All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Amelia Strom, Leonardo Iaccarino, Lauren Edwards, Orit H Lesman-Segev, David N Soleimani-Meigooni, Julie Pham, Suzanne L Baker, Susan Landau, William J Jagust, Bruce L Miller, Howard J Rosen, Maria Luisa Gorno-Tempini, Gil D Rabinovici, Renaud La Joi. Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease. Brain : a journal of neurology. 2021-08-10. PMID:34373896. cortical hypometabolism reflects local atrophy and tau pathology in symptomatic alzheimer's disease. 2021-08-10 2023-08-13 human
Amelia Strom, Leonardo Iaccarino, Lauren Edwards, Orit H Lesman-Segev, David N Soleimani-Meigooni, Julie Pham, Suzanne L Baker, Susan Landau, William J Jagust, Bruce L Miller, Howard J Rosen, Maria Luisa Gorno-Tempini, Gil D Rabinovici, Renaud La Joi. Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease. Brain : a journal of neurology. 2021-08-10. PMID:34373896. overall, in two independent groups of patients at symptomatic stages of alzheimer's disease, cortical hypometabolism mainly reflected structural neurodegeneration and tau, but not amyloid, pathology. 2021-08-10 2023-08-13 human
Mercedes Arnes, Maria E Alaniz, Caline S Karam, Joshua D Cho, Gonzalo Lopez, Jonathan A Javitch, Ismael Santa-Mari. Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep. Frontiers in aging neuroscience. vol 11. 2021-08-09. PMID:31824299. since in alzheimer's disease and related tauopathies tau proteostasis is compromised, here we sought to understand the role of tau protein in neuronal circadian biology and related behavior. 2021-08-09 2023-08-13 Not clear
Fumihiko Yasuno, Hiroyuki Minam. Significant effects of cholinesterase inhibitors on tau pathology in the Alzheimer's disease continuum: An in vivo positron emission tomography study. International journal of geriatric psychiatry. vol 36. issue 8. 2021-08-09. PMID:33594726. significant effects of cholinesterase inhibitors on tau pathology in the alzheimer's disease continuum: an in vivo positron emission tomography study. 2021-08-09 2023-08-13 human
Fumihiko Yasuno, Hiroyuki Minam. Significant effects of cholinesterase inhibitors on tau pathology in the Alzheimer's disease continuum: An in vivo positron emission tomography study. International journal of geriatric psychiatry. vol 36. issue 8. 2021-08-09. PMID:33594726. no prior study has assessed the effects of cholinesterase inhibitors (cheis) on tau pathology in the brains of patients with alzheimer's disease (ad). 2021-08-09 2023-08-13 human
Elizabeth E Moore, Dandan Liu, Judy Li, Samantha J Schimmel, Francis E Cambronero, James G Terry, Sangeeta Nair, Kimberly R Pechman, Marissa E Moore, Susan P Bell, Joshua A Beckman, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, John Jeffrey Carr, Angela L Jefferso. Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. Neurology. vol 97. issue 4. 2021-08-09. PMID:34031194. to test the hypothesis that increased aortic stiffening is associated with greater csf evidence of core alzheimer disease pathology (β-amyloid [aβ], phosphorylated tau [p-tau]), neurodegeneration (total tau [t-tau]), synaptic dysfunction (neurogranin), neuroaxonal injury (neurofilament light [nfl]), and neuroinflammation (ykl-40, soluble triggering receptor expressed on myeloid cells 2 [strem2]), we analyzed pulse wave velocity (pwv) data and csf data among older adults. 2021-08-09 2023-08-13 Not clear
Huan He, Yuying Liu, Yunxiang Sun, Feng Din. Misfolding and Self-Assembly Dynamics of Microtubule-Binding Repeats of the Alzheimer-Related Protein Tau. Journal of chemical information and modeling. vol 61. issue 6. 2021-08-09. PMID:34032430. pathological aggregation of intrinsically disordered tau protein, driven by the interactions between microtubule-binding (mtb) domains, is associated with alzheimer's disease. 2021-08-09 2023-08-13 Not clear
Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. co-occurrence of tau and α-synuclein pathologies in a subset of alzheimer's disease patients has led to the idea that mixed pathologies may play a unique characteristic role in the alzheimer's disease neurodegenerative cascade. 2021-08-07 2023-08-13 mouse
Ellen Singleton, Oskar Hansson, Yolande A L Pijnenburg, Renaud La Joie, William G Mantyh, Pontus Tideman, Erik Stomrud, Antoine Leuzy, Maurits Johansson, Olof Strandberg, Ruben Smith, Evi Berendrecht, Bruce L Miller, Leonardo Iaccarino, Lauren Edwards, Amelia Strom, Emma E Wolters, Emma Coomans, Denise Visser, Sandeep S V Golla, Hayel Tuncel, Femke Bouwman, John Cornelis Van Swieten, Janne M Papma, Bart van Berckel, Philip Scheltens, Anke A Dijkstra, Gil D Rabinovici, Rik Ossenkoppel. Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. 2021-08-07. PMID:33850001. heterogeneous distribution of tau pathology in the behavioural variant of alzheimer's disease. 2021-08-07 2023-08-13 Not clear
