| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolas R Barthélemy, Balazs Toth, Paul T Manser, Sandra Sanabria-Bohórquez, Edmond Teng, Michael Keeley, Randall J Bateman, Robby M Weimer, Kristin R Wildsmit. Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer's Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated. Journal of Alzheimer's disease : JAD. 2021-11-22. PMID:34806603. |
site-specific cerebrospinal fluid tau hyperphosphorylation in response to alzheimer's disease brain pathology: not all tau phospho-sites are hyperphosphorylated. |
2021-11-22 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Balazs Toth, Paul T Manser, Sandra Sanabria-Bohórquez, Edmond Teng, Michael Keeley, Randall J Bateman, Robby M Weimer, Kristin R Wildsmit. Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer's Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated. Journal of Alzheimer's disease : JAD. 2021-11-22. PMID:34806603. |
understanding patterns of association between csf phosphorylated tau (p-tau) species and clinical disease severity will aid alzheimer's disease (ad) diagnosis and treatment. |
2021-11-22 |
2023-08-13 |
Not clear |
| Erden Eren, Jack F V Hunt, Michelle Shardell, Sahil Chawla, Joyce Tran, Jeffrey Gu, Nick M Vogt, Sterling C Johnson, Barbara B Bendlin, Dimitrios Kapogianni. Extracellular vesicle biomarkers of Alzheimer's disease associated with sub-clinical cognitive decline in late middle age. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 9. 2021-11-19. PMID:32588967. |
neuronal extracellular vesicle (nev) tau and insulin signaling biomarkers may detect preclinical alzheimer's disease and age-associated cognitive decline. |
2021-11-19 |
2023-08-13 |
Not clear |
| Mitchel A Kling, Dayan B Goodenowe, Vijitha Senanayake, Siamak MahmoudianDehkordi, Matthias Arnold, Tyler J Massaro, Rebecca Baillie, Xianlin Han, Yuk-Yee Leung, Andrew J Saykin, Kwangsik Nho, Alexandra Kueider-Paisley, Jessica D Tenenbaum, Li-San Wang, Leslie M Shaw, John Q Trojanowski, Rima F Kaddurah-Daou. Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 9. 2021-11-19. PMID:32715599. |
circulating ethanolamine plasmalogen indices in alzheimer's disease: relation to diagnosis, cognition, and csf tau. |
2021-11-19 |
2023-08-13 |
Not clear |
| Mette Habekost, Per Qvist, Mark Denham, Ida E Holm, Arne Lund Jørgense. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Molecular neurobiology. vol 58. issue 5. 2021-11-19. PMID:33415685. |
to model alzheimer's disease and other tauopathies, it is essential that alternative splicing of the mapt transcript in these neurons produces the relevant tau isoforms. |
2021-11-19 |
2023-08-13 |
human |
| Charles Arber, Argyro Alatza, Claire A Leckey, Ross W Paterson, Henrik Zetterberg, Selina Wra. Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia. Journal of neurochemistry. vol 159. issue 2. 2021-11-19. PMID:33539581. |
mass spectrometry analysis of tau and amyloid-beta in ipsc-derived models of alzheimer's disease and dementia. |
2021-11-19 |
2023-08-13 |
human |
| Jenna N Adams, Anne Maass, David Berron, Theresa M Harrison, Suzanne L Baker, Wesley P Thomas, Morgan Stanfill, William J Jagus. Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 17. 2021-11-19. PMID:33731446. |
tau deposition begins in the medial temporal lobe (mtl) in aging and alzheimer's disease (ad), and mtl neural dysfunction is commonly observed in these groups. |
2021-11-19 |
2023-08-13 |
human |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
the many faces of post-ischemic tau protein in brain neurodegeneration of the alzheimer's disease type. |
2021-11-19 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of alzheimer's disease neuropathology. |
2021-11-19 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
pathological changes in the tau protein, at the gene and protein level due to cerebral ischemia, can lead to the development of alzheimer's disease-type neuropathology and dementia. |
2021-11-19 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
in this review, we update our understanding of proteomic and genomic changes in the tau protein in post-ischemic brain injury and present the relationship between the modified tau protein and post-ischemic neuropathology and present a positive correlation between the modified tau protein and a post-ischemic neuropathology that has characteristics of alzheimer's disease-type neurodegeneration. |
