| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, Philip Scheltens, Jeffrey L Dage, Femke Bouwman, Kaj Blennow, Niklas Mattsson-Carlgren, Shorena Janelidze, Oskar Hansso. Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers. EMBO molecular medicine. vol 13. issue 8. 2021-10-25. PMID:34254442. |
pet, csf and plasma biomarkers of tau pathology may be differentially associated with alzheimer's disease (ad)-related demographic, cognitive, genetic and neuroimaging markers. |
2021-10-25 |
2023-08-13 |
human |
| Zirong Chen, FeiFan Chang, Linyin Yao, Fan Yuan, Junsheng Hong, Dawei Wu, Yongxiang We. Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2021-10-25. PMID:34693486. |
exosomal phospho-tau-181(p-t181-tau), total tau (t-tau), and amyloid-β peptide 42 (aβ42) have been proved the capacity for the amnestic mild cognitive impairment (mci) and the diagnosis of alzheimer's disease (ad). |
2021-10-25 |
2023-08-13 |
Not clear |
| Kamalini G Ranasinghe, Cathrine Petersen, Kiwamu Kudo, Danielle Mizuiri, Katherine P Rankin, Gil D Rabinovici, Maria Luisa Gorno-Tempini, William W Seeley, Salvatore Spina, Bruce L Miller, Keith Vossel, Lea T Grinberg, Srikantan S Nagaraja. Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-10-22. PMID:33884753. |
neurophysiological manifestations selectively associated with amyloid beta and tau depositions in alzheimer's disease (ad) are useful network biomarkers to identify peptide specific pathological processes. |
2021-10-22 |
2023-08-13 |
Not clear |
| Ruocheng Dong, Burcu F Darst, Yuetiva Deming, Yue Ma, Qiongshi Lu, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelma. CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-22. PMID:33969169. |
csf metabolites associate with csf tau and improve prediction of alzheimer's disease status. |
2021-10-22 |
2023-08-13 |
Not clear |
| Ruocheng Dong, Burcu F Darst, Yuetiva Deming, Yue Ma, Qiongshi Lu, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelma. CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-22. PMID:33969169. |
cerebrospinal fluid (csf) total tau (t-tau) and phosphorylated tau (p-tau) are biomarkers of alzheimer's disease (ad), yet much is unknown about ad-associated changes in tau metabolism and tau tangle etiology. |
2021-10-22 |
2023-08-13 |
Not clear |
| Heidi Strand, Lamya Garabet, Börje Bjelke, Cindhya Sithiravel, Ingrid Marie Hardang, Morten K Mo. β-Amyloid in Cerebrospinal Fluid: How to Keep It Floating (Not Sticking) by Standardization of Preanalytic Processes and Collection Tubes. The journal of applied laboratory medicine. vol 6. issue 5. 2021-10-22. PMID:34059876. |
phosphorylated tau (ptau), total tau (ttau), and β-amyloid (aβ) are established cerebrospinal fluid (csf) biomarkers used to help diagnose alzheimer disease. |
2021-10-22 |
2023-08-13 |
Not clear |
| He-Ao Zhang, Chun-Xu Yuan, Ke-Fu Liu, Qi-Fan Yang, Juan Zhao, Hui Li, Qing-Hu Yang, Da Song, Zhen-Zhen Quan, Hong Qin. Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy. Neural regeneration research. vol 17. issue 1. 2021-10-22. PMID:34100451. |
in this study, nscs were transplanted into the hippocampal ca1 region of the rtg (tau p301l) 4510 mouse model, a tauopathy model that is thought to reflect the tau pathology associated with alzheimer's disease. |
2021-10-22 |
2023-08-13 |
mouse |
| Zhi Rua. Extracellular vesicles drive tau spreading in Alzheimer's disease. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269203. |
extracellular vesicles drive tau spreading in alzheimer's disease. |
2021-10-22 |
2023-08-13 |
Not clear |
| Yi-Tong Lin, Qing-Qing Shi, Lei Zhang, Cai-Ping Yue, Zhi-Jun He, Xue-Xia Li, Qian-Jun He, Qiong Liu, Xiu-Bo D. Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269217. |
the results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×tg alzheimer's disease mice. |
2021-10-22 |
2023-08-13 |
mouse |
| Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. |
