| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina B Young, Susan M Landau, Theresa M Harrison, Kathleen L Poston, Elizabeth C Mormin. Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [ NeuroImage. vol 243. 2021-10-29. PMID:34487825. |
influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [ tau pet has allowed for critical insights into in vivo patterns of tau accumulation and change in individuals early in the alzheimer's disease (ad) continuum. |
2021-10-29 |
2023-08-13 |
Not clear |
| Antoine Leuzy, Shorena Janelidze, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Dirk Jacobs, Claudia Cicognola, Erik Stomrud, Eugeen Vanmechelen, Jeffrey L Dage, Oskar Hansso. Comparing the Clinical Utility and Diagnostic Performance of CSF P-Tau181, P-Tau217, and P-Tau231 Assays. Neurology. vol 97. issue 17. 2021-10-29. PMID:34493616. |
phosphorylated tau (p-tau) in csf is considered an important biomarker in alzheimer disease (ad) and has been incorporated in recent diagnostic criteria. |
2021-10-29 |
2023-08-13 |
Not clear |
| D Boche, J A R Nicol. Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32643143. |
alzheimer's disease (ad) pathology is multi-faceted, including extracellular accumulation of amyloid-β (aβ), accumulation of tau within neurons, glial activation and loss of neurons and synapses. |
2021-10-28 |
2023-08-13 |
human |
| K E McAleese, L Walker, D Erskine, M Johnson, D Koss, A J Thomas, J Attem. Concomitant LATE-NC in Alzheimer's disease is not associated with increased tau or amyloid-β pathological burden. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32896913. |
concomitant late-nc in alzheimer's disease is not associated with increased tau or amyloid-β pathological burden. |
2021-10-28 |
2023-08-13 |
Not clear |
| Aurelio J Dregni, Harrison K Wang, Haifan Wu, Pu Duan, Jia Jin, William F DeGrado, Mei Hon. Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy. Journal of the American Chemical Society. vol 143. issue 20. 2021-10-28. PMID:33983722. |
many neurodegenerative diseases such as alzheimer's disease are characterized by pathological β-sheet filaments of the tau protein, which spread in a prion-like manner in patient brains. |
2021-10-28 |
2023-08-13 |
Not clear |
| Caitlin S Latimer, Nicole F Liachk. Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer's disease. GeroScience. vol 43. issue 4. 2021-10-28. PMID:34185246. |
tau and tdp-43 synergy: a novel therapeutic target for sporadic late-onset alzheimer's disease. |
2021-10-28 |
2023-08-13 |
Not clear |
| Caitlin S Latimer, Nicole F Liachk. Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer's disease. GeroScience. vol 43. issue 4. 2021-10-28. PMID:34185246. |
alzheimer's disease (ad) is traditionally defined by the presence of two types of protein aggregates in the brain: amyloid plaques comprised of the protein amyloid-β (aβ) and neurofibrillary tangles containing the protein tau. |
2021-10-28 |
2023-08-13 |
Not clear |
| Chinmaya Panda, Clara Voelz, Pardes Habib, Christian Mevissen, Thomas Pufe, Cordian Beyer, Sharad Gupta, Alexander Slowi. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cells. vol 10. issue 7. 2021-10-28. PMID:34209408. |
intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary tangles is a hallmark of alzheimer's disease (ad). |
2021-10-28 |
2023-08-13 |
human |
| Kamlesh M Makwana, Matthew P Sarnowski, Jiayuan Miao, Yu-Shan Lin, Juan R Del Vall. N-Amination Converts Amyloidogenic Tau Peptides into Soluble Antagonists of Cellular Seeding. ACS chemical neuroscience. vol 12. issue 20. 2021-10-28. PMID:34609825. |
the spread of neurofibrillary tangles composed of tau protein aggregates is a hallmark of alzheimer's and related neurodegenerative diseases. |
2021-10-28 |
2023-08-13 |
Not clear |
| Eun Hyun Seo, Ho Jae Lim, Hyung-Jun Yoon, Kyu Yeong Choi, Jang Jae Lee, Jun Young Park, Seong Hye Choi, Hoowon Kim, Byeong C Kim, Kun Ho Le. Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer's continuum. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34627371. |
visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in alzheimer's continuum. |
2021-10-28 |
2023-08-13 |
Not clear |
| Eun Hyun Seo, Ho Jae Lim, Hyung-Jun Yoon, Kyu Yeong Choi, Jang Jae Lee, Jun Young Park, Seong Hye Choi, Hoowon Kim, Byeong C Kim, Kun Ho Le. Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer's continuum. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34627371. |
