| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Lantero Rodriguez, Thomas K Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashto. Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32720099. |
the neuropathological confirmation of amyloid-β (aβ) plaques and tau neurofibrillary tangles (nft) remains the gold standard for a definitive diagnosis of alzheimer's disease (ad). |
2021-08-06 |
2023-08-13 |
Not clear |
| Arne Ittner, Prita Riana Asih, Amanda R P Tan, Emmanuel Prikas, Josefine Bertz, Kristie Stefanoska, Yijun Lin, Alexander M Volkerling, Yazi D Ke, Fabien Delerue, Lars M Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32725265. |
hyperphosphorylation of the neuronal tau protein contributes to alzheimer's disease (ad) by promoting tau pathology and neuronal and cognitive deficits. |
2021-08-06 |
2023-08-13 |
mouse |
| Arne Ittner, Prita Riana Asih, Amanda R P Tan, Emmanuel Prikas, Josefine Bertz, Kristie Stefanoska, Yijun Lin, Alexander M Volkerling, Yazi D Ke, Fabien Delerue, Lars M Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32725265. |
furthermore, genome editing of the t205 codon in the murine mapt gene showed that this single side chain in endogenous tau critically modulates memory deficits in app-transgenic alzheimer's mice. |
2021-08-06 |
2023-08-13 |
mouse |
| Sreeja Lakshmi, Shamprasad Varija Raghu, Preetham Elumalai, Sureshkumar Siva. Alkoxy glycerol enhanced activity of Oxyresveratrol in Alzheimer's disease by rescuing Tau protein. Neuroscience letters. vol 759. 2021-08-06. PMID:34023407. |
alkoxy glycerol enhanced activity of oxyresveratrol in alzheimer's disease by rescuing tau protein. |
2021-08-06 |
2023-08-13 |
drosophila_melanogaster |
| Ting-Ting Hou, Yun-Dan Han, Lin Cong, Cui-Cui Liu, Xiao-Yan Liang, Fu-Zhong Xue, Yi-Feng D. Apolipoprotein E Facilitates Amyloid-β Oligomer-Induced Tau Phosphorylation. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065788. |
hyperphosphorylated tau is one of the key characteristics of alzheimer's disease (ad), and tau pathology correlates with cognitive impairment in ad better than amyloid-β (aβ) pathology. |
2021-08-05 |
2023-08-13 |
mouse |
| Laetitia Miguel, Thierry Frebourg, Dominique Campion, Magalie Lecourtoi. Moderate Overexpression of Tau in Drosophila Exacerbates Amyloid-β-Induced Neuronal Phenotypes and Correlates with Tau Oligomerization. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065789. |
alzheimer's disease (ad) is neuropathologically defined by two key hallmarks: extracellular senile plaques composed primarily of amyloid-β (aβ) peptide and intraneuronal neurofibrillary tangles, containing abnormally hyperphosphorylated tau protein. |
2021-08-05 |
2023-08-13 |
drosophila_melanogaster |
| Maureen Okafor, Jonathon A Nye, Mahsa Shokouhi, Leslie M Shaw, Felicia Goldstein, Ihab Hajja. 18F-Flortaucipir PET Associations with Cerebrospinal Fluid, Cognition, and Neuroimaging in Mild Cognitive Impairment due to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065800. |
tau positron emission tomography (pet) imaging is used in research, but its relation to cerebrospinal fluid (csf) tau and other alzheimer's disease (ad)-related clinical measures is unclear in mild cognitive impairment with ad biomarkers (mci-ad). |
2021-08-05 |
2023-08-13 |
Not clear |
| Osama Garwain, V Siddartha Yerramilli, Kate Romero, Suzanne Scarlat. The Gαq/phospholipase Cβ signaling system represses tau aggregation. Cellular signalling. vol 71. 2021-08-05. PMID:32247043. |
alzheimer's disease is typified by calcium dysfunction and neurofibrillary tangles of tau aggregates along with mitotic proteins. |
2021-08-05 |
2023-08-13 |
Not clear |
| Osama Garwain, V Siddartha Yerramilli, Kate Romero, Suzanne Scarlat. The Gαq/phospholipase Cβ signaling system represses tau aggregation. Cellular signalling. vol 71. 2021-08-05. PMID:32247043. |
taken together, our studies show that the loss of plcβ1 can promote alzheimer's disease by a combination of its catalytic activity and its interaction with mitotic proteins thus offering an orthogonal method to control tau aggregation. |
2021-08-05 |
2023-08-13 |
Not clear |
| Jan R Detrez, Inès R H Ben-Nejma, Kristof Van Kolen, Debby Van Dam, Peter Paul De Deyn, Erik Fransen, Marleen Verhoye, Jean-Pierre Timmermans, Rony Nuydens, Annemie Van der Linden, Georgios A Keliris, Winnok H De Vo. Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice. Neurobiology of disease. vol 143. 2021-08-05. PMID:32653674. |
progressive accumulation of hyperphosphorylated tau is a hallmark of various neurodegenerative disorders including alzheimer's disease. |
2021-08-05 |
2023-08-13 |
mouse |
