| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields, Walter K Kremers, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Alan J Thomas, John-Paul Taylor, Kejal Kantarc. Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:34114602. |
dementia with lewy bodies (dlb) is neuropathologically defined by the presence of α-synuclein aggregates, but many dlb cases show concurrent alzheimer's disease pathology in the form of amyloid-β plaques and tau neurofibrillary tangles. |
2021-12-09 |
2023-08-13 |
human |
| Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields, Walter K Kremers, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Alan J Thomas, John-Paul Taylor, Kejal Kantarc. Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:34114602. |
higher functional connectivity between regions was associated with higher tau covariance in cognitively unimpaired, alzheimer's disease and dlb. |
2021-12-09 |
2023-08-13 |
human |
| Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields, Walter K Kremers, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Alan J Thomas, John-Paul Taylor, Kejal Kantarc. Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:34114602. |
furthermore, we found an association between the brain's functional network architecture and the distribution of tau pathology that has recently been described in alzheimer's disease. |
2021-12-09 |
2023-08-13 |
human |
| Paul A Yushkevich, Mónica Muñoz López, María Mercedes Iñiguez de Onzoño Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R Das, Emilio Artacho-Pérula, Marı'a Del Mar Arroyo Jiménez, Marı'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa-Prieto, Marta Córcoles Parada, Edward B Lee, John Q Trojanowski, Daniel T Ohm, Laura E M Wisse, David A Wolk, David J Irwin, Ricardo Insaust. Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34259858. |
tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in alzheimer's disease and related dementias. |
2021-12-09 |
2023-08-13 |
human |
| Ali R Khan, Julie Ottoy, Maged Goubra. Towards a comprehensive 3D mapping of tau progression in early Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34424288. |
towards a comprehensive 3d mapping of tau progression in early alzheimer's disease. |
2021-12-09 |
2023-08-13 |
Not clear |
| Yalun Zhang, Yi Zhang, Yahyah Aman, Cheung Toa Ng, Wing-Hin Chau, Zhigang Zhang, Ming Yue, Christopher Bohm, Yizhen Jia, Siwen Li, Qiuju Yuan, Jennifer Griffin, Kin Chiu, Dana S M Wong, Binbin Wang, Dongyan Jin, Ekaterina Rogaeva, Paul E Fraser, Evandro F Fang, Peter St George-Hyslop, You-Qiang Son. Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34428276. |
here, we show that pax6, a transcription factor essential for eye and brain development which is quiescent in adults, is increased in the brains of patients with alzheimer's disease and in app transgenic mice, and plays a key role between amyloid-β and tau hyperphosphorylation. |
2021-12-09 |
2023-08-13 |
mouse |
| Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlar. Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 2. 2021-12-08. PMID:33410108. |
the accumulation of neurofibrillary tangles (nfts), which is composed of abnormally hyperphosphorylated tau aggregates, is the classic neuropathology associated with cognitive dysfunction in tauopathies such as alzheimer's disease (ad). |
2021-12-08 |
2023-08-13 |
mouse |
| Airi Tarutani, Haruka Miyata, Takashi Nonaka, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Andrew C Robinson, David M A Mann, Taisuke Tomita, Masato Hasegaw. Human tauopathy-derived tau strains determine the substrates recruited for templated amplification. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33693528. |
specifically, three-repeat tau and four-repeat tau in alzheimer's disease, three-repeat tau in pick's disease (pid) and four-repeat tau in progressive supranuclear palsy (psp) and corticobasal degeneration (cbd) form amyloid-like fibrous structures that accumulate in neurons and/or glial cells. |
2021-12-08 |
2023-08-13 |
human |
| Airi Tarutani, Haruka Miyata, Takashi Nonaka, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Andrew C Robinson, David M A Mann, Taisuke Tomita, Masato Hasegaw. Human tauopathy-derived tau strains determine the substrates recruited for templated amplification. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33693528. |
the seeding activity towards full-length four-repeat tau substrate was highest in cbd-tau seeds, followed by psp-tau and alzheimer's disease (ad)-tau seeds, while ad-tau seeds showed higher seeding activity than pid-tau seeds towards three-repeat tau substrate. |
2021-12-08 |
2023-08-13 |
human |
| Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sande. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33742656. |
