| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sofia Lövestam, Fujiet Adrian Koh, Bart van Knippenberg, Abhay Kotecha, Alexey G Murzin, Michel Goedert, Sjors H W Schere. Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy. eLife. vol 11. 2022-03-04. PMID:35244536. |
assembly of recombinant tau into filaments identical to those of alzheimer's disease and chronic traumatic encephalopathy. |
2022-03-04 |
2023-08-13 |
human |
| Hiroyuki Inuzuka, Jing Liu, Wenyi Wei, Abdol-Hossein Rezaeia. PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives. Acta materia medica. vol 1. issue 1. 2022-03-03. PMID:35237768. |
the aggregation of misfolded proteins like β-amyloid, α-synuclein, tau, and polyglutamates are hallmarked in alzheimer's disease (ad), which are undruggable targets, and usually do not respond to conventional small-molecule agents. |
2022-03-03 |
2023-08-13 |
Not clear |
| Madeleine Grigg-Damberger, Nancy Foldvary-Schaefe. Sleep Biomarkers Help Predict the Development of Alzheimer Disease. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2022-03-03. PMID:35239558. |
overexpression of the wake-promoting neurotransmitter orexin may predispose patients with mild cognitive impairment and alzheimer disease to increased wakefulness, decreasing time they need to clear from the brain the neurotoxic accumulation of amyloid-beta and especially tau. |
2022-03-03 |
2023-08-13 |
Not clear |
| Jacob W Vogel, Oskar Hansso. Subtypes of Alzheimer's disease: questions, controversy, and meaning. Trends in neurosciences. 2022-03-01. PMID:35227519. |
the distribution of alzheimer's disease (ad) tau pathology varies systematically and causes a diverse array of syndromes. |
2022-03-01 |
2023-08-13 |
Not clear |
| Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Cecile Tissot, Isabelle Rivals, Philippe Gervais, Fabien Caillé, Martin Moussion, Michel Bottlaender, Marie Sarazi. Tau-PET imaging predicts cognitive decline and brain atrophy progression in early Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. 2022-03-01. PMID:35228270. |
to explore whether regional tau binding measured at baseline is associated with the rapidity of alzheimer's disease (ad) progression over 2 years, as assessed by the decline in specified cognitive domains, and the progression of regional brain atrophy, in comparison with amyloid-positron emission tomography (pet), mri and cerebrospinal fluid (csf) biomarkers. |
2022-03-01 |
2023-08-13 |
Not clear |
| Todd E Gold. Disease-Modifying Therapies for Alzheimer's Disease: More Questions than Answers. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-03-01. PMID:35229269. |
scientific advances over the last four decades have steadily infused the alzheimer's disease (ad) field with great optimism that therapies targeting aβ, amyloid, tau, and innate immune activation states in the brain would provide disease modification. |
2022-03-01 |
2023-08-13 |
Not clear |
| Sigrid Klotz, Gerda Ricken, Matthias Preusser, Karin Dieckmann, Georg Widhalm, Karl Rössler, Peter Fischer, Ognian Kalev, Adelheid Wöhrer, Gabor G Kovacs, Ellen Gelp. Enhanced expression of autophagy-related p62 without increased deposits of neurodegeneration-associated proteins in glioblastoma and surrounding tissue - An autopsy-based study. Brain pathology (Zurich, Switzerland). 2022-03-01. PMID:35229396. |
these findings suggested a preexisting neurodegenerative pathology, which followed a typical distributional pattern: ten cases with alzheimer disease neuropathological changes, including two severe cases, eight cases with primary age-related tauopathy, six cases with aging-related tau astrogliopathy and one case with progressive supranuclear palsy. |
2022-03-01 |
2023-08-13 |
Not clear |
| Jimin Hong, Seung Kwan Kang, Ian Alberts, Jiaying Lu, Raphael Sznitman, Jae Sung Lee, Axel Rominger, Hongyoon Choi, Kuangyu Sh. Image-level trajectory inference of tau pathology using variational autoencoder for Flortaucipir PET. European journal of nuclear medicine and molecular imaging. 2022-02-28. PMID:35226120. |
alzheimer's disease (ad) studies revealed that abnormal deposition of tau spreads in a specific spatial pattern, namely braak stage. |
2022-02-28 |
2023-08-13 |
Not clear |
| Alexis Moscoso, Thomas K Karikari, Michel J Grothe, Nicholas J Ashton, Juan Lantero-Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöl. CSF biomarkers and plasma p-tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial design. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-28. PMID:35226405. |
