All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Rongcan Luo, Yu Fan, Jing Yang, Maosen Ye, Deng-Feng Zhang, Kun Guo, Xiao Li, Rui Bi, Min Xu, Lu-Xiu Yang, Yu Li, Xiaoqian Ran, Hong-Yan Jiang, Chen Zhang, Liwen Tan, Nengyin Sheng, Yong-Gang Ya. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal transduction and targeted therapy. vol 6. issue 1. 2021-11-15. PMID:34465723. alzheimer's disease (ad) is characterized by progressive synaptic dysfunction, neuronal death, and brain atrophy, with amyloid-β (aβ) plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumulation in the brain tissue, which all lead to loss of cognitive function. 2021-11-15 2023-08-13 Not clear
Rhett J Britton, James M Hutchison, Charles R Sander. The transmembrane amyloid precursor C99 protein exhibits non-specific interaction with tau. Biochemical and biophysical research communications. vol 576. 2021-11-15. PMID:34481234. historically, the two most prominent proteins in alzheimer's disease (ad) research have been the amyloid precursor protein (app) and the microtubule assembly protein tau. 2021-11-15 2023-08-13 Not clear
Shoaib Manzoor, Moustafa T Gabr, Bisma Rasool, Kavita Pal, Nasimul Hod. Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34562674. dual targeting of acetylcholinesterase and tau aggregation: design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for alzheimer's disease. 2021-11-15 2023-08-13 Not clear
Pamela J McMillan, Timothy J Strovas, Misa Baum, Brooke K Mitchell, Randall J Eck, Nzinga Hendricks, Jeanna M Wheeler, Caitlin S Latimer, C Dirk Keene, Brian C Kraeme. Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-14. PMID:34187600. pathological tau drives ectopic nuclear speckle scaffold protein srrm2 accumulation in neuron cytoplasm in alzheimer's disease. 2021-11-14 2023-08-13 mouse
Francisca Randez-Gil, Lino Bojunga, Francisco Estruch, Joris Winderickx, Maurizio Del Poeta, Jose A Priet. Sphingolipids and Inositol Phosphates Regulate the Tau Protein Phosphorylation Status in Humanized Yeast. Frontiers in cell and developmental biology. vol 8. 2021-11-13. PMID:33282871. hyperphosphorylation of protein tau is a hallmark of alzheimer's disease (ad). 2021-11-13 2023-08-13 Not clear
Benjamin Combs, Kyle R Christensen, Collin Richards, Andrew Kneynsberg, Rebecca L Mueller, Sarah L Morris, Gerardo A Morfini, Scott T Brady, Nicholas M Kanaa. Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-13. PMID:34607969. pathologic tau modifications are characteristic of alzheimer's disease and related dementias, but mechanisms of tau toxicity continue to be debated. 2021-11-13 2023-08-13 rat
Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen, Dan Li. The role of pathological tau in synaptic dysfunction in Alzheimer's diseases. Translational neurodegeneration. vol 10. issue 1. 2021-11-13. PMID:34753506. the role of pathological tau in synaptic dysfunction in alzheimer's diseases. 2021-11-13 2023-08-13 Not clear
Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen, Dan Li. The role of pathological tau in synaptic dysfunction in Alzheimer's diseases. Translational neurodegeneration. vol 10. issue 1. 2021-11-13. PMID:34753506. alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (aβ) overload and hyperphosphorylated tau accumulation in the brain. 2021-11-13 2023-08-13 Not clear
Johan Gobom, Lucilla Parnetti, Pedro Rosa-Neto, Martin Vyhnalek, Serge Gauthier, Samuela Cataldi, Ondrej Lerch, Jan Laczo, Katerina Cechova, Marcus Clarin, Andrea I Benet, Tharick A Pascoal, Neserine Rahmouni, Manu Vandijck, Else Huyck, Nathalie Le Bastard, Jenna Stevenson, Mira Chamoun, Daniel Alcolea, Alberto Lleó, Ulf Andreasson, Marcel M Verbeek, Giovanni Bellomo, Roberta Rinaldi, Nicholas Ashton, Henrik Zetterberg, Katerina Sheardova, Jakub Hort, Kaj Blenno. Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid. Clinical chemistry and laboratory medicine. 2021-11-13. PMID:34773730. the core cerebrospinal fluid (csf) biomarkers; total tau (ttau), phospho-tau (ptau), amyloid β 1-42 (aβ 1-42), and the aβ 1-42/aβ 1-40 ratio have transformed alzheimer's disease (ad) research and are today increasingly used in clinical routine laboratories as diagnostic tools. 2021-11-13 2023-08-13 Not clear
Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience. vol 14. 2021-11-12. PMID:33986642. additionally, tau is a central player in the pathogenesis of several diseases such as alzheimer's disease and several frontotemporal dementias. 2021-11-12 2023-08-13 rat
Jennifer Grundman, Brian Spencer, Floyd Sarsoza, Robert A Rissma. Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression. PloS one. vol 16. issue 9. 2021-11-12. PMID:34587152. our analyses show overexpression of different tau isoforms and their interactions with amyloid-beta in sh-sy5y cells result in isoform-specific changes in the transcriptome, with locus-specific transposable element dysregulation patterns paralleling those seen in patients with alzheimer's disease and progressive supranuclear palsy. 2021-11-12 2023-08-13 human
Elena Moreno-Castillo, Yoanna M Álvarez-Ginarte, Mario E Valdés-Tresanco, Luis A Montero-Cabrera, Ernesto Moreno, Pedro A Valient. Understanding the disrupting mechanism of the Tau aggregation motif " Journal of molecular recognition : JMR. vol 33. issue 9. 2021-11-11. PMID:32227525. understanding the disrupting mechanism of the tau aggregation motif " alzheimer's disease is a progressive neurodegenerative disorder characterized by the abnormal processing of the tau and the amyloid precursor proteins. 2021-11-11 2023-08-13 Not clear
Angela Marie Jablonski, Lee Warren, Marija Usenovic, Heather Zhou, Jonathan Sugam, Sophie Parmentier-Batteur, Bhavya Volet. Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:33564035. astrocytic expression of the alzheimer's disease risk allele, apoeε4, potentiates neuronal tau pathology in multiple preclinical models. 2021-11-11 2023-08-13 mouse
Sunwoo Chung, Jinhee Yang, Haeng Jun Kim, Eun Mi Hwang, Wonik Lee, Kyujin Suh, Hayoung Choi, Inhee Mook-Jun. Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model. Progress in neurobiology. vol 203. 2021-11-11. PMID:34004220. plexin-a4 mediates amyloid-β-induced tau pathology in alzheimer's disease animal model. 2021-11-11 2023-08-13 mouse
Sunwoo Chung, Jinhee Yang, Haeng Jun Kim, Eun Mi Hwang, Wonik Lee, Kyujin Suh, Hayoung Choi, Inhee Mook-Jun. Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model. Progress in neurobiology. vol 203. 2021-11-11. PMID:34004220. amyloid-β (aβ) and tau are major pathological hallmarks of alzheimer's disease (ad). 2021-11-11 2023-08-13 mouse
Nada H Ashour, Dalia M El-Tanbouly, Nesrine S El Sayed, Mahmoud M Khatta. Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89. Progress in neuro-psychopharmacology & biological psychiatry. vol 111. 2021-11-11. PMID:34051306. in conclusion, boosting pka, by rof, modulated pxr/abcb1 expression and arginase/nos activities to restrict the main post-translational modifications of tau, aβ deposition and, accordingly, cognitive deterioration of sporadic alzheimer's disease. 2021-11-11 2023-08-13 mouse
Tuan D Samdin, Adam G Kreutzer, James S Nowic. Exploring amyloid oligomers with peptide model systems. Current opinion in chemical biology. vol 64. 2021-11-11. PMID:34229162. the assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as alzheimer's, parkinson's, and huntington's diseases, frontotemporal dementias, and type ii diabetes. 2021-11-11 2023-08-13 Not clear
Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. alzheimer's disease is the most common form of dementia characterized by intracellular aggregates of hyperphosphorylated tau protein and extracellular accumulation of amyloid β (aβ) peptides. 2021-11-11 2023-08-13 mouse
Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. due to the convergent role of p2x7 blockade in both aβ and tau background, p2x7 inhibitors might prove to be ideal candidate drugs to curb the devastating cognitive decline in alzheimer's disease and tauopathies. 2021-11-11 2023-08-13 mouse
Yuan Hu, Danjing Yang, Ying Tu, Keke Chai, Lei Chu, Shuo Shi, Tianming Ya. Dynamic-Inspired Perspective on the Molecular Inhibitor of Tau Aggregation by Glucose Gallates Based on Human Neurons. ACS chemical neuroscience. vol 12. issue 21. 2021-11-11. PMID:34649422. a molecular inhibitor of tau protein aggregation offers an attractive therapeutic possibility as disease-modifying treatment of alzheimer's disease. 2021-11-11 2023-08-13 human