| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy F T Arnsten, Dibyadeep Datta, Kelly Del Tredici, Heiko Braa. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 1. 2021-10-25. PMID:33075193. |
hypothesis: tau pathology is an initiating factor in sporadic alzheimer's disease. |
2021-10-25 |
2023-08-13 |
human |
| Hong Xu, Mia O'Reilly, Garrett S Gibbons, Lakshmi Changolkar, Jennifer D McBride, Dawn M Riddle, Bin Zhang, Anna Stieber, Jeffrey Nirschl, Soo-Jung Kim, Kevt-Her Hoxha, Kurt R Brunden, Gerard D Schellenberg, John Q Trojanowski, Virginia M-Y Le. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics. Acta neuropathologica. vol 141. issue 2. 2021-10-25. PMID:33385254. |
here, we used biochemically enriched brain-derived tau seeds from alzheimer's disease (ad), corticobasal degeneration (cbd) and progressive supranuclear palsy (psp) patient brains with a modified seeding protocol to template the recruitment of recombinant 2n4r (t40) tau in vitro. |
2021-10-25 |
2023-08-13 |
human |
| Juan Carlos Polanco, Gabriel Rhys Hand, Adam Briner, Chuanzhou Li, Jürgen Göt. Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol. Acta neuropathologica. vol 141. issue 2. 2021-10-25. PMID:33417012. |
the microtubule-associated protein tau has a critical role in alzheimer's disease and other tauopathies. |
2021-10-25 |
2023-08-13 |
mouse |
| Niklas Mattsson-Carlgren, Shorena Janelidze, Randall J Bateman, Ruben Smith, Erik Stomrud, Geidy E Serrano, Eric M Reiman, Sebastian Palmqvist, Jeffrey L Dage, Thomas G Beach, Oskar Hansso. Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau. EMBO molecular medicine. vol 13. issue 6. 2021-10-25. PMID:33949133. |
alzheimer's disease is characterized by β-amyloid plaques and tau tangles. |
2021-10-25 |
2023-08-13 |
Not clear |
| Niklas Mattsson-Carlgren, Shorena Janelidze, Randall J Bateman, Ruben Smith, Erik Stomrud, Geidy E Serrano, Eric M Reiman, Sebastian Palmqvist, Jeffrey L Dage, Thomas G Beach, Oskar Hansso. Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau. EMBO molecular medicine. vol 13. issue 6. 2021-10-25. PMID:33949133. |
plasma levels of phospho-tau217 (p-tau217) accurately differentiate alzheimer's disease dementia from other dementias, but it is unclear to what degree this reflects β-amyloid plaque accumulation, tau tangle accumulation, or both. |
2021-10-25 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, Philip Scheltens, Jeffrey L Dage, Femke Bouwman, Kaj Blennow, Niklas Mattsson-Carlgren, Shorena Janelidze, Oskar Hansso. Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers. EMBO molecular medicine. vol 13. issue 8. 2021-10-25. PMID:34254442. |
tau pet correlates with different alzheimer's disease-related features compared to csf and plasma p-tau biomarkers. |
2021-10-25 |
2023-08-13 |
human |
| Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, Philip Scheltens, Jeffrey L Dage, Femke Bouwman, Kaj Blennow, Niklas Mattsson-Carlgren, Shorena Janelidze, Oskar Hansso. Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers. EMBO molecular medicine. vol 13. issue 8. 2021-10-25. PMID:34254442. |
pet, csf and plasma biomarkers of tau pathology may be differentially associated with alzheimer's disease (ad)-related demographic, cognitive, genetic and neuroimaging markers. |
2021-10-25 |
2023-08-13 |
human |
| Zirong Chen, FeiFan Chang, Linyin Yao, Fan Yuan, Junsheng Hong, Dawei Wu, Yongxiang We. Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2021-10-25. PMID:34693486. |
exosomal phospho-tau-181(p-t181-tau), total tau (t-tau), and amyloid-β peptide 42 (aβ42) have been proved the capacity for the amnestic mild cognitive impairment (mci) and the diagnosis of alzheimer's disease (ad). |
2021-10-25 |
2023-08-13 |
Not clear |
| Kamalini G Ranasinghe, Cathrine Petersen, Kiwamu Kudo, Danielle Mizuiri, Katherine P Rankin, Gil D Rabinovici, Maria Luisa Gorno-Tempini, William W Seeley, Salvatore Spina, Bruce L Miller, Keith Vossel, Lea T Grinberg, Srikantan S Nagaraja. Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-10-22. PMID:33884753. |
