All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Michael A Kelberman, Claire R Anderson, Eli Chlan, Jacki M Rorabaugh, Katharine E McCann, David Weinshenke. Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-02-11. PMID:35147547. the locus coeruleus (lc) is one of the earliest brain regions to accumulate hyperphosphorylated tau, but a lack of animal models that recapitulate this pathology has hampered our understanding of its contributions to alzheimer's disease (ad) pathophysiology. 2022-02-11 2023-08-13 rat
Katherine W Turk, Alexandra Geada, Victor E Alvarez, Weiming Xia, Jonathan D Cherry, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Yorghos Tripodis, Bertrand R Huber, Andrew E Budson, Brigid Dwyer, Neil W Kowall, Robert C Cantu, Lee E Goldstein, Douglas I Katz, Robert A Stern, Michael L Alosco, Jesse Mez, Ann C McKee, Thor D Stei. A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-02-10. PMID:35139894. a comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and alzheimer disease. 2022-02-10 2023-08-13 human
Katherine W Turk, Alexandra Geada, Victor E Alvarez, Weiming Xia, Jonathan D Cherry, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Yorghos Tripodis, Bertrand R Huber, Andrew E Budson, Brigid Dwyer, Neil W Kowall, Robert C Cantu, Lee E Goldstein, Douglas I Katz, Robert A Stern, Michael L Alosco, Jesse Mez, Ann C McKee, Thor D Stei. A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-02-10. PMID:35139894. cerebrospinal fluid (csf) tau and beta-amyloid levels in chronic traumatic encephalopathy (cte), a disease which can be clinically indistinguishable from alzheimer's disease (ad), are largely unknown. 2022-02-10 2023-08-13 human
Martin Flach, Cedric Leu, Alfonso Martinisi, Zhiva Skachokova, Stephan Frank, Markus Tolnay, Henning Stahlberg, David T Winkle. Trans-seeding of Alzheimer-related tau protein by a yeast prion. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-10. PMID:35142027. abnormal tau protein aggregates constitute a hallmark of alzheimer's disease. 2022-02-10 2023-08-13 mouse
Alisa Cario, Adriana Savastano, Neil B Wood, Zhu Liu, Michael J Previs, Adam G Hendricks, Markus Zweckstetter, Christopher L Berge. The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 7. 2022-02-09. PMID:35135879. tau misregulation and point mutations are linked to neurodegenerative diseases, including progressive supranuclear palsy (psp), pick's disease, and alzheimer's disease. 2022-02-09 2023-08-13 Not clear
Juan R Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports. vol 12. issue 1. 2022-02-09. PMID:35136118. although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as alzheimer's disease has been associated with its ability to phosphorylate tau in neurons. 2022-02-09 2023-08-13 mouse
Cécile Tissot, Joseph Therriault, Peter Kunach, Andréa L Benedet, Tharick A Pascoal, Nicholas J Ashton, Thomas K Karikari, Stijn Servaes, Firoza Z Lussier, Mira Chamoun, Dana L Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, João Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Net. Comparing tau status determined via plasma pTau181, pTau231 and [ EBioMedicine. vol 76. 2022-02-08. PMID:35134647. comparing tau status determined via plasma ptau181, ptau231 and [ tau in alzheimer's disease (ad) is assessed via cerebrospinal fluid (csf) and positron emission tomography (pet). 2022-02-08 2023-08-13 Not clear
Heidy Jimenez, Leslie Adrien, Adam Wolin, John Eun, Eric H Chang, Ethan S Burstein, Jesus Gomar, Peter Davies, Jeremy Koppe. The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT- and rTg(P301L)4510 mouse models of Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 8. issue 1. 2022-02-07. PMID:35128032. the impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the p301l/comt- and rtg(p301l)4510 mouse models of alzheimer's disease. 2022-02-07 2023-08-13 mouse
Patrick Vagenknecht, Artur Luzgin, Maiko Ono, Bin Ji, Makoto Higuchi, Daniela Noain, Cinzia A Maschio, Jens Sobek, Zhenyue Chen, Uwe Konietzko, Juan A Gerez, Roland Riek, Daniel Razansky, Jan Klohs, Roger M Nitsch, Xose Luis Dean-Ben, Ruiqing N. Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography. European journal of nuclear medicine and molecular imaging. 2022-02-07. PMID:35128565. abnormal tau accumulation within the brain plays an important role in tauopathies such as alzheimer's disease and frontotemporal dementia. 2022-02-07 2023-08-13 Not clear
Heikki Lukkarinen, Anna Jeppsson, Carsten Wikkelsö, Kaj Blennow, Henrik Zetterberg, Radu Constantinescu, Anne M Remes, Sanna-Kaisa Herukka, Mikko Hiltunen, Tuomas Rauramaa, Katarina Nägga, Ville Leinonen, Mats Tullber. Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients. Fluids and barriers of the CNS. vol 19. issue 1. 2022-02-06. PMID:35123528. we aimed to evaluate csf biomarkers reflecting alzheimer's disease (ad)-related amyloid β (aβ) aggregation, tau pathology, neuroinflammation and axonal degeneration in relation to the clinical features of pre- and post-shunt surgery in inph patients. 2022-02-06 2023-08-13 Not clear
