| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yen Ying Lim, Paul Maruff, Nicolas R Barthélemy, Alison Goate, Jason Hassenstab, Chihiro Sato, Anne M Fagan, Tammie L S Benzinger, Chengjie Xiong, Carlos Cruchaga, Johannes Levin, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Colin L Masters, Stephen Salloway, Peter R Schofield, John C Morris, Randall J Bateman, Eric McDad. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. JAMA neurology. 2022-01-31. PMID:35099506. |
allelic variation in the brain-derived neurotrophic factor (bdnf) val66met polymorphism moderates increases in cerebrospinal fluid (csf) levels of tau and phosphorylated tau 181 (p-tau181), measured using immunoassay, and cognitive decline in presymptomatic dominantly inherited alzheimer disease (diad). |
2022-01-31 |
2023-08-13 |
Not clear |
| Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong, Zhentao Zhan. Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-01-30. PMID:35093145. |
islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in alzheimer's disease. |
2022-01-30 |
2023-08-13 |
Not clear |
| Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong, Zhentao Zhan. Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-01-30. PMID:35093145. |
the pathologic accumulation and aggregation of tau is a hallmark of tauopathies including alzheimer's disease (ad). |
2022-01-30 |
2023-08-13 |
Not clear |
| Robin de Flores, Sandhitsu R Das, Long Xie, Laura E M Wisse, Xueying Lyu, Preya Shah, Paul A Yushkevich, David A Wol. Medial temporal lobe networks in Alzheimer's disease: structural and molecular vulnerabilities. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-28. PMID:35086906. |
given the crucial role of the mtl and networks in the physiopathology of alzheimer's disease (ad), the present study aimed at i) investigate whether mtl atrophy propagates specifically within the at and pm networks, and ii) evaluate the vulnerability of these networks to ad proteinopathies.to do that, we used neuroimaging data acquired in human male and female in three distinct cohorts: i) resting-state functional mri from the aging brain cohort to define the at and pm networks (n=68), ii) longitudinal structural mri from adnigo/2 to highlight structural covariance patterns (n=349), and iii) pet data from adni3 to evaluate the networks' vulnerability to amyloid and tau (n=186).our results suggest that the atrophy of distinct mtl subregions propagates within the at and pm networks in a dissociable manner. |
2022-01-28 |
2023-08-13 |
human |
| Pamela V Martino Adami, Adelina Orellana, Pablo García, Luca Kleineidam, Emilio Alarcón-Martín, Laura Montrreal, Nuria Aguilera, Ana Espinosa, Carla Abdelnour, Maitee Rosende-Roca, Juan Pablo Tartari, Liliana Vargas, Ana Mauleón, Ester Esteban-De Antonio, Rogelio López-Cuevas, Maria Carolina Dalmasso, Rafael Campos Martin, Kayenat Parveen, Victor M Andrade Fuentes, Najaf Amin, Shahzad Ahmad, M Arfan Ikram, Piotr Lewczuk, Johannes Kornhuber, Oliver Peters, Lutz Frölich, Eckart Rüther, Jens Wiltfang, Lluis Tarraga, Merce Boada, Wolfgang Maier, Itziar de Rojas, Amanda Cano, Angela Sanabria, Montserrat Alegret, Isabel Hernández, Marta Marquié, Sergi Valero, Cornelia M van Duijn, Michael Wagner, Frank Jessen, Anja Schneider, María Eugenia Sáez Goñi, Antonio González Pérez, Agustín Ruiz, Alfredo Ramíre. Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type. Brain : a journal of neurology. 2022-01-28. PMID:35088840. |
our findings support the use of csf matrix metalloproteinase 10 as a prognostic marker for dementia of the alzheimer's type and its inclusion to the [a/t/(n)] scheme to incorporate pathologic aspects beyond amyloid and tau. |
