| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatjana A Ishunin. Alternative splicing in aging and Alzheimer's disease: Highlighting the role of tau and estrogen receptor α isoforms in the hypothalamus. Handbook of clinical neurology. vol 182. 2021-07-28. PMID:34266591. |
in alzheimer's disease (ad) pivotal (tau gene, in particular), risk, candidate and other genes show significant alterations in as. |
2021-07-28 |
2023-08-13 |
human |
| Elliott J Mufson, Christy Kelley, Sylvia E Pere. Chronic traumatic encephalopathy and the nucleus basalis of Meynert. Handbook of clinical neurology. vol 182. 2021-07-28. PMID:34266614. |
most recently, molecular pathobiology has been used in the field of cte, with an emphasis on the cholinergic neurons located within the nucleus basalis of meynert, which develop tau pathology and are associated with cognitive dysfunction similar to that found in alzheimer's disease (ad). |
2021-07-28 |
2023-08-13 |
human |
| Xueling Yuan, Zhuo Wang, Lei Zhang, Rubo Sui, Suliman Kha. Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease. International journal of biological macromolecules. vol 183. 2021-07-27. PMID:33965487. |
exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in alzheimer's disease. |
2021-07-27 |
2023-08-13 |
cat |
| Xueling Yuan, Zhuo Wang, Lei Zhang, Rubo Sui, Suliman Kha. Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease. International journal of biological macromolecules. vol 183. 2021-07-27. PMID:33965487. |
aggregation of tau protein into the form of insoluble amyloid fibrils is linked with alzheimer's disease. |
2021-07-27 |
2023-08-13 |
cat |
| Lei Zhang, Zhuo Wang, Xueling Yuan, Rubo Sui, Mojtaba Falahat. Evaluation of heptelidic acid as a potential inhibitor for tau aggregation-induced Alzheimer's disease and associated neurotoxicity. International journal of biological macromolecules. vol 183. 2021-07-27. PMID:33971235. |
evaluation of heptelidic acid as a potential inhibitor for tau aggregation-induced alzheimer's disease and associated neurotoxicity. |
2021-07-27 |
2023-08-13 |
Not clear |
| Lei Zhang, Zhuo Wang, Xueling Yuan, Rubo Sui, Mojtaba Falahat. Evaluation of heptelidic acid as a potential inhibitor for tau aggregation-induced Alzheimer's disease and associated neurotoxicity. International journal of biological macromolecules. vol 183. 2021-07-27. PMID:33971235. |
tau is a major component of protein plaques in tauopathies, especially alzheimer's disease (ad). |
2021-07-27 |
2023-08-13 |
Not clear |
| Irene Benito-Cuesta, Lara Ordoñez-Gutierrez, Francisco Wandosel. Trehalose Reduces the Secreted Beta-Amyloid Levels in Primary Neurons Independently of Autophagy Induction. Metabolites. vol 11. issue 7. 2021-07-27. PMID:34206776. |
these properties make trehalose an interesting therapeutic candidate against proteinopathies such as alzheimer's disease (ad), which is characterized by deposits of aggregated amyloid-beta (aβ) and hyperphosphorylated tau. |
2021-07-27 |
2023-08-13 |
mouse |
| Kyle Eckhoff, Robert Morris, Valeria Zuluaga, Rebecca Polsky, Feng Chen. The Association between Tau Protein Level in Cerebrospinal Fluid and Cognitive Status: A Large-Scale Analysis of GAAIN Database. Brain sciences. vol 11. issue 7. 2021-07-27. PMID:34209512. |
in this paper, a large-scale analysis of five datasets (more than 2500 people) from the global alzheimer's association interactive network (gaain) databases was performed to investigate the association between the level of tau protein, including total tau and phosphorylated tau (p-tau), in cerebrospinal fluid (csf) and cognitive status. |
2021-07-27 |
2023-08-13 |
mouse |
| Kyle Eckhoff, Robert Morris, Valeria Zuluaga, Rebecca Polsky, Feng Chen. The Association between Tau Protein Level in Cerebrospinal Fluid and Cognitive Status: A Large-Scale Analysis of GAAIN Database. Brain sciences. vol 11. issue 7. 2021-07-27. PMID:34209512. |
in addition, transcriptomic data derived from mouse microglial cells showed multiple genes upregulated in toll-like receptor signaling and alzheimer's disease pathways, including tnf, tlr2, il-1β, and cox subunits, suggesting that the mechanism of action that relates p-tau and mmse scores may be through overactivation of pro-inflammatory microglial activity by aβ peptides, tnf-mediated hyperphosphorylation of tau, and the infectious spread of pathological tau across healthy neurons. |
2021-07-27 |
2023-08-13 |
mouse |
| Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K Karikari, María Carmona-Iragui, Nicholas J Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Daniel Alcolea, Rafael Blesa, Kaj Blennow, Juan Forte. Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome. Nature communications. vol 12. issue 1. 2021-07-27. PMID:34262030. |
plasma tau phosphorylated at threonine 181 (p-tau181) predicts alzheimer's disease (ad) pathology with high accuracy in the general population. |
2021-07-27 |
2023-08-13 |
Not clear |
| Janine Utz, Judith Berner, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Juan Manuel Maler, Philipp Spitze. Cerebrospinal Fluid of Patients With Alzheimer's Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles. Frontiers in aging neuroscience. vol 13. 2021-07-24. PMID:34295239. |
in alzheimer's disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau. |
2021-07-24 |
2023-08-13 |
Not clear |
| Janine Utz, Judith Berner, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Juan Manuel Maler, Philipp Spitze. Cerebrospinal Fluid of Patients With Alzheimer's Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles. Frontiers in aging neuroscience. vol 13. 2021-07-24. PMID:34295239. |
the established cerebrospinal fluid markers aβ, tau and phospho-tau reflect the histopathological hallmarks of alzheimer's disease but do not indicate disease progression. |
2021-07-24 |
2023-08-13 |
Not clear |
| Lindsay H Burns, Hoau-Yan Wan. Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer's disease. Neuroimmunology and neuroinflammation. vol 4. issue 12. 2021-07-24. PMID:34295950. |
altered filamin a enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in alzheimer's disease. |
2021-07-24 |
2023-08-13 |
Not clear |
| Lindsay H Burns, Hoau-Yan Wan. Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer's disease. Neuroimmunology and neuroinflammation. vol 4. issue 12. 2021-07-24. PMID:34295950. |
alzheimer's disease (ad) is a neurodegenerative disease with proteopathy characterized by abnormalities in amyloid beta (aβ) and tau proteins. |
2021-07-24 |
2023-08-13 |
Not clear |
| Mamen Regalado-Reyes, Ruth Benavides-Piccione, Isabel Fernaud-Espinosa, Javier DeFelipe, Gonzalo León-Espinos. Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation. Cerebral cortex communications. vol 1. issue 1. 2021-07-24. PMID:34296096. |
tau protein hyperphosphorylation and aggregation have been associated with loss or alterations of dendritic spines in neurodegenerative diseases, such as alzheimer's disease (ad). |
2021-07-24 |
2023-08-13 |
Not clear |
| Alejandro Cáceres, Juan R Gonzále. Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis. Neurobiology of aging. vol 96. 2021-07-23. PMID:32977080. |
female-specific risk of alzheimer's disease is associated with tau phosphorylation processes: a transcriptome-wide interaction analysis. |
2021-07-23 |
2023-08-13 |
Not clear |
| Alejandro Cáceres, Juan R Gonzále. Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis. Neurobiology of aging. vol 96. 2021-07-23. PMID:32977080. |
the levels of tau phosphorylation differ between sexes in alzheimer's disease (ad). |
2021-07-23 |
2023-08-13 |
Not clear |
| Baihong Guo, Yangmei Huang, Qingtao Gao, Qiang Zho. Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice. Neurobiology of aging. vol 96. 2021-07-23. PMID:33039900. |
one major pathological process in alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (mts) and functions associated with tau. |
2021-07-23 |
2023-08-13 |
mouse |
| Anna H Boerwinkle, Julie K Wisch, Charles D Chen, Brian A Gordon, Omar H Butt, Suzanne E Schindler, Courtney Sutphen, Shaney Flores, Aylin Dincer, Tammie L S Benzinger, Anne M Fagan, John C Morris, Beau M Ance. Temporal Correlation of CSF and Neuroimaging in the Amyloid-Tau-Neurodegeneration Model of Alzheimer Disease. Neurology. vol 97. issue 1. 2021-07-23. PMID:33931538. |
to evaluate temporal correlations between csf and neuroimaging (pet and mri) measures of amyloid, tau, and neurodegeneration in relation to alzheimer disease (ad) progression. |
2021-07-23 |
2023-08-13 |
Not clear |
| Sebastiaan Bijttebier, Clara Theunis, Farid Jahouh, Dina Rodrigues Martins, Marc Verhemeldonck, Karolien Grauwen, Lieve Dillen, Marc Mercke. Development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients. Journal of chromatography. A. vol 1651. 2021-07-22. PMID:34107398. |
development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from alzheimer disease patients. |
2021-07-22 |
2023-08-13 |
human |