| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordan Lam, Justin Lee, Charles Y Liu, Andres M Lozano, Darrin J Le. Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction. Neuromodulation : journal of the International Neuromodulation Society. vol 24. issue 2. 2021-08-18. PMID:33377280. |
treatments for alzheimer's disease are urgently needed given its enormous human and economic costs and disappointing results of clinical trials targeting the primary amyloid and tau pathology. |
2021-08-18 |
2023-08-13 |
human |
| Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kon. Amyloid and tau positive mild cognitive impairment: clinical and biomarker characteristics of dementia progression. Chinese medical journal. vol 134. issue 14. 2021-08-18. PMID:34397597. |
according to the amyloid, tau, neurodegeneration research framework classification, amyloid and tau positive (a+t+) mild cognitive impairment (mci) individuals are defined as prodromal alzheimer disease. |
2021-08-18 |
2023-08-13 |
Not clear |
| Yu Guo, Hong-Qi Li, Lin Tan, Shi-Dong Chen, Yu-Xiang Yang, Ya-Hui Ma, Chuan-Tao Zuo, Qiang Dong, Lan Tan, Jin-Tai Y. Discordant Alzheimer's neurodegenerative biomarkers and their clinical outcomes. Annals of clinical and translational neurology. vol 7. issue 10. 2021-08-17. PMID:32949193. |
in the 2018 atn framework, alzheimer's neurodegenerative biomarkers comprised cerebrospinal fluid (csf) total tau, |
2021-08-17 |
2023-08-13 |
Not clear |
| Monique P Singulani, Vanessa J R De Paula, Orestes V Forlenz. Mitochondrial dysfunction in Alzheimer's disease: Therapeutic implications of lithium. Neuroscience letters. vol 760. 2021-08-17. PMID:34161823. |
alzheimer's disease (ad) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of abnormal tau proteins within neurons and amyloid plaques in the brain parenchyma, which leads to progressive loss of neurons in the brain. |
2021-08-17 |
2023-08-13 |
Not clear |
| Marie P Schützmann, Filip Hasecke, Sarah Bachmann, Mara Zielinski, Sebastian Hänsch, Gunnar F Schröder, Hans Zempel, Wolfgang Hoye. Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting. Nature communications. vol 12. issue 1. 2021-08-17. PMID:34330900. |
amyloid-β peptide (aβ) forms metastable oligomers >50 kda, termed aβos, that are more effective than aβ amyloid fibrils at triggering alzheimer's disease-related processes such as synaptic dysfunction and tau pathology, including tau mislocalization. |
2021-08-17 |
2023-08-13 |
Not clear |
| Huiqin Zhang, Yu Cao, Lina Ma, Yun Wei, Hao L. Possible Mechanisms of Tau Spread and Toxicity in Alzheimer's Disease. Frontiers in cell and developmental biology. vol 9. 2021-08-17. PMID:34395435. |
possible mechanisms of tau spread and toxicity in alzheimer's disease. |
2021-08-17 |
2023-08-13 |
Not clear |
| Huiqin Zhang, Yu Cao, Lina Ma, Yun Wei, Hao L. Possible Mechanisms of Tau Spread and Toxicity in Alzheimer's Disease. Frontiers in cell and developmental biology. vol 9. 2021-08-17. PMID:34395435. |
the protein loses its ability to bind mts in tauopathies, and detached tau can misfold and induce the pathological changes that characterize alzheimer's disease (ad). |
2021-08-17 |
2023-08-13 |
Not clear |
| Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inou. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ vaccines. vol 5. issue 1. 2021-08-16. PMID:32219000. |
pathological aggregates of tau proteins accumulate in the brains of neurodegenerative tauopathies including alzheimer's disease and frontotemporal lobar degeneration (ftld-tau). |
2021-08-16 |
2023-08-13 |
mouse |
| Meghan K Cash, Kenneth Rockwood, John D Fisk, Sultan Darves. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of aging. vol 103. 2021-08-16. PMID:33789210. |
in sporadic alzheimer's disease (spad), acetylcholinesterase and butyrylcholinesterase, co-regulators of acetylcholine, are associated with β-amyloid plaques and tau neurofibrillary tangles in patterns suggesting a contribution to neurotoxicity. |
2021-08-16 |
2023-08-13 |
Not clear |
| Nikhil Dave, Austin S Vural, Ignazio S Piras, Wendy Winslow, Likith Surendra, Joanna K Winstone, Thomas G Beach, Matthew J Huentelman, Ramon Velazque. Identification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer's disease and related tauopathies. Acta neuropathologica. vol 142. issue 2. 2021-08-16. PMID:33978814. |
identification of retinoblastoma binding protein 7 (rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in alzheimer's disease and related tauopathies. |
2021-08-16 |
2023-08-13 |
mouse |
| Nikhil Dave, Austin S Vural, Ignazio S Piras, Wendy Winslow, Likith Surendra, Joanna K Winstone, Thomas G Beach, Matthew J Huentelman, Ramon Velazque. Identification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer's disease and related tauopathies. Acta neuropathologica. vol 142. issue 2. 2021-08-16. PMID:33978814. |
evidence indicates that tau hyper-phosphorylation and subsequent neurofibrillary tangle formation contribute to the extensive neuronal death in alzheimer's disease (ad) and related tauopathies. |
2021-08-16 |
2023-08-13 |
mouse |
