| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner, Jürgen Göt. Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular brain. vol 17. issue 1. 2024-02-12. PMID:38347594. |
the most studied of these modifications is phosphorylation, which affects tau's aggregation and loss- and gain-of-functions, including the interaction with microtubules, in alzheimer's disease and primary tauopathies. |
2024-02-12 |
2024-02-15 |
Not clear |
| Wei Li, Hong-Lian Li, Jian-Zhi Wang, Rong Liu, Xiaochuan Wan. Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases. Cell & bioscience. vol 14. issue 1. 2024-02-12. PMID:38347638. |
for example, the main pathological features of alzheimer's disease are the aggregation of beta-amyloid protein and abnormal phosphorylation of tau protein. |
2024-02-12 |
2024-02-15 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
impaired sleep is associated with tau deposition on impaired sleep is commonly associated with alzheimer's disease (ad), although the underlying mechanisms remain unclear. |
2024-02-11 |
2024-02-14 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
using data from the alzheimer's disease neuroimaging initiative, we investigated whether a medical history of impaired sleep, informant-reported nighttime behaviors, and sleep-affecting medications are associated with beta-amyloid and tau deposition on pet and cognitive change, cross-sectionally and longitudinally. |
2024-02-11 |
2024-02-14 |
Not clear |
| D M Sithara Dissanayaka, Vijay Jayasena, Stephanie R Rainey-Smith, Ralph N Martins, W M A D Binosha Fernand. The Role of Diet and Gut Microbiota in Alzheimer's Disease. Nutrients. vol 16. issue 3. 2024-02-10. PMID:38337696. |
alzheimer's disease (ad), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (aβ) plaques and hyperphosphorylated tau tangles. |
2024-02-10 |
2024-02-12 |
Not clear |
| Natalia Santos, Luthary Segura, Amber Lewis, Thuong Pham, Kwan H Chen. Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer's and Diabetic Diseases. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338484. |
the molecular events of protein misfolding and self-aggregation of tau and amylin are associated with the progression of alzheimer's and diabetes, respectively. |
2024-02-10 |
2024-02-12 |
Not clear |
| Tânia Soares Martins, Steven Pelech, Maria Ferreira, Beatriz Pinho, Kevin Leandro, Luís Pereira de Almeida, Benedict Breitling, Niels Hansen, Hermann Esselmann, Jens Wiltfang, Odete A B da Cruz E Silva, Ana Gabriela Henrique. Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338863. |
phosphorylation plays a key role in alzheimer's disease (ad) pathogenesis, impacting distinct processes such as amyloid-beta (aβ) peptide production and tau phosphorylation. |
2024-02-10 |
2024-02-12 |
Not clear |
| Zhirui Li, Zixuan Fan, Qian Zhan. The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2024-02-10. PMID:38339929. |
the associations of phosphorylated tau 181 and tau 231 levels in plasma and cerebrospinal fluid with cognitive function in alzheimer's disease: a systematic review and meta-analysis. |
2024-02-10 |
2024-02-12 |
Not clear |
| Zhirui Li, Zixuan Fan, Qian Zhan. The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2024-02-10. PMID:38339929. |
cerebrospinal fluid (csf) or blood biomarkers like phosphorylated tau proteins (p-tau) are used to detect alzheimer's disease (ad) early. |
2024-02-10 |
2024-02-12 |
Not clear |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
generation of tau dephosphorylation-targeting chimeras for the treatment of alzheimer's disease and related tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in alzheimer's disease (ad) and many other tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jung-Min Pyun, Young Ho Park, Young Chul Youn, Min Ju Kang, Kyu Hwan Shim, Jae-Won Jang, Jihwan You, Kwangsik Nho, SangYun Ki. Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity. Translational psychiatry. vol 14. issue 1. 2024-02-10. PMID:38341444. |
