| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clark Funnell, Howard H Feldman, Ian R A Mackenzie, Mari L DeMarc. Applying the Alzheimer Disease ATN Diagnostic Framework in Atypical Dementia. Alzheimer disease and associated disorders. vol 34. issue 4. 2021-09-08. PMID:33215886. |
cerebrospinal fluid (csf) biomarkers amyloid-β and tau have been validated for the antemortem diagnosis of alzheimer disease (ad) and are included in the at(n) research framework for ad. |
2021-09-08 |
2023-08-13 |
Not clear |
| Jinwang Ye, Ying Yin, Yaling Yin, Huaqiu Zhang, Huali Wan, Lu Wang, Yue Zuo, Di Gao, Mengzhu Li, Jun Li, Yanchao Liu, Dan Ke, Jian-Zhi Wan. Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration. Aging cell. vol 19. issue 9. 2021-09-07. PMID:32815315. |
intracellular accumulating of the hyperphosphorylated tau plays a pivotal role in neurodegeneration of alzheimer disease (ad), but the mechanisms underlying the gradually aggravated tau hyperphosphorylation remain elusive. |
2021-09-07 |
2023-08-13 |
Not clear |
| Matteo Manca, Allison Krau. Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays. Biomolecules. vol 10. issue 9. 2021-09-07. PMID:32854212. |
to date, rt-quic assays have been developed for the detection of protein seeds related to known prion diseases of mammals, the αsyn aggregates of parkinson's disease, dementia with lewy bodies, and multiple system atrophy, and the tau aggregates of alzheimer's disease, chronic traumatic encephalopathy, and other tauopathies including progressive supranuclear palsy. |
2021-09-07 |
2023-08-13 |
human |
| b' Preethy Sasidharan Nair, Pirre Raijas, Minna Ahvenainen, Anju K Philips, Liisa Ukkola-Vuoti, Irma J\\xc3\\xa4rvel\\xc3\\xa. Music-listening regulates human microRNA expression. Epigenetics. vol 16. issue 5. 2021-09-07. PMID:32867562.' |
mir-132 plays a critical role in regulating tau protein levels and is important for preventing tau protein aggregation that causes alzheimer's disease. |
2021-09-07 |
2023-08-13 |
human |
| Juan Ramón Perea, Marta Bolós, Jesús Avil. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. vol 10. issue 10. 2021-09-07. PMID:33066368. |
microglia in alzheimer's disease in the context of tau pathology. |
2021-09-07 |
2023-08-13 |
Not clear |
| Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry, Cheryl Kirstein, Mark S Kind. Effects of GrandFusion Diet on Cognitive Impairment in Transgenic Mouse Model of Alzheimer's Disease. Nutrients. vol 13. issue 1. 2021-09-07. PMID:33396967. |
alzheimer's disease (ad) is the result of the deposition of amyloid β (aβ) peptide into amyloid fibrils and tau into neurofibrillary tangles. |
2021-09-07 |
2023-08-13 |
mouse |
| Yunna Kim, Seung-Hun Ch. Lindera glauca Blume ameliorates amyloid-β Neurochemistry international. vol 147. 2021-09-07. PMID:34000331. |
lindera glauca blume ameliorates amyloid-β alzheimer's disease (ad) is a neurodegenerative disorder presenting cognitive decline accompanied by deposits of amyloid-β (aβ) and tau hyperphosphorylation. |
2021-09-07 |
2023-08-13 |
mouse |
| Sofia Bergström, Julia Remnestål, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, Kim Kultima, Lena Kilander, Malin Löwenmark, Martin Ingelsson, Kaj Blennow, Henrik Zetterberg, Bengt Nellgård, Frederic Brosseron, Michael T Heneka, Beatriz Bosch, Raquel Sanchez-Valle, Anna Månberg, Per Svenningsson, Peter Nilsso. Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease. Annals of clinical and translational neurology. vol 8. issue 7. 2021-09-07. PMID:34129723. |
decreased amyloid beta (aβ) 42 together with increased tau and phospho-tau in cerebrospinal fluid (csf) is indicative of alzheimer's disease (ad). |
2021-09-07 |
2023-08-13 |
Not clear |
| Ekta J Shah, Katherine Gurdziel, Douglas M Rude. Sex-Differences in Traumatic Brain Injury in the Absence of Tau in Genes. vol 12. issue 6. 2021-09-07. PMID:34198629. |
traumatic brain injury triggers accumulation of tau protein and the subsequent development of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2021-09-07 |
2023-08-13 |
Not clear |
| Hadeel Alyenbaawi, W Ted Allison, Sue-Ann Mo. Prion-Like Propagation Mechanisms in Tauopathies and Traumatic Brain Injury: Challenges and Prospects. Biomolecules. vol 10. issue 11. 2021-09-06. PMID:33121065. |
the accumulation of tau protein in the form of filamentous aggregates is a hallmark of many neurodegenerative diseases such as alzheimer's disease (ad) and chronic traumatic encephalopathy (cte). |
