| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heidi I L Jacobs, Alex Becker, Kenneth Kwong, Diana Munera, Liliana A Ramirez-Gomez, Justin S Sanchez, Emma G Thibault, Clara Vila-Castelar, Ana Y Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Yakeel T Quiro. Locus coeruleus integrity predicts tau accumulation and memory dysfunction in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108958. |
locus coeruleus integrity predicts tau accumulation and memory dysfunction in autosomal dominant alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewer. Klotho-VS heterozygosity modifies amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108970. |
klotho-vs heterozygosity modifies amyloid-dependent tau accumulation and memory impairment in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Colin Groo. Associations between the APOE-ε2 and APOE-ε4 alleles with resistance and resilience against Alzheimer's disease pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108977. |
to examine associations between the apoe-ε2 and apoe-ε4 alleles and core alzheimer's disease (ad) pathological hallmarks as measured by amyloid-β (aβ) and tau pet in older individuals without dementia. |
2022-02-03 |
2023-08-13 |
Not clear |
| Panos Theofilas, Andrew J Ambrose, David Butler, Chao Wang, Dulce O Morales, Cathrine Petersen, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108991. |
tau post-translational modifications (ptms) are associated with progressive tau accumulation and neuronal loss in tauopathies, including forms of frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
tau seeds are widespread in the brain at the earliest stages of alzheimer's disease-related changes. |
2022-02-03 |
2023-08-13 |
Not clear |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
alzheimer's disease (ad) is pathologically characterized by the systematic spread of 3r/4r tau species with progressing disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Laura J Blair, Marangelie Criado-Marrer. Contribution of ER stress to tau-mediated toxicity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109058. |
in alzheimer's disease (ad), the accumulation of tau is linked with cell death, but the major cell death pathway remains to be identified. |
2022-02-03 |
2023-08-13 |
mouse |
| Justin R Welden, Giorgi Margvelani, Chi Jing Leow, Jessica Blackburn, Peter T Nelson, Stefan Stam. Proteins translated from tau circular RNAs as drivers for Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109060. |
proteins translated from tau circular rnas as drivers for alzheimer's disease and frontotemporal dementia. |
2022-02-03 |
2023-08-13 |
mouse |
| Justin R Welden, Giorgi Margvelani, Chi Jing Leow, Jessica Blackburn, Peter T Nelson, Stefan Stam. Proteins translated from tau circular RNAs as drivers for Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109060. |
neurofibrillary tangles formed by the microtubule protein tau (mapt) are the pathologic hallmark of tauopathies, including alzheimer's disease and ∼1/2 of frontotemporal lobar degeneration (ftld-tau) cases. |
2022-02-03 |
2023-08-13 |
mouse |
| Dibyadeep Datta, SueAnn Mentone, Yury Morozov, Christopher H van Dyck, Amy F T Arnste. Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109064. |
tau pathology emerges in a distinct spatial and temporal pattern in alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
human |
| Xue Wang, Mariet Allen, Joseph S Reddy, Minerva M Carrasquillo, Yan W Asmann, Cory C Funk, Thuy Nguyen, Kimberly G Malphrus, Steven G Younkin, Dennis W Dickson, Nathan D Price, Todd E Golde, Nilufer Ertekin-Tane. Conserved architecture of brain transcriptome changes between Alzheimer's disease and progressive supranuclear palsy in pathologically affected and unaffected regions. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109068. |
alzheimer's disease (ad) is a complex proteinopathy with abnormal accumulation of amyloid β and tau in which the temporal cortex (tcx) is severely affected. |
2022-02-03 |
2023-08-13 |
Not clear |
| Claire Chevalier, Moira Marizzoni, Giulia Quattrini, Nicola Lopizzo, Diego Albani, Jorge Jovicich, Annamaria Cattaneo, Giovanni B Frison. Peripheral inflammation and AD-related hippocampal neurodegeneration in prodromal AD patients. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109076. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the presence of beta-amyloid (aβ42) and phosphorylated tau (p-tau) deposits in the brain, neurodegeneration in specific brain regions, and inflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Mark Stephen Kindy, Dorothy K. GM6 attenuates Alzheimer's disease pathology through a reduction in fibrinogen levels and by regulation of Aβ, p-tau and inflammation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109082. |
alzheimer's disease (ad) is characterized by cerebral amyloid-b (ab) deposition, vascular alterations, tau pathology, microglia activation, and inflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Stepan Lerner, Tatiana Karelin. Quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109086. |
the hyperphosphorylated tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Stepan Lerner, Tatiana Karelin. Quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109086. |
in animal models of alzheimer's disease (ad), tau hyperphosphorylation reduces ltp. |
2022-02-03 |
2023-08-13 |
Not clear |
| Laura Vegas-Gomez, George A Edwards, Omar Hasan, Nazaret Gamez Ruiz, Jonathan Schulz, Claudio Soto, Paul E Schulz, Ines Moreno-Gonzale. Correlation between 18F-THK5351 tau PET imaging and the progression of neuropathology and clinical signs in a mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109088. |
in alzheimer's disease (ad), nfts are accompanied by extracellular amyloid-beta (aβ), but primary tauopathy disorders are marked by the accumulation of tau protein alone. |
2022-02-03 |
2023-08-13 |
mouse |
| Amber Penning, Giorgia Tosoni, Hannah Walgrave, Oxana Garritsen, Sarah Snoeck, Katleen Craessaerts, Leen Wolfs, Nicky Thrupp, Mark Fiers, Carlo Sala Frigerio, Bart De Strooper, Evgenia Salt. Unbiased profiling of miR-132 targetome with implications in adult hippocampal neurogenesis and Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109102. |
microrna-132 (mir-132), a potent neuroimmune regulator, is robustly downregulated in the brain of alzheimer's disease (ad) patients and its deficiency has been functionally linked to amyloid deposition, tau hyperphosphorylation and memory decline, in both human and rodents. |
2022-02-03 |
2023-08-13 |
mouse |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
non-amnestic presentations of alzheimer's disease (naad) correspond to focal cortical areas of high tau pathology that map to clinical symptoms. |
2022-02-03 |
2023-08-13 |
Not clear |
| Debomoy K Lahiri, Ruizhi Wang, Bryan Maloney, Nipun Chopra, John S Beck, Scott E Count. Alteration of a specific microRNA regulating neprilysin expression in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109106. |
alzheimer's disease (ad) is characterized by accumulation of amyloid β (aβ) plaques and aggregates of hyperphosphorylated tau protein. |
2022-02-03 |
2023-08-13 |
Not clear |
| Tulsi Patel, Evan Udine, Xue Wang, Mariet Allen, Ozkan Is, Frederick Q Tutor-New, Troy Carnwath, Kaancan Deniz, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Zachary Quicksall, Laura Lewis-Tuffin, Joseph S Reddy, Minerva M Carrasquillo, Julia E Crook, Takahisa Kanekiyo, Melissa E Murray, Guojun Bu, Dennis W Dickson, Nilufer Ertekin-Tane. Cell type-specific gene expression changes in Alzheimer's patients with varying levels of cerebral amyloid angiopathy. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109107. |
tau neurofibrillary tangles and senile plaques comprised of insoluble amyloid beta are the major histopathological hallmarks of alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |