| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Pagnon de la Vega, Carl Näslund, RoseMarie Brundin, Lars Lannfelt, Malin Löwenmark, Lena Kilander, Martin Ingelsson, Vilmantas Giedraiti. Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer's disease and frontotemporal dementia. BMC genomics. vol 23. issue 1. 2022-02-05. PMID:35120450. |
mutations in the tau gene (mapt) lead to frontotemporal dementia (ftd), whereas mutations in the genes for the amyloid-β precursor protein (app) and the presenilins (psen1, psen2) cause early-onset, dominantly inherited forms of alzheimer's disease (ad). |
2022-02-05 |
2023-08-13 |
Not clear |
| Anuradha Venkatramani, Sandipan Mukherjee, Anuradha Kumari, Dulal Pand. Shikonin impedes phase separation and aggregation of tau and protects SH-SY5Y cells from the toxic effects of tau oligomers. International journal of biological macromolecules. 2022-02-05. PMID:35120943. |
tauopathies such as alzheimer's and parkinson's diseases involve the abnormal deposition of tau aggregates in the brain and neuronal tissues. |
2022-02-05 |
2023-08-13 |
Not clear |
| Suren A Tatulia. Challenges and hopes for Alzheimer's disease. Drug discovery today. 2022-02-05. PMID:35121174. |
recent drug development efforts targeting alzheimer's disease (ad) have failed to produce effective disease-modifying agents for many reasons, including the substantial presymptomatic neuronal damage that is caused by the accumulation of the amyloid β (aβ) peptide and tau protein abnormalities, deleterious adverse effects of drug candidates, and inadequate design of clinical trials. |
2022-02-05 |
2023-08-13 |
Not clear |
| Rebecca L Kow, Aristide H Black, Aleen D Saxton, Nicole F Liachko, Brian C Kraeme. Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration. GeroScience. 2022-02-05. PMID:35122183. |
neurodegenerative diseases with tau pathology, or tauopathies, include alzheimer's disease and related dementia disorders. |
2022-02-05 |
2023-08-13 |
mouse |
| Noah Tjiang, Hans Zempe. A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons. Cellular and molecular life sciences : CMLS. vol 79. issue 2. 2022-02-04. PMID:35119496. |
loss of neuronal polarity and missorting of the axonal microtubule-associated-protein tau are hallmarks of alzheimer's disease (ad) and related tauopathies. |
2022-02-04 |
2023-08-13 |
mouse |
| Cynthia Picard, Gabriel Aumont-Rodrigue, Judes Poirie. Apolipoprotein B gene regulation under healthy and neuropathological conditions. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108839. |
we have recently identified apolipoprotein b (apob) as a putative csf indicator of early synaptic and tau pathology in cognitively unimpaired individuals with a parental history of alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Antonia M H Piergies, Panos Theofilas, Song Li, Cathrine Petersen, Alexander J Ehrenberg, Rana April Eser, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, William W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108846. |
caspase-6-cleaved tau is relevant in alzheimer's disease but not in 4-repeat tauopathies: diagnostic and therapeutic implications. |
2022-02-03 |
2023-08-13 |
Not clear |
| Antonia M H Piergies, Panos Theofilas, Song Li, Cathrine Petersen, Alexander J Ehrenberg, Rana April Eser, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, William W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108846. |
we previously demonstrated that neuronal active caspase-6 co-occurs with phosphorylated tau (p-tau) during the earliest stages of alzheimer's disease (ad) and that the percentage of neurons positive for both active caspase-6 and p-tau increases as the disease progresses. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ozkan Is, Xue Wang, Tulsi Patel, Zachary Quicksall, Laura Lewis-Tuffin, Kaancan Deniz, Frederick Q Tutor-New, Troy Carnwath, Thuy Nguyen, Kimberly G Malphrus, Melissa E Murray, Dennis W Dickson, Mariet Allen, Nilufer Ertekin-Tane. Pathology-related alterations in gene expression in Alzheimer's disease: Single cell resolution. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108849. |
alzheimer's disease is pathologically defined by the presence of extracellular amyloid beta plaques and intracellular tau tangles, resulting in neurodegeneration and reactive gliosis in affected brain regions such as temporal cortex (tcx). |
2022-02-03 |
2023-08-13 |
Not clear |
| Jatin Machhi, Pravin Yeapuri, Yaman Lu, R Lee Mosley, Howard E Gendelma. CD4+ T cell effector activities accelerate Alzheimer's disease pathologies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108872. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by cognitive impairments linked to pathological deposition of misfolded self-protein amyloid beta (aβ) which in kind facilitates tau aggregation and neurodegeneration. |
2022-02-03 |
2023-08-13 |
Not clear |
| Saskia J Pollack, Dina Dakkak, Tong Guo, Patricia Gómez-Suaga, Wendy Noble, Diane P Hange. Defects in the autophagy lysosomal pathway in a cell model of disease-associated tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108903. |
intracellular accumulation of insoluble tau is an important hallmark of alzheimer's disease (ad) and related tauopathies. |
2022-02-03 |
2023-08-13 |
mouse |
| Whitney M Freeze, Susanne J van Veluw, Willemijn J Jansen, Heidi I L Jacob. Locus coeruleus hypopigmentation is associated with an increased risk of cerebral microangiopathy in autopsy cases with cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108930. |
the locus coeruleus (lc) is the main source of noradrenaline (na) production in the brain, and one of the earliest sites of hyperphosphorylated tau in alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
human |
| Heidi I L Jacobs, Alex Becker, Kenneth Kwong, Diana Munera, Liliana A Ramirez-Gomez, Justin S Sanchez, Emma G Thibault, Clara Vila-Castelar, Ana Y Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Yakeel T Quiro. Locus coeruleus integrity predicts tau accumulation and memory dysfunction in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108958. |
locus coeruleus integrity predicts tau accumulation and memory dysfunction in autosomal dominant alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewer. Klotho-VS heterozygosity modifies amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108970. |
klotho-vs heterozygosity modifies amyloid-dependent tau accumulation and memory impairment in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Colin Groo. Associations between the APOE-ε2 and APOE-ε4 alleles with resistance and resilience against Alzheimer's disease pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108977. |
to examine associations between the apoe-ε2 and apoe-ε4 alleles and core alzheimer's disease (ad) pathological hallmarks as measured by amyloid-β (aβ) and tau pet in older individuals without dementia. |
2022-02-03 |
2023-08-13 |
Not clear |
| Panos Theofilas, Andrew J Ambrose, David Butler, Chao Wang, Dulce O Morales, Cathrine Petersen, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108991. |
tau post-translational modifications (ptms) are associated with progressive tau accumulation and neuronal loss in tauopathies, including forms of frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
tau seeds are widespread in the brain at the earliest stages of alzheimer's disease-related changes. |
2022-02-03 |
2023-08-13 |
Not clear |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
alzheimer's disease (ad) is pathologically characterized by the systematic spread of 3r/4r tau species with progressing disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Laura J Blair, Marangelie Criado-Marrer. Contribution of ER stress to tau-mediated toxicity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109058. |
in alzheimer's disease (ad), the accumulation of tau is linked with cell death, but the major cell death pathway remains to be identified. |
2022-02-03 |
2023-08-13 |
mouse |
| Justin R Welden, Giorgi Margvelani, Chi Jing Leow, Jessica Blackburn, Peter T Nelson, Stefan Stam. Proteins translated from tau circular RNAs as drivers for Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109060. |
proteins translated from tau circular rnas as drivers for alzheimer's disease and frontotemporal dementia. |
2022-02-03 |
2023-08-13 |
mouse |