Sagar Gaikwad, Nicha Puangmalai, Alice Bittar, Mauro Montalbano, Stephanie Garcia, Salome McAllen, Nemil Bhatt, Minal Sonawane, Urmi Sengupta, Rakez Kaye. Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia. Cell reports. vol 36. issue 3. 2021-08-07. PMID:34289368. tau oligomer induced hmgb1 release contributes to cellular senescence and neuropathology linked to alzheimer's disease and frontotemporal dementia. 2021-08-07 2023-08-13 mouse
Sagar Gaikwad, Nicha Puangmalai, Alice Bittar, Mauro Montalbano, Stephanie Garcia, Salome McAllen, Nemil Bhatt, Minal Sonawane, Urmi Sengupta, Rakez Kaye. Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia. Cell reports. vol 36. issue 3. 2021-08-07. PMID:34289368. aging, pathological tau oligomers (tauo), and chronic inflammation in the brain play a central role in tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd). 2021-08-07 2023-08-13 mouse
Neelam Younas, Saima Zafar, Mohsin Shafiq, Aneeqa Noor, Anna Siegert, Amandeep Singh Arora, Alexey Galkin, Ayesha Zafar, Mathias Schmitz, Christine Stadelmann, Olivier Andreoletti, Isidre Ferrer, Inga Zer. SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer's disease. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32577828. sfpq and tau: critical factors contributing to rapid progression of alzheimer's disease. 2021-08-06 2023-08-13 mouse
Juan Lantero Rodriguez, Thomas K Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashto. Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32720099. the neuropathological confirmation of amyloid-β (aβ) plaques and tau neurofibrillary tangles (nft) remains the gold standard for a definitive diagnosis of alzheimer's disease (ad). 2021-08-06 2023-08-13 Not clear
Arne Ittner, Prita Riana Asih, Amanda R P Tan, Emmanuel Prikas, Josefine Bertz, Kristie Stefanoska, Yijun Lin, Alexander M Volkerling, Yazi D Ke, Fabien Delerue, Lars M Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32725265. hyperphosphorylation of the neuronal tau protein contributes to alzheimer's disease (ad) by promoting tau pathology and neuronal and cognitive deficits. 2021-08-06 2023-08-13 mouse
Arne Ittner, Prita Riana Asih, Amanda R P Tan, Emmanuel Prikas, Josefine Bertz, Kristie Stefanoska, Yijun Lin, Alexander M Volkerling, Yazi D Ke, Fabien Delerue, Lars M Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32725265. furthermore, genome editing of the t205 codon in the murine mapt gene showed that this single side chain in endogenous tau critically modulates memory deficits in app-transgenic alzheimer's mice. 2021-08-06 2023-08-13 mouse
Sreeja Lakshmi, Shamprasad Varija Raghu, Preetham Elumalai, Sureshkumar Siva. Alkoxy glycerol enhanced activity of Oxyresveratrol in Alzheimer's disease by rescuing Tau protein. Neuroscience letters. vol 759. 2021-08-06. PMID:34023407. alkoxy glycerol enhanced activity of oxyresveratrol in alzheimer's disease by rescuing tau protein. 2021-08-06 2023-08-13 drosophila_melanogaster
Ting-Ting Hou, Yun-Dan Han, Lin Cong, Cui-Cui Liu, Xiao-Yan Liang, Fu-Zhong Xue, Yi-Feng D. Apolipoprotein E Facilitates Amyloid-β Oligomer-Induced Tau Phosphorylation. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065788. hyperphosphorylated tau is one of the key characteristics of alzheimer's disease (ad), and tau pathology correlates with cognitive impairment in ad better than amyloid-β (aβ) pathology. 2021-08-05 2023-08-13 mouse
Laetitia Miguel, Thierry Frebourg, Dominique Campion, Magalie Lecourtoi. Moderate Overexpression of Tau in Drosophila Exacerbates Amyloid-β-Induced Neuronal Phenotypes and Correlates with Tau Oligomerization. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065789. alzheimer's disease (ad) is neuropathologically defined by two key hallmarks: extracellular senile plaques composed primarily of amyloid-β (aβ) peptide and intraneuronal neurofibrillary tangles, containing abnormally hyperphosphorylated tau protein. 2021-08-05 2023-08-13 drosophila_melanogaster
Maureen Okafor, Jonathon A Nye, Mahsa Shokouhi, Leslie M Shaw, Felicia Goldstein, Ihab Hajja. 18F-Flortaucipir PET Associations with Cerebrospinal Fluid, Cognition, and Neuroimaging in Mild Cognitive Impairment due to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065800. tau positron emission tomography (pet) imaging is used in research, but its relation to cerebrospinal fluid (csf) tau and other alzheimer's disease (ad)-related clinical measures is unclear in mild cognitive impairment with ad biomarkers (mci-ad). 2021-08-05 2023-08-13 Not clear
Osama Garwain, V Siddartha Yerramilli, Kate Romero, Suzanne Scarlat. The Gαq/phospholipase Cβ signaling system represses tau aggregation. Cellular signalling. vol 71. 2021-08-05. PMID:32247043. alzheimer's disease is typified by calcium dysfunction and neurofibrillary tangles of tau aggregates along with mitotic proteins. 2021-08-05 2023-08-13 Not clear