| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabel J Sible, Daniel A Natio. Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers. Brain imaging and behavior. 2021-09-28. PMID:34581957. |
a similar pattern emerged in subsets with alzheimer's disease pathophysiology (i.e., abnormal levels of both amyloid-beta and phosphorylated tau). |
2021-09-28 |
2023-08-13 |
human |
| Marta Milà-Alomà, Gemma Salvadó, Juan Domingo Gispert, Natalia Vilor-Tejedor, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, Eider M Arenaza-Urquijo, Marta Crous-Bou, José Maria González-de-Echávarri, Carolina Minguillon, Karine Fauria, Maryline Simon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, José Luis Molinuev. Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32573951. |
amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the alzheimer's continuum. |
2021-09-27 |
2023-08-13 |
Not clear |
| Chia-Chen Liu, Yu Yamazaki, Michael G Heckman, Yuka A Martens, Lin Jia, Akari Yamazaki, Nancy N Diehl, Jing Zhao, Na Zhao, Michael DeTure, Mary D Davis, Lindsey M Felton, Wenhui Qiao, Yonghe Li, Hongmei Li, Yuan Fu, Na Wang, Melissa Wren, Tomonori Aikawa, Marie-Louise Holm, Hiroshi Oue, Cynthia Linares, Mariet Allen, Minerva M Carrasquillo, Melissa E Murray, Ronald C Petersen, Nilüfer Ertekin-Taner, Dennis W Dickson, Takahisa Kanekiyo, Guojun B. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32827351. |
tau and apolipoprotein e modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in alzheimer's disease. |
2021-09-27 |
2023-08-13 |
Not clear |
| Yuemang Yao, Goodwell Nzou, Thibault Alle, Wangchen Tsering, Shaniya Maimaiti, John Q Trojanowski, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunde. Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32918367. |
the hallmark pathologies of the alzheimer's disease (ad) brain are amyloid beta (aβ)-containing senile plaques and neurofibrillary tangles formed from the microtubule (mt)-binding tau protein. |
2021-09-27 |
2023-08-13 |
mouse |
| H-Y Wang, Z Pei, K-C Lee, E Lopez-Brignoni, B Nikolov, C A Crowley, M R Marsman, R Barbier, N Friedmann, L H Burn. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. The journal of prevention of Alzheimer's disease. vol 7. issue 4. 2021-09-27. PMID:32920628. |
the most common dementia worldwide, alzheimer's disease is often diagnosed via biomarkers in cerebrospinal fluid, including reduced levels of aβ1-42, and increases in total tau and phosphorylated tau-181. |
2021-09-27 |
2023-08-13 |
mouse |
| H-Y Wang, Z Pei, K-C Lee, E Lopez-Brignoni, B Nikolov, C A Crowley, M R Marsman, R Barbier, N Friedmann, L H Burn. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. The journal of prevention of Alzheimer's disease. vol 7. issue 4. 2021-09-27. PMID:32920628. |
the result is reduced tau hyperphosphorylation and neuroinflammation, with multiple functional improvements demonstrated in transgenic mice and postmortem alzheimer's disease brain. |
2021-09-27 |
2023-08-13 |
mouse |
| Meng-Shan Tan, Yu-Xiang Yang, Hui-Fu Wang, Wei Xu, Chen-Chen Tan, Chuan-Tao Zuo, Qiang Dong, Lan Tan, Jin-Tai Y. PET Amyloid and Tau Status Are Differently Affected by Patient Features. Journal of Alzheimer's disease : JAD. vol 78. issue 3. 2021-09-27. PMID:33104024. |
amyloid-β (aβ) plaques and tau neurofibrillary tangles are two neuropathological hallmarks of alzheimer's disease (ad), which both can be visualized in vivo using pet radiotracers, opening new opportunities to study disease mechanisms. |
2021-09-27 |
2023-08-13 |
Not clear |
| Linda J C van Waalwijk van Doorn, Mohsen Ghafoorian, Esther M C van Leijsen, Jurgen A H R Claassen, Andrea Arighi, Marco Bozzali, Jorge Cannas, Enrica Cavedo, Paolo Eusebi, Lucia Farotti, Chiara Fenoglio, Juan Fortea, Giovanni B Frisoni, Daniela Galimberti, Viviana Greco, Sanna-Kaisa Herukka, Yawu Liu, Alberto Lleó, Alexandre de Mendonça, Flavio M Nobili, Lucilla Parnetti, Agnese Picco, Maria Pikkarainen, Nicola Salvadori, Elio Scarpini, Hilkka Soininen, Roberto Tarducci, Andrea Urbani, Eduard Vilaplana, Olga Meulenbroek, Bram Platel, Marcel M Verbeek, H Bea Kuiperi. White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers. Journal of Alzheimer's disease : JAD. vol 79. issue 1. 2021-09-27. PMID:33252070. |
the cerebrospinal fluid (csf) biomarkers amyloid-β 1-42 (aβ42), total and phosphorylated tau (t-tau, p-tau) are increasingly used to assist in the clinical diagnosis of alzheimer's disease (ad). |
2021-09-27 |
2023-08-13 |
Not clear |
| Ivan Koychev, Katrin Jansen, Alina Dette, Liu Shi, Heinz Hollin. Blood-Based ATN Biomarkers of Alzheimer's Disease: A Meta-Analysis. Journal of Alzheimer's disease : JAD. vol 79. issue 1. 2021-09-27. PMID:33252080. |
