| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L Newell, Ruben Vidal, Holly J Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H W Scheres, Michel Goeder. Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33723967. |
cryo-em structures of tau filaments from alzheimer's disease with pet ligand apn-1607. |
2021-11-16 |
2023-08-13 |
human |
| Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L Newell, Ruben Vidal, Holly J Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H W Scheres, Michel Goeder. Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33723967. |
tau and aβ assemblies of alzheimer's disease (ad) can be visualized in living subjects using positron emission tomography (pet). |
2021-11-16 |
2023-08-13 |
human |
| Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L Newell, Ruben Vidal, Holly J Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H W Scheres, Michel Goeder. Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33723967. |
since it is not known where in the tau folds pet ligands bind, we used electron cryo-microscopy (cryo-em) to determine the binding sites of apn-1607 in the alzheimer fold. |
2021-11-16 |
2023-08-13 |
human |
| Chihiro Sato, Nipun Mallipeddi, Nupur Ghoshal, Brenton A Wright, Gregory S Day, Albert A Davis, Albert H Kim, Gregory J Zipfel, Randall J Bateman, Audrey Gabelle, Nicolas R Barthélem. MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology. Annals of clinical and translational neurology. vol 8. issue 9. 2021-11-16. PMID:34342183. |
tau hyperphosphorylation at threonine 217 (pt217) in cerebrospinal fluid (csf) has recently been linked to early amyloidosis and could serve as a highly sensitive biomarker for alzheimer's disease (ad). |
2021-11-16 |
2023-08-13 |
Not clear |
| Xu-Qiao Chen, Ahmad Salehi, Matthew L Pearn, Cassia Overk, Phuong D Nguyen, Alexander M Kleschevnikov, Maria Maccecchini, William C Moble. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 2. 2021-11-15. PMID:32975365. |
recent clinical trials targeting amyloid beta (aβ) and tau in alzheimer's disease (ad) have yet to demonstrate efficacy. |
2021-11-15 |
2023-08-13 |
mouse |
| Fabian Kreilaus, Rebecca Masanetz, Georgia Watt, Magdalena Przybyla, Arne Ittner, Lars Ittner, Tim Kar. The behavioural phenotype of 14-month-old female TAU58/2 transgenic mice. Behavioural brain research. vol 397. 2021-11-15. PMID:33017638. |
frontotemporal dementia (ftd) and alzheimer's disease (ad) exhibit intracellular inclusions [neurofibrillary tangles (nft's)] of microtubule-associated protein tau that contributes to neuronal dysfunction and death. |
2021-11-15 |
2023-08-13 |
mouse |
| Xiaoqin Tan, Zhibin Liang, Yingui Li, Yingkun Zhi, Lang Yi, Shasha Bai, Kelly H Forest, Robert A Nichols, Yan Dong, Qing X L. Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice. Behavioural brain research. vol 398. 2021-11-15. PMID:33069740. |
β-amyloid (aβ) elevation, tau hyperphosphorylation, and neuroinflammation are major hallmarks of alzheimer's disease (ad). |
2021-11-15 |
2023-08-13 |
mouse |
| Yuta Takaichi, James K Chambers, Kei Takahashi, Yoshiyuki Soeda, Riki Koike, Etsuko Katsumata, Chiaki Kita, Fuko Matsuda, Makoto Haritani, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchid. Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus). Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33413691. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β (aβ) as senile plaques and cerebral amyloid angiopathy, and hyperphosphorylated tau (hp-tau) as neurofibrillary tangles in the brain. |
2021-11-15 |
2023-08-13 |
human |
| Nora Bengoa-Vergniory, Elisavet Velentza-Almpani, Ana Maria Silva, Connor Scott, Mariana Vargas-Caballero, Magdalena Sastre, Richard Wade-Martins, Javier Alegre-Abarrategu. Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33509301. |
multimerization is a key process in prion-like disorders such as alzheimer's disease (ad), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis. |
2021-11-15 |
2023-08-13 |
Not clear |
| Lishu Duan, Mufeng Hu, Joseph A Tamm, Yelena Y Grinberg, Fang Shen, Yating Chai, Hualin Xi, Lauren Gibilisco, Brinda Ravikumar, Vivek Gautam, Eric Karran, Matthew Townsend, Robert V Talania. Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33536571. |
arrayed crispr reveals genetic regulators of tau aggregation, autophagy and mitochondria in alzheimer's disease model. |
2021-11-15 |
2023-08-13 |
human |
| Jie Zheng, Na Tian, Fei Liu, Yidian Zhang, Jingfen Su, Yang Gao, Mingmin Deng, Linyu Wei, Jingwang Ye, Honglian Li, Jian-Zhi Wan. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal transduction and targeted therapy. vol 6. issue 1. 2021-11-15. PMID:34262014. |
