| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuhan Ma, Jing Wang, Dihui Xu, Yabing Chen, Xiaodong Ha. Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway. The Science of the total environment. vol 794. 2021-09-06. PMID:34323745. |
in this study, we observed β-amyloid (aβ) accumulation and tau hyperphosphorylation (p-tau) at sites of ser396 and thr205 in mouse hippocampus and cortex, alzheimer's disease (ad) like changes, after chronic exposure to mc-lr at different concentrations (1, 7.5, 15 and 30 μg/l) for 180 days. |
2021-09-06 |
2023-08-13 |
mouse |
| Lasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K Överby, Poul Henning Jense. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32716602. |
pkr kinase directly regulates tau expression and alzheimer's disease-related tau phosphorylation. |
2021-09-04 |
2023-08-13 |
mouse |
| Lasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K Överby, Poul Henning Jense. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32716602. |
deposition of extensively hyperphosphorylated tau in specific brain cells is a clear pathological hallmark in alzheimer's disease and a number of other neurodegenerative disorders, collectively termed the tauopathies. |
2021-09-04 |
2023-08-13 |
mouse |
| Lasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K Överby, Poul Henning Jense. PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32716602. |
these findings indicate that pkr, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as alzheimer's disease and chronic traumatic encephalopathy where inflammation is severe. |
2021-09-04 |
2023-08-13 |
mouse |
| Ajantha Abey, Danielle Davies, Claire Goldsbury, Michael Buckland, Michael Valenzuela, Thomas Dunca. Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32810333. |
distribution of tau hyperphosphorylation in canine dementia resembles early alzheimer's disease and other tauopathies. |
2021-09-04 |
2023-08-13 |
human |
| Becky C Carlyle, Savannah E Kandigian, Johannes Kreuzer, Sudeshna Das, Bianca A Trombetta, Yikai Kuo, David A Bennett, Julie A Schneider, Vladislav A Petyuk, Robert R Kitchen, Robert Morris, Angus C Nairn, Bradley T Hyman, Wilhelm Haas, Steven E Arnol. Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics. Neurobiology of aging. vol 105. 2021-09-03. PMID:34052751. |
alzheimer's disease (ad) is defined by the presence of abundant amyloid-β (aβ) and tau neuropathology. |
2021-09-03 |
2023-08-13 |
human |
| Kanoh Kondo, Teikichi Ikura, Hikari Tanaka, Kyota Fujita, Sumire Takayama, Yuki Yoshioka, Kazuhiko Tagawa, Hidenori Homma, Su Liu, Ryosuke Kawasaki, Yong Huang, Nobutoshi Ito, Shin-Ichi Tate, Hitoshi Okazaw. Hepta-Histidine Inhibits Tau Aggregation. ACS chemical neuroscience. vol 12. issue 16. 2021-09-03. PMID:34319089. |
tau aggregation is a central hallmark of tauopathies such as frontotemporal lobar degeneration and progressive supranuclear palsy as well as of alzheimer's disease, and it has been a target for therapeutic development. |
2021-09-03 |
2023-08-13 |
Not clear |
| Dongqin Wu, Di Gao, Haitao Yu, Guilin Pi, Rui Xiong, Huiyang Lei, Xin Wang, Enjie Liu, Jinwang Ye, Huilin Yu, Yang Gao, Ting He, Tao Jiang, Fei Sun, Jingfen Su, Guoda Song, Wenju Peng, Ying Yang, Jian-Zhi Wan. Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway. Clinical and translational medicine. vol 11. issue 6. 2021-09-02. PMID:34185417. |
tau accumulation and cholinergic impairment are characteristic pathologies in alzheimer's disease (ad). |
2021-09-02 |
2023-08-13 |
mouse |
| Mohan Zhang, Qiuping Wu, Ruoxi Zhao, Xuanbao Yao, Xiubo Du, Qiong Liu, Guohua Lv, Shifeng Xia. Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease. Food & function. vol 12. issue 17. 2021-09-02. PMID:34269361. |
isobavachalcone ameliorates cognitive deficits, and aβ and tau pathologies in triple-transgenic mice with alzheimer's disease. |
2021-09-02 |
2023-08-13 |
mouse |
| Elisabeth H Thijssen, Renaud La Joie, Amelia Strom, Corrina Fonseca, Leonardo Iaccarino, Amy Wolf, Salvatore Spina, Isabel E Allen, Yann Cobigo, Hilary Heuer, Lawren VandeVrede, Nicholas K Proctor, Argentina Lario Lago, Suzanne Baker, Rajeev Sivasankaran, Agnieszka Kieloch, Arvind Kinhikar, Lili Yu, Marie-Anne Valentin, Andreas Jeromin, Henrik Zetterberg, Oskar Hansson, Niklas Mattsson-Carlgren, Danielle Graham, Kaj Blennow, Joel H Kramer, Lea T Grinberg, William W Seeley, Howard Rosen, Bradley F Boeve, Bruce L Miller, Charlotte E Teunissen, Gil D Rabinovici, Julio C Rojas, Jeffrey L Dage, Adam L Boxe. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. The Lancet. Neurology. vol 20. issue 9. 2021-09-02. PMID:34418401. |
plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. |
2021-09-02 |
2023-08-13 |
human |
