| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marten Beeg, Elisabetta Battocchio, Ada De Luigi, Laura Colombo, Carmina Natale, Alfredo Cagnotto, Alessandro Corbelli, Fabio Fiordaliso, Luisa Diomede, Mario Salmona, Marco Gobb. Nonphosphorylated tau slows down Aβ The Journal of biological chemistry. vol 296. 2021-08-23. PMID:33865852. |
nonphosphorylated tau slows down aβ the formation of neurofibrillary tangles and amyloid plaques accompanies the progression of alzheimer's disease. |
2021-08-23 |
2023-08-13 |
Not clear |
| Lin Zhu, Linlin Xu, Xiaohui Wu, Fei Deng, Rujiang Ma, Yang Liu, Fan Huang, Linqi Sh. Tau-Targeted Multifunctional Nanoinhibitor for Alzheimer's Disease. ACS applied materials & interfaces. vol 13. issue 20. 2021-08-23. PMID:33999598. |
with the failure of various amyloid-β-targeted drugs for alzheimer's disease (ad) in clinical trials, tau protein has gained growing attention as an alternative therapeutic target in recent years. |
2021-08-23 |
2023-08-13 |
Not clear |
| Mara Mathe. Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease? Seminars in cell & developmental biology. vol 116. 2021-08-23. PMID:34099360. |
these by-products of neural activity can aggregate into the tau tangle and amyloid plaque signatures of alzheimer's disease. |
2021-08-23 |
2023-08-13 |
Not clear |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
alzheimer's disease comprises amyloid-β and hyperphosphorylated tau accumulation, imbalanced neuronal activity, aberrant oscillatory rhythms, and cognitive deficits. |
2021-08-23 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
non-demented with alzheimer's disease neuropathology (ndan) defines a novel clinical entity with amyloid-β and tau pathologies but preserved cognition. |
2021-08-23 |
2023-08-13 |
mouse |
| Manuel Yepe. The plasminogen activating system in the pathogenesis of Alzheimer's disease. Neural regeneration research. vol 16. issue 10. 2021-08-22. PMID:33642369. |
alzheimer's disease (ad) accounts for approximately 60-80% of all cases of dementia, and neuropathologically is characterized by extracellular deposits of insoluble amyloid-β (aβ) and intracellular aggregates of hyperphosphorylated tau. |
2021-08-22 |
2023-08-13 |
Not clear |
| Huang Kuang, Yu-Ge Zhu, Zhi-Feng Zhou, Mei-Wen Yang, Fen-Fang Hong, Shu-Long Yan. Sleep disorders in Alzheimer's disease: the predictive roles and potential mechanisms. Neural regeneration research. vol 16. issue 10. 2021-08-21. PMID:33642368. |
sleep disorders further impair cognitive function and accelerate the accumulation of amyloid-β and tau in patients with alzheimer's disease. |
2021-08-21 |
2023-08-13 |
Not clear |
| Audrey J Weber, Jeremy H Herskowit. Perspectives on ROCK2 as a Therapeutic Target for Alzheimer's Disease. Frontiers in cellular neuroscience. vol 15. 2021-08-21. PMID:33790742. |
recent studies indicate that dysregulation of autophagy contributes to the development of misfolded tau aggregates among entorhinal cortex (ec) excitatory neurons in early alzheimer's disease (ad). |
2021-08-21 |
2023-08-13 |
Not clear |
| Jacob W Vogel, Yasser Iturria-Medina, Olof T Strandberg, Ruben Smith, Elizabeth Levitis, Alan C Evans, Oskar Hansso. Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-08-21. PMID:34354079. |
author correction: spread of pathological tau proteins through communicating neurons in human alzheimer's disease. |
2021-08-21 |
2023-08-13 |
human |
| Rong Huang, Sai Tian, Haoqiang Zhang, Wenwen Zhu, Shaohua Wan. Chronic hyperglycemia induces tau hyperphosphorylation by downregulating OGT-involved O-GlcNAcylation in vivo and in vitro. Brain research bulletin. vol 156. 2021-08-20. PMID:31931119. |
the involvement of aberrant o-glcnacylation has been identified in hyperglycemia and dm, as well as the pathogenesis of alzheimer's disease via competition with tau phosphorylation. |
2021-08-20 |
2023-08-13 |
Not clear |
| Agnieszka Wnuk, Karolina Przepiórska, Joanna Rzemieniec, Bernadeta Pietrzak, Małgorzata Kajt. Selective Targeting of Non-nuclear Estrogen Receptors with PaPE-1 as a New Treatment Strategy for Alzheimer's Disease. Neurotoxicity research. vol 38. issue 4. 2021-08-20. PMID:33025361. |
alzheimer's disease (ad) is a multifactorial and severe neurodegenerative disorder characterized by progressive memory decline, the presence of aβ plaques and tau tangles, brain atrophy, and neuronal loss. |
