All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Caitlin N Suire, Samer O Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K Brizuela, Paul Saftig, Dennis W Dickson, Terrone L Rosenberry, Malcolm A Leissrin. Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32631408. cathepsin d (catd) is a lysosomal protease that degrades both the amyloid β-protein (aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset alzheimer disease (ad). 2021-06-24 2023-08-13 Not clear
Kyu Hwan Shim, Min Ju Kang, Jee Won Suh, Jung-Min Pyun, Nayoung Ryoo, Young Ho Park, Young Chul Youn, Jae-Won Jang, Jee Hyang Jeong, Kyung Won Park, Seong Hye Choi, Kyoungho Suk, Ho-Won Lee, Pan-Woo Ko, Chan-Nyoung Lee, Tae-Sung Lim, Seong Soo A An, SangYun Ki. CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32660565. csf total tau/α-synuclein ratio improved the diagnostic performance for alzheimer's disease as an indicator of tau phosphorylation. 2021-06-24 2023-08-13 Not clear
Ian Fyf. Tau species has potential for Alzheimer disease blood test. Nature reviews. Neurology. vol 16. issue 10. 2021-06-24. PMID:32792665. tau species has potential for alzheimer disease blood test. 2021-06-24 2023-08-13 Not clear
Tengfei Guo, Deniz Korman, Renaud La Joie, Leslie M Shaw, John Q Trojanowski, William J Jagust, Susan M Landa. Normalization of CSF pTau measurement by Aβ Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32799929. normalization of csf ptau measurement by aβ alzheimer's disease (ad)-related tauopathy can be measured with csf phosphorylated tau (ptau) and tau pet. 2021-06-24 2023-08-13 Not clear
Daniel J Norton, Mario A Parra, Reisa A Sperling, Ana Baena, Edmarie Guzman-Velez, David S Jin, Nicholas Andrea, Juna Khang, Aaron Schultz, Dorene M Rentz, Enmanuelle Pardilla-Delgado, Joshua Fuller, Keith Johnson, Eric M Reiman, Francisco Lopera, Yakeel T Quiro. Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32825838. visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant alzheimer's disease. 2021-06-24 2023-08-13 Not clear
Hanna Cho, Min Seok Baek, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32967721. principal components of tau positron emission tomography and longitudinal tau accumulation in alzheimer's disease. 2021-06-24 2023-08-13 Not clear
Hanna Cho, Min Seok Baek, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32967721. we aimed to investigate the clinical correlates of principal components (pcs) of tau positron emission tomography (pet) and their predictability for longitudinal changes in tau accumulation in alzheimer's disease (ad). 2021-06-24 2023-08-13 Not clear
Anna Rubinski, Nicolai Franzmeier, Julia Neitzel, Michael Ewer. FDG-PET hypermetabolism is associated with higher tau-PET in mild cognitive impairment at low amyloid-PET levels. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33076977. fdg-pet hypermetabolism can be observed in mild cognitive impairment (mci), but the link to primary pathologies of alzheimer's diseases (ad) including amyloid and tau is unclear. 2021-06-24 2023-08-13 Not clear
Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33129364. effect of apoe ε4 genotype on amyloid-β and tau accumulation in alzheimer's disease. 2021-06-24 2023-08-13 Not clear
Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33129364. to assess the effects of apolipoprotein e (apoe) ε4 genotype on amyloid-β (aβ) and tau burden and their longitudinal changes in alzheimer's disease (ad) spectrum. 2021-06-24 2023-08-13 Not clear
Filippo Baldacci, Simone Lista, Maria Laura Manca, Patrizia A Chiesa, Enrica Cavedo, Pablo Lemercier, Henrik Zetterberg, Kaj Blennow, Marie-Odile Habert, Marie Claude Potier, Bruno Dubois, Andrea Vergallo, Harald Hampe. Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33183357. plasma neurofilament light (nfl) and total tau (t-tau) proteins are candidate biomarkers for early stages of alzheimer's disease (ad). 2021-06-24 2023-08-13 Not clear
Nicole D Anderson, Elsa Beana, Haopei Yang, Stefan Köhle. Deficits in recent but not lifetime familiarity in amnestic mild cognitive impairment. Neuropsychologia. vol 151. 2021-06-24. PMID:33359882. accumulation of neurofibrillary tau in preclinical alzheimer's disease begins in perirhinal cortex, a medial temporal lobe region linked to familiarity. 2021-06-24 2023-08-13 Not clear