the amyloid tau neurodegeneration (atn) framework was proposed to define the biological state underpinning alzheimer's disease (ad). |
2021-09-27 |
2023-08-13 |
Not clear |
| Andrea Stojakovic, Su-Youne Chang, Jarred Nesbitt, Nicholas P Pichurin, Mark A Ostroot, Tomonori Aikawa, Takahisa Kanekiyo, Eugenia Trushin. Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice. Journal of Alzheimer's disease : JAD. vol 79. issue 1. 2021-09-27. PMID:33285637. |
accumulation of hyperphosphorylated tau (ptau) protein is associated with synaptic dysfunction in alzheimer's disease (ad). |
2021-09-27 |
2023-08-13 |
mouse |
| Dong Xian-Hui, Ma Dong-Xue, Zhang Tian-Ci, He Xiao-Ping, Xu Li-Jun, Liu Ya-Lei, Li Hao, Gao Wei-Jua. The Effect of TCM-Induced HAMP on Key Enzymes in the Hydrolysis of AD Model Cells. Neurochemical research. vol 46. issue 5. 2021-09-27. PMID:33683629. |
alzheimer's disease (ad) process is characterized classically by two hallmark pathologies: β-amyloid (aβ) plaque deposition and neurofibrillary tangles of hyperphosphorylated tau. |
2021-09-27 |
2023-08-13 |
mouse |
| Xuewei Dong, Ruxi Qi, Qin Qiao, Xuhua Li, Fangying Li, Jiaqian Wan, Qingwen Zhang, Guanghong We. Heparin remodels the microtubule-binding repeat R3 of Tau protein towards fibril-prone conformations. Physical chemistry chemical physics : PCCP. vol 23. issue 36. 2021-09-27. PMID:34494046. |
intracellular fibrillary inclusions formed by tau protein are characterized as the hallmark of tauopathies, including alzheimer's disease and frontotemporal dementia. |
2021-09-27 |
2023-08-13 |
human |
| Lili Zhu, Yehong Gong, Hao Lju, Gongwu Sun, Qingwen Zhang, Zhenyu Qia. Mechanisms of melatonin binding and destabilizing the protofilament and filament of tau R3-R4 domains revealed by molecular dynamics simulation. Physical chemistry chemical physics : PCCP. vol 23. issue 36. 2021-09-27. PMID:34514491. |
the accumulation of β-amyloid (aβ) and tau protein is considered to be an important pathological characteristic of alzheimer's disease (ad). |
2021-09-27 |
2023-08-13 |
Not clear |
| Piotr Hanczyc, Piotr Fit. Laser Emission of Thioflavin T Uncovers Protein Aggregation in Amyloid Nucleation Phase. ACS photonics. vol 8. issue 9. 2021-09-25. PMID:34557567. |
seeding with alzheimer patient's csf containing aβ42 and tau aggregates revealed that only aβ42 oligomers allowed generating ase. |
2021-09-25 |
2023-08-13 |
human |
| Alireza Majdi, Saeed Sadigh-Eteghad, Sepideh Rahigh Aghsan, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Ali Namvaran, Javad Mahmoud. Amyloid-β, tau, and the cholinergic system in Alzheimer's disease: seeking direction in a tangle of clues. Reviews in the neurosciences. vol 31. issue 4. 2021-09-24. PMID:32017704. |
amyloid-β, tau, and the cholinergic system in alzheimer's disease: seeking direction in a tangle of clues. |
2021-09-24 |
2023-08-13 |
Not clear |
| Steven S Plotkin, Neil R Cashma. Passive immunotherapies targeting Aβ and tau in Alzheimer's disease. Neurobiology of disease. vol 144. 2021-09-24. PMID:32682954. |
passive immunotherapies targeting aβ and tau in alzheimer's disease. |
2021-09-24 |
2023-08-13 |
Not clear |
| Steven S Plotkin, Neil R Cashma. Passive immunotherapies targeting Aβ and tau in Alzheimer's disease. Neurobiology of disease. vol 144. 2021-09-24. PMID:32682954. |
amyloid-β (aβ) and tau proteins currently represent the two most promising targets to treat alzheimer's disease. |
2021-09-24 |
2023-08-13 |
Not clear |
| Christos Proukaki. Somatic mutations in neurodegeneration: An update. Neurobiology of disease. vol 144. 2021-09-24. PMID:32712267. |
in common sporadic neurodegenerative disorders, relevant mutations have been reported in synucleinopathies, comprising somatic gains of snca in parkinson's disease and multiple system atrophy, and in alzheimer's disease, where a novel recombination mechanism leading to somatic variants of app, as well as an excess of somatic snvs affecting tau phosphorylation, have been reported. |
2021-09-24 |
2023-08-13 |
human |
| Brendan P Luce. It's complicated: The relationship between sleep and Alzheimer's disease in humans. Neurobiology of disease. vol 144. 2021-09-24. PMID:32738506. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by an asymptomatic period of amyloid-β (aβ) deposition as insoluble extracellular plaque, intracellular tau aggregation, neuronal and synaptic loss, and subsequent cognitive dysfunction and dementia. |
2021-09-24 |
2023-08-13 |
Not clear |
| Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease. vol 144. 2021-09-24. PMID:32829029. |
tau aggregates consisting of hyperphosphorylated tau fibrils are associated with many neurodegenerative diseases, including alzheimer's disease, pick's disease, frontotemporal dementia, and progressive supranuclear palsy. |
2021-09-24 |
2023-08-13 |
mouse |