| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Ibanez, Justin B Mille. Editorial for the Genetics of Alzheimer's Disease Special Issue: October 2021. Genes. vol 12. issue 11. 2021-11-30. PMID:34828400. |
alzheimer's disease is a complex and multifactorial condition regulated by both genetics and lifestyle, which ultimately results in the accumulation of β-amyloid (aβ) and tau proteins in the brain, loss of gray matter, and neuronal death [...]. |
2021-11-30 |
2023-08-13 |
Not clear |
| Valentina Latina, Giacomo Giacovazzo, Pietro Calissano, Anna Atlante, Federico La Regina, Francesca Malerba, Marco Dell'Aquila, Egidio Stigliano, Bijorn Omar Balzamino, Alessandra Micera, Roberto Coccurello, Giuseppina Amador. Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer's Disease (sAD) Mouse Model. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830036. |
tau cleavage contributes to cognitive dysfunction in strepto-zotocin-induced sporadic alzheimer's disease (sad) mouse model. |
2021-11-30 |
2023-08-13 |
mouse |
| Valentina Latina, Giacomo Giacovazzo, Pietro Calissano, Anna Atlante, Federico La Regina, Francesca Malerba, Marco Dell'Aquila, Egidio Stigliano, Bijorn Omar Balzamino, Alessandra Micera, Roberto Coccurello, Giuseppina Amador. Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer's Disease (sAD) Mouse Model. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830036. |
tau cleavage plays a crucial role in the onset and progression of alzheimer's disease (ad), a widespread neurodegenerative disease whose incidence is expected to increase in the next years. |
2021-11-30 |
2023-08-13 |
mouse |
| Frank Y Shan, Kar-Ming Fung, Tarek Zieneldien, Janice Kim, Chuanhai Cao, Jason H Huan. Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders. Life (Basel, Switzerland). vol 11. issue 11. 2021-11-30. PMID:34833002. |
furthermore, α-synuclein also appears to contribute to the fibrilization of tau and amyloid beta, which are crucial proteins in alzheimer's disease, advocating for α-synuclein's preeminent role in neurodegeneration. |
2021-11-30 |
2023-08-13 |
Not clear |
| Heiko Kroth, Felix Oden, Andreia Monica Serra, Jerome Molette, Andre Mueller, Mathias Berndt, Francesca Capotosti, Emanuele Gabellieri, Heribert Schmitt-Willich, David Hickman, Andrea Pfeifer, Ludger Dinkelborg, Andrew Stephen. Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core. Bioorganic & medicinal chemistry. vol 52. 2021-11-30. PMID:34839158. |
tau aggregates represent a critical pathology in alzheimer's disease (ad) and other forms of dementia. |
2021-11-30 |
2023-08-13 |
human |
| Supriyo Saha, Dilipkumar Pal, Satish B Nims. Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders. Current drug targets. vol 22. issue 12. 2021-11-29. PMID:33494672. |
this enzyme mainly phosphorylates tau protein with the increased amount in neuronal fibres together with beta-amyloid plaques that cause neuronal diseases like alzheimer's, parkinson's and many more. |
2021-11-29 |
2023-08-13 |
mouse |
| Eleni Gkanatsiou, Charlotte Sahlin, Erik Portelius, Malin Johannesson, Linda Söderberg, Johanna Fälting, Hans Basun, Christer Möller, Tomas Odergren, Henrik Zetterberg, Kaj Blennow, Lars Lannfelt, Gunnar Brinkmal. Characterization of monomeric and soluble aggregated Aβ in Down's syndrome and Alzheimer's disease brains. Neuroscience letters. vol 754. 2021-11-29. PMID:33848613. |
the major characteristics of alzheimer's disease (ad) are amyloid plaques, consisting of aggregated beta amyloid (aβ) peptides, together with tau pathology (tangles, neuropil treads and dystrophic neurites surrounding the plaques), in the brain. |
2021-11-29 |
2023-08-13 |
human |
| Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jianping Jia, Keqiang Y. Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease. The EMBO journal. vol 40. issue 17. 2021-11-29. PMID:34260075. |
gut inflammation triggers c/ebpβ/δ-secretase-dependent gut-to-brain propagation of aβ and tau fibrils in alzheimer's disease. |
2021-11-29 |
2023-08-13 |
mouse |
| Mar Pacheco-Herrero, Luis O Soto-Rojas, Heidy Reyes-Sabater, Linda Garcés-Ramirez, Fidel de la Cruz López, Ignacio Villanueva-Fierro, José Luna-Muño. Current Status and Challenges of Stem Cell Treatment for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 84. issue 3. 2021-11-29. PMID:34633316. |
neurodegenerative diseases called tauopathies, such as alzheimer's disease (ad), frontotemporal dementia, progressive supranuclear palsy, and parkinson's disease, among others, are characterized by the pathological processing and accumulation of tau protein. |
2021-11-29 |
2023-08-13 |
Not clear |
| Prechiel A Barredo, Marvin Jose F Fernandez, Christopher E Ambe, Mannix P Balana. Tau fibril with membrane lipids: Insight from computational modeling and simulations. PloS one. vol 16. issue 10. 2021-11-29. PMID:34653235. |
the microtubule-binding protein tau has been the center of researches concerning alzheimer's disease (ad) due to several clinical trials of β-amyloid therapies failing recently. |
2021-11-29 |
2023-08-13 |
Not clear |
| Amandine Grim. Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation? Cells. vol 10. issue 10. 2021-11-29. PMID:34685510. |