Flora H Duits, Kirsten E J Wesenhagen, Laura Ekblad, Emma Wolters, Eline A J Willemse, Philip Scheltens, Wiesje M van der Flier, Charlotte E Teunissen, Pieter Jelle Visser, Betty M Tijm. Four subgroups based on tau levels in Alzheimer's disease observed in two independent cohorts. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33397464. four subgroups based on tau levels in alzheimer's disease observed in two independent cohorts. 2021-06-24 2023-08-13 Not clear
Jing Di, Ibrar Siddique, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bita. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33397489. previously, we evaluated the effect of clr01 in the 3 × tg mouse model of alzheimer's disease, which overexpresses mutant human presenilin 1, amyloid β-protein precursor, and tau and found that subcutaneous administration of the compound for 1 month led to a robust reduction of amyloid plaques, neurofibrillary tangles, and microgliosis. 2021-06-24 2023-08-13 mouse
Jing Di, Ibrar Siddique, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bita. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33397489. clr01 also has been demonstrated to inhibit tau aggregation in vitro and tau seeding in cell culture, yet because in alzheimer's disease (ad) and in the 3 × tg model, tau hyperphosphorylation and aggregation are thought to be downstream of aβ insults, the study in this model left open the question whether clr01 affected tau in vivo directly or indirectly. 2021-06-24 2023-08-13 mouse
Anna Zettergren, Jodie Lord, Nicholas J Ashton, Andrea L Benedet, Thomas K Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blenno. Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33419453. association between polygenic risk score of alzheimer's disease and plasma phosphorylated tau in individuals from the alzheimer's disease neuroimaging initiative. 2021-06-24 2023-08-13 Not clear
Anna Zettergren, Jodie Lord, Nicholas J Ashton, Andrea L Benedet, Thomas K Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blenno. Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33419453. recent studies suggest that plasma phosphorylated tau181 (p-tau181) is a highly specific biomarker for alzheimer's disease (ad)-related tau pathology. 2021-06-24 2023-08-13 Not clear
Justin S Sanchez, Bernard J Hanseeuw, Francisco Lopera, Reisa A Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E Martinez, Joshua T Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I L Jacobs, Aaron P Schultz, Jennifer R Gatchel, J Alex Becker, Samantha R Katz, Danielle V Mayblyum, Julie C Price, Eric M Reiman, Keith A Johnson, Yakeel T Quiro. Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33451357. longitudinal amyloid and tau accumulation in autosomal dominant alzheimer's disease: findings from the colombia-boston (colbos) biomarker study. 2021-06-24 2023-08-13 Not clear
Justin S Sanchez, Bernard J Hanseeuw, Francisco Lopera, Reisa A Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E Martinez, Joshua T Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I L Jacobs, Aaron P Schultz, Jennifer R Gatchel, J Alex Becker, Samantha R Katz, Danielle V Mayblyum, Julie C Price, Eric M Reiman, Keith A Johnson, Yakeel T Quiro. Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33451357. neuroimaging studies of autosomal dominant alzheimer's disease (adad) enable characterization of the trajectories of cerebral amyloid-β (aβ) and tau accumulation in the decades prior to clinical symptom onset. 2021-06-24 2023-08-13 Not clear
Emma M Coomans, Deborah N Schoonhoven, Hayel Tuncel, Sander C J Verfaillie, Emma E Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P Sweeney, J Michael Ryan, Robert C Schuit, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S V Golla, Arjan Hillebrand, Alida A Gouw, Bart N M van Bercke. In vivo tau pathology is associated with synaptic loss and altered synaptic function. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33546722. the mechanism of synaptic loss in alzheimer's disease is poorly understood and may be associated with tau pathology. 2021-06-24 2023-08-13 Not clear