| David Wallon, Susana Boluda, Anne Rovelet-Lecrux, Manon Thierry, Julien Lagarde, Laetitia Miguel, Magalie Lecourtois, Antoine Bonnevalle, Marie Sarazin, Michel Bottlaender, Mathieu Mula, Serge Marty, Natsuko Nakamura, Catherine Schramm, François Sellal, Thérèse Jonveaux, Camille Heitz, Isabelle Le Ber, Stéphane Epelbaum, Eloi Magnin, Aline Zarea, Stéphane Rousseau, Olivier Quenez, Didier Hannequin, Florence Clavaguera, Dominique Campion, Charles Duyckaerts, Gaël Nicola. Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers. Acta neuropathologica. vol 142. issue 2. 2021-08-16. PMID:34095977. |
microduplications of the 17q21.31 chromosomal region encompassing the mapt gene, which encodes the tau protein, were identified in patients with a progressive disorder initially characterized by severe memory impairment with or without behavioral changes that can clinically mimic alzheimer disease. |
2021-08-16 |
2023-08-13 |
human |
| Audra York, Angela Everhart, Michael P Vitek, Kirby W Gottschalk, Carol A Colto. Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease. ASN neuro. vol 13. 2021-08-16. PMID:34121475. |
metabolism-based gene differences in neurons expressing hyperphosphorylated at8- positive (at8+) tau in alzheimer's disease. |
2021-08-16 |
2023-08-13 |
human |
| Grace I Hallinan, Md Rejaul Hoq, Manali Ghosh, Frank S Vago, Anllely Fernandez, Holly J Garringer, Ruben Vidal, Wen Jiang, Bernardino Ghett. Structure of Tau filaments in Prion protein amyloidoses. Acta neuropathologica. vol 142. issue 2. 2021-08-16. PMID:34128081. |
we report that tau filaments in prp-caa (q160x) and gss (f198s) are composed of 3-repeat and 4-repeat tau isoforms, having a striking similarity to nfts in alzheimer disease (ad). |
2021-08-16 |
2023-08-13 |
human |
| b' Cristina Rosell-Cardona, Christian Gri\\xc3\\xb1an-Ferr\\xc3\\xa9, Anna P\\xc3\\xa9rez-Bosque, Javier Polo, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Concepci\\xc3\\xb3 Amat, Miquel Moret\\xc3\\xb3, Llu\\xc3\\xafsa Mir\\xc3\\xb. Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer\'s Disease Hallmarks in SAMP8 Mice. Nutrients. vol 13. issue 7. 2021-08-16. PMID:34371878.' |
alzheimer's disease (ad) is characterized by the aberrant processing of amyloid precursor protein (app) and the accumulation of hyperphosphorylated tau, both of which are accompanied by neuroinflammation. |
2021-08-16 |
2023-08-13 |
mouse |
| Simon Dujardin, Caitlin Commins, Aurelien Lathuiliere, Pieter Beerepoot, Analiese R Fernandes, Tarun V Kamath, Mark B De Los Santos, Naomi Klickstein, Diana L Corjuc, Bianca T Corjuc, Patrick M Dooley, Arthur Viode, Derek H Oakley, Benjamin D Moore, Kristina Mullin, Dinorah Jean-Gilles, Ryan Clark, Kevin Atchison, Renee Moore, Lori B Chibnik, Rudolph E Tanzi, Matthew P Frosch, Alberto Serrano-Pozo, Fiona Elwood, Judith A Steen, Matthew E Kennedy, Bradley T Hyma. Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature medicine. vol 27. issue 2. 2021-08-14. PMID:33514949. |
author correction: tau molecular diversity contributes to clinical heterogeneity in alzheimer's disease. |
2021-08-14 |
2023-08-13 |
Not clear |
| Sophie Schmidt, Caroline Stapf, Sandra Schmutzler, Ingolf Lachmann, Thomas Arendt, Max Holzer, Mandy Sonntag, Markus Morawsk. Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L - Acan mouse model. The European journal of neuroscience. vol 53. issue 12. 2021-08-13. PMID:32737917. |
in addition, pns were proposed to carry neuroprotective functions as pn-ensheathed neurons are mostly spared of tau pathology in brains of alzheimer patients. |
2021-08-13 |
2023-08-13 |
mouse |
| Alfonso Martinisi, Martin Flach, Frederik Sprenger, Stephan Frank, Markus Tolnay, David T Winkle. Severe oligomeric tau toxicity can be reversed without long-term sequelae. Brain : a journal of neurology. vol 144. issue 3. 2021-08-13. PMID:33484116. |
tau is a microtubule stabilizing protein that forms abnormal aggregates in many neurodegenerative disorders, including alzheimer's disease. |
2021-08-13 |
2023-08-13 |
mouse |
| Georges Naasan, Suzanne M Shdo, Estrella Morenas Rodriguez, Salvatore Spina, Lea Grinberg, Lucia Lopez, Anna Karydas, William W Seeley, Bruce L Miller, Katherine P Ranki. Psychosis in neurodegenerative disease: differential patterns of hallucination and delusion symptoms. Brain : a journal of neurology. vol 144. issue 3. 2021-08-13. PMID:33501939. |
we conducted a retrospective chart review of 372 patients with autopsy-confirmed neurodegenerative pathology: 111 with alzheimer's disease, 59 with lewy body disease and concomitant alzheimer's disease, 133 with frontotemporal lobar degeneration (ftld) with tau inclusions (including progressive supranuclear palsy, corticobasal degeneration or pick's disease), and 69 with ftld and tdp inclusions (ftld-tdp, including types a-c). |
2021-08-13 |
2023-08-13 |
Not clear |
| Yuxing Xia, Stefan Prokop, Benoit I Giasso. "Don't Phos Over Tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies. Molecular neurodegeneration. vol 16. issue 1. 2021-08-13. PMID:34090488. |
"don't phos over tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in alzheimer's disease and other tauopathies. |
2021-08-13 |
2023-08-13 |
Not clear |