| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koping Chang, Alexander Barrett, Khoa Pham, Juan C Troncos. Lateral geniculate body is spared of tau pathology in Pick disease. Journal of neuropathology and experimental neurology. 2024-02-27. PMID:38412343. |
the pathobiology of tau is of great importance for understanding the mechanisms of neurodegeneration in aging and age-associated disorders such as alzheimer disease (ad) and frontotemporal dementias. |
2024-02-27 |
2024-03-01 |
Not clear |
| James Naude, Meng Wang, Rebeca Leon, Eric Smith, Zahinoor Ismai. Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment. medRxiv : the preprint server for health sciences. 2024-02-26. PMID:38405711. |
phosphorylated tau (p-tau) is a hallmark biological manifestation of alzheimer disease (ad). |
2024-02-26 |
2024-02-28 |
human |
| Nuo Jia, Dhasarathan Ganesan, Hongyuan Guan, Yu Young Jeong, Sinsuk Han, Marialaina Nissenbaum, Alexander W Kusnecov, Qian Ca. Mitochondrial bioenergetics stimulates autophagy for pathological tau clearance in tauopathy neurons. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405759. |
hyperphosphorylation and aggregation of microtubule-associated tau is a pathogenic hallmark of tauopathies and a defining feature of alzheimer's disease (ad). |
2024-02-26 |
2024-02-28 |
mouse |
| Haoshen Shi, Nazanin Mirzaei, Yosef Koronyo, Miyah R Davis, Edward Robinson, Gila M Braun, Ousman Jallow, Altan Rentsendorj, V Krishnan Ramanujan, Justyna Fert-Bober, Andrei A Kramerov, Alexander V Ljubimov, Lon S Schneider, Warren G Tourtellotte, Debra Hawes, Julie A Schneider, Keith L Black, Rakez Kayed, Maj-Linda B Selenica, Daniel C Lee, Dieu-Trang Fuchs, Maya Koronyo-Hamaou. Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405854. |
this study identifies and quantifies diverse pathological tau isoforms in the retina of both early and advanced-stage alzheimer's disease (ad) and determines their relationship with disease status. |
2024-02-26 |
2024-02-28 |
Not clear |
| Bang Wang, Xiaoshu Pan, I-Ting Teng, Xiaowei Li, Firas Kobeissy, Zo-Yu Wu, Jiepei Zhu, Guangzheng Cai, He Yan, Xin Yan, Mingwei Liang, Fahong Yu, Jianrong Lu, Zunyi Yang, Elisa Biondi, William Haskins, Y Charles Cao, Steven A Benner, Weihong Tan, Kevin Wan. Functional Selection of Tau Oligomerization-Inhibiting Aptamers. Angewandte Chemie (International ed. in English). 2024-02-26. PMID:38407551. |
pathological hyperphosphorylation and aggregation of microtubule-associated tau protein contribute to alzheimer's disease (ad) and other related tauopathies. |
2024-02-26 |
2024-02-28 |
Not clear |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
other comorbid tauopathies likely contributed in part to these differences: when cases with concurrent alzheimer dementia or frontal temporal lobar degeneration with tau pathology were excluded, differences were largely retained, but only remained significant for faq (p = 0.042), meta-cognition index t score (p = 0.014) and age of parkinsonian motor symptom onset (p = 0.046). |
2024-02-26 |
2024-02-28 |
human |
| Bo-Yu Kuang, Yu-Chen Zhu, Jin-Ping Liang, Shi-Feng Chu, Nai-Hong Chen, Yan-Tao Yan. [Exosome and prevention of Alzheimer's disease: based on theory of kidney storing essence]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 1. 2024-02-25. PMID:38403338. |
alzheimer's disease(ad) is one of the common neurodegenerative diseases, with the main pathological features of aβ deposition and tau phosphorylation, which activate neurotoxic reactions and eventually lead to neuronal dysfunction and cell death, severely impairing the patient's cognitive and memory functions. |
