| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia Klein, Xinyu Yan, Aubrey Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S Honig, Adam M Brickman, Yaakov Stern, D P Devanand, Seonjoo Lee, William C Kreis. Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33646153. |
olfactory impairment is related to tau pathology and neuroinflammation in alzheimer's disease. |
2021-09-14 |
2023-08-13 |
Not clear |
| Julia Klein, Xinyu Yan, Aubrey Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S Honig, Adam M Brickman, Yaakov Stern, D P Devanand, Seonjoo Lee, William C Kreis. Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33646153. |
olfactory impairment is evident in alzheimer's disease (ad); however, its precise relationships with clinical biomarker measures of tau pathology and neuroinflammation are not well understood. |
2021-09-14 |
2023-08-13 |
Not clear |
| Anastasia Noël, Bénédicte Foveau, Andréa C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33649324. |
active caspase-6 (casp6) and tau cleaved by casp6 at amino acids 402 (tau∆d402) and 421 (tau∆d421) are present in early alzheimer disease intraneuronal neurofibrillary tangles, which are made primarily of filamentous tau aggregates. |
2021-09-14 |
2023-08-13 |
mouse |
| Michael D Devous, Adam S Fleisher, Michael J Pontecorvo, Ming Lu, Andrew Siderowf, Michael Navitsky, Ian Kennedy, Sudeepti Southekal, Thomas S Harris, Mark A Mintu. Relationships Between Cognition and Neuropathological Tau in Alzheimer's Disease Assessed by 18F Flortaucipir PET. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33682705. |
relationships between cognition and neuropathological tau in alzheimer's disease assessed by 18f flortaucipir pet. |
2021-09-14 |
2023-08-13 |
Not clear |
| Michael D Devous, Adam S Fleisher, Michael J Pontecorvo, Ming Lu, Andrew Siderowf, Michael Navitsky, Ian Kennedy, Sudeepti Southekal, Thomas S Harris, Mark A Mintu. Relationships Between Cognition and Neuropathological Tau in Alzheimer's Disease Assessed by 18F Flortaucipir PET. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33682705. |
tau neurofibrillary tangle burden increases with alzheimer's disease (ad) stage and correlates with degree of cognitive impairment. |
2021-09-14 |
2023-08-13 |
Not clear |
| Jodie Lord, Anna Zettergren, Nicholas J Ashton, Thomas K Karikari, Andrea L Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proits. A genome-wide association study of plasma phosphorylated tau181. Neurobiology of aging. vol 106. 2021-09-14. PMID:34119372. |
plasma phosphorylated tau at threonine-181 (p-tau181) demonstrates promise as an accessible blood-based biomarker specific to alzheimer's disease (ad), with levels recently demonstrating high predictive accuracy for ad-relevant pathology. |
2021-09-14 |
2023-08-13 |
human |
| Wei Siang Lee, Daniel Cs Tan, Yuanyuan Deng, Annika van Hummel, Stefania Ippati, Claire Stevens, Paulina Carmona-Mora, Daryl Ariawan, Liming Hou, Holly Stefen, Tamara Tomanic, Mian Bi, Florence Tomasetig, Adam Martin, Thomas Fath, Stephen Palmer, Yazi D Ke, Lars M Ittne. Syntaxins 6 and 8 facilitate tau into secretory pathways. The Biochemical journal. vol 478. issue 7. 2021-09-13. PMID:33769438. |
tau pathology initiates in defined brain regions and is known to spread along neuronal connections as symptoms progress in alzheimer's disease (ad) and other tauopathies. |
2021-09-13 |
2023-08-13 |
Not clear |
| Xian-Ji Pan, Afzal Misrani, Sidra Tabassum, Li Yan. Mitophagy pathways and Alzheimer's disease: From pathogenesis to treatment. Mitochondrion. vol 59. 2021-09-13. PMID:33872797. |
alzheimer's disease (ad) is an age-dependent, incurable mental illness that is associated with the accumulation of aggregates of amyloid-beta (aβ) and hyperphosphorylated tau fragments (p-tau). |
2021-09-13 |
2023-08-13 |
mouse |
| Susanne Wegmann, Jacek Biernat, Eckhard Mandelko. A current view on Tau protein phosphorylation in Alzheimer's disease. Current opinion in neurobiology. vol 69. 2021-09-13. PMID:33892381. |
a current view on tau protein phosphorylation in alzheimer's disease. |
2021-09-13 |
2023-08-13 |
Not clear |
| Susanne Wegmann, Jacek Biernat, Eckhard Mandelko. A current view on Tau protein phosphorylation in Alzheimer's disease. Current opinion in neurobiology. vol 69. 2021-09-13. PMID:33892381. |