2021-11-19 |
2023-08-13 |
Not clear |
| Brian Spencer, Robert A Rissman, Cassia Overk, Eliezer Maslia. Novel Brain-Penetrating Single Chain Antibodies Directed Against 3RTau for the Treatment of Alzheimer's Disease and Related Dementias. Methods in molecular biology (Clifton, N.J.). vol 2383. 2021-11-19. PMID:34766306. |
alzheimer's disease (ad), pick's disease, fronto-temporal lobar degeneration, cortico-basal degeneration, and primary age related tauopathy are examples of neurodegenerative disorders with tau accumulation and jointly referred as "tauopathies." |
2021-11-19 |
2023-08-13 |
Not clear |
| Akram Tayanloo-Beik, Zahra Kiasalari, Mehrdad Roghan. Paeonol Ameliorates Cognitive Deficits in Streptozotocin Murine Model of Sporadic Alzheimer's Disease via Attenuation of Oxidative Stress, Inflammation, and Mitochondrial Dysfunction. Journal of molecular neuroscience : MN. 2021-11-19. PMID:34797511. |
intracerebroventricular (icv) microinjection of diabetogenic drug streptozotocin (stz) in rodents consistently produces a model of sporadic alzheimer's disease (sad) which is characterized by tau pathology and concomitant cognitive decline, insulin resistance, neuroinflammation, oxidative stress, and mitochondrial malfunction. |
2021-11-19 |
2023-08-13 |
rat |
| Jogeshwar Mukherjee, Christopher Liang, Krystal K Patel, Phuc Q Lam, Rommani Monda. Development and evaluation of [ Synapse (New York, N.Y.). vol 75. issue 1. 2021-11-18. PMID:32722889. |
development and evaluation of [ alzheimer's disease (ad) is a neurodegenerative disease characterized by aggregation of tau protein into paired helical filaments causing neurofibrillary tangles (nft) in the brain. |
2021-11-18 |
2023-08-13 |
Not clear |
| Minli Yan, Tingting Zhen. Role of the endolysosomal pathway and exosome release in tau propagation. Neurochemistry international. vol 145. 2021-11-18. PMID:33582164. |
the progressive deposition of misfolded and aggregated forms of tau protein in the brain is a pathological hallmark of tauopathies, such as alzheimer's disease (ad) and frontotemporal degeneration (ftd). |
2021-11-18 |
2023-08-13 |
Not clear |
| Longfei Li, Ruirui Shi, Jianlan Gu, Yunn Chyn Tung, Yan Zhou, Dingwei Zhou, Ruozhen Wu, Dandan Chu, Nana Jin, Kevin Deng, Jiawei Xu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Alzheimer's disease brain contains tau fractions with differential prion-like activities. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33597014. |
alzheimer's disease brain contains tau fractions with differential prion-like activities. |
2021-11-18 |
2023-08-13 |
Not clear |
| Longfei Li, Ruirui Shi, Jianlan Gu, Yunn Chyn Tung, Yan Zhou, Dingwei Zhou, Ruozhen Wu, Dandan Chu, Nana Jin, Kevin Deng, Jiawei Xu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Alzheimer's disease brain contains tau fractions with differential prion-like activities. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33597014. |
neurofibrillary tangles (nfts) made of abnormally hyperphosphorylated tau are a hallmark of alzheimer's disease (ad) and related tauopathies. |
2021-11-18 |
2023-08-13 |
Not clear |
| Vivek K Sharma, Thakur G Sing. CREB: A Multifaceted Target for Alzheimer's Disease. Current Alzheimer research. vol 17. issue 14. 2021-11-18. PMID:33602089. |
alzheimer's disease (ad) is a persistent neuropathological stipulation manifested in the form of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau tangles, neuroinflammation, and apoptotic cell death. |
2021-11-18 |
2023-08-13 |
Not clear |
| Rinie Bajracharya, David Brici, Liviu-Gabriel Bodea, Phillip W Janowicz, Jürgen Götz, Rebecca M Nisbe. Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33712083. |
one of the main pathological hallmarks of alzheimer's disease (ad) is the intraneuronal accumulation of hyperphosphorylated tau. |
2021-11-18 |
2023-08-13 |
mouse |
| Valentina Latina, Giacomo Giacovazzo, Federica Cordella, Bijorn Omar Balzamino, Alessandra Micera, Monica Varano, Cristina Marchetti, Francesca Malerba, Rita Florio, Bruno Bruni Ercole, Federico La Regina, Anna Atlante, Roberto Coccurello, Silvia Di Angelantonio, Pietro Calissano, Giuseppina Amador. Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33750467. |
systemic delivery of a specific antibody targeting the pathological n-terminal truncated tau peptide reduces retinal degeneration in a mouse model of alzheimer's disease. |
2021-11-18 |
2023-08-13 |
mouse |