| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satoshi Muraoka, Weiwei Lin, Kayo Takamatsu-Yukawa, Jianqiao Hu, Seiko Ikezu, Michael A DeTure, Dennis W Dickson, Andrew Emili, Tsuneya Ikez. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging and disease. vol 12. issue 6. 2021-09-17. PMID:34527416. |
extracellular vesicles (evs) are known to carry pathogenic molecules, such as tau in alzheimer's disease and cte suggesting their contribution in pathogenesis. |
2021-09-17 |
2023-08-13 |
Not clear |
| Bruno P Imbimbo, Stefania Ippati, Mark Watling, Claudia Balducc. A critical appraisal of tau-targeting therapies for primary and secondary tauopathies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-17. PMID:34533272. |
alzheimer's disease is a secondary tauopathy with tau forming hyperphosphorylated insoluble aggregates. |
2021-09-17 |
2023-08-13 |
Not clear |
| Zack Hall, Billy Chien, Yi Zhao, Shannon L Risacher, Andrew J Saykin, Yu-Chien Wu, Qiuting We. Tau deposition and structural connectivity demonstrate differential association patterns with neurocognitive tests. Brain imaging and behavior. 2021-09-17. PMID:34533771. |
tau neurofibrillary tangles have a central role in the pathogenesis of alzheimer's disease (ad). |
2021-09-17 |
2023-08-13 |
human |
| Hortense Fanet, Marine Tournissac, Manon Leclerc, Vicky Caron, Cyntia Tremblay, Sylvie Vancassel, Frédéric Calo. Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer's Disease, Without Altering Amyloid-β and Tau Pathologies. Journal of Alzheimer's disease : JAD. vol 79. issue 2. 2021-09-16. PMID:33337360. |
tetrahydrobiopterin improves recognition memory in the triple-transgenic mouse model of alzheimer's disease, without altering amyloid-β and tau pathologies. |
2021-09-16 |
2023-08-13 |
mouse |
| Marcos Pais, Júlia Loureiro, Vagner do Vale, Marcia Radanovic, Leda Talib, Florindo Stella, Orestes Forlenz. Heterogeneity of Cerebrospinal Fluid Biomarkers Profiles in Individuals with Distinct Levels of Cognitive Decline: A Cross-Sectional Study. Journal of Alzheimer's disease : JAD. vol 81. issue 3. 2021-09-16. PMID:33843685. |
decreased cerebrospinal fluid (csf) concentrations of the amyloid-β (aβ), along with increased total (t-tau) and phosphorylated tau protein (p-tau), are widely accepted as core biomarkers of alzheimer's disease (ad) pathology. |
2021-09-16 |
2023-08-13 |
Not clear |
| Alan M Henrique, Nathália G Gianetti, Merari F R Ferrar. Parkin is downregulated among autophagy-related proteins prior to hyperphosphorylation of Tau in TS65DN mice. Biochemical and biophysical research communications. vol 561. 2021-09-16. PMID:34015759. |
with this in mind, we aimed to investigate whether alterations in expression of autophagy-related proteins would show before hyperphosphorylation of tau, a hallmark of alzheimer's disease (ad). |
2021-09-16 |
2023-08-13 |
mouse |
| Wen-Jie Cai, Yan Tian, Ya-Hui Ma, Qiang Dong, Lan Tan, Jin-Tai Y. Associations of Anxiety with Amyloid, Tau, and Neurodegeneration in Older Adults without Dementia: A Longitudinal Study. Journal of Alzheimer's disease : JAD. vol 82. issue 1. 2021-09-16. PMID:34024826. |
the pathophysiological process of amyloid-β, tau deposition, and neurodegeneration of alzheimer's disease (ad) begin in a preclinical phase, while anxiety is associated with an increased risk of ad in preclinical phase. |
2021-09-16 |
2023-08-13 |
Not clear |
| Jeffrey A Lam, Emily R Murray, Kasey E Yu, Marina Ramsey, Tanya T Nguyen, Jyoti Mishra, Brian Martis, Michael L Thomas, Ellen E Le. Neurobiology of loneliness: a systematic review. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34230607. |
loneliness was also related to biological markers associated with alzheimer's disease (e.g., amyloid and tau burden). |
2021-09-16 |
2023-08-13 |
human |
| Daisuke Ibi, Kazuki Hirashima, Yuya Kojima, Kahori Sumiya, Sari Kondo, Mirai Yamamoto, Toshihiro Ando, Masayuki Hiramats. Preventive Effects of Continuous Betaine Intake on Cognitive Impairment and Aberrant Gene Expression in Hippocampus of 3xTg Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 79. issue 2. 2021-09-15. PMID:33337369. |
the deposition of amyloid-β (aβ) and hyperphosphorylation of tau are well-known as the pathophysiological features of alzheimer's disease (ad), leading to oxidative stress and synaptic deficits followed by cognitive symptoms. |
2021-09-15 |
2023-08-13 |
mouse |
| Alejandra Martínez-Maldonado, Miguel Ángel Ontiveros-Torres, Charles R Harrington, José Francisco Montiel-Sosa, Raúl García-Tapia Prandiz, Patricia Bocanegra-López, Andrew Michael Sorsby-Vargas, Marely Bravo-Muñoz, Benjamín Florán-Garduño, Ignacio Villanueva-Fierro, George Perry, Linda Garcés-Ramírez, Fidel de la Cruz, Sandra Martínez-Robles, Mar Pacheco-Herrero, José Luna-Muño. Molecular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459640. |
