| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S V Golla, Marijke den Hollander, Lyduine E Collij, Emma Weltings, Sophie van der Landen, Emma E Wolters, Albert D Windhorst, Frederik Barkhof, Eco J C de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twins show comparable tau PET load and spatial distribution. Brain : a journal of neurology. 2022-01-13. PMID:35022652. |
considering also the presence of dissimilarities in tau pathology in identical twin-pairs, our results additionally support a role for (potentially modifiable) environmental factors in the onset of alzheimer's disease pathological processes, which may be of interest for future prevention strategies. |
2022-01-13 |
2023-08-13 |
human |
| Yu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S Baskar, Kelvin Kwan, David J Margolis, Peng Jiang, Alexander Kusnecov, Qian Ca. Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy. Brain : a journal of neurology. 2022-01-13. PMID:35022692. |
mitochondrial defects are a hallmark of early pathophysiology in alzheimer's disease, with pathologically phosphorylated tau reported to induce mitochondrial toxicity. |
2022-01-13 |
2023-08-13 |
mouse |
| Li Zeng, Hailun Jiang, Ghulam Md Ashraf, Jianghong Liu, Linlin Wang, Kaiyue Zhao, Mimin Liu, Zhuorong Li, Rui Li. Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease. Molecular therapy. Nucleic acids. vol 27. 2022-01-13. PMID:35024240. |
implications of mir-148a-3p/p35/pten signaling in tau hyperphosphorylation and autoregulatory feedforward of akt/creb in alzheimer's disease. |
2022-01-13 |
2023-08-13 |
mouse |
| Prama Putra, Travis B Thompson, Pavanjit Chaggar, Alain Goriel. Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration. Network neuroscience (Cambridge, Mass.). vol 5. issue 4. 2022-01-13. PMID:35024537. |
a hallmark of alzheimer's disease is the aggregation of insoluble amyloid-beta plaques and tau protein neurofibrillary tangles. |
2022-01-13 |
2023-08-13 |
Not clear |
| Prama Putra, Travis B Thompson, Pavanjit Chaggar, Alain Goriel. Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration. Network neuroscience (Cambridge, Mass.). vol 5. issue 4. 2022-01-13. PMID:35024537. |
we apply this approach to a six-stage 'braak pattern' of tau proteins, in alzheimer's disease, motivated by a recent observation that seed-competent tau precedes tau aggregation. |
2022-01-13 |
2023-08-13 |
Not clear |
| Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P De Deyn, Maria Bjerke, Guy Nagels, Charlotte E Teunissen, Sebastiaan Engelborgh. Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers. Brain : a journal of neurology. 2022-01-13. PMID:35026840. |
alzheimer's disease cerebrospinal fluid (csf) biomarkers 42 amino acid long amyloid-β peptide (aβ1-42), total tau protein (t-tau), and tau protein phosphorylated at threonine 181 (p-tau181) are considered surrogate biomarkers of alzheimer's disease pathology, and significantly improve diagnostic accuracy. |
2022-01-13 |
2023-08-13 |
Not clear |
| Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P De Deyn, Maria Bjerke, Guy Nagels, Charlotte E Teunissen, Sebastiaan Engelborgh. Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers. Brain : a journal of neurology. 2022-01-13. PMID:35026840. |
our data suggest that similarly to what has been reported for aβ1-42, plateau levels of p-tau181 and t-tau are reached during the disease course, albeit at later disease stages, reducing the potential of tau biomarkers to monitor alzheimer's disease pathology as the disease progresses. |
2022-01-13 |
2023-08-13 |
Not clear |
| Francesca Parolini, Roberto Tira, Carlo Giorgio Barracchia, Francesca Munari, Stefano Capaldi, Mariapina D'Onofrio, Michael Assfal. Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner. International journal of biological macromolecules. 2022-01-12. PMID:35016968. |
phase separation of the alzheimer's related protein tau into liquid condensates is facilitated by polyanions and is regulated by post-translational modifications. |
2022-01-12 |
2023-08-13 |
Not clear |
| Angie K Torres, Bastián I Rivera, Catalina M Polanco, Claudia Jara, Cheril Tapia-Roja. Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017410. |
phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and alzheimer's disease. |
2022-01-12 |
2023-08-13 |
Not clear |
| Angie K Torres, Bastián I Rivera, Catalina M Polanco, Claudia Jara, Cheril Tapia-Roja. Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017410. |
finally, we show evidence and argue about the presence of phosphorylated tau phf-1 inside mitochondria in alzheimer's disease, which could be considered as an early event in the neurodegenerative process. |
2022-01-12 |