2021-09-06 |
2023-08-13 |
Not clear |
| Wim Hendricus Quint, Irena Matečko-Burmann, Irene Schilcher, Tina Löffler, Michael Schöll, Björn Marcus Burmann, Thomas Vogel. Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein. Journal of Alzheimer's disease : JAD. vol 80. issue 2. 2021-09-06. PMID:33579845. |
alzheimer's disease (ad) and other tauopathies are neurodegenerative disorders characterized by cellular accumulation of aggregated tau protein. |
2021-09-06 |
2023-08-13 |
Not clear |
| Quan Feng Liu, Suganya Kanmani, Jinhyuk Lee, Geun-Woo Kim, Songhee Jeon, Byung-Soo Ko. Neoline Improves Memory Impairment and Reduces Amyloid-β Level and Tau Phosphorylation Through AMPK Activation in the Mouse Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD. vol 81. issue 2. 2021-09-06. PMID:33814448. |
neoline improves memory impairment and reduces amyloid-β level and tau phosphorylation through ampk activation in the mouse alzheimer's disease model. |
2021-09-06 |
2023-08-13 |
mouse |
| Yuhan Ma, Jing Wang, Dihui Xu, Yabing Chen, Xiaodong Ha. Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway. The Science of the total environment. vol 794. 2021-09-06. PMID:34323745. |
in this study, we observed β-amyloid (aβ) accumulation and tau hyperphosphorylation (p-tau) at sites of ser396 and thr205 in mouse hippocampus and cortex, alzheimer's disease (ad) like changes, after chronic exposure to mc-lr at different concentrations (1, 7.5, 15 and 30 μg/l) for 180 days. |
2021-09-06 |
2023-08-13 |
mouse |
| Lasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K Överby, Poul Henning Jense. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32716602. |
pkr kinase directly regulates tau expression and alzheimer's disease-related tau phosphorylation. |
2021-09-04 |
2023-08-13 |
mouse |
| Lasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K Överby, Poul Henning Jense. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32716602. |
deposition of extensively hyperphosphorylated tau in specific brain cells is a clear pathological hallmark in alzheimer's disease and a number of other neurodegenerative disorders, collectively termed the tauopathies. |
2021-09-04 |
2023-08-13 |
mouse |
| Lasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K Överby, Poul Henning Jense. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32716602. |
these findings indicate that pkr, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as alzheimer's disease and chronic traumatic encephalopathy where inflammation is severe. |
2021-09-04 |
2023-08-13 |
mouse |
| Ajantha Abey, Danielle Davies, Claire Goldsbury, Michael Buckland, Michael Valenzuela, Thomas Dunca. Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32810333. |
distribution of tau hyperphosphorylation in canine dementia resembles early alzheimer's disease and other tauopathies. |
2021-09-04 |
2023-08-13 |
human |
| Becky C Carlyle, Savannah E Kandigian, Johannes Kreuzer, Sudeshna Das, Bianca A Trombetta, Yikai Kuo, David A Bennett, Julie A Schneider, Vladislav A Petyuk, Robert R Kitchen, Robert Morris, Angus C Nairn, Bradley T Hyman, Wilhelm Haas, Steven E Arnol. Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics. Neurobiology of aging. vol 105. 2021-09-03. PMID:34052751. |
alzheimer's disease (ad) is defined by the presence of abundant amyloid-β (aβ) and tau neuropathology. |
2021-09-03 |
2023-08-13 |
human |
| Kanoh Kondo, Teikichi Ikura, Hikari Tanaka, Kyota Fujita, Sumire Takayama, Yuki Yoshioka, Kazuhiko Tagawa, Hidenori Homma, Su Liu, Ryosuke Kawasaki, Yong Huang, Nobutoshi Ito, Shin-Ichi Tate, Hitoshi Okazaw. Hepta-Histidine Inhibits Tau Aggregation. ACS chemical neuroscience. vol 12. issue 16. 2021-09-03. PMID:34319089. |
tau aggregation is a central hallmark of tauopathies such as frontotemporal lobar degeneration and progressive supranuclear palsy as well as of alzheimer's disease, and it has been a target for therapeutic development. |
2021-09-03 |
2023-08-13 |
Not clear |
| Dongqin Wu, Di Gao, Haitao Yu, Guilin Pi, Rui Xiong, Huiyang Lei, Xin Wang, Enjie Liu, Jinwang Ye, Huilin Yu, Yang Gao, Ting He, Tao Jiang, Fei Sun, Jingfen Su, Guoda Song, Wenju Peng, Ying Yang, Jian-Zhi Wan. Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway. Clinical and translational medicine. vol 11. issue 6. 2021-09-02. PMID:34185417. |
tau accumulation and cholinergic impairment are characteristic pathologies in alzheimer's disease (ad). |
2021-09-02 |
2023-08-13 |
mouse |