2022-01-28 |
2023-08-13 |
human |
| Lei Cao, Yanyan Kong, Bin Ji, Yutong Ren, Yihui Guan, Ruiqing N. Positron Emission Tomography in Animal Models of Tauopathies. Frontiers in aging neuroscience. vol 13. 2022-01-27. PMID:35082657. |
the microtubule-associated protein tau (mapt) plays an important role in alzheimer's disease and primary tauopathy diseases. |
2022-01-27 |
2023-08-13 |
mouse |
| Lei Cao, Yanyan Kong, Bin Ji, Yutong Ren, Yihui Guan, Ruiqing N. Positron Emission Tomography in Animal Models of Tauopathies. Frontiers in aging neuroscience. vol 13. 2022-01-27. PMID:35082657. |
tau synergically interacts with amyloid-beta in alzheimer's disease leading to detrimental consequence. |
2022-01-27 |
2023-08-13 |
mouse |
| Lei Cao, Yanyan Kong, Bin Ji, Yutong Ren, Yihui Guan, Ruiqing N. Positron Emission Tomography in Animal Models of Tauopathies. Frontiers in aging neuroscience. vol 13. 2022-01-27. PMID:35082657. |
thus, tau has been an important target for therapeutics development for alzheimer's disease and primary tauopathy diseases. |
2022-01-27 |
2023-08-13 |
mouse |
| Andrew M Stern, Lei Liu, Shanxue Jin, Wen Liu, Angela L Meunier, Maria Ericsson, Michael B Miller, Megan Batson, Tingwan Sun, Sagar Kathuria, David Reczek, Laurent Pradier, Dennis J Selko. A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer's disease brain. Brain : a journal of neurology. 2022-01-27. PMID:35084489. |
aqueously soluble oligomers of amyloid β-peptide (oaβ) may be the principal neurotoxic forms of aβ in alzheimer disease (ad), initiating downstream events that include tau hyperphosphorylation, neuritic/synaptic injury, microgliosis and neuron loss. |
2022-01-27 |
2023-08-13 |
mouse |
| Laura Vallés-Saiz, Rocio Peinado-Cahuchola, Jesús Ávila, Félix Hernánde. Microtubule-associated protein tau in murine kidney: role in podocyte architecture. Cellular and molecular life sciences : CMLS. vol 79. issue 2. 2022-01-27. PMID:35084555. |
altered tau metabolism is related to different tauopathies being the most important alzheimer's disease where aberrant hyperphosphorylated and aggregated tau is found in the central nervous system. |
2022-01-27 |
2023-08-13 |
mouse |
| Johanna Giovannini, Willy Smeralda, Marie Jouanne, Jana Sopkova-de Oliveira Santos, Marco Catto, Anne Sophie Voisin-Chire. Tau protein aggregation: key features to improve drug discovery screening. Drug discovery today. 2022-01-27. PMID:35085785. |
tau pathologies include a broad spectrum of diseases, with alzheimer's disease (ad) being the most common tauopathy. |
2022-01-27 |
2023-08-13 |
Not clear |
| Heping Zhang, Fan Lu, Panhong Liu, Zhaohui Qiu, Jianling Li, Xiaotong Wang, Hui Xu, Yandong Zhao, Xuemin Li, Huadong Wang, Daxiang Lu, Renbin Q. A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-01-26. PMID:35080740. |
a direct interaction between rhogdiα/tau alleviates hyperphosphorylation of tau in alzheimer's disease and vascular dementia. |
2022-01-26 |
2023-08-13 |
Not clear |
| Maria Eduarda Schneider, Lucía Guillade, Miguel A Correa-Duarte, Felismina T C Moreir. Development of a biosensor for phosphorylated Tau 181 protein detection in Early-Stage Alzheimer's disease. Bioelectrochemistry (Amsterdam, Netherlands). vol 145. 2022-01-25. PMID:35078121. |
development of a biosensor for phosphorylated tau 181 protein detection in early-stage alzheimer's disease. |
2022-01-25 |
2023-08-13 |
Not clear |
