All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Stefan J Teipel, Martin Dyrba, Tommaso Ballarini, Frederic Brosseron, Davide Bruno, Katharina Buerger, Nicoleta-Carmen Cosma, Peter Dechent, Laura Dobisch, Emrah Düzel, Michael Ewers, Klaus Fliessbach, John D Haynes, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D Metzger, Matthias H Munk, Oliver Peters, Nunzio Pomara, Lukas Preis, Josef Priller, Alfredo Ramírez, Nina Roy, Klaus Scheffler, Anja Schneider, Björn H Schott, Annika Spottke, Eike J Spruth, Michael Wagner, Jens Wiltfang, Frank Jessen, Michael T Henek. Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924387. inflammation has been described as a key pathogenic event in alzheimer's disease (ad), downstream of amyloid and tau pathology. 2021-12-20 2023-08-13 Not clear
Sze Chung Yuen, Simon Ming-Yuen Lee, Siu-Wai Leun. Putative Factors Interfering Cell Cycle Re-Entry in Alzheimer's Disease: An Omics Study with Differential Expression Meta-Analytics and Co-Expression Profiling. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924393. neuronal cell cycle re-entry (ccr) is a mechanism, along with amyloid-β (aβ) oligomers and hyperphosphorylated tau proteins, contributing to toxicity in alzheimer's disease (ad). 2021-12-20 2023-08-13 Not clear
Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kaye. Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes. Frontiers in molecular neuroscience. vol 14. 2021-12-20. PMID:34924950. tau protein is a known contributor in several neurodegenerative diseases, including alzheimer's disease (ad) and frontotemporal dementia (ftd). 2021-12-20 2023-08-13 human
Pei-Pei Guan, Long-Long Cao, Yi Yang, Pu Wan. Calcium Ions Aggravate Alzheimer's Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits. Frontiers in molecular neuroscience. vol 14. 2021-12-20. PMID:34924952. alzheimer's disease (ad) is a neurodegenerative disease that is characterized by the production and deposition of β-amyloid protein (aβ) and hyperphosphorylated tau, leading to the formation of β-amyloid plaques (aps) and neurofibrillary tangles (nfts). 2021-12-20 2023-08-13 Not clear
Murat Bilgel, Alisa Bannerjee, Andrea Shafer, Yang An, Susan M Resnic. Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults. Neuroimage. Reports. vol 1. issue 4. 2021-12-20. PMID:34927122. studies have found that vascular risk factors are associated with greater amyloid-β (aβ) and tau burden, which are hallmark neuropathologies of alzheimer's disease (ad). 2021-12-20 2023-08-13 human
Antoine Leuzy, Ruben Smith, Nicholas C Cullen, Olof Strandberg, Jacob W Vogel, Alexa Pichet Binette, Edilio Borroni, Shorena Janelidze, Tomas Ohlsson, Jonas Jögi, Rik Ossenkoppele, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Gregory Klein, Erik Stomrud, Oskar Hansso. Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease. JAMA neurology. 2021-12-20. PMID:34928318. biomarker-based prediction of longitudinal tau positron emission tomography in alzheimer disease. 2021-12-20 2023-08-13 Not clear
Antoine Leuzy, Ruben Smith, Nicholas C Cullen, Olof Strandberg, Jacob W Vogel, Alexa Pichet Binette, Edilio Borroni, Shorena Janelidze, Tomas Ohlsson, Jonas Jögi, Rik Ossenkoppele, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Gregory Klein, Erik Stomrud, Oskar Hansso. Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease. JAMA neurology. 2021-12-20. PMID:34928318. there is currently no consensus as to which biomarkers best predict longitudinal tau accumulation at different clinical stages of alzheimer disease (ad). 2021-12-20 2023-08-13 Not clear
Margaret Hayne, Aaron DiAntoni. Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival. Neurobiology of disease. 2021-12-19. PMID:34923110. in post-mitotic neurons, the microtubule associated protein tau is a particularly well-studied pp2a substrate as hyperphosphorylation of tau is a hallmark of alzheimer's disease. 2021-12-19 2023-08-13 drosophila_melanogaster
Lenka Hruba, Pavel Polishchuk, Viswanath Das, Marian Hajduch, Petr Dzuba. An identification of MARK inhibitors using high throughput MALDI-TOF mass spectrometry. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 146. 2021-12-19. PMID:34923338. map/microtubule affinity-regulating kinases (marks) were recently identified as potential drug targets for alzheimer's disease (ad) due to their role in pathological hyperphosphorylation of tau protein. 2021-12-19 2023-08-13 Not clear
Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta Del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I Casas, Harald H H W Schmidt, Manuela G Lópe. Implication of type 4 NADPH oxidase (NOX4) in tauopathy. Redox biology. vol 49. 2021-12-18. PMID:34922273. aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as alzheimer's disease (ad) and frontotemporal dementia. 2021-12-18 2023-08-13 mouse
