:35275527. |
alzheimer's disease (ad) is the most common form of dementia and typically characterized by the accumulation amyloid-β plaques and tau tangles. |
2022-03-11 |
2023-08-13 |
human |
| Sojung Yoon, Sung Eun Kim, Younhee Ko, Gwang Hun Jeong, Keum Hwa Lee, Jinhee Lee, Marco Solmi, Louis Jacob, Lee Smith, Andrew Stickley, Andre F Carvalho, Elena Dragioti, Andreas Kronbichler, Ai Koyanagi, Sung Hwi Hong, Trevor Thompson, Hans Oh, Gonzalo Salazar de Pablo, Joaquim Radua, Jae Il Shin, Paolo Fusar-Pol. Differential expression of MicroRNAs in Alzheimer's disease: a systematic review and meta-analysis. Molecular psychiatry. 2022-03-10. PMID:35264731. |
alzheimer's disease (ad) results in progressive cognitive decline owing to the accumulation of amyloid plaques and hyperphosphorylated tau. |
2022-03-10 |
2023-08-13 |
Not clear |