| Justine D Manos, Christina N Preiss, Nandini Venkat, Joseph Tamm, Peter Reinhardt, Taekyung Kwon, Jessica Wu, Allison D Winter, Thomas R Jahn, Kiran Yanamandra, Katherine Titterton, Eric Karran, Xavier Langloi. Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model. iScience. vol 25. issue 1. 2022-01-24. PMID:35072001. |
tau pathobiology has emerged as a key component underlying alzheimer's disease (ad) progression; however, human neuronal |
2022-01-24 |
2023-08-13 |
human |
| Anna Bergauer, Robin van Osch, Silke van Elferen, Sofia Gyllvik, Hrishikesh Venkatesh, Rudy Schreibe. The diagnostic potential of fluid and imaging biomarkers in chronic traumatic encephalopathy (CTE). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 146. 2022-01-22. PMID:35062068. |
future research could incorporate machine learning methodologies to differentiate between the tau accumulation patterns detected by pet/fmri in alzheimer's and cte patients. |
2022-01-22 |
2023-08-13 |
Not clear |
| Tara E Tracy, Jesus Madero-Pérez, Danielle L Swaney, Timothy S Chang, Michelle Moritz, Csaba Konrad, Michael E Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q Trojanowski, Virginia M Y Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J Krogan, Daniel H Geschwind, Li Ga. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022-01-22. PMID:35063084. |
tau (mapt) drives neuronal dysfunction in alzheimer disease (ad) and other tauopathies. |
2022-01-22 |
2023-08-13 |
human |
| Ryszard Pluta, Jacek Kiś, Sławomir Januszewski, Mirosław Jabłoński, Stanisław J Czuczwa. Cross-Talk between Amyloid, Tau Protein and Free Radicals in Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy. Antioxidants (Basel, Switzerland). vol 11. issue 1. 2022-01-21. PMID:35052650. |
cross-talk between amyloid, tau protein and free radicals in post-ischemic brain neurodegeneration in the form of alzheimer's disease proteinopathy. |
2022-01-21 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Jacek Kiś, Sławomir Januszewski, Mirosław Jabłoński, Stanisław J Czuczwa. Cross-Talk between Amyloid, Tau Protein and Free Radicals in Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy. Antioxidants (Basel, Switzerland). vol 11. issue 1. 2022-01-21. PMID:35052650. |
finally, we hypothesize that modified amyloid and the tau protein, along with the oxidative stress generated, are new key elements in the vicious circle important in the development of post-ischemic neurodegeneration in a type of alzheimer's disease proteinopathy. |
2022-01-21 |
2023-08-13 |
Not clear |
| Le Minh Tu Phan, Sungbo Ch. Fluorescent Aptasensor and Colorimetric Aptablot for p-tau231 Detection: Toward Early Diagnosis of Alzheimer's Disease. Biomedicines. vol 10. issue 1. 2022-01-21. PMID:35052773. |
the pathology of alzheimer's disease (ad), the most common cause of dementia, is considered to be mainly driven by two major hallmarks (tau and amyloid beta). |
2022-01-21 |
2023-08-13 |
Not clear |
| Anton Meinicke, Wolfgang Härtig, Karsten Winter, Joana Puchta, Bianca Mages, Dominik Michalski, Alexander Emmer, Markus Otto, Karl-Titus Hoffmann, Willi Reimann, Matthias Krause, Stefan Scho. Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content. Biomolecules. vol 12. issue 1. 2022-01-21. PMID:35053244. |
exploring whether sp-g might play a role in alzheimer's disease (ad), 3xtg-ad mice were investigated and displayed age-dependent hippocampal deposits of β-amyloid and hyperphosphorylated tau separately from clustered, sp-g-containing dots with additional reelin-ir-which was used as established marker for disease progression in this specific context. |
2022-01-21 |
2023-08-13 |
mouse |