| Elisabeth H Thijssen, Renaud La Joie, Amelia Strom, Corrina Fonseca, Leonardo Iaccarino, Amy Wolf, Salvatore Spina, Isabel E Allen, Yann Cobigo, Hilary Heuer, Lawren VandeVrede, Nicholas K Proctor, Argentina Lario Lago, Suzanne Baker, Rajeev Sivasankaran, Agnieszka Kieloch, Arvind Kinhikar, Lili Yu, Marie-Anne Valentin, Andreas Jeromin, Henrik Zetterberg, Oskar Hansson, Niklas Mattsson-Carlgren, Danielle Graham, Kaj Blennow, Joel H Kramer, Lea T Grinberg, William W Seeley, Howard Rosen, Bradley F Boeve, Bruce L Miller, Charlotte E Teunissen, Gil D Rabinovici, Julio C Rojas, Jeffrey L Dage, Adam L Boxe. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. The Lancet. Neurology. vol 20. issue 9. 2021-09-02. PMID:34418401. |
plasma tau phosphorylated at threonine 217 (p-tau217) and plasma tau phosphorylated at threonine 181 (p-tau181) are associated with alzheimer's disease tau pathology. |
2021-09-02 |
2023-08-13 |
human |
| Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Jeiran Choupan, Ryan P Cabeen, Kirsten M Lynch, Malcolm S Crawford, Haoyu Lan, Wendy J Mack, Helena C Chui, John M Ringman, Arthur W Tog. Volumetric distribution of perivascular space in relation to mild cognitive impairment. Neurobiology of aging. vol 99. 2021-09-01. PMID:33422892. |
surprisingly, we noted lower pvs presence in the anterosuperior medial temporal lobe (asmtl) (1.29 times lower pvs volume fraction in cognitively impaired individuals, p < 0.0001), which was associated with entorhinal neurofibrillary tau tangle deposition (beta (standard error) = -0.98 (0.4); p = 0.014), one of the hallmarks of early alzheimer's disease pathology. |
2021-09-01 |
2023-08-13 |
human |
| Yan Yan, Hua Yan, Ying Teng, Qin Wang, Ping Yang, Le Zhang, Han Cheng, Siwen F. Long non-coding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease. The journal of gene medicine. vol 22. issue 12. 2021-08-31. PMID:32891070. |
long non-coding rna 00507/mirna-181c-5p/ttbk1/mapt axis regulates tau hyperphosphorylation in alzheimer's disease. |
2021-08-31 |
2023-08-13 |
Not clear |
| Yan Yan, Hua Yan, Ying Teng, Qin Wang, Ping Yang, Le Zhang, Han Cheng, Siwen F. Long non-coding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease. The journal of gene medicine. vol 22. issue 12. 2021-08-31. PMID:32891070. |
tau hyperphosphorylation is involved in the progression of alzheimer's disease (ad). |
2021-08-31 |
2023-08-13 |
Not clear |
| Nikolay Solovyev, Ahmed H El-Khatib, Marta Costas-Rodríguez, Karima Schwab, Elizabeth Griffin, Andrea Raab, Bettina Platt, Franz Theuring, Jochen Vogl, Frank Vanhaeck. Cu, Fe, and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy. The Journal of biological chemistry. vol 296. 2021-08-31. PMID:33453282. |
alzheimer's disease (ad) is characterized by accumulation of tau and amyloid-beta in the brain, and recent evidence suggests a correlation between associated protein aggregates and trace elements, such as copper, iron, and zinc. |
2021-08-31 |
2023-08-13 |
mouse |
| Mohammad Nasir Uddin, Montasir Elahi, Shotaro Shimonaka, Soichiro Kakuta, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattor. Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy. Biochemical and biophysical research communications. vol 543. 2021-08-31. PMID:33517128. |
sh-sy5y cells were transfected with c-terminal tau fragment tau-ctf24 (residues 243-441), and alzheimer's disease (ad), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd) brain seeds were introduced. |
2021-08-31 |
2023-08-13 |
Not clear |
| Measho H Abreha, Shamsideen Ojelade, Eric B Dammer, Zachary T McEachin, Duc M Duong, Marla Gearing, Gary J Bassell, James J Lah, Allan I Levey, Joshua M Shulman, Nicholas T Seyfrie. TBK1 interacts with tau and enhances neurodegeneration in tauopathy. The Journal of biological chemistry. vol 296. 2021-08-31. PMID:33965374. |
one of the defining pathological features of alzheimer's disease (ad) is the deposition of neurofibrillary tangles (nfts) composed of hyperphosphorylated tau in the brain. |
2021-08-31 |
2023-08-13 |
human |
| Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Md Saidur Rahman, Md Mamunur Rashid, Bonglee Ki. Exposure to Environmental Arsenic and Emerging Risk of Alzheimer's Disease: Perspective Mechanisms, Management Strategy, and Future Directions. Toxics. vol 9. issue 8. 2021-08-31. PMID:34437506. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2021-08-31 |
2023-08-13 |
human |
| Christian Humpe. NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimer's Disease? Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453299. |
alzheimer's disease (ad) is a severe neurodegenerative disorder of the brain characterized by extracellular beta-amyloid plaques, intraneuronal tau inclusions, vascular impairment, inflammation, neurodegeneration, and memory loss. |
2021-08-31 |
2023-08-13 |
Not clear |
| Brad Dickerson, Alireza Atr. Molecular Imaging Biomarkers in Dementia: Amyloid and tau PET imaging aids evaluation of patients suspected of having Alzheimer disease or other dementias. Practical neurology (Fort Washington, Pa.). vol 19. issue 9. 2021-08-31. PMID:34456638. |
molecular imaging biomarkers in dementia: amyloid and tau pet imaging aids evaluation of patients suspected of having alzheimer disease or other dementias. |
2021-08-31 |
2023-08-13 |
Not clear |