elevated phosphorylation and aggregation of tau are widely considered pathological hallmarks in alzheimer's disease (ad) and other tauopathies, triggering the quest for tau posttranslational modifications in the disease context. |
2021-09-13 |
2023-08-13 |
Not clear |
| Lauren E McCollum, Sandhitsu R Das, Long Xie, Robin de Flores, Jieqiong Wang, Sharon X Xie, Laura E M Wisse, Paul A Yushkevich, David A Wol. Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau. NeuroImage. Clinical. vol 31. 2021-09-13. PMID:34119903. |
the national institute on aging and alzheimer's association (nia-aa) a/t/(n) [β-amyloid/tau/(neurodegeneration)] ad research framework, which classifies research participants according to three binary biomarkers [β-amyloid (a+/a-), tau (t+/t-), and neurodegeneration (n+/n-)], provides an indirect means of identifying such cases. |
2021-09-13 |
2023-08-13 |
human |
| Jeffrey S Phillips, Frederick J Nitchie, Fulvio Da Re, Christopher A Olm, Philip A Cook, Corey T McMillan, David J Irwin, James C Gee, Jacob G Dubroff, Murray Grossman, Ilya M Nasralla. Rates of longitudinal change in Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-13. PMID:34515411. |
rates of longitudinal change in longitudinal positron emission tomography (pet) studies of tau accumulation in alzheimer's disease (ad) have noted reduced increases or frank decreases in tau signal. |
2021-09-13 |
2023-08-13 |
Not clear |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
tracking longitudinal tau tangles accumulation across the alzheimer's disease continuum is crucial to better understand the natural history of tau pathology and for clinical trials. |
2021-09-13 |
2023-08-13 |
human |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
we studied 125 living individuals (65 cognitively unimpaired elderly amyloid-β negative, 22 cognitively unimpaired elderly amyloid-β positive, 21 mild cognitive impairment amyloid-β positive, 17 alzheimer's disease dementia amyloid-β positive) with baseline amyloid-β [18f]azd4694 pet and baseline and follow-up tau [18f]mk-6240 pet. |
2021-09-13 |
2023-08-13 |
human |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
in addition, we assessed in vivo [18f]mk-6240 suvr and postmortem phosphorylated tau pathology in two alzheimer's disease dementia participants who deceased after the pet scans. |
2021-09-13 |
2023-08-13 |
human |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
mild cognitive impairment and alzheimer's dementia amyloid-β positive patients showed tau accumulation in braak iii-vi, but not in braak i-ii regions. |
2021-09-13 |
2023-08-13 |
human |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
our results suggest that [18f]mk-6240 suvr is able to detect longitudinal tau accumulation in asymptomatic and symptomatic alzheimer's disease. |
2021-09-13 |
2023-08-13 |
human |
| Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. |
finally, our postmortem findings supported [18f]mk-6240 suvr as a biomarker to stage tau pathology in alzheimer's disease patients. |
2021-09-13 |
2023-08-13 |
human |
| Masato Hosokawa, Masami Masuda-Suzukake, Hiroshi Shitara, Aki Shimozawa, Genjiro Suzuki, Hiromi Kondo, Takashi Nonaka, William Campbell, Tetsuaki Arai, Masato Hasegaw. Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms. Brain : a journal of neurology. 2021-09-13. PMID:34515757. |
although a number of models for tau propagation have been reported, most utilize 4-repeat human tau transgenic mice or adult wild-type mice expressing only endogenous 4-repeat tau and these models have not been able to reproduce the pathology of alzheimer's disease in which 3-repeat and 4-repeat tau accumulate simultaneously, or that of pick's disease in which only 3-repeat tau is aggregated. |
2021-09-13 |
2023-08-13 |
mouse |
| Masato Hosokawa, Masami Masuda-Suzukake, Hiroshi Shitara, Aki Shimozawa, Genjiro Suzuki, Hiromi Kondo, Takashi Nonaka, William Campbell, Tetsuaki Arai, Masato Hasegaw. Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms. Brain : a journal of neurology. 2021-09-13. PMID:34515757. |
at 8-9 months following intracerebral injection of mice, histopathological and biochemical analyses revealed that the abnormal accumulation of tau was seed-dependent, with 3- and 4-repeat tau in alzheimer's disease-injected brains, 4-repeat tau only in corticobasal degeneration-injected brains, and 3-repeat tau only in pick disease-injected brains, all of which contained isoforms related to those found in the injected seeds. |
2021-09-13 |
2023-08-13 |
mouse |