discriminatory ability of next-generation tau pet tracers for alzheimer's disease. |
2021-12-08 |
2023-08-13 |
human |
| Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sande. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33742656. |
a next generation of tau pet tracers for the imaging of alzheimer's disease and other dementias has recently been developed. |
2021-12-08 |
2023-08-13 |
human |
| Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sande. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33742656. |
the four radiotracers depicted tau inclusions composed of paired helical filaments with high specificity, both in cases with alzheimer's disease and in primary tauopathy cases with concomitant alzheimer's disease pathology. |
2021-12-08 |
2023-08-13 |
human |
| Adam Martersteck, Jaiashre Sridhar, Christina Coventry, Sandra Weintraub, M-Marsel Mesulam, Emily Rogalsk. Relationships among tau burden, atrophy, age, and naming in the aphasic variant of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 11. 2021-12-08. PMID:34494711. |
relationships among tau burden, atrophy, age, and naming in the aphasic variant of alzheimer's disease. |
2021-12-08 |
2023-08-13 |
Not clear |
| Emilie Caroux, Virginie Redeker, Karine Madiona, Ronald Melk. Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau. The Journal of biological chemistry. vol 297. issue 5. 2021-12-08. PMID:34592311. |
the rigid core of intracellular tau filaments from alzheimer's disease (ad), pick's disease (pid), and corticobasal disease (cbd) brains has been shown to differ in their cryo-em atomic structure. |
2021-12-08 |
2023-08-13 |
human |
| Brendan P Lucey, Julie Wisch, Anna H Boerwinkle, Eric C Landsness, Cristina D Toedebusch, Jennifer S McLeland, Omar H Butt, Jason Hassenstab, John C Morris, Beau M Ances, David M Holtzma. Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease. Brain : a journal of neurology. 2021-12-08. PMID:34668959. |
to test this hypothesis, we monitored sleep-wake activity over 4-6 nights in 100 participants who underwent standardized cognitive testing longitudinally, apoe genotyping, and measurement of alzheimer's disease biomarkers, total tau and amyloid-β42 in the csf. |
2021-12-08 |
2023-08-13 |
human |
| Khadga Raj, G D Gupta, Shamsher Sing. Spermine protects aluminium chloride and iron-induced neurotoxicity in rat model of Alzheimer's disease via attenuation of tau phosphorylation, Amyloid-β (1-42) and NF-κB pathway. Inflammopharmacology. vol 29. issue 6. 2021-12-08. PMID:34727278. |
spermine protects aluminium chloride and iron-induced neurotoxicity in rat model of alzheimer's disease via attenuation of tau phosphorylation, amyloid-β (1-42) and nf-κb pathway. |
2021-12-08 |
2023-08-13 |
rat |
| Rebecca M Parodi-Rullán, Sabzali Javadov, Silvia Fossat. Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer's Disease. Cells. vol 10. issue 11. 2021-12-08. PMID:34831125. |
alzheimer's disease (ad) is the most prevalent cause of dementia and is pathologically characterized by the presence of parenchymal senile plaques composed of amyloid β (aβ) and intraneuronal neurofibrillary tangles of hyperphosphorylated tau protein. |
2021-12-08 |
2023-08-13 |
Not clear |
| SpiroAnthony Stathas, Victor E Alvarez, Weiming Xia, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Morgan Pothast, Arsal Shah, Hunter Kelley, Camille Esnault, Robert McCormack, Erin Dixon, Lucas Fishbein, Jonathan D Cherry, Bertrand R Huber, Yorghos Tripodis, Michael L Alosco, Jesse Mez, Ann C McKee, Thor D Stei. Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-12-08. PMID:34854540. |
tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and alzheimer's disease. |
2021-12-08 |
2023-08-13 |
Not clear |
| SpiroAnthony Stathas, Victor E Alvarez, Weiming Xia, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Morgan Pothast, Arsal Shah, Hunter Kelley, Camille Esnault, Robert McCormack, Erin Dixon, Lucas Fishbein, Jonathan D Cherry, Bertrand R Huber, Yorghos Tripodis, Michael L Alosco, Jesse Mez, Ann C McKee, Thor D Stei. Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-12-08. PMID:34854540. |
post-translation modifications to tau in cte have not been well delineated or compared to alzheimer's disease (ad). |
2021-12-08 |
2023-08-13 |
Not clear |
| Viktoriya Zhuravleva, João Vaz-Silva, Mei Zhu, Patricia Gomes, Joana M Silva, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L Waite. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell death & disease. vol 12. issue 12. 2021-12-08. PMID:34876559. |
chronic stress and elevated glucocorticoids (gcs), the major stress hormones, are risk factors for alzheimer's disease (ad) and promote ad pathomechanisms, including overproduction of toxic amyloid-β (aβ) peptides and intraneuronal accumulation of hyperphosphorylated tau protein. |
2021-12-08 |
2023-08-13 |
Not clear |