clinical trials targeting tau in alzheimer's disease (ad) need to recruit individuals at risk of tau accumulation. |
2022-02-28 |
2023-08-13 |
Not clear |
| Toshihiko Tashim. Delivery of Intravenously Administered Antibodies Targeting Alzheimer's Disease-Relevant Tau Species into the Brain Based on Receptor-Mediated Transcytosis. Pharmaceutics. vol 14. issue 2. 2022-02-26. PMID:35214143. |
delivery of intravenously administered antibodies targeting alzheimer's disease-relevant tau species into the brain based on receptor-mediated transcytosis. |
2022-02-26 |
2023-08-13 |
Not clear |
| Li-Fan Lin, Yun-Ting Jhao, Chuang-Hsin Chiu, Lu-Han Sun, Ta-Kai Chou, Chyng-Yann Shiue, Cheng-Yi Cheng, Kuo-Hsing M. Bezafibrate Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 2. 2022-02-26. PMID:35215222. |
since tau pathology is a neuropathological hallmark of alzheimer's disease (ad), bezafibrate may be a potential drug for the treatment of ad. |
2022-02-26 |
2023-08-13 |
mouse |
| Peter Hermann, Philip Haller, Stefan Goebel, Timothy Bunck, Christian Schmidt, Jens Wiltfang, Inga Zer. Total and Phosphorylated Cerebrospinal Fluid Tau in the Differential Diagnosis of Sporadic Creutzfeldt-Jakob Disease and Rapidly Progressive Alzheimer's Disease. Viruses. vol 14. issue 2. 2022-02-26. PMID:35215868. |
total and phosphorylated cerebrospinal fluid tau in the differential diagnosis of sporadic creutzfeldt-jakob disease and rapidly progressive alzheimer's disease. |
2022-02-26 |
2023-08-13 |
Not clear |
| Samuel C Bartley, Madison T Proctor, Hongjie Xia, Evelyn Ho, Dong S Kang, Kristen Schuster, Maíra A Bicca, Henrique S Seckler, Kirsten L Viola, Steven M Patrie, Neil L Kelleher, Fernando G De Mello, William L Klei. An Essential Role for Alzheimer's-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216328. |
the expression of the aβo proteoforms was selectively associated with transiently expressed phosphorylated tau (ptau) proteoforms that, like aβos, are linked to alzheimer's disease (ad). |
2022-02-26 |
2023-08-13 |
human |
| J J Gomar, G Tan, J Halpern, M L Gordon, B Greenwald, J Koppe. Increased retention of tau PET ligand [ Translational psychiatry. vol 12. issue 1. 2022-02-26. PMID:35217635. |
increased retention of tau pet ligand [ psychosis in alzheimer's disease (ad) represents a distinct disease subtype with a more rapid progression of illness evidenced by an increased velocity of cognitive decline and a hastened mortality. |
2022-02-26 |
2023-08-13 |
Not clear |
| Lena Wischhof, Aasha Adhikari, Mrityunjoy Mondal, Anaïs Marsal-Cots, Jacek Biernat, Eva Maria Mandelkow, Eckhard Mandelkow, Dan Ehninger, Pierluigi Nicotera, Daniele Ban. Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau. The Journal of biological chemistry. 2022-02-26. PMID:35218773. |
aberrant tau homeostasis has been implicated in the pathogenesis of several neurodegenerative disorders, including alzheimer's disease (ad). |
2022-02-26 |
2023-08-13 |
human |
| Paulo J da Costa, Malika Hamdane, Luc Buée, Franck Marti. Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203451. |
moreover, tau proteins are turned into aggregates and consequently trigger many neurodegenerative diseases termed tauopathies, of which alzheimer's disease (ad) is the figurehead. |
2022-02-25 |
2023-08-13 |
Not clear |
| Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203506. |
nasal rifampicin halts the progression of tauopathy by inhibiting tau oligomer propagation in alzheimer brain extract-injected mice. |
2022-02-25 |
2023-08-13 |
mouse |
| Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203506. |
the cell-to-cell transmission of tau aggregates is considered a mechanism underlying the intracerebral spreading of tau pathology in alzheimer's disease (ad) and other tauopathies. |
2022-02-25 |
2023-08-13 |
mouse |
| Margreet B Koopman, Luca Ferrari, Stefan G D Rüdige. How do protein aggregates escape quality control in neurodegeneration? Trends in neurosciences. 2022-02-25. PMID:35210101. |
we focus primarily on the protein tau, which aggregates in alzheimer's disease (ad) and other tauopathies. |
2022-02-25 |
2023-08-13 |
Not clear |
| Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L Villemagne, Nobuyuki Okamur. Imaging of Reactive Astrogliosis by Positron Emission Tomography. Frontiers in neuroscience. vol 16. 2022-02-25. PMID:35210989. |
many neurodegenerative diseases are neuropathologically characterized by neuronal loss, gliosis, and the deposition of misfolded proteins such as β-amyloid (aβ) plaques and tau tangles in alzheimer's disease (ad). |
2022-02-25 |
2023-08-13 |
Not clear |