All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Mamali Das, Kasi Pandima Dev. Dihydroactinidiolide regulates Nrf2/HO-1 expression and inhibits caspase-3/Bax pathway to protect SH-SY5Y human neuroblastoma cells from oxidative stress induced neuronal apoptosis. Neurotoxicology. vol 84. 2021-06-22. PMID:33617922. alzheimer's disease (ad) etiology has been studied for a long time and it is found to be multifaceted involving the accumulation of amyloid β and tau protein. 2021-06-22 2023-08-13 human
Roberta Cascella, Cristina Cecch. Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 22. issue 9. 2021-06-22. PMID:34066371. alzheimer's disease (ad) is the most common age-related neurodegenerative disorder that is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles consisting of abnormally phosphorylated tau protein, and neuronal loss leading to cognitive decline and dementia. 2021-06-22 2023-08-13 Not clear
Ping Kwan, Haruki Konno, Ka Yan Chan, Larry Bau. Rationale for the development of an Alzheimer's disease vaccine. Human vaccines & immunotherapeutics. vol 16. issue 3. 2021-06-21. PMID:31526227. however, amyloid β (aβ) or tau, which can act like infectious proteins, or prions, might induce alzheimer's disease (ad). 2021-06-21 2023-08-13 Not clear
Xinyue Zhang, Bin Jiao, Ling Weng, Yafang Zhou, Lina Guo, Xin Wang, Lu Zhou, Xixi Liu, Xuewen Xiao, Hui Liu, Xiangyu Zhu, Chenping Li, Yuan Zhu, Qijie Yang, Zhuojie Lin, Yaling Jiang, Yafei Wen, Hui Zhou, Lu Shen, Xinxin Lia. Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population. The European journal of neuroscience. vol 52. issue 8. 2021-06-21. PMID:32506655. recently, functional studies have demonstrated that legumain (lgmn) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of alzheimer's disease (ad). 2021-06-21 2023-08-13 Not clear
Jeremy D Baker, Rikki L Uhrich, Timothy J Strovas, Aleen D Saxton, Brian C Kraeme. Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA-Protein Interaction. ACS chemical neuroscience. vol 11. issue 15. 2021-06-21. PMID:32589834. neurofibrillary tangles composed of aberrantly aggregating tau protein are a hallmark of alzheimer's disease and related dementia disorders. 2021-06-21 2023-08-13 mouse
Liangping Li, Jiawen Liang, Hongjun F. An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33171143. an update on the association between traumatic brain injury and alzheimer's disease: focus on tau pathology and synaptic dysfunction. 2021-06-21 2023-08-13 Not clear
Liangping Li, Jiawen Liang, Hongjun F. An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33171143. an update on the association between traumatic brain injury and alzheimer's disease: focus on tau pathology and synaptic dysfunction. 2021-06-21 2023-08-13 Not clear
Evan Lester, Felicia K Ooi, Nadine Bakkar, Jacob Ayers, Amanda L Woerman, Joshua Wheeler, Robert Bowser, George A Carlson, Stanley B Prusiner, Roy Parke. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. vol 109. issue 10. 2021-06-21. PMID:33848474. tau aggregates contribute to neurodegenerative diseases, including frontotemporal dementia and alzheimer's disease (ad). 2021-06-21 2023-08-13 mouse
Hao Li, Nannan Li, Yingqi Tang, Jin Yong Le. Histidine Tautomeric Effect on the Key Fragment R3 of Tau Protein from Atomistic Simulations. ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:33978396. self-assembly of hyperphosphorylated tau proteins into neurofibrillary tangles (nft) is a hallmark of alzheimer's disease. 2021-06-21 2023-08-13 Not clear
Arpan Pradhan, Satyendra Mishra, Avadhesha Surolia, Dulal Pand. C1 Inhibits Liquid-Liquid Phase Separation and Oligomerization of Tau and Protects Neuroblastoma Cells against Toxic Tau Oligomers. ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:34008959. the pathological aggregation of tau is one of the major contributing factors for several neurodegenerative tauopathies, including alzheimer's disease. 2021-06-21 2023-08-13 Not clear
Anna Pasieka, Dawid Panek, Natalia Szałaj, Alba Espargaró, Anna Więckowska, Barbara Malawska, Raimon Sabaté, Marek Bajd. Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:34019757. dual inhibitors of amyloid-β and tau aggregation with amyloid-β disaggregating properties: extended in alzheimer's disease, neurons slowly degenerate due to the accumulation of misfolded amyloid β and tau proteins. 2021-06-21 2023-08-13 Not clear