intraneuronal accumulation of hyperphosphorylated tau is a hallmark pathology shown in over twenty neurodegenerative disorders, collectively termed as tauopathies, including the most common alzheimer's disease (ad). |
2021-11-15 |
2023-08-13 |
mouse |
| Marianna Hellén, Arnab Bhattacharjee, Riikka-Liisa Uronen, Henri J Huttune. Membrane interaction and disulphide-bridge formation in the unconventional secretion of Tau. Bioscience reports. vol 41. issue 8. 2021-11-15. PMID:34308969. |
misfolded, pathological tau protein propagates from cell to cell causing neuronal degeneration in alzheimer's disease and other tauopathies. |
2021-11-15 |
2023-08-13 |
Not clear |
| Caterina Motta, Martina Assogna, Chiara Giuseppina Bonomi, Alfredo Paolo Mascolo, Vincenzo De Lucia, Roberta Semprini, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martoran. Diabetes mellitus contributes to higher cerebrospinal fluid tau levels selectively in Alzheimer's disease patients with the APOE4 genotype. European journal of neurology. vol 28. issue 12. 2021-11-15. PMID:34309155. |
diabetes mellitus contributes to higher cerebrospinal fluid tau levels selectively in alzheimer's disease patients with the apoe4 genotype. |
2021-11-15 |
2023-08-13 |
Not clear |
| Caterina Motta, Martina Assogna, Chiara Giuseppina Bonomi, Alfredo Paolo Mascolo, Vincenzo De Lucia, Roberta Semprini, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martoran. Diabetes mellitus contributes to higher cerebrospinal fluid tau levels selectively in Alzheimer's disease patients with the APOE4 genotype. European journal of neurology. vol 28. issue 12. 2021-11-15. PMID:34309155. |
diabetes mellitus (dm) is considered a risk factor for alzheimer's disease (ad) and shares some pathological pathways, such as activation of amyloid cascade and tau phosphorylation. |
2021-11-15 |
2023-08-13 |
Not clear |
| Sarah J Banks, Murray J Andrews, Leonardino Digma, John Madsen, Emilie T Reas, Jessica Z K Caldwell, Linda K McEvoy, Chun Chieh Fan, Anders M Dale, James B Brewe. Sex differences in Alzheimer's disease: do differences in tau explain the verbal memory gap? Neurobiology of aging. vol 107. 2021-11-15. PMID:34399127. |
sex differences in alzheimer's disease: do differences in tau explain the verbal memory gap? |
2021-11-15 |
2023-08-13 |
human |
| Miren Ettcheto, Amanda Cano, Elena Sanchez-López, Ester Verdaguer, Jaume Folch, Carme Auladell, Antoni Camin. Masitinib for the treatment of Alzheimer's disease. Neurodegenerative disease management. vol 11. issue 4. 2021-11-15. PMID:34412534. |
masitinib is a potent and selective phenylaminothiazole-type tyrosine kinase inhibitor which is currently in phase iii studies for the treatment of alzheimer's disease (ad) with the aim of modifying its evolution and with multiple pharmacological targets such as inhibition of mast cells activity, inhibition of microglia activation, modulation of aβ and tau protein signaling pathway and prevention of synaptic damage. |
2021-11-15 |
2023-08-13 |
Not clear |
| Rongcan Luo, Yu Fan, Jing Yang, Maosen Ye, Deng-Feng Zhang, Kun Guo, Xiao Li, Rui Bi, Min Xu, Lu-Xiu Yang, Yu Li, Xiaoqian Ran, Hong-Yan Jiang, Chen Zhang, Liwen Tan, Nengyin Sheng, Yong-Gang Ya. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal transduction and targeted therapy. vol 6. issue 1. 2021-11-15. PMID:34465723. |
alzheimer's disease (ad) is characterized by progressive synaptic dysfunction, neuronal death, and brain atrophy, with amyloid-β (aβ) plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumulation in the brain tissue, which all lead to loss of cognitive function. |
2021-11-15 |
2023-08-13 |
Not clear |
| Rhett J Britton, James M Hutchison, Charles R Sander. The transmembrane amyloid precursor C99 protein exhibits non-specific interaction with tau. Biochemical and biophysical research communications. vol 576. 2021-11-15. PMID:34481234. |
historically, the two most prominent proteins in alzheimer's disease (ad) research have been the amyloid precursor protein (app) and the microtubule assembly protein tau. |
2021-11-15 |
2023-08-13 |
Not clear |
| Shoaib Manzoor, Moustafa T Gabr, Bisma Rasool, Kavita Pal, Nasimul Hod. Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34562674. |
dual targeting of acetylcholinesterase and tau aggregation: design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for alzheimer's disease. |
2021-11-15 |
2023-08-13 |
Not clear |
| Pamela J McMillan, Timothy J Strovas, Misa Baum, Brooke K Mitchell, Randall J Eck, Nzinga Hendricks, Jeanna M Wheeler, Caitlin S Latimer, C Dirk Keene, Brian C Kraeme. Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-14. PMID:34187600. |
pathological tau drives ectopic nuclear speckle scaffold protein srrm2 accumulation in neuron cytoplasm in alzheimer's disease. |
2021-11-14 |
2023-08-13 |
mouse |