| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca L Kow, Timothy J Strovas, Pamela J McMillan, Ashley M Jacobi, Mark A Behlke, Aleen D Saxton, Caitlin S Latimer, C Dirk Keene, Brian C Kraeme. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Neurobiology of disease. vol 147. 2021-11-01. PMID:33184027. |
aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like alzheimer's disease. |
2021-11-01 |
2023-08-13 |
mouse |
| Rebecca L Kow, Timothy J Strovas, Pamela J McMillan, Ashley M Jacobi, Mark A Behlke, Aleen D Saxton, Caitlin S Latimer, C Dirk Keene, Brian C Kraeme. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Neurobiology of disease. vol 147. 2021-11-01. PMID:33184027. |
alzheimer's disease patients with low toe1 levels exhibited significantly increased pathological tau deposition and loss of neun staining. |
2021-11-01 |
2023-08-13 |
mouse |
| Anna Siegert, Marija Rankovic, Filippo Favretto, Tina Ukmar-Godec, Timo Strohäker, Stefan Becker, Markus Zweckstette. Interplay between tau and α-synuclein liquid-liquid phase separation. Protein science : a publication of the Protein Society. vol 30. issue 7. 2021-11-01. PMID:33452693. |
liquid-liquid phase separation (llps) of proteins has recently been shown to be important for protein aggregation involved in amyotrophic lateral sclerosis, whereas tau phase separation has been linked to alzheimer's disease. |
2021-11-01 |
2023-08-13 |
Not clear |
| Saeed Najafi, Yanxian Lin, Andrew P Longhini, Xuemei Zhang, Kris T Delaney, Kenneth S Kosik, Glenn H Fredrickson, Joan-Emma Shea, Songi Ha. Liquid-liquid phase separation of Tau by self and complex coacervation. Protein science : a publication of the Protein Society. vol 30. issue 7. 2021-11-01. PMID:33955104. |
the liquid-liquid phase separation (llps) of tau has been postulated to play a role in modulating the aggregation property of tau, a process known to be critically associated with the pathology of a broad range of neurodegenerative diseases including alzheimer's disease. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yuxing Xia, Brach M Bell, Benoit I Giasso. Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation. Scientific reports. vol 11. issue 1. 2021-11-01. PMID:34426645. |
alzheimer's disease is the leading cause of dementia and a defining hallmark is the progressive brain deposition of tau aggregates. |
2021-11-01 |
2023-08-13 |
Not clear |
| Analiese R Fernandes, Simon Dujardin, Anastasie Maté de Gérando, Bradley T Hyman, Matthew P Frosc. Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds. Journal of neuropathology and experimental neurology. vol 80. issue 10. 2021-11-01. PMID:34498073. |
for tau species derived from human alzheimer disease tissue (brain homogenate and sarkosyl-insoluble fibrils), both autoclaving and incubation in 90.6% formic acid were sufficient to reduce tau bioactivity. |
2021-11-01 |
2023-08-13 |
mouse |
| Subashchandrabose Chinnathambi, Nalini Vijay Gorantl. Implications of Valosin-containing Protein in Promoting Autophagy to Prevent Tau Aggregation. Neuroscience. vol 476. 2021-11-01. PMID:34509548. |
in the case of tau aggregation associated with alzheimer's disease, the importance of vcp is poorly understood. |
2021-11-01 |
2023-08-13 |
Not clear |
| Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. |
the effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in alzheimer's diseases. |
2021-11-01 |
2023-08-13 |
Not clear |
| M Senda, K Ishii, K Ito, T Ikeuchi, H Matsuda, T Iwatsubo, A Iwata, R Ihara, K Suzuki, K Kasuga, Y Ikari, Y Niimi, H Arai, A Tamaoka, Y Arahata, Y Itoh, H Tachibana, Y Ichimiya, S Washizuka, T Odawara, K Ishii, K Ono, T Yokota, A Nakanishi, E Matsubara, H Mori, H Shimad. A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 8. issue 4. 2021-11-01. PMID:34585225. |
pet (positron emission tomography) and csf (cerebrospinal fluid) provide the "atn" (amyloid, tau, neurodegeneration) classification and play an essential role in early and differential diagnosis of alzheimer's disease (ad). |
2021-11-01 |
2023-08-13 |
human |
| Anis Barati, Raheleh Masoudi, Reza Yousefi, Malihezaman Monsefi, Abbas Mirshafie. Tau and amyloid beta differentially affect the innate immune genes expression in Drosophila models of Alzheimer's disease and β- D Mannuronic acid (M2000) modulates the dysregulation. Gene. vol 808. 2021-11-01. PMID:34600048. |
tau and amyloid beta differentially affect the innate immune genes expression in drosophila models of alzheimer's disease and β- d mannuronic acid (m2000) modulates the dysregulation. |