alzheimer's disease (ad) and progressive supranuclear palsy (psp) are examples of neurodegenerative diseases, characterized by abnormal tau inclusions, that are called tauopathies. |
2021-09-15 |
2023-08-13 |
human |
| Ruozhen Wu, Jianlan Gu, Dingwei Zhou, Yunn Chyn Tung, Nana Jin, Dandan Chu, Wen Hu, Jerzy Wegiel, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Seeding-Competent Tau in Gray Matter Versus White Matter of Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459649. |
seeding-competent tau in gray matter versus white matter of alzheimer's disease brain. |
2021-09-15 |
2023-08-13 |
Not clear |
| Ruozhen Wu, Jianlan Gu, Dingwei Zhou, Yunn Chyn Tung, Nana Jin, Dandan Chu, Wen Hu, Jerzy Wegiel, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Seeding-Competent Tau in Gray Matter Versus White Matter of Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459649. |
neurofibrillary pathology of abnormally hyperphosphorylated tau spreads along neuroanatomical connections, underlying the progression of alzheimer's disease (ad). |
2021-09-15 |
2023-08-13 |
Not clear |
| Ingmar Skoog, Silke Kern, Jenna Najar, Rita Guerreiro, Jose Bras, Margda Waern, Henrik Zetterberg, Kaj Blennow, Anna Zettergre. A Non-APOE Polygenic Risk Score for Alzheimer's Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 76. issue 6. 2021-09-15. PMID:33512503. |
the effect of alzheimer's disease (ad) polygenic risk scores (prs) on amyloid and tau pathophysiology and neurodegeneration in cognitively unimpaired older adults is not known in detail. |
2021-09-15 |
2023-08-13 |
Not clear |
| Danmin Pan, Jin-Hua Gu, Jin Zhang, Yae Hu, Fei Liu, Khalid Iqbal, Nevena Cekic, David J Vocadlo, Chun-Ling Dai, Cheng-Xin Gon. Thiamme2-G, a Novel O-GlcNAcase Inhibitor, Reduces Tau Hyperphosphorylation and Rescues Cognitive Impairment in Mice. Journal of Alzheimer's disease : JAD. vol 81. issue 1. 2021-09-15. PMID:33814439. |
abnormal hyperphosphorylation of microtubule-associated protein tau plays a pivotal role in alzheimer's disease (ad). |
2021-09-15 |
2023-08-13 |
mouse |
| Montasir Elahi, Yumiko Motoi, Shotaro Shimonaka, Yoko Ishida, Hiroyuki Hioki, Masashi Takanashi, Koichi Ishiguro, Yuzuru Imai, Nobutaka Hattor. High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology. Human molecular genetics. vol 30. issue 18. 2021-09-15. PMID:33890983. |
high-fat diet-induced activation of sgk1 promotes alzheimer's disease-associated tau pathology. |
2021-09-15 |
2023-08-13 |
mouse |
| Kaitlin E Cassady, Jenna N Adams, Xi Chen, Anne Maass, Theresa M Harrison, Susan Landau, Suzanne Baker, William Jagus. Alzheimer's Pathology Is Associated with Dedifferentiation of Intrinsic Functional Memory Networks in Aging. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 10. 2021-09-15. PMID:34037210. |
in presymptomatic alzheimer's disease (ad), beta-amyloid plaques (aβ) and tau tangles accumulate in distinct spatiotemporal patterns within the brain, tracking closely with episodic memory decline. |
2021-09-15 |
2023-08-13 |
Not clear |
| Mitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Naoyuki Sat. ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 7. 2021-09-15. PMID:34283221. |
elisa evaluation of tau accumulation in the brains of patients with alzheimer disease. |
2021-09-15 |
2023-08-13 |
Not clear |
| Mitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Naoyuki Sat. ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 7. 2021-09-15. PMID:34283221. |
despite the routine use of sandwich enzyme-linked immunosorbent assays (elisas) for quantifying tau levels in csf and plasma, tau accumulations in the brains of patients with alzheimer disease (ad) have rarely been evaluated by this method. |
2021-09-15 |
2023-08-13 |
Not clear |
| Meissam Ali, Uzma Saleem, Fareeha Anwar, Muhammad Imran, Humaira Nadeem, Bashir Ahmad, Tahir Ali, Atta-Ur-Rehman, Tariq Ismai. Screening of Synthetic Isoxazolone Derivative Role in Alzheimer's Disease: Computational and Pharmacological Approach. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33486698. |
the aim of this study was to explore the anti-alzheimer's potential of a newly synthesized 3,4,5-trimethoxy isoxazolone derivative (tmi) that attenuated the beta amyloid (aβ1-42) and tau protein levels in streptozotocin (stz) induced alzheimer's disease mouse model. |
2021-09-14 |
2023-08-13 |
mouse |
| Xiao Liu, Kaiyue Wang, Xing Wei, Tian Xie, Bin Lv, Qian Zhou, Xiaoying Wan. Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer's Disease and Potential Active Drug Treatments. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33523396. |
the most important neuropathological features of alzheimer's disease (ad) are extracellular amyloid-β protein (aβ) deposition, tau protein hyperphosphorylation and activation of neurometabolic reaction in the brain accompanied by neuronal and synaptic damage, and impaired learning and memory function. |
2021-09-14 |
2023-08-13 |
Not clear |