2023-08-13 |
Not clear |
| Alejandro R Roda, Gabriel Serra-Mir, Laia Montoliu-Gaya, Lidia Tiessler, Sandra Villega. Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017413. |
amyloid-beta peptide and tau protein crosstalk in alzheimer's disease. |
2022-01-12 |
2023-08-13 |
Not clear |
| Xi-Chen Zhu, Lu Liu, Wen-Zhuo Dai, Tao M. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017447. |
complement component (3b/4b) receptor 1 (cr1) expression is positively related to the abundance of phosphorylated microtubule-associated protein tau (tau), and cr1 expression is associated with susceptibility to alzheimer's disease. |
2022-01-12 |
2023-08-13 |
mouse |
| Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Patricia Villanueva-Anguita, Isabel Ubeda-Banon, Alicia Flores-Cuadrado, Alino Martinez-Marcos, Daniel Saiz-Sanche. Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008592. |
alzheimer's disease (ad), the most prevalent neurodegenerative disorder, is characterized by executive dysfunction and memory impairment mediated by the accumulation of extracellular amyloid-β peptide (aβ) and intracellular hyperphosphorylated tau protein. |
2022-01-11 |
2023-08-13 |
human |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008731. |
in the hippocampus, studies have revealed dysregulation of the genes for the amyloid protein precursor metabolism and tau protein that is identical in nature to alzheimer's disease. |
2022-01-11 |
2023-08-13 |
Not clear |
| Laura Bonfili, Chunmei Gong, Francesca Lombardi, Maria Grazia Cifone, Anna Maria Eleuter. Strategic Modification of Gut Microbiota through Oral Bacteriotherapy Influences Hypoxia Inducible Factor-1α: Therapeutic Implication in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008786. |
dysbiosis contributes to alzheimer's disease (ad) pathogenesis, and oral bacteriotherapy represents a promising preventative and therapeutic opportunity to remodel gut microbiota and to delay ad onset and progression by reducing neuroinflammation and amyloid and tau proteins aggregation. |
2022-01-11 |
2023-08-13 |
mouse |
| Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T Anderson, Elena Ivanova, Hening Lin, Botir T Sagdullaev, Jianer Chen, William L Klein, Kirsten L Viola, Sam Gandy, Vahram Haroutunian, M Flint Beal, David Eliezer, Sheng Zhang, Gary E Gibso. Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nature communications. vol 13. issue 1. 2022-01-11. PMID:35013160. |
altered succinylation of mitochondrial proteins, app and tau in alzheimer's disease. |
2022-01-11 |
2023-08-13 |
mouse |
| Zoeb Jiwaji, Sachin S Tiwari, Rolando X Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M Smith, Peta Greer, Matthew Ball, Peter C Kind, Paul M Matthews, Colin Smith, Owen Dando, Tara L Spires-Jones, Jeffrey A Johnson, Siddharthan Chandran, Giles E Hardingha. Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology. Nature communications. vol 13. issue 1. 2022-01-11. PMID:35013236. |
alzheimer's disease (ad) alters astrocytes, but the effect of aß and tau pathology is poorly understood. |
2022-01-11 |
2023-08-13 |
Not clear |
| Tao Zhang, Yongfang Xia, Li Hu, Dongmei Chen, Chen-Ling Gan, Long Wang, Yingxue Mei, Guihua Lan, Xindong Shui, Yuan Tian, Ruomeng Li, Mi Zhang, Tae Ho Le. Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease. International journal of biological sciences. vol 18. issue 2. 2022-01-10. PMID:35002518. |
death-associated protein kinase 1 mediates aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in alzheimer's disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Ellen Grober, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Rebecca E Amariglio, Aaron Schultz, Richard B Lipton, Ali Ezzat. Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2022-01-10. PMID:35005192. |
to assess the relationship between memory performance defined by the stages of objective memory impairment (somi) system and the alzheimer's disease (ad) atn (amyloid beta [a], pathologic tau [t], and neurodegeneration [n]) biomarker system. |
2022-01-10 |
2023-08-13 |
Not clear |
| Leonardo A Rivera-Rivera, Laura Eisenmenger, Karly A Cody, Thomas Reher, Tobey Betthauser, Robert V Cadman, Howard A Rowley, Cynthia M Carlsson, Nathaniel A Chin, Sterling C Johnson, Kevin M Johnso. Cerebrovascular stiffness and flow dynamics in the presence of amyloid and tau biomarkers. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2022-01-10. PMID:35005194. |
this work investigated the relationship between cerebrovascular disease (cvd) markers and alzheimer's disease (ad) biomarkers of amyloid beta deposition, and neurofibrillary tau tangles in subjects spanning the ad clinical spectrum. |
2022-01-10 |
2023-08-13 |
human |