2024-02-25 |
2024-02-28 |
human |
| Dhwani S Korde, Christian Humpe. A Combination of Heavy Metals and Intracellular Pathway Modulators Induces Alzheimer Disease-like Pathologies in Organotypic Brain Slices. Biomolecules. vol 14. issue 2. 2024-02-24. PMID:38397402. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder that is characterized by amyloid-beta (aβ) plaques and tau neurofibrillary tangles (nft). |
2024-02-24 |
2024-02-26 |
mouse |
| Mai Yamakawa, Jessica E Rexac. Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer's Disease. Biomedicines. vol 12. issue 2. 2024-02-24. PMID:38397909. |
alzheimer's disease (ad) is a multi-stage neurodegenerative disorder characterized by beta-amyloid accumulation, hyperphosphorylated tau deposits, neurodegeneration, neuroinflammation, and cognitive impairment. |
2024-02-24 |
2024-02-26 |
human |
| Magdalena Pszczołowska, Kamil Walczak, Weronika Misków, Katarzyna Antosz, Joanna Batko, Julia Karska, Jerzy Lesze. Molecular cross-talk between long COVID-19 and Alzheimer's disease. GeroScience. 2024-02-23. PMID:38393535. |
some of its symptoms affect the nervous system and resemble symptoms of alzheimer's disease (ad)-a neurodegenerative condition caused by the accumulation of amyloid beta and hyperphosphorylation of tau proteins. |
2024-02-23 |
2024-02-25 |
Not clear |
| Malin Wennström, Nina Schultz, Paula Mille Gallardo, The Netherlands Brain Bank, Geidy E Serrano, Thomas G Beach, Suchira Bose, Oskar Hansso. The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology. Cells. vol 13. issue 4. 2024-02-23. PMID:38391945. |
to investigate if the three p-tau variants are found to the same degree in different tau structures and if their co-localization is affected by the diagnosis and presence of aß plaques, we immunostained sections of the entorhinal cortex (ec) and inferior temporal gyrus (itg) from non-demented controls (nc), patients with alzheimer's disease (ad), and primary age-related tauopathy (part) against p-tau217, p-tau231, and p-tau205 together with methoxi-x04. |
2024-02-23 |
2024-02-25 |
human |
| Stanisł Aw J Czuczwar, Janusz Kocki, Barbara Miziak, Jacek Bogucki, Anna Bogucka-Kocka, Ryszard Plut. Alpha-, Beta-, and Gamma-Secretase, Amyloid Precursor Protein, and Tau Protein Genes in the Hippocampal CA3 Subfield in an Ischemic Model of Alzheimer's Disease with Survival up to 2 Years. Journal of Alzheimer's disease : JAD. 2024-02-23. PMID:38393914. |
alpha-, beta-, and gamma-secretase, amyloid precursor protein, and tau protein genes in the hippocampal ca3 subfield in an ischemic model of alzheimer's disease with survival up to 2 years. |
2024-02-23 |
2024-02-26 |
Not clear |
| Yujing Liu, Yun Tan, Guopan Cheng, Yaqiong Ni, Aihua Xie, Xiaozhen Zhu, Chao Yin, Yi Zhang, Tongkai Che. Customized Intranasal Hydrogel Delivering Methylene Blue Ameliorates Cognitive Dysfunction Against Alzheimer's Disease. Advanced materials (Deerfield Beach, Fla.). 2024-02-23. PMID:38395039. |
the accumulation of hyperphosphorylated tau protein aggregates is a key pathogenic event in alzheimer's disease (ad) and induces mitochondrial dysfunction and reactive oxygen species (ros) overproduction. |
2024-02-23 |
2024-02-26 |
mouse |
| Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brand. Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction. Nature communications. vol 15. issue 1. 2024-02-23. PMID:38396035. |
tauopathies such as alzheimer's disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. |