Karl Hansson, Rahil Dahlén, Oskar Hansson, Elin Pernevik, Ross Paterson, Jonathan M Schott, Nadia Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobo. Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's disease. Clinical mass spectrometry (Del Mar, Calif.). vol 14 Pt B. 2021-12-17. PMID:34917763. use of the tau protein-to-peptide ratio in csf to improve diagnostic classification of alzheimer's disease. 2021-12-17 2023-08-13 Not clear
Karl Hansson, Rahil Dahlén, Oskar Hansson, Elin Pernevik, Ross Paterson, Jonathan M Schott, Nadia Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobo. Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's disease. Clinical mass spectrometry (Del Mar, Calif.). vol 14 Pt B. 2021-12-17. PMID:34917763. cerebrospinal fluid (csf) tau and phospho-tau are well established biomarkers of alzheimer's disease. 2021-12-17 2023-08-13 Not clear
Kurt A Jellinge. Recent update on the heterogeneity of the Alzheimer's disease spectrum. Journal of neural transmission (Vienna, Austria : 1996). 2021-12-17. PMID:34919190. alzheimer's disease (ad), the most common form of dementia worldwide, is a mixed proteinopathy (β-amyloid, tau and other proteins). 2021-12-17 2023-08-13 Not clear
Allan I Levey, Deqiang Qiu, Liping Zhao, William T Hu, Duc M Duong, Lenora Higginbotham, Eric B Dammer, Nicholas T Seyfried, Thomas S Wingo, Chadwick M Hales, Malú Gámez Tansey, David S Goldstein, Anees Abrol, Vince D Calhoun, Felicia C Goldstein, Ihab Hajjar, Anne M Fagan, Doug Galasko, Steven D Edland, John Hanfelt, James J Lah, David Weinshenke. A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment. Brain : a journal of neurology. 2021-12-17. PMID:34919634. the locus coeruleus (lc) is the initial site of alzheimer's disease neuropathology, with hyperphosphorylated tau appearing in early adulthood followed by neurodegeneration in dementia. 2021-12-17 2023-08-13 human
Ramesh Kandimalla, Maria Manczak, Jangampalli Adi Pradeepkiran, Hallie Morton, P Hemachandra Redd. A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic tau mouse model of Alzheimer disease. Human molecular genetics. 2021-12-17. PMID:34919689. a partial reduction of drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic tau mouse model of alzheimer disease. 2021-12-17 2023-08-13 mouse
Ramesh Kandimalla, Maria Manczak, Jangampalli Adi Pradeepkiran, Hallie Morton, P Hemachandra Redd. A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic tau mouse model of Alzheimer disease. Human molecular genetics. 2021-12-17. PMID:34919689. the purpose of our study is to understand the impact of a partial dynamin-related protein 1 (drp1) on cognitive behavior, mitophagy, autophagy, and mitochondrial and synaptic activities in transgenic tau mice in alzheimer's disease (ad). 2021-12-17 2023-08-13 mouse
Stephen L P Lippi, Caroline L C Neely, Anthony L Amay. Trace concentrations, heavy implications: Influences of biometals on major brain pathologies of Alzheimer's disease. The international journal of biochemistry & cell biology. 2021-12-15. PMID:34906694. alzheimer's disease (ad) is a neurodegenerative condition that involves accumulation of toxic protein species, notably amyloid-β plaques and neurofibrillary tau tangles that are associated with cognitive decline. 2021-12-15 2023-08-13 Not clear
Thanaphong Phongpreecha, Chandresh R Gajera, Candace C Liu, Kausalia Vijayaragavan, Alan L Chang, Martin Becker, Ramin Fallahzadeh, Rosemary Fernandez, Nadia Postupna, Emily Sherfield, Dmitry Tebaykin, Caitlin Latimer, Carol A Shively, Thomas C Register, Suzanne Craft, Kathleen S Montine, Edward J Fox, Kathleen L Poston, C Dirk Keene, Michael Angelo, Sean C Bendall, Nima Aghaeepour, Thomas J Montin. Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE. Science advances. vol 7. issue 51. 2021-12-15. PMID:34910503. single-synapse analyses of alzheimer's disease implicate pathologic tau, dj1, cd47, and apoe. 2021-12-15 2023-08-13 Not clear
Erin E Congdon, Yixiang Jiang, Einar M Sigurdsso. Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly. Seminars in cell & developmental biology. 2021-12-13. PMID:34896021. alzheimer's disease is the most common tauopathy, but the group consists of over 20 different diseases, many of which have tau pathology as their primary feature. 2021-12-13 2023-08-13 Not clear
Nikoleta Csicsatkova, Peter Szalay, Katarina Matyasova, Veronika Mate, Martin Cente, Tomas Smolek, Veronika Brezovakova, Lucie Kawecka, Norbert Zilka, Santosh Jadha. Transcriptomic signature of Alzheimer's disease tau seed-induced pathology. General physiology and biophysics. vol 40. issue 6. 2021-12-13. PMID:34897025. transcriptomic signature of alzheimer's disease tau seed-induced pathology. 2021-12-13 2023-08-13 Not clear