Juan Carlos Polanco, Jürgen Göt. Exosomal and vesicle-free tau seeds-propagation and convergence in endolysosomal permeabilization. The FEBS journal. 2021-06-21. PMID:34092031. in alzheimer's disease (ad), β-amyloid peptides aggregate to form amyloid plaques, and the microtubule-associated protein tau forms neurofibrillary tangles. 2021-06-21 2023-08-13 Not clear
Shorena Janelidze, Sebastian Palmqvist, Antoine Leuzy, Erik Stomrud, Inge M W Verberk, Henrik Zetterberg, Nicholas J Ashton, Pedro Pesini, Leticia Sarasa, José Antonio Allué, Charlotte E Teunissen, Jeffrey L Dage, Kaj Blennow, Niklas Mattsson-Carlgren, Oskar Hansso. Detecting amyloid positivity in early Alzheimer's disease using combinations of plasma Aβ42/Aβ40 and p-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-06-21. PMID:34151519. we studied usefulness of combining blood amyloid beta (aβ)42/aβ40, phosphorylated tau (p-tau)217, and neurofilament light (nfl) to detect abnormal brain aβ deposition in different stages of early alzheimer's disease (ad). 2021-06-21 2023-08-13 Not clear
Ahmad Abu Turab Naqvi, Deeba Shamim Jairajpuri, Omar Mohammed Ali Noman, Afzal Hussain, Asimul Islam, Faizan Ahmad, Mohammed F Alajmi, Md Imtaiyaz Hassa. Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 38. issue 13. 2021-06-18. PMID:31512980. hyperphosphorylation of tau protein causes the formation of paired helical fragments and neurofibrillary tangles, the hallmarks of alzheimer's disease. 2021-06-18 2023-08-13 Not clear
Parveen Salahuddin, Rizwan Hasan Khan, Vladimir N Uversk. Comprehensive analysis of the molecular docking of small molecule inhibitors to the Aβ Journal of biomolecular structure & dynamics. vol 38. issue 15. 2021-06-18. PMID:31779527. comprehensive analysis of the molecular docking of small molecule inhibitors to the aβ alzheimer's disease (ad) is the most common form of age-related neurodegeneration occurs because of deposition of proteins in the form of extracellular plaques containing aggregated amyloid beta (aβ) peptide and intracellular neurofibrillary tangles composed of aggregated microtubule-binding protein tau. 2021-06-18 2023-08-13 Not clear
Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Par. Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations. Redox biology. vol 32. 2021-06-18. PMID:32046944. both the accumulation of amyloid-β (aβ) in plaques and phosphorylation of tau protein (p-tau) in neurofibrillary tangles have been identified as two major symptomatic features of alzheimer's disease (ad). 2021-06-18 2023-08-13 mouse
Azhaar Ashraf, Jérôme Jeandriens, Harold G Parkes, Po-Wah S. Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis. Redox biology. vol 32. 2021-06-18. PMID:32199332. iron dyshomeostasis is implicated in alzheimer's disease (ad) alongside β-amyloid and tau pathologies. 2021-06-18 2023-08-13 Not clear
Kimberly L Fiock, Martin E Smalley, John F Crary, Anca M Pasca, Marco M Heft. Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393582. although best known for its role in alzheimer's disease (ad), tau is expressed throughout brain development, although it remains unclear when and which cell types this expression occurs and how it affects disease states in both fetal and neonatal periods. 2021-06-18 2023-08-13 human
Swapna Bera, Nilanjan Gayen, Sk Abdul Mohid, Dipita Bhattacharyya, Janarthanan Krishnamoorthy, Dibakar Sarkar, Jihye Choi, Nirakar Sahoo, Atin K Mandal, DongKuk Lee, Anirban Bhuni. Comparison of Synthetic Neuronal Model Membrane Mimics in Amyloid Aggregation at Atomic Resolution. ACS chemical neuroscience. vol 11. issue 13. 2021-06-18. PMID:32492332. alzheimer's disease (ad) is a severe neurodegenerative disorder caused by abnormal accumulation of toxic amyloid plaques of the amyloid-beta (aβ) or the tau proteins in the brain. 2021-06-18 2023-08-13 Not clear
David J Townsend, Barbora Mala, Eleri Hughes, Rohanah Hussain, Giuliano Siligardi, Nigel J Fullwood, David A Middleto. Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation ACS chemical neuroscience. vol 11. issue 14. 2021-06-18. PMID:32520518. circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation potential drug treatments for alzheimer's disease (ad) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. 2021-06-18 2023-08-13 Not clear