| Benjamin Lochocki, Baayla D C Boon, Sander R Verheul, Liron Zada, Jeroen J M Hoozemans, Freek Ariese, Johannes F de Boe. Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer's disease human brain tissue. Communications biology. vol 4. issue 1. 2021-08-05. PMID:33859370. |
alzheimer's disease (ad) neuropathology is characterized by hyperphosphorylated tau containing neurofibrillary tangles and amyloid-beta (aβ) plaques. |
2021-08-05 |
2023-08-13 |
human |
| Fernanda Dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, Régis Mateus Hözer, Felippo Bifi, Cristiane Matté, Christianne Gazzana Salbego, Vera Maria Treis Trindad. Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau. The Journal of nutritional biochemistry. vol 87. 2021-08-04. PMID:33065257. |
alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta (aβ) peptide, which induces synaptic dysfunction, alteration of intracellular signaling pathways, hyperphosphorylation of the tau protein, and cognitive impairment. |
2021-08-04 |
2023-08-13 |
rat |
| Xu Hou, Jens O Watzlawik, Casey Cook, Chia-Chen Liu, Silvia S Kang, Wen-Lang Lin, Michael DeTure, Michael G Heckman, Nancy N Diehl, Fadi S Hanna Al-Shaikh, Ronald L Walton, Owen A Ross, Heather L Melrose, Nilüfer Ertekin-Taner, Guojun Bu, Leonard Petrucelli, John D Fryer, Melissa E Murray, Dennis W Dickson, Fabienne C Fiesel, Wolfdieter Springe. Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-08-04. PMID:33090691. |
mitophagy alterations in alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology. |
2021-08-04 |
2023-08-13 |
Not clear |
| Aisling M Chaney, Francisco R Lopez-Picon, Sophie Serrière, Rui Wang, Daniela Bochicchio, Samuel D Webb, Matthias Vandesquille, Michael K Harte, Christina Georgiadou, Catherine Lawrence, Julie Busson, Johnny Vercouillie, Clovis Tauber, Frédéric Buron, Sylvain Routier, Tristan Reekie, Anniina Snellman, Michael Kassiou, Johanna Rokka, Karen E Davies, Juha O Rinne, Dervis A Salih, Frances A Edwards, Llwyd D Orton, Stephen R Williams, Sylvie Chalon, Hervé Bouti. Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study. Theranostics. vol 11. issue 14. 2021-08-04. PMID:34093845. |
mouse models of alzheimer's disease (ad) are valuable but do not fully recapitulate human ad pathology, such as spontaneous tau fibril accumulation and neuronal loss, necessitating the development of new ad models. |
2021-08-04 |
2023-08-13 |
mouse |
| Siddhartha Mondragón-Rodríguez, Humberto Salgado-Burgos, Fernando Peña-Orteg. Circuitry and Synaptic Dysfunction in Alzheimer's Disease: A New Tau Hypothesis. Neural plasticity. vol 2020. 2021-08-03. PMID:32952546. |
circuitry and synaptic dysfunction in alzheimer's disease: a new tau hypothesis. |
2021-08-03 |
2023-08-13 |
Not clear |
| Yao Sun, Yongqing Guo, Xuejian Feng, Lu Fu, Yayuan Zheng, Yue Dong, Yong Zhang, Xianghui Yu, Wei Kong, Hui W. Norovirus P particle-based tau vaccine-generated phosphorylated tau antibodies markedly ameliorate tau pathology and improve behavioral deficits in mouse model of Alzheimer's disease. Signal transduction and targeted therapy. vol 6. issue 1. 2021-08-03. PMID:33579892. |
norovirus p particle-based tau vaccine-generated phosphorylated tau antibodies markedly ameliorate tau pathology and improve behavioral deficits in mouse model of alzheimer's disease. |
2021-08-03 |
2023-08-13 |
mouse |
| Sujin Kim, Yunkwon Nam, Min-Joo Ham, Chisoo Park, Minho Moon, Doo-Han Yo. Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer's Disease: A Hypothetical Review. Frontiers in aging neuroscience. vol 13. 2021-08-03. PMID:34335229. |
alzheimer's disease (ad) is an irreversible neurodegenerative brain disorder with aggregation of amyloid-beta (aβ) and tau as the pathological hallmarks. |
2021-08-03 |
2023-08-13 |
Not clear |
| Amelie Schäfer, Mathias Peirlinck, Kevin Linka, Ellen Kuh. Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease. Frontiers in physiology. vol 12. 2021-08-03. PMID:34335308. |
bayesian physics-based modeling of tau propagation in alzheimer's disease. |
2021-08-03 |
2023-08-13 |
Not clear |
| Amelie Schäfer, Mathias Peirlinck, Kevin Linka, Ellen Kuh. Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease. Frontiers in physiology. vol 12. 2021-08-03. PMID:34335308. |
amyloid-β and hyperphosphorylated tau protein are known drivers of neuropathology in alzheimer's disease. |
2021-08-03 |
2023-08-13 |
Not clear |
| Qin Li, Chunmei Xiong, Hongli Liu, Huizhen Ge, Xiaojun Yao, Huanxiang Li. Computational Insights Into the Inhibition Mechanism of Proanthocyanidin B2 on Tau Hexapeptide (PHF6) Oligomer. Frontiers in chemistry. vol 9. 2021-08-03. PMID:34336783. |
the formation of amyloid fibrils from tau is a key pathogenic feature of alzheimer's disease (ad). |
2021-08-03 |
2023-08-13 |
Not clear |