| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas J Ashton, Wagner S Brum, Guglielmo Di Molfetta, Andrea L Benedet, Burak Arslan, Erin Jonaitis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero-Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterber. Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology. JAMA neurology. 2024-01-22. PMID:38252443. |
diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for alzheimer disease pathology. |
2024-01-22 |
2024-01-24 |
Not clear |
| Nicholas J Ashton, Wagner S Brum, Guglielmo Di Molfetta, Andrea L Benedet, Burak Arslan, Erin Jonaitis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero-Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterber. Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology. JAMA neurology. 2024-01-22. PMID:38252443. |
phosphorylated tau (p-tau) is a specific blood biomarker for alzheimer disease (ad) pathology, with p-tau217 considered to have the most utility. |
2024-01-22 |
2024-01-24 |
Not clear |
| Johan Gobom, Ann Brinkmalm, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterber. Alzheimer's disease biomarker analysis using targeted mass spectrometry. Molecular & cellular proteomics : MCP. 2024-01-21. PMID:38246483. |
alzheimer's disease (ad) is characterised by several neuropathological changes, mainly extracellular amyloid aggregates (plaques), intraneuronal inclusions of phosphorylated tau (tangles), as well as neuronal and synaptic degeneration, accompanied by tissue reactions to these processes (astrocytosis and microglial activation) that precede neuronal network disturbances in the symptomatic phase of the disease. |
2024-01-21 |
2024-01-24 |
Not clear |
| Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease. Cell reports. vol 43. issue 2. 2024-01-20. PMID:38244198. |
spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in alzheimer's disease. |
2024-01-20 |
2024-01-23 |
Not clear |
| Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease. Cell reports. vol 43. issue 2. 2024-01-20. PMID:38244198. |
amyloid-β (aβ) and tau proteins accumulate within distinct neuronal systems in alzheimer's disease (ad). |
2024-01-20 |
2024-01-23 |
Not clear |
| Jangampalli Adi Pradeepkiran, Priyanka Rawat, Arubala P Reddy, Erika Orlov, P Hemachandra Redd. DDQ Anti-aging properties expressed with improved mitophagy in mutant Tau HT22 neuronal cells. Mitochondrion. 2024-01-20. PMID:38244850. |
the purpose of our study is to develop age-related phosphorylated tau (p-tau) inhibitors, for alzheimer's disease (ad). |
2024-01-20 |
2024-01-23 |
Not clear |
| Susan M Landau, JiaQie Lee, Alice Murphy, Tyler J Ward, Theresa M Harrison, Suzanne L Baker, Charles DeCarli, Danielle Harvey, Duygu Tosun, Michael W Weiner, Robert A Koeppe, William J Jagus. Individuals with Alzheimer's disease and low tau burden: Characteristics and implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-01-19. PMID:38241084. |
individuals with alzheimer's disease and low tau burden: characteristics and implications. |
2024-01-19 |
2024-01-22 |
Not clear |
| Susan M Landau, JiaQie Lee, Alice Murphy, Tyler J Ward, Theresa M Harrison, Suzanne L Baker, Charles DeCarli, Danielle Harvey, Duygu Tosun, Michael W Weiner, Robert A Koeppe, William J Jagus. Individuals with Alzheimer's disease and low tau burden: Characteristics and implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-01-19. PMID:38241084. |
abnormal amyloid-beta (aβ) and tau deposition define alzheimer's disease (ad), but non-elevated tau is relatively frequent in patients on the ad pathway. |
2024-01-19 |
2024-01-22 |
Not clear |
| Qing-Qing Tao, Xue Cai, Yan-Yan Xue, Weigang Ge, Liang Yue, Xiao-Yan Li, Rong-Rong Lin, Guo-Ping Peng, Wenhao Jiang, Sainan Li, Kun-Mu Zheng, Bin Jiang, Jian-Ping Jia, Tiannan Guo, Zhi-Ying W. Alzheimer's disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling. Innovation (Cambridge (Mass.)). vol 5. issue 1. 2024-01-18. PMID:38235188. |
amyloid-β, tau pathology, and biomarkers of neurodegeneration make up the core diagnostic biomarkers of alzheimer disease (ad). |
2024-01-18 |
2024-01-20 |
human |
| Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyma. Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology. 2024-01-18. PMID:38236720. |
alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. |
2024-01-18 |
2024-01-21 |
human |
| Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyma. Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology. 2024-01-18. PMID:38236720. |