Sheelakumari Raghavan, Scott A Przybelski, Robert I Reid, Timothy G Lesnick, Vijay K Ramanan, Hugo Botha, Billie J Matchett, Melissa E Murray, R Ross Reichard, David S Knopman, Jonathan Graff-Radford, David T Jones, Val J Lowe, Michelle M Mielke, Mary M Machulda, Ronald C Petersen, Kejal Kantarci, Jennifer L Whitwell, Keith A Josephs, Clifford R Jack, Prashanthi Vemur. White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition. Acta neuropathologica communications. vol 10. issue 1. 2022-02-06. PMID:35123591. we identified two independent cohorts with multi-shell diffusion mri, amyloid and tau pet, and cognitive assessments: specifically, a population-based cohort of 347 elderly randomly sampled from the olmsted county, minnesota, population and a clinical research-based cohort of 61 amyloid positive alzheimer's dementia participants. 2022-02-06 2023-08-13 human
María Pagnon de la Vega, Carl Näslund, RoseMarie Brundin, Lars Lannfelt, Malin Löwenmark, Lena Kilander, Martin Ingelsson, Vilmantas Giedraiti. Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer's disease and frontotemporal dementia. BMC genomics. vol 23. issue 1. 2022-02-05. PMID:35120450. mutations in the tau gene (mapt) lead to frontotemporal dementia (ftd), whereas mutations in the genes for the amyloid-β precursor protein (app) and the presenilins (psen1, psen2) cause early-onset, dominantly inherited forms of alzheimer's disease (ad). 2022-02-05 2023-08-13 Not clear
Anuradha Venkatramani, Sandipan Mukherjee, Anuradha Kumari, Dulal Pand. Shikonin impedes phase separation and aggregation of tau and protects SH-SY5Y cells from the toxic effects of tau oligomers. International journal of biological macromolecules. 2022-02-05. PMID:35120943. tauopathies such as alzheimer's and parkinson's diseases involve the abnormal deposition of tau aggregates in the brain and neuronal tissues. 2022-02-05 2023-08-13 Not clear
Suren A Tatulia. Challenges and hopes for Alzheimer's disease. Drug discovery today. 2022-02-05. PMID:35121174. recent drug development efforts targeting alzheimer's disease (ad) have failed to produce effective disease-modifying agents for many reasons, including the substantial presymptomatic neuronal damage that is caused by the accumulation of the amyloid β (aβ) peptide and tau protein abnormalities, deleterious adverse effects of drug candidates, and inadequate design of clinical trials. 2022-02-05 2023-08-13 Not clear
Rebecca L Kow, Aristide H Black, Aleen D Saxton, Nicole F Liachko, Brian C Kraeme. Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration. GeroScience. 2022-02-05. PMID:35122183. neurodegenerative diseases with tau pathology, or tauopathies, include alzheimer's disease and related dementia disorders. 2022-02-05 2023-08-13 mouse
Noah Tjiang, Hans Zempe. A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons. Cellular and molecular life sciences : CMLS. vol 79. issue 2. 2022-02-04. PMID:35119496. loss of neuronal polarity and missorting of the axonal microtubule-associated-protein tau are hallmarks of alzheimer's disease (ad) and related tauopathies. 2022-02-04 2023-08-13 mouse
Cynthia Picard, Gabriel Aumont-Rodrigue, Judes Poirie. Apolipoprotein B gene regulation under healthy and neuropathological conditions. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108839. we have recently identified apolipoprotein b (apob) as a putative csf indicator of early synaptic and tau pathology in cognitively unimpaired individuals with a parental history of alzheimer's disease (ad). 2022-02-03 2023-08-13 Not clear
Antonia M H Piergies, Panos Theofilas, Song Li, Cathrine Petersen, Alexander J Ehrenberg, Rana April Eser, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, William W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108846. caspase-6-cleaved tau is relevant in alzheimer's disease but not in 4-repeat tauopathies: diagnostic and therapeutic implications. 2022-02-03 2023-08-13 Not clear
Antonia M H Piergies, Panos Theofilas, Song Li, Cathrine Petersen, Alexander J Ehrenberg, Rana April Eser, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, William W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108846. we previously demonstrated that neuronal active caspase-6 co-occurs with phosphorylated tau (p-tau) during the earliest stages of alzheimer's disease (ad) and that the percentage of neurons positive for both active caspase-6 and p-tau increases as the disease progresses. 2022-02-03 2023-08-13 Not clear
Ozkan Is, Xue Wang, Tulsi Patel, Zachary Quicksall, Laura Lewis-Tuffin, Kaancan Deniz, Frederick Q Tutor-New, Troy Carnwath, Thuy Nguyen, Kimberly G Malphrus, Melissa E Murray, Dennis W Dickson, Mariet Allen, Nilufer Ertekin-Tane. Pathology-related alterations in gene expression in Alzheimer's disease: Single cell resolution. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108849. alzheimer's disease is pathologically defined by the presence of extracellular amyloid beta plaques and intracellular tau tangles, resulting in neurodegeneration and reactive gliosis in affected brain regions such as temporal cortex (tcx). 2022-02-03 2023-08-13 Not clear