we compared tau burden measured by pet, brain volume assessed by mri, cross-sectional cognitive function, longitudinal cognitive decline and polygenic risk score (prs) between pet/plasma groups (pet-/plasma-, pet-/plasma+, pet+/plasma-, pet+/plasma+) using alzheimer's disease neuroimaging initiative database. |
2024-02-10 |
2024-02-14 |
human |
| Corrina S Fonseca, Suzanne L Baker, Lindsey Dobyns, Mustafa Janabi, William J Jagust, Theresa M Harriso. Tau accumulation and atrophy predict amyloid independent cognitive decline in aging. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-09. PMID:38334195. |
amyloid beta (aβ) and tau pathology are cross-sectionally associated with atrophy and cognitive decline in aging and alzheimer's disease (ad). |
2024-02-09 |
2024-02-11 |
Not clear |
| Ana-Caroline Raulin, Sydney V Doss, Michael G Heckman, Emily C Craver, Zonghua Li, Tadafumi C Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A Martens, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Michael DeTure, R Ross Reichard, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Emmaline K Kounaves, Melissa E Murray, Dennis W Dickson, Ronald C Petersen, Guojun Bu, Takahisa Kanekiy. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta neuropathologica communications. vol 12. issue 1. 2024-02-09. PMID:38336940. |
impact of apoe on amyloid and tau accumulation in argyrophilic grain disease and alzheimer's disease. |
2024-02-09 |
2024-02-12 |
Not clear |
| Ana-Caroline Raulin, Sydney V Doss, Michael G Heckman, Emily C Craver, Zonghua Li, Tadafumi C Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A Martens, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Michael DeTure, R Ross Reichard, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Emmaline K Kounaves, Melissa E Murray, Dennis W Dickson, Ronald C Petersen, Guojun Bu, Takahisa Kanekiy. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta neuropathologica communications. vol 12. issue 1. 2024-02-09. PMID:38336940. |
alzheimer's disease (ad), characterized by the deposition of amyloid-β (aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau (ptau), is increasingly recognized as a complex disease with multiple pathologies. |
2024-02-09 |
2024-02-12 |
Not clear |
| Belfin Robinson, Shankar Bhamidi, Eran Daya. The spatial distribution of coupling between tau and neurodegeneration in amyloid-β positive mild cognitive impairment. Neurobiology of aging. vol 136. 2024-02-08. PMID:38330641. |
synergies between amyloid-β (aβ), tau, and neurodegeneration persist along the alzheimer's disease (ad) continuum. |
2024-02-08 |
2024-02-11 |
human |
| Ahmed A Elbatrawy, Taiwo A Ademoye, Heba Alnakhala, Arati Tripathi, Ashique Zami, Raluca Ostafe, Ulf Dettmer, Jessica S Forti. Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils. Bioorganic & medicinal chemistry. vol 100. 2024-02-08. PMID:38330847. |
tau and α-synuclein aggregates are the main histopathological hallmarks present in alzheimer's disease (ad), parkinson's disease (pd), and other neurodegenerative disorders. |
2024-02-08 |
2024-02-11 |
Not clear |
| Mo Chen, Xuejian Feng, Jiaxin Liu, Jianan Wang, Xu Yang, Xianghui Yu, Wei Kong, Bo Sun, Hui W. Prokaryote-derived phosphorylated Tau epitope vaccine is immunogenic and non-T-cell activated in the mice model. Vaccine. 2024-02-08. PMID:38331660. |
accumulation of phosphorylated tau protein is a prominent pathological hallmark of alzheimer's disease (ad). |
2024-02-08 |
2024-02-11 |
mouse |
| Zachary Hoglund, Nancy Ruiz-Uribe, Eric Del Sastre, Benjamin Woost, Joshua Bailey, Bradley T Hyman, Theodore Zwang, Rachel E Bennet. Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328111. |
brain vasculature accumulates tau and is spatially related to tau tangle pathology in alzheimer's disease. |
2024-02-08 |
2024-02-10 |
human |
| Grigorii Sultanakhmetov, Iori Kato, Akiko Asada, Taro Saito, Kanae And. Microtubule-affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model. Genes to cells : devoted to molecular & cellular mechanisms. 2024-02-08. PMID:38329182. |
accumulation of abnormally phosphorylated tau and its aggregation constitute a significant hallmark of alzheimer's disease (ad). |
2024-02-08 |
2024-02-10 |
drosophila_melanogaster |