we characterized the aqueous extractable and sarkosyl insoluble fibrillar tau species derived from human alzheimer brain using mass spectrometry and in vitro bioassays. |
2024-01-18 |
2024-01-21 |
human |
| Y Ito, S Takeda, T Nakajima, A Oyama, H Takeshita, K Miki, Y Takami, Y Takeya, M Shimamura, H Rakugi, R Morishit. High-Fat Diet-Induced Diabetic Conditions Exacerbate Cognitive Impairment in a Mouse Model of Alzheimer's Disease Via a Specific Tau Phosphorylation Pattern. The journal of prevention of Alzheimer's disease. vol 11. issue 1. 2024-01-17. PMID:38230726. |
high-fat diet-induced diabetic conditions exacerbate cognitive impairment in a mouse model of alzheimer's disease via a specific tau phosphorylation pattern. |
2024-01-17 |
2024-01-19 |
mouse |
| Mehrzad Moghadasi, Fatemeh Akbari, Parisa Najaf. Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer's disease. Molecular biology reports. vol 51. issue 1. 2024-01-16. PMID:38227208. |
interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of alzheimer's disease. |
2024-01-16 |
2024-01-18 |
rat |
| Brad Richardson, Thomas Goedert, Shmma Quraishe, Katrin Deinhardt, Amritpal Mudhe. How do neurons age? A focused review on the aging of the microtubular cytoskeleton. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227514. |
several recent studies have suggested that there is an age-related increase in the phosphorylation of the key microtubule stabilizing protein tau, a modification, which is known to destabilize the cytoskeleton in alzheimer's disease. |
2024-01-16 |
2024-01-18 |
Not clear |
| b' Laia Gutierrez-Tordera, Christopher Papandreou, Nil Novau-Ferr\\xc3\\xa9, Pablo Garc\\xc3\\xada-Gonz\\xc3\\xa1lez, Melina Rojas, Marta Marqui\\xc3\\xa9, Luis A Chapado, Christos Papagiannopoulos, No\\xc3\\xa8lia Fern\\xc3\\xa0ndez-Castillo, Sergi Valero, Jaume Folch, Miren Ettcheto, Antoni Camins, Merc\\xc3\\xa8 Boada, Agust\\xc3\\xadn Ruiz, M\\xc3\\xb2nica Bull\\xc3\\xb. Exploring small non-coding RNAs as blood-based biomarkers to predict Alzheimer\'s disease. Cell & bioscience. vol 14. issue 1. 2024-01-16. PMID:38229129.' |
alzheimer's disease (ad) diagnosis relies on clinical symptoms complemented with biological biomarkers, the amyloid tau neurodegeneration (atn) framework. |
2024-01-16 |
2024-01-19 |
Not clear |
| Ying Zhang, Jiaying Lu, Min Wang, Chuantao Zuo, Jiehui Jian. Influence of Gender on Tau Precipitation in Alzheimer's Disease According to ATN Research Framework. Phenomics (Cham, Switzerland). vol 3. issue 6. 2024-01-15. PMID:38223687. |
influence of gender on tau precipitation in alzheimer's disease according to atn research framework. |
2024-01-15 |
2024-01-17 |
Not clear |
| Ying Zhang, Jiaying Lu, Min Wang, Chuantao Zuo, Jiehui Jian. Influence of Gender on Tau Precipitation in Alzheimer's Disease According to ATN Research Framework. Phenomics (Cham, Switzerland). vol 3. issue 6. 2024-01-15. PMID:38223687. |
tau proteins accumulation and their spreading pattern were affected by gender in cognitive impairment patients, especially in the progression of alzheimer's disease (ad). |
2024-01-15 |
2024-01-17 |
Not clear |
| Chen Hai-Chao, Cao Jia-Xin, Zhang Yi-Shu, Ma Yue-Zhang, Zhang Lu, Su Xiao-Mei, Gao Li-Ping, Jing Yu- Hon. High salt diet exacerbates cognitive deficits and neurovascular abnormalities in APP/PS1 mice and induces AD-like changes in wild-type mice. The Journal of nutritional biochemistry. 2024-01-13. PMID:38218348. |
although clinical data do not clearly indicate the relationship between hsd and the prevalence of alzheimer's disease (ad), animal experiments have shown that hsd can cause hyperphosphorylation of tau protein and cognition impairment. |
2024-01-13 |
2024-01-16 |
mouse |
| Wei Ma, Kui Lu, Hua-Min Liang, Jin-Yuan Zhan. Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study. Current Alzheimer research. 2024-01-12. PMID:38213171. |
alzheimer's disease (ad) is a persistent neuropathological injury that manifests via neuronal/synaptic death, age spot development, tau hyperphosphorylation, neuroinflammation, and apoptosis. |
2024-01-12 |
2024-01-14 |
rat |
| Mridula Bhalla, C Justin Le. Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state. Molecular brain. vol 17. issue 1. 2024-01-12. PMID:38216963. |
alzheimer's disease (ad) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-aminobutyric acid (gaba) and reactive oxygen species from astrocytes, and subsequent neurodegeneration. |
2024-01-12 |
2024-01-15 |
mouse |