2024-02-23 |
2024-02-26 |
human |
| Adam S Fleisher, Leanne M Munsie, David G S Perahia, Scott W Andersen, Ixavier A Higgins, Paula M Hauck, Albert C Lo, John R Sims, Miroslaw Brys, Mark Mintu. Assessment of Efficacy and Safety of Zagotenemab: Results From PERISCOPE-ALZ, a Phase 2 Study in Early Symptomatic Alzheimer Disease. Neurology. vol 102. issue 5. 2024-02-22. PMID:38386949. |
zagotenemab (ly3303560), a monoclonal antibody that preferentially targets misfolded, extracellular, aggregated tau, was assessed in the periscope-alz phase 2 study to determine its ability to slow cognitive and functional decline relative to placebo in early symptomatic alzheimer disease (ad). |
2024-02-22 |
2024-02-25 |
Not clear |
| Withsakorn Sangsuwan, Kriangsak Faikhruea, Kotchakorn Supabowornsathit, Don Sangsopon, Praewphan Ingrungruanglert, Hathaichanok Chuntakaruk, Napatsaporn Nuntavanotayan, Kittiporn Nakprasit, Nipan Israsena, Thanyada Rungrotmongkol, Pitak Chuawong, Tirayut Vilaivan, Chanat Aonbangkhe. Design, Synthesis, and Characterization of Novel Styryl Dyes as Fluorescent Probes for Tau Aggregate Detection in Vitro and in Cells. Chemistry, an Asian journal. 2024-02-20. PMID:38377056. |
this work offers novel and non-cytotoxic fluorescent probes with desirable photophysical properties, which could potentially be used for studying tau aggregates in living cells, prompting further development of new fluorescent probes for early alzheimer's disease detection. |
2024-02-20 |
2024-02-23 |
Not clear |
| Vaishnavi S Jadhav, Jade G Stair, Randall J Eck, Samuel N Smukowski, Heather N Currey, Laura Garcia Toscano, Joshua C Hincks, Caitlin S Latimer, Paul N Valdmanis, Brian C Kraemer, Nicole F Liachk. Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets. Neurobiology of disease. 2024-02-20. PMID:38378122. |
alzheimer's disease (ad), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (aβ) and tau aggregates in the brain. |
2024-02-20 |
2024-02-23 |
caenorhabditis_elegans |
| Abrar Younas, Neelam Younas, Muhammad Javed Iqbal, Isidre Ferrer, Inga Zer. Comparative interactome mapping of Tau-protein in classical and rapidly progressive Alzheimer's disease identifies subtype-specific pathways. Neuropathology and applied neurobiology. vol 50. issue 1. 2024-02-20. PMID:38374702. |
tau is a key player in alzheimer's disease (ad) and other tauopathies. |
2024-02-20 |
2024-02-22 |
Not clear |
| Rebecca Beardmore, Matthew Durkin, Faizan Zayee-Mellick, Laurie C Lau, James A R Nicoll, Clive Holmes, Delphine Boch. Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology. Neuropathology and applied neurobiology. vol 50. issue 1. 2024-02-20. PMID:38374720. |
in alzheimer's disease (ad), the locus coeruleus (lc) undergoes early and extensive neuronal loss, preceded by abnormal intracellular tau aggregation, decades before the onset of clinical disease. |
2024-02-20 |
2024-02-22 |
human |
| A C Macedo, D F P A Durço, C Tissot, J Therriault, A O Vilela de Faria, É Aumont, S Servaes, N Rahmouni, J Fernandez-Arias, Y-T Wang, F Z Lussier, A Bieger, E R Zimmer, T A Pascoal, S Gauthier, P Rosa-Net. Clinical Correlates of the PET-based Braak Staging Framework in Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 11. issue 2. 2024-02-20. PMID:38374747. |
however, the agreement between clinical and pathological alzheimer's disease diagnosis, whose diagnosis assessment includes amyloid and braak histopathological tau staging, is not completely convergent. |
2024-02-20 |
2024-02-22 |
Not clear |