given that tau accumulation, not amyloid-β (aβ) burden, is more closely connected with cognitive impairment in alzheimer's disease (ad), a detailed understanding of the tau-related characteristics of cognitive function is critical in both clinical and research settings. |
2021-10-28 |
2023-08-13 |
Not clear |
| Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntne. Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34656177. |
to better understand the etiology and pathomechanisms of alzheimer's disease, several transgenic animal models that overexpress human tau or human amyloid-beta (aβ) have been developed. |
2021-10-28 |
2023-08-13 |
human |
| Rose Irwin, Ofrah Faust, Ivana Petrovic, Sharon Grayer Wolf, Hagen Hofmann, Rina Rosenzwei. Hsp40s play complementary roles in the prevention of tau amyloid formation. eLife. vol 10. 2021-10-27. PMID:34369377. |
the microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles associated with neurodegenerative conditions, such as alzheimer's disease. |
2021-10-27 |
2023-08-13 |
Not clear |
| Gemin Zhu, Yuan Fang, Xiaoli Cui, Ruihua Jia, Xiaogang Kang, Rui Zha. Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway. Journal of natural medicines. 2021-10-27. PMID:34705126. |
alzheimer's disease (ad) is a common neurodegenerative disease characterized by neuronal degeneration and hyperphosphorylated tau. |
2021-10-27 |
2023-08-13 |
Not clear |
| Alexa Pichet Binette, Guillaume Theaud, François Rheault, Maggie Roy, D Louis Collins, Johannes Levin, Hiroshi Mori, Jae Hong Lee, Martin Rhys Farlow, Peter Schofield, Jasmeer P Chhatwal, Colin L Masters, Tammie Benzinger, John Morris, Randall Bateman, John Cs Breitner, Judes Poirier, Julie Gonneaud, Maxime Descoteaux, Sylvia Villeneuv. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease. eLife. vol 10. 2021-10-26. PMID:33983116. |
bundle-specific associations between white matter microstructure and aβ and tau pathology in preclinical alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Alexa Pichet Binette, Guillaume Theaud, François Rheault, Maggie Roy, D Louis Collins, Johannes Levin, Hiroshi Mori, Jae Hong Lee, Martin Rhys Farlow, Peter Schofield, Jasmeer P Chhatwal, Colin L Masters, Tammie Benzinger, John Morris, Randall Bateman, John Cs Breitner, Judes Poirier, Julie Gonneaud, Maxime Descoteaux, Sylvia Villeneuv. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease. eLife. vol 10. 2021-10-26. PMID:33983116. |
beta-amyloid (aβ) and tau proteins, the pathological hallmarks of alzheimer's disease (ad), are believed to spread through connected regions of the brain. |
2021-10-26 |
2023-08-13 |
Not clear |
| Kanta Horie, Nicolas R Barthélemy, Chihiro Sato, Randall J Batema. Corrigendum to: CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 9. 2021-10-26. PMID:34215872. |
corrigendum to: csf tau microtubule binding region identifies tau tangle and clinical stages of alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Jannatun Nayem Namme, Asim Kumar Bepari, Hirohide Takebayash. Cofilin Signaling in the CNS Physiology and Neurodegeneration. International journal of molecular sciences. vol 22. issue 19. 2021-10-26. PMID:34639067. |
for instance, oxidative stress-induced increase in cofilin dephosphorylation is linked to the accumulation of tau tangles and amyloid-beta plaques in alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Douglas H Kelle. Brain cerebrospinal fluid flow. Physical review fluids. vol 6. issue 7. 2021-10-26. PMID:34671708. |
according to the glymphatic hypothesis, in physiological conditions, cerebrospinal fluid flows primarily during sleep and serves to remove metabolic wastes like the amyloid-beta and tau proteins whose accumulation is believed to cause alzheimer's disease. |
2021-10-26 |
2023-08-13 |
human |
| Ines Moreno-Gonzalez, George A Edwards, Omar Hasan, Nazaret Gamez, Jonathan E Schulz, Juan Jose Fernandez-Valenzuela, Antonia Gutierrez, Claudio Soto, Paul E Schul. Longitudinal Assessment of Tau-Associated Pathology by Diagnostics (Basel, Switzerland). vol 11. issue 10. 2021-10-26. PMID:34679572. |
in alzheimer's disease (ad), nfts are accompanied by extracellular amyloid-beta (aβ), but primary tauopathy disorders are marked by the accumulation of tau protein alone, including forms of frontotemporal dementia (ftd), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), among others. |
2021-10-26 |
2023-08-13 |
Not clear |