neurophysiological manifestations selectively associated with amyloid beta and tau depositions in alzheimer's disease (ad) are useful network biomarkers to identify peptide specific pathological processes. |
2021-10-22 |
2023-08-13 |
Not clear |
| Ruocheng Dong, Burcu F Darst, Yuetiva Deming, Yue Ma, Qiongshi Lu, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelma. CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-22. PMID:33969169. |
csf metabolites associate with csf tau and improve prediction of alzheimer's disease status. |
2021-10-22 |
2023-08-13 |
Not clear |
| Ruocheng Dong, Burcu F Darst, Yuetiva Deming, Yue Ma, Qiongshi Lu, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelma. CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-22. PMID:33969169. |
cerebrospinal fluid (csf) total tau (t-tau) and phosphorylated tau (p-tau) are biomarkers of alzheimer's disease (ad), yet much is unknown about ad-associated changes in tau metabolism and tau tangle etiology. |
2021-10-22 |
2023-08-13 |
Not clear |
| Heidi Strand, Lamya Garabet, Börje Bjelke, Cindhya Sithiravel, Ingrid Marie Hardang, Morten K Mo. β-Amyloid in Cerebrospinal Fluid: How to Keep It Floating (Not Sticking) by Standardization of Preanalytic Processes and Collection Tubes. The journal of applied laboratory medicine. vol 6. issue 5. 2021-10-22. PMID:34059876. |
phosphorylated tau (ptau), total tau (ttau), and β-amyloid (aβ) are established cerebrospinal fluid (csf) biomarkers used to help diagnose alzheimer disease. |
2021-10-22 |
2023-08-13 |
Not clear |
| He-Ao Zhang, Chun-Xu Yuan, Ke-Fu Liu, Qi-Fan Yang, Juan Zhao, Hui Li, Qing-Hu Yang, Da Song, Zhen-Zhen Quan, Hong Qin. Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy. Neural regeneration research. vol 17. issue 1. 2021-10-22. PMID:34100451. |
in this study, nscs were transplanted into the hippocampal ca1 region of the rtg (tau p301l) 4510 mouse model, a tauopathy model that is thought to reflect the tau pathology associated with alzheimer's disease. |
2021-10-22 |
2023-08-13 |
mouse |
| Zhi Rua. Extracellular vesicles drive tau spreading in Alzheimer's disease. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269203. |
extracellular vesicles drive tau spreading in alzheimer's disease. |
2021-10-22 |
2023-08-13 |
Not clear |
| Yi-Tong Lin, Qing-Qing Shi, Lei Zhang, Cai-Ping Yue, Zhi-Jun He, Xue-Xia Li, Qian-Jun He, Qiong Liu, Xiu-Bo D. Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269217. |
the results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×tg alzheimer's disease mice. |
2021-10-22 |
2023-08-13 |
mouse |
| Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. |
tau phosphorylation and opa1 proteolysis are unrelated events: implications for alzheimer's disease. |
2021-10-22 |
2023-08-13 |
mouse |
| Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. |
this study focuses on one particular aspect of this question by investigating the functional interaction between the microtubule-associated protein tau and the mitochondrial inner membrane fusion machinery, which shows alterations in alzheimer's brains. |
2021-10-22 |
2023-08-13 |
mouse |
| Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. |
these results irrefutably demonstrate that there is no direct functional interaction between posttranslational tau modifications and the regulation of the oma1-opa1 pathway, which implies a common root cause modulating both pathways in alzheimer's. |
2021-10-22 |
2023-08-13 |
mouse |
| D G Garbuz, O G Zatsepina, M B Evgen'e. [Beta Amyloid, Tau Protein, and Neuroinflammation: An Attempt to Integrate Different Hypotheses of Alzheimer's Disease Pathogenesis]. Molekuliarnaia biologiia. vol 55. issue 5. 2021-10-22. PMID:34671002. |
[beta amyloid, tau protein, and neuroinflammation: an attempt to integrate different hypotheses of alzheimer's disease pathogenesis]. |
2021-10-22 |
2023-08-13 |
Not clear |
| Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jone. Soluble forms of tau are toxic in Alzheimer's disease. Translational neuroscience. vol 3. issue 3. 2021-10-21. PMID:23029602. |
soluble forms of tau are toxic in alzheimer's disease. |
2021-10-21 |
2023-08-12 |
Not clear |