2021-08-20 |
2023-08-13 |
mouse |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
hippocampal subfield volume loss in older adults with amnestic mild cognitive impairment (amci) and depression history are associated with amyloid beta and tau pathology, thereby increasing the risk for alzheimer's disease (ad). |
2021-08-20 |
2023-08-13 |
Not clear |
| Xiaohui Lin, Xueyi Wen, Zaiwa Wei, Keyi Guo, Fang Shi, Tingting Huang, Wenjing Wang, Jinou Zhen. Vitamin K2 protects against Aβ42-induced neurotoxicity by activating autophagy and improving mitochondrial function in Drosophila. Neuroreport. vol 32. issue 6. 2021-08-20. PMID:33788812. |
alzheimer disease is characterized by progressive decline in cognitive function due to neurodegeneration induced by accumulation of aβ and hyperphosphorylated tau protein. |
2021-08-20 |
2023-08-13 |
drosophila_melanogaster |
| Leonardo Iaccarino, Renaud La Joie, Lauren Edwards, Amelia Strom, Daniel R Schonhaut, Rik Ossenkoppele, Julie Pham, Taylor Mellinger, Mustafa Janabi, Suzanne L Baker, David Soleimani-Meigooni, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovic. Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 1. 2021-08-19. PMID:32808011. |
a deeper understanding of the spatial relationships of β-amyloid (aβ), tau, and neurodegeneration in alzheimer's disease (ad) could provide insight into pathogenesis and clinical trial design. |
2021-08-19 |
2023-08-13 |
human |
| Joanna M Cooper, Aurelien Lathuiliere, Mary Migliorini, Allison L Arai, Mashhood M Wani, Simon Dujardin, Selen C Muratoglu, Bradley T Hyman, Dudley K Stricklan. Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. The Journal of biological chemistry. vol 296. 2021-08-19. PMID:33930462. |
in alzheimer's disease (ad), pathological forms of tau are transferred from cell to cell and "seed" aggregation of cytoplasmic tau. |
2021-08-19 |
2023-08-13 |
Not clear |
| Oskar Hansso. Biomarkers for neurodegenerative diseases. Nature medicine. vol 27. issue 6. 2021-08-19. PMID:34083813. |
positron emission tomography methods detecting amyloid-β and tau pathology in alzheimer's disease have been increasingly used to improve the design of clinical trials and observational studies. |
2021-08-19 |
2023-08-13 |
Not clear |
| Anjanet Loon, Frank Zamudio, Awa Sanneh, Breanna Brown, Shayna Smeltzer, Milene L Brownlow, Zainuddin Quadri, Melinda Peters, Edwin Weeber, Kevin Nash, Daniel C Lee, Marcia N Gordon, Dave Morgan, Maj-Linda B Selenic. Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice. GeroScience. 2021-08-19. PMID:34410588. |
c-terminal cleaved tau at d421 (∆d421-tau) accumulates in the brains of alzheimer's disease (ad) patients. |
2021-08-19 |
2023-08-13 |
mouse |
| Jose L Cantero, Mercedes Atienza, Carmen Lage, Laszlo Zaborszky, Eduard Vilaplana, Sara Lopez-Garcia, Ana Pozueta, Eloy Rodriguez-Rodriguez, Rafael Blesa, Daniel Alcolea, Alberto Lleo, Pascual Sanchez-Juan, Juan Forte. Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 4. 2021-08-18. PMID:31799623. |
atrophy of basal forebrain initiates with tau pathology in individuals at risk for alzheimer's disease. |
2021-08-18 |
2023-08-13 |
human |
| Jose L Cantero, Mercedes Atienza, Carmen Lage, Laszlo Zaborszky, Eduard Vilaplana, Sara Lopez-Garcia, Ana Pozueta, Eloy Rodriguez-Rodriguez, Rafael Blesa, Daniel Alcolea, Alberto Lleo, Pascual Sanchez-Juan, Juan Forte. Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 4. 2021-08-18. PMID:31799623. |
evidence suggests that the basal forebrain (bf) cholinergic system degenerates early in the course of alzheimer's disease (ad), likely due to the vulnerability of bf cholinergic neurons to tau pathology. |
2021-08-18 |
2023-08-13 |
human |
| Hyo-Moon Cho, Thi-Kim-Quy Ha, Thi-Phuong Doan, Basanta Dhodary, Jin-Pyo An, Ba-Wool Lee, Jun-Li Yang, Won-Keun O. Neuroprotective Effects of Triterpenoids from Journal of natural products. vol 83. issue 7. 2021-08-18. PMID:32569471. |
neuroprotective effects of triterpenoids from alzheimer's disease (ad), a neurocognitive impairment affecting human mental capacity, is related to the accumulation of amyloid-β peptide (aβ) and the hyperphosphorylation of tau protein. |
2021-08-18 |
2023-08-13 |
human |