abnormal tau protein is a hallmark of tauopathies, including alzheimer's disease (ad). |
2021-11-29 |
2023-08-13 |
chicken |
| Sandip K Nandi, Deepanmol Singh, Jyoti Upadhay, Neeti Gupta, Nayan Dhiman, Sanjeev Kumar Mittal, Neeraj Mahindro. Identification of tear-based protein and non-protein biomarkers: Its application in diagnosis of human diseases using biosensors. International journal of biological macromolecules. vol 193. issue Pt A. 2021-11-29. PMID:34728300. |
in this review, we highlight some recent advancements in identification of tear-based protein biomarkers like lacryglobin and cystatin sa for cancer; interleukin-6 and immunoglobulin-a antibody for covid-19; tau, amyloid-β-42 and lysozyme-c for alzheimer's disease; peroxiredoxin-6 and α-synuclein for parkinson's disease; kallikrein, angiotensin converting enzyme and lipocalin-1 for glaucoma; lactotransferrin and lipophilin-a for diabetic retinopathy and zinc-alpha-2 glycoprotein-1, prolactin and calcium binding protein-a4 for eye thyroid disease. |
2021-11-29 |
2023-08-13 |
human |
| Tomohiro Tsuchida, Kouki Susa, Tomohiro Kibiki, Takahiro Tsuchiya, Katsushiro Miyamoto, Yasuko In, Katsuhiko Minoura, Taizo Taniguchi, Toshimasa Ishida, Koji Tomo. Structural study of the recognition mechanism of tau antibody Tau2r3 with the key sequence (VQIINK) in tau aggregation. Biochemical and biophysical research communications. vol 585. 2021-11-29. PMID:34784549. |
one of the histopathological features of alzheimer's disease (ad) is higher order neurofibrillary tangles formed by abnormally aggregated tau protein. |
2021-11-29 |
2023-08-13 |
Not clear |
| Diana M Acosta, Chiara Mancinelli, Clay Bracken, David Elieze. Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. The Journal of biological chemistry. 2021-11-28. PMID:34838590. |
post-translationally modified tau is the primary component of tau neurofibrillary tangles, a pathological hallmark of alzheimer's disease and other tauopathies. |
2021-11-28 |
2023-08-13 |
Not clear |
| Ashif Iqubal, Syed Obaidur Rahman, Musheer Ahmed, Pratichi Bansal, Md Rafi Haider, Mohammad Kashif Iqubal, Abul Kalam Najmi, Faheem Hyder Pottoo, Syed Ehtaishamul Haqu. Current Quest in Natural Bioactive Compounds for Alzheimer's Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence. Current drug targets. vol 22. issue 6. 2021-11-26. PMID:33302832. |
pathologically, alzheimer's disease (ad) is characterized by the presence of β-amyloid (aβ) plaques, hyper-phosphorylated tau proteins, and neurofibrillary tangles, however, persistence oxidative-nitrative stress, endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory cytokines, pro-apoptotic proteins along with altered neurotransmitters level are common etiological attributes in its pathogenesis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Joseph R Winer, Allison Morehouse, Laura Fenton, Theresa M Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L Baker, William J Jagust, Matthew P Walke. Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 36. 2021-11-26. PMID:34290080. |
alzheimer's disease is associated with poor sleep, but the impact of tau and β-amyloid (aβ) pathology on sleep remains largely unknown. |
2021-11-26 |
2023-08-13 |
human |
| Yaochen Chuang, Iatkio Van, Yonghua Zhao, Youhua X. Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34407393. |
the mechanism of alzheimer's disease is closely associated with the aggregation of amyloid-β protein and causes neurotoxicity and extracellular accumulation in the brain and to intracellular neurofibrillary tangles caused by tau protein hyperphosphorylation in the brain tissue. |
2021-11-26 |
2023-08-13 |
Not clear |
| Yaochen Chuang, Iatkio Van, Yonghua Zhao, Youhua X. Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34407393. |
the decrease of sirtuin1 level would cause alzheimer's disease by means of promoting the amyloidogenic pathway to generate amyloid-β species and thereby triggering amyloid-β cascade reaction, such as tau protein hyperphosphorylation, neuron autophagy, neuroinflammation, oxidative stress, and neuron apoptosis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Henika Patel, Pablo Martinez, Abigail Perkins, Xavier Taylor, Nur Jury, David McKinzie, Cristian A Lasagna-Reeve. Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy. Neurobiology of aging. vol 109. 2021-11-26. PMID:34655981. |
pathological aggregation of tau and neuroinflammatory changes mark the clinical course of alzheimer's disease and related tauopathies. |
2021-11-26 |
2023-08-13 |
mouse |
| Erica Barini, Gudrun Plotzky, Yulia Mordashova, Jonas Hoppe, Esther Rodriguez-Correa, Sonja Julier, Florie LePrieult, Ina Mairhofer, Mario Mezler, Sandra Biesinger, Miroslav Cik, Marcus W Meinhardt, Ebru Ercan-Herbst, Dagmar E Ehrnhoefer, Andreas Striebinger, Karen Bodie, Corinna Klein, Laura Gasparini, Kerstin Schlege. Tau in the brain interstitial fluid is fragmented and seeding-competent. Neurobiology of aging. vol 109. 2021-11-26. PMID:34655982. |
in alzheimer disease, tau pathology is thought to propagate from cell to cell throughout interconnected brain areas. |
2021-11-26 |
2023-08-13 |
mouse |