2021-11-01 |
2023-08-13 |
drosophila_melanogaster |
| Mehdi Shojaie, Solale Tabarestani, Mercedes Cabrerizo, Steven T DeKosky, David E Vaillancourt, David Loewenstein, Ranjan Duara, Malek Adjouad. PET Imaging of Tau Pathology and Amyloid-β, and MRI for Alzheimer's Disease Feature Fusion and Multimodal Classification. Journal of Alzheimer's disease : JAD. 2021-11-01. PMID:34719488. |
pet imaging of tau pathology and amyloid-β, and mri for alzheimer's disease feature fusion and multimodal classification. |
2021-11-01 |
2023-08-13 |
Not clear |
| Christiana Bjorkli, Claire Louet, Trude Helen Flo, Mary Hemler, Axel Sandvig, Ioanna Sandvi. In Vivo Microdialysis in Mice Captures Changes in Alzheimer's Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology. Journal of Alzheimer's disease : JAD. 2021-11-01. PMID:34719495. |
preclinical models of alzheimer's disease (ad) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (aβ) and tau in cerebrospinal fluid (csf). |
2021-11-01 |
2023-08-13 |
mouse |
| Angie K Torres, Claudia Jara, Han S Park-Kang, Catalina M Polanco, Diego Tapia, Fabián Alarcón, Adely de la Peña, Jesus Llanquinao, Gabriela Vargas-Mardones, Javiera A Indo, Nibaldo C Inestrosa, Cheril Tapia-Roja. Synaptic Mitochondria: An Early Target of Amyloid-β and Tau in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2021-11-01. PMID:34719499. |
synaptic mitochondria: an early target of amyloid-β and tau in alzheimer's disease. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L Newell, Ruben Vidal, Holly J Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H W Scheres, Michel Goeder. Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta neuropathologica. vol 141. issue 6. 2021-10-30. PMID:33830331. |
correction to: cryo-em structures of tau filaments from alzheimer's disease with pet ligand apn-1607. |
2021-10-30 |
2023-08-13 |
Not clear |
| Ansab Akhtar, Mahendra Bishnoi, Sangeeta Pilkhwal Sa. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. Brain research bulletin. vol 164. 2021-10-29. PMID:32784004. |
sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of alzheimer's disease through modulation of brain insulin resistance induced tau pathology. |
2021-10-29 |
2023-08-13 |
rat |
| Fan Yang, Samadrita Roy Chowdhury, Heidi I L Jacobs, Jorge Sepulcre, Van J Wedeen, Keith A Johnson, Joyita Dutt. Longitudinal predictive modeling of tau progression along the structural connectome. NeuroImage. vol 237. 2021-10-29. PMID:33957234. |
tau neurofibrillary tangles, a pathophysiological hallmark of alzheimer's disease (ad), exhibit a stereotypical spatiotemporal trajectory that is strongly correlated with disease progression and cognitive decline. |
2021-10-29 |
2023-08-13 |
human |
| Minjae Kim, Sang Joon Kim, Ji Eun Park, Jessica Yun, Woo Hyun Shim, Jungsu S Oh, Minyoung Oh, Jee Hoon Roh, Sang Won Seo, Seung Jun Oh, Jae Seung Ki. Combination of automated brain volumetry on MRI and quantitative tau deposition on THK-5351 PET to support diagnosis of Alzheimer's disease. Scientific reports. vol 11. issue 1. 2021-10-29. PMID:33990649. |
combination of automated brain volumetry on mri and quantitative tau deposition on thk-5351 pet to support diagnosis of alzheimer's disease. |
2021-10-29 |
2023-08-13 |
human |
| Christina B Young, Susan M Landau, Theresa M Harrison, Kathleen L Poston, Elizabeth C Mormin. Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [ NeuroImage. vol 243. 2021-10-29. PMID:34487825. |
influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [ tau pet has allowed for critical insights into in vivo patterns of tau accumulation and change in individuals early in the alzheimer's disease (ad) continuum. |
2021-10-29 |
2023-08-13 |
Not clear |
| Antoine Leuzy, Shorena Janelidze, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Dirk Jacobs, Claudia Cicognola, Erik Stomrud, Eugeen Vanmechelen, Jeffrey L Dage, Oskar Hansso. Comparing the Clinical Utility and Diagnostic Performance of CSF P-Tau181, P-Tau217, and P-Tau231 Assays. Neurology. vol 97. issue 17. 2021-10-29. PMID:34493616. |
phosphorylated tau (p-tau) in csf is considered an important biomarker in alzheimer disease (ad) and has been incorporated in recent diagnostic criteria. |
2021-10-29 |
2023-08-13 |
Not clear |
| D Boche, J A R Nicol. Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32643143. |
alzheimer's disease (ad) pathology is multi-faceted, including extracellular accumulation of amyloid-β (aβ), accumulation of tau within neurons, glial activation and loss of neurons and synapses. |
2021-10-28 |
2023-08-13 |
human |