| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed A Elbatrawy, Taiwo A Ademoye, Heba Alnakhala, Arati Tripathi, Ashique Zami, Raluca Ostafe, Ulf Dettmer, Jessica S Forti. Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils. Bioorganic & medicinal chemistry. vol 100. 2024-02-08. PMID:38330847. |
tau and α-synuclein aggregates are the main histopathological hallmarks present in alzheimer's disease (ad), parkinson's disease (pd), and other neurodegenerative disorders. |
2024-02-08 |
2024-02-11 |
Not clear |
| Mo Chen, Xuejian Feng, Jiaxin Liu, Jianan Wang, Xu Yang, Xianghui Yu, Wei Kong, Bo Sun, Hui W. Prokaryote-derived phosphorylated Tau epitope vaccine is immunogenic and non-T-cell activated in the mice model. Vaccine. 2024-02-08. PMID:38331660. |
accumulation of phosphorylated tau protein is a prominent pathological hallmark of alzheimer's disease (ad). |
2024-02-08 |
2024-02-11 |
mouse |
| Zachary Hoglund, Nancy Ruiz-Uribe, Eric Del Sastre, Benjamin Woost, Joshua Bailey, Bradley T Hyman, Theodore Zwang, Rachel E Bennet. Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328111. |
brain vasculature accumulates tau and is spatially related to tau tangle pathology in alzheimer's disease. |
2024-02-08 |
2024-02-10 |
human |
| Grigorii Sultanakhmetov, Iori Kato, Akiko Asada, Taro Saito, Kanae And. Microtubule-affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model. Genes to cells : devoted to molecular & cellular mechanisms. 2024-02-08. PMID:38329182. |
accumulation of abnormally phosphorylated tau and its aggregation constitute a significant hallmark of alzheimer's disease (ad). |
2024-02-08 |
2024-02-10 |
drosophila_melanogaster |
| Mohammad Reza Ashrafi-Kooshk, Fatemeh Norouzi, Ashkan Zare Karizak, Shahin Ahmadian, Ali Akabar Moosavi-Movahedi, Gholamhossein Riaz. Crosstalk between tau protein autoproteolysis and amyloid fibril formation. International journal of biological macromolecules. 2024-02-07. PMID:38325678. |
thus, targeting proteolysis of tau would be beneficial for the development of therapeutics for alzheimer's disease and related tauopathies. |
2024-02-07 |
2024-02-10 |
Not clear |
| Liang He, Xiyuan Duan, Shikuo Li, Ruqiang Zhang, Xulei Dai, Meilin L. Unveiling the role of astrocytes in postoperative cognitive dysfunction. Ageing research reviews. 2024-02-07. PMID:38325753. |
alzheimer's disease (ad) is the most common neurodegenerative disorder, characterized by progressive cognitive decline and the accumulation of amyloid-beta plaques, tau tangles, and neuroinflammation in the brain. |
2024-02-07 |
2024-02-10 |
Not clear |
| Lin Huang, Qinjie Li, Yao Lu, Fengfeng Pan, Liang Cui, Ying Wang, Ya Miao, Tianlu Chen, Yatian Li, Jingnan Wu, Xiaochun Chen, Jianping Jia, Qihao Gu. Consensus on rapid screening for prodromal Alzheimer's disease in China. General psychiatry. vol 37. issue 1. 2024-02-05. PMID:38313393. |
alzheimer's disease (ad) is a common cause of dementia, characterised by cerebral amyloid-β deposition, pathological tau and neurodegeneration. |
2024-02-05 |
2024-02-07 |
human |
| Hyun-Sik Yang, Wai-Ying W Yau, Becky C Carlyle, Bianca A Trombetta, Can Zhang, Zahra Shirzadi, Aaron P Schultz, Jeremy J Pruzin, Colleen D Fitzpatrick, Dylan R Kirn, Jennifer S Rabin, Rachel F Buckley, Timothy J Hohman, Dorene M Rentz, Rudolph E Tanzi, Keith A Johnson, Reisa A Sperling, Steven E Arnold, Jasmeer P Chhatwa. Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease. Brain : a journal of neurology. 2024-02-05. PMID:38315899. |
plasma vegfa and pgf impact longitudinal tau and cognition in preclinical alzheimer's disease. |
2024-02-05 |
2024-02-09 |
Not clear |
| Hyun-Sik Yang, Wai-Ying W Yau, Becky C Carlyle, Bianca A Trombetta, Can Zhang, Zahra Shirzadi, Aaron P Schultz, Jeremy J Pruzin, Colleen D Fitzpatrick, Dylan R Kirn, Jennifer S Rabin, Rachel F Buckley, Timothy J Hohman, Dorene M Rentz, Rudolph E Tanzi, Keith A Johnson, Reisa A Sperling, Steven E Arnold, Jasmeer P Chhatwa. Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease. Brain : a journal of neurology. 2024-02-05. PMID:38315899. |
together, our findings implicate low vegfa and high pgf in accelerating early neocortical tau pathology and cognitive decline in preclinical alzheimer's disease. |
2024-02-05 |
2024-02-09 |
Not clear |
| Qing Wang, Suzanne E Schindler, Gengsheng Chen, Nicole S Mckay, Austin McCullough, Shaney Flores, Jingxia Liu, Zhexian Sun, Sicheng Wang, Wenshang Wang, Jason Hassenstab, Carlos Cruchaga, Richard J Perrin, Anne M Fagan, John C Morris, Yong Wang, Tammie L S Benzinge. Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging. Neurology. vol 102. issue 4. 2024-02-05. PMID:38315956. |
alzheimer disease (ad) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it is now acknowledged that neuroinflammation, particularly in white matter (wm), significantly contributes to the development and progression of ad. |