tau phosphorylation and opa1 proteolysis are unrelated events: implications for alzheimer's disease. |
2021-10-22 |
2023-08-13 |
mouse |
| Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. |
this study focuses on one particular aspect of this question by investigating the functional interaction between the microtubule-associated protein tau and the mitochondrial inner membrane fusion machinery, which shows alterations in alzheimer's brains. |
2021-10-22 |
2023-08-13 |
mouse |
| Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. |
these results irrefutably demonstrate that there is no direct functional interaction between posttranslational tau modifications and the regulation of the oma1-opa1 pathway, which implies a common root cause modulating both pathways in alzheimer's. |
2021-10-22 |
2023-08-13 |
mouse |
| D G Garbuz, O G Zatsepina, M B Evgen'e. [Beta Amyloid, Tau Protein, and Neuroinflammation: An Attempt to Integrate Different Hypotheses of Alzheimer's Disease Pathogenesis]. Molekuliarnaia biologiia. vol 55. issue 5. 2021-10-22. PMID:34671002. |
[beta amyloid, tau protein, and neuroinflammation: an attempt to integrate different hypotheses of alzheimer's disease pathogenesis]. |
2021-10-22 |
2023-08-13 |
Not clear |
| Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jone. Soluble forms of tau are toxic in Alzheimer's disease. Translational neuroscience. vol 3. issue 3. 2021-10-21. PMID:23029602. |
soluble forms of tau are toxic in alzheimer's disease. |
2021-10-21 |
2023-08-12 |
Not clear |
| Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jone. Soluble forms of tau are toxic in Alzheimer's disease. Translational neuroscience. vol 3. issue 3. 2021-10-21. PMID:23029602. |
accumulation of neurofibrillary tangles (nft), intracellular inclusions of fibrillar forms of tau, is a hallmark of alzheimer disease. |
2021-10-21 |
2023-08-12 |
Not clear |
| Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jone. Soluble forms of tau are toxic in Alzheimer's disease. Translational neuroscience. vol 3. issue 3. 2021-10-21. PMID:23029602. |
here we review the data supporting soluble tau as toxic to neurons and synapses in the brain and the implications of these data for development of therapeutic strategies for alzheimer's disease and other tauopathies. |
2021-10-21 |
2023-08-12 |
Not clear |
| Ehren L Newman, Christopher F Shay, Michael E Hasselm. Malignant synaptic growth and Alzheimer's disease. Future neurology. vol 7. issue 5. 2021-10-21. PMID:23420180. |
we will include discussion of its relationship, in terms of points of alignment and points of contention, to other models of alzheimer's disease, including the cholinergic hypothesis and the tau and β-amyloid models of alzheimer's disease. |
2021-10-21 |
2023-08-12 |
Not clear |
| Umesh K Jinwal, John Koren, Chad A Dicke. Reconstructing the Hsp90/Tau Machine. Current enzyme inhibition. vol 9. issue 1. 2021-10-21. PMID:23798910. |
recent work demonstrates that age-related changes to the cellular chaperone repertoire contributes to abnormal buildup of the microtubule-associated protein tau that accumulates in a group of diseases termed tauopathies, the most common being alzheimer's disease (ad). |
2021-10-21 |
2023-08-12 |
Not clear |
| Yu Wang, Yu Feng, Qunying Fu, Lei L. Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression. Experimental and therapeutic medicine. vol 6. issue 3. 2021-10-21. PMID:24137274. |
panax notoginsenoside rb1 ameliorates alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating tau protein expression. |
2021-10-21 |
2023-08-12 |
Not clear |
| Fiona J Baird, Craig L Bennet. Microtubule defects & Neurodegeneration. Journal of genetic syndromes & gene therapy. vol 4. 2021-10-21. PMID:24563812. |
the importance of mt dynamics and stability is underscored by the critical role tau protein plays in mt-associated stabilization versus the dysfunction seen in alzheimer's disease, frontotemporal dementia and other tauopathies. |
2021-10-21 |
2023-08-12 |
mouse |