All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Fang-Lin Weng, Ling H. Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422896. accumulation of phosphorylated tau (p-tau) has long been an underappreciated hallmark of alzheimer's disease. 2021-09-28 2023-08-13 Not clear
Fang-Lin Weng, Ling H. Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422896. this review endeavors to exam the potential role of ups in p-tau aggregation, and how pathogenic tau may inflict other abnormalities such as amyloid beta accumulation in alzheimer's disease. 2021-09-28 2023-08-13 Not clear
Feng Han, Jing Chen, Aaron Belkin-Rosen, Yameng Gu, Liying Luo, Orfeu M Buxton, Xiao Li. Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease-related pathology. PLoS biology. vol 19. issue 6. 2021-09-28. PMID:34061820. the glymphatic system plays an important role in clearing the amyloid-β (aβ) and tau proteins that are closely linked to alzheimer disease (ad) pathology. 2021-09-28 2023-08-13 Not clear
Chaahat S B Singh, Kyung Bok Choi, Lonna Munro, Hong Yue Wang, Cheryl G Pfeifer, Wilfred A Jefferie. Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics. EBioMedicine. vol 71. 2021-09-28. PMID:34534764. cognitive decline leading to dementia, accompanied by the accumulation of amyloid-beta (aβ) in neuritic plaques together with the appearance of neurofibrillary tangles (nft) composed of hyperphosphorylated tau protein (tau), are previously noted hallmarks of alzheimer's disease (ad). 2021-09-28 2023-08-13 Not clear
Claire Sexton, Heather Snyder, Dirk Beher, Adam L Boxer, Pat Brannelly, Jean-Pierre Brion, Luc Buée, Angela M Cacace, Gaël Chételat, Martin Citron, Sarah L DeVos, Kristophe Diaz, Howard H Feldman, Bess Frost, Alison M Goate, Michael Gold, Bradley Hyman, Keith Johnson, Celeste M Karch, Diana R Kerwin, Walter J Koroshetz, Irene Litvan, Huw R Morris, Catherine J Mummery, James Mutamba, Marc C Patterson, Yakeel T Quiroz, Gil D Rabinovici, Amy Rommel, Melanie B Shulman, Leticia M Toledo-Sherman, Stacie Weninger, Kristin R Wildsmith, Susan L Worley, Maria C Carrill. Current directions in tau research: Highlights from Tau 2020. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-28. PMID:34581500. in february 2020, leading tau experts from around the world convened for the first-ever tau2020 global conference in washington, dc, co-organized and cosponsored by the rainwater charitable foundation, the alzheimer's association, and curepsp. 2021-09-28 2023-08-13 Not clear
Isabel J Sible, Daniel A Natio. Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers. Brain imaging and behavior. 2021-09-28. PMID:34581957. a subset (n = 252) underwent lumbar puncture to determine alzheimer's disease cerebral spinal fluid amyloid-beta and phosphorylated tau biomarker abnormality. 2021-09-28 2023-08-13 human
Isabel J Sible, Daniel A Natio. Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers. Brain imaging and behavior. 2021-09-28. PMID:34581957. a similar pattern emerged in subsets with alzheimer's disease pathophysiology (i.e., abnormal levels of both amyloid-beta and phosphorylated tau). 2021-09-28 2023-08-13 human
Marta Milà-Alomà, Gemma Salvadó, Juan Domingo Gispert, Natalia Vilor-Tejedor, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, Eider M Arenaza-Urquijo, Marta Crous-Bou, José Maria González-de-Echávarri, Carolina Minguillon, Karine Fauria, Maryline Simon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, José Luis Molinuev. Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32573951. amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the alzheimer's continuum. 2021-09-27 2023-08-13 Not clear
Chia-Chen Liu, Yu Yamazaki, Michael G Heckman, Yuka A Martens, Lin Jia, Akari Yamazaki, Nancy N Diehl, Jing Zhao, Na Zhao, Michael DeTure, Mary D Davis, Lindsey M Felton, Wenhui Qiao, Yonghe Li, Hongmei Li, Yuan Fu, Na Wang, Melissa Wren, Tomonori Aikawa, Marie-Louise Holm, Hiroshi Oue, Cynthia Linares, Mariet Allen, Minerva M Carrasquillo, Melissa E Murray, Ronald C Petersen, Nilüfer Ertekin-Taner, Dennis W Dickson, Takahisa Kanekiyo, Guojun B. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32827351. tau and apolipoprotein e modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in alzheimer's disease. 2021-09-27 2023-08-13 Not clear
Yuemang Yao, Goodwell Nzou, Thibault Alle, Wangchen Tsering, Shaniya Maimaiti, John Q Trojanowski, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunde. Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32918367. the hallmark pathologies of the alzheimer's disease (ad) brain are amyloid beta (aβ)-containing senile plaques and neurofibrillary tangles formed from the microtubule (mt)-binding tau protein. 2021-09-27 2023-08-13 mouse
H-Y Wang, Z Pei, K-C Lee, E Lopez-Brignoni, B Nikolov, C A Crowley, M R Marsman, R Barbier, N Friedmann, L H Burn. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. The journal of prevention of Alzheimer's disease. vol 7. issue 4. 2021-09-27. PMID:32920628. the most common dementia worldwide, alzheimer's disease is often diagnosed via biomarkers in cerebrospinal fluid, including reduced levels of aβ1-42, and increases in total tau and phosphorylated tau-181. 2021-09-27 2023-08-13 mouse
H-Y Wang, Z Pei, K-C Lee, E Lopez-Brignoni, B Nikolov, C A Crowley, M R Marsman, R Barbier, N Friedmann, L H Burn. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. The journal of prevention of Alzheimer's disease. vol 7. issue 4. 2021-09-27. PMID:32920628. the result is reduced tau hyperphosphorylation and neuroinflammation, with multiple functional improvements demonstrated in transgenic mice and postmortem alzheimer's disease brain. 2021-09-27 2023-08-13 mouse
Meng-Shan Tan, Yu-Xiang Yang, Hui-Fu Wang, Wei Xu, Chen-Chen Tan, Chuan-Tao Zuo, Qiang Dong, Lan Tan, Jin-Tai Y. PET Amyloid and Tau Status Are Differently Affected by Patient Features. Journal of Alzheimer's disease : JAD. vol 78. issue 3. 2021-09-27. PMID:33104024. amyloid-β (aβ) plaques and tau neurofibrillary tangles are two neuropathological hallmarks of alzheimer's disease (ad), which both can be visualized in vivo using pet radiotracers, opening new opportunities to study disease mechanisms. 2021-09-27 2023-08-13 Not clear
Linda J C van Waalwijk van Doorn, Mohsen Ghafoorian, Esther M C van Leijsen, Jurgen A H R Claassen, Andrea Arighi, Marco Bozzali, Jorge Cannas, Enrica Cavedo, Paolo Eusebi, Lucia Farotti, Chiara Fenoglio, Juan Fortea, Giovanni B Frisoni, Daniela Galimberti, Viviana Greco, Sanna-Kaisa Herukka, Yawu Liu, Alberto Lleó, Alexandre de Mendonça, Flavio M Nobili, Lucilla Parnetti, Agnese Picco, Maria Pikkarainen, Nicola Salvadori, Elio Scarpini, Hilkka Soininen, Roberto Tarducci, Andrea Urbani, Eduard Vilaplana, Olga Meulenbroek, Bram Platel, Marcel M Verbeek, H Bea Kuiperi. White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers. Journal of Alzheimer's disease : JAD. vol 79. issue 1. 2021-09-27. PMID:33252070. the cerebrospinal fluid (csf) biomarkers amyloid-β 1-42 (aβ42), total and phosphorylated tau (t-tau, p-tau) are increasingly used to assist in the clinical diagnosis of alzheimer's disease (ad). 2021-09-27 2023-08-13 Not clear
Ivan Koychev, Katrin Jansen, Alina Dette, Liu Shi, Heinz Hollin. Blood-Based ATN Biomarkers of Alzheimer's Disease: A Meta-Analysis. Journal of Alzheimer's disease : JAD. vol 79. issue 1. 2021-09-27. PMID:33252080. the amyloid tau neurodegeneration (atn) framework was proposed to define the biological state underpinning alzheimer's disease (ad). 2021-09-27 2023-08-13 Not clear
Andrea Stojakovic, Su-Youne Chang, Jarred Nesbitt, Nicholas P Pichurin, Mark A Ostroot, Tomonori Aikawa, Takahisa Kanekiyo, Eugenia Trushin. Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice. Journal of Alzheimer's disease : JAD. vol 79. issue 1. 2021-09-27. PMID:33285637. accumulation of hyperphosphorylated tau (ptau) protein is associated with synaptic dysfunction in alzheimer's disease (ad). 2021-09-27 2023-08-13 mouse
Dong Xian-Hui, Ma Dong-Xue, Zhang Tian-Ci, He Xiao-Ping, Xu Li-Jun, Liu Ya-Lei, Li Hao, Gao Wei-Jua. The Effect of TCM-Induced HAMP on Key Enzymes in the Hydrolysis of AD Model Cells. Neurochemical research. vol 46. issue 5. 2021-09-27. PMID:33683629. alzheimer's disease (ad) process is characterized classically by two hallmark pathologies: β-amyloid (aβ) plaque deposition and neurofibrillary tangles of hyperphosphorylated tau. 2021-09-27 2023-08-13 mouse
Xuewei Dong, Ruxi Qi, Qin Qiao, Xuhua Li, Fangying Li, Jiaqian Wan, Qingwen Zhang, Guanghong We. Heparin remodels the microtubule-binding repeat R3 of Tau protein towards fibril-prone conformations. Physical chemistry chemical physics : PCCP. vol 23. issue 36. 2021-09-27. PMID:34494046. intracellular fibrillary inclusions formed by tau protein are characterized as the hallmark of tauopathies, including alzheimer's disease and frontotemporal dementia. 2021-09-27 2023-08-13 human
Lili Zhu, Yehong Gong, Hao Lju, Gongwu Sun, Qingwen Zhang, Zhenyu Qia. Mechanisms of melatonin binding and destabilizing the protofilament and filament of tau R3-R4 domains revealed by molecular dynamics simulation. Physical chemistry chemical physics : PCCP. vol 23. issue 36. 2021-09-27. PMID:34514491. the accumulation of β-amyloid (aβ) and tau protein is considered to be an important pathological characteristic of alzheimer's disease (ad). 2021-09-27 2023-08-13 Not clear
Piotr Hanczyc, Piotr Fit. Laser Emission of Thioflavin T Uncovers Protein Aggregation in Amyloid Nucleation Phase. ACS photonics. vol 8. issue 9. 2021-09-25. PMID:34557567. seeding with alzheimer patient's csf containing aβ42 and tau aggregates revealed that only aβ42 oligomers allowed generating ase. 2021-09-25 2023-08-13 human