2024-02-05 |
2024-02-09 |
Not clear |
| Frederike C Oertel, Daniel Casillas, Yann Cobigo, Shivany Condor Montes, Hilary W Heuer, Makenna Chapman, Alexandra Beaudry-Richard, Henriette Reinsberg, Ahmed Abdelhak, Christian Cordano, Bradley F Boeve, Bradford C Dickerson, Murray Grossman, Edward Huey, David J Irwin, Irene Litvan, Alexander Pantelyat, M Carmela Tartaglia, Lawren Vandevrede, Adam Boxer, Ari J Gree. Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies". Acta neuropathologica. vol 147. issue 1. 2024-02-03. PMID:38308717. |
scientific commentary on: "phosphorylated tau in the retina correlates with tau pathology in the brain in alzheimer's disease and primary tauopathies". |
2024-02-03 |
2024-02-06 |
Not clear |
| Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowit. Local structural preferences in shaping tau amyloid polymorphism. Nature communications. vol 15. issue 1. 2024-02-03. PMID:38310108. |
furthermore, in-cell experiments revealed that pam4 deletion hampers the cellular seeding efficiency of tau aggregates extracted from alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy patients, underscoring pam4's pivotal role in these tauopathies. |
2024-02-03 |
2024-02-06 |
Not clear |
| Malamati Kourti, Athanasios Metaxa. A systematic review and meta-analysis of tau phosphorylation in mouse models of familial Alzheimer's disease. Neurobiology of disease. 2024-02-02. PMID:38307366. |
a systematic review and meta-analysis of tau phosphorylation in mouse models of familial alzheimer's disease. |
2024-02-02 |
2024-02-05 |
mouse |
| Soo Hyun Cho, Shina Kim, Seong-Min Choi, Byeong Chae Ki. ATN Classification and Clinical Progression of the Amyloid-Negative Group in Alzheimer's Disease Neuroimaging Initiative Participants. Chonnam medical journal. vol 60. issue 1. 2024-02-02. PMID:38304128. |
alzheimer's disease has recently been classified using three biological markers (amyloid [a], tau [t], and neurodegeneration [n]) to help elucidate its progression. |
2024-02-02 |
2024-02-04 |
human |
| Isabel J Sible, Daniel A Natio. Blood Pressure Variability and Plasma Alzheimer's Disease Biomarkers in the SPRINT Trial. Journal of Alzheimer's disease : JAD. 2024-02-02. PMID:38306042. |
recent observational studies suggest higher blood pressure (bp) variability (bpv) is associated with alzheimer's disease (ad) biomarkers amyloid-beta (aβ) and tau. |
2024-02-02 |
2024-02-04 |
Not clear |
| Liyuan Jiao, Ziye Jing, Wenjie Zhang, Xuesen Su, Hualei Yan, Shouyuan Tia. Codon Pattern and Context Analysis in Genes Triggering Alzheimer's Disease and Latent Tau Protein Aggregation Post-Anesthesia Exhibited Unique Molecular Patterns Associated with Functional Aspects. Journal of Alzheimer's disease : JAD. 2024-02-02. PMID:38306048. |
codon pattern and context analysis in genes triggering alzheimer's disease and latent tau protein aggregation post-anesthesia exhibited unique molecular patterns associated with functional aspects. |
2024-02-02 |
2024-02-04 |
Not clear |
| Liyuan Jiao, Ziye Jing, Wenjie Zhang, Xuesen Su, Hualei Yan, Shouyuan Tia. Codon Pattern and Context Analysis in Genes Triggering Alzheimer's Disease and Latent Tau Protein Aggregation Post-Anesthesia Exhibited Unique Molecular Patterns Associated with Functional Aspects. Journal of Alzheimer's disease : JAD. 2024-02-02. PMID:38306048. |
previous reports have demonstrated post-operative dementia and alzheimer's disease (ad), and increased amyloid-β levels and tau hyperphosphorylation have been observed in animal models post-anesthesia. |
2024-02-02 |
2024-02-04 |
Not clear |
| Pasquale Mone, Antonio De Luca, Urna Kansakar, Gaetano Santull. Leukocytes and Endothelial Cells Participate in the Pathogenesis of Alzheimer's Disease: Identifying New Biomarkers Mirroring Metabolic Alterations. Journal of Alzheimer's disease : JAD. 2024-02-02. PMID:38306052. |
alzheimer's disease (ad) is a neurodegenerative disorder marked by amyloid-β accumulation, tau dysfunction, and neuroinflammation, involving endothelial cells and leukocytes. |
2024-02-02 |
2024-02-04 |
Not clear |
| Samantha M Rossano, Aubrey S Johnson, Anna Smith, Galen Ziaggi, Andrew Roetman, Diana Guzman, Amarachukwu Okafor, Julia Klein, Zeljko Tomljanovic, Yaakov Stern, Adam M Brickman, Seonjoo Lee, William C Kreisl, Patrick La. Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-01. PMID:38298155. |
evidence suggests microglial activation precedes regional tau and neurodegeneration in alzheimer's disease (ad). |
2024-02-01 |
2024-02-03 |
Not clear |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. The Journal of clinical investigation. vol 134. issue 3. 2024-02-01. PMID:38299587. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2